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The map label for this gene is hom [H]

Identifier: 183219491

GI number: 183219491

Start: 64057

End: 65340

Strand: Reverse

Name: hom [H]

Synonym: LEPBI_I0064

Alternate gene names: 183219491

Gene position: 65340-64057 (Counterclockwise)

Preceding gene: 183219493

Following gene: 183219490

Centisome position: 1.82

GC content: 45.33

Gene sequence:

>1284_bases
ATGAAAGAAGTTCGTATTGGTCTATTGGGTGCCGGAGTTGTCGGCACAAGTCTACTCCAACTCTTGGACAAAAACCGAGA
AAAAATCCAACGTCAGTATGGAATCAACTTACAACTAACAGCCATCGCCACCCGTAGCCCGGGAAAACTCCAAGGAAAAA
CGAACGTTCCTGTGAGTGACGATGTACTTTCCGTTACGAAACGTTCGGATATTGATATGATTGTCGAATTGATGGGCGGA
ACTGACACAGCCTATACAGCCGTTCGTTCCGCACTGGAACATGGCAAAACAGTGATTACAGCCAACAAGGCATTGTTATC
TGAAAAAGGCCGCGAACTCTACGCCATTGCCGAGACATCAGGTGTTGAGATTGGATATGAGGCTGCTGTTGCCGGTTCGA
TTCCAATCATTCGGACCTTACGTGATGGACTTGCTTCTTGTGAATTTGAAGTGATCTGTGGGATTCTGAATGGAACCACC
AACTTTATTTTGACCAAAATGGAGCAAGAATCTTGGGACTATGCCACCGCCTTAAAAAAAGCCCAAGAACTCGGATTTGC
CGAGGCAGATCCTACCTTTGACGTAGAAGGCATTGATGCCGGTCATAAAATCAGCTTACTCGCAAGCCTCGCGTTTCGTG
AATCCGTCTCCTTTCAAACTGTCTCGGTCAAAGGGATCTCTGAATTACAATCCATGGACATCCAGGCAGCCCTCTCTCTC
GGTTACCGGATCAAACTTTTAGGAATCTCTAAACGAAGTTCGGCGGGAATTCTGACCAAGGTGCACCCAACTCTTGTCCC
ACTCGACCATCCACTTGCAAATGTCATGAATGAATCCAATGCGGTTTTTTATAAAACCAAAGAAGCGGATTCAGGAATGA
TCACGGGCAAAGGAGCTGGTGGTTTGCCAACAGCAAGTGCGGTACTTTCTGATATCATCTACTACGCTTCTCGACTTGGC
AGTCAAAACATTGCAAAAGAAAACAATTTGTTCCCTGAAGGAAAACGCTTCCCTGAACCTGAGAATTTAGTTCGTTATTA
CCTTCGTTTCTCTACTGTAGACAAACCTGGGGTGCTTGCAGAAATTTCCCAAGTCCTTGGCCGTCATAATATTTCCATTG
CATCCGTCCAACAAAAGGAATCCACTTCAGAACCAGTTTCCGTCATTGTGGTCACCCATGCGGCAACGGAAGGGGAATTC
CAAAAATCATTAATGGAAATTGATACCATGACAAATATCATCAAACAAAAGACAGTCGCTATCCGTCTCTTGGAGAACCT
TTAG

Upstream 100 bases:

>100_bases
CATAAAATCAGAAAAAGCTGAAGAACTTCTTCTCAAATTTGTTTTTTTTTAAAATTTTTTTAAGTGTGTTTCCGTTTCTC
CTAAGAAATCATGATCCTAG

Downstream 100 bases:

>100_bases
AATTATGGCAAAGTTTGAATTCCCTTCCCTTGTCATTGAAACAACTTCAATCGAGATCAAAGGGGAAGTGGTGCAATTGG
TATCGTTTGTAGGCCAAATC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MKEVRIGLLGAGVVGTSLLQLLDKNREKIQRQYGINLQLTAIATRSPGKLQGKTNVPVSDDVLSVTKRSDIDMIVELMGG
TDTAYTAVRSALEHGKTVITANKALLSEKGRELYAIAETSGVEIGYEAAVAGSIPIIRTLRDGLASCEFEVICGILNGTT
NFILTKMEQESWDYATALKKAQELGFAEADPTFDVEGIDAGHKISLLASLAFRESVSFQTVSVKGISELQSMDIQAALSL
GYRIKLLGISKRSSAGILTKVHPTLVPLDHPLANVMNESNAVFYKTKEADSGMITGKGAGGLPTASAVLSDIIYYASRLG
SQNIAKENNLFPEGKRFPEPENLVRYYLRFSTVDKPGVLAEISQVLGRHNISIASVQQKESTSEPVSVIVVTHAATEGEF
QKSLMEIDTMTNIIKQKTVAIRLLENL

Sequences:

>Translated_427_residues
MKEVRIGLLGAGVVGTSLLQLLDKNREKIQRQYGINLQLTAIATRSPGKLQGKTNVPVSDDVLSVTKRSDIDMIVELMGG
TDTAYTAVRSALEHGKTVITANKALLSEKGRELYAIAETSGVEIGYEAAVAGSIPIIRTLRDGLASCEFEVICGILNGTT
NFILTKMEQESWDYATALKKAQELGFAEADPTFDVEGIDAGHKISLLASLAFRESVSFQTVSVKGISELQSMDIQAALSL
GYRIKLLGISKRSSAGILTKVHPTLVPLDHPLANVMNESNAVFYKTKEADSGMITGKGAGGLPTASAVLSDIIYYASRLG
SQNIAKENNLFPEGKRFPEPENLVRYYLRFSTVDKPGVLAEISQVLGRHNISIASVQQKESTSEPVSVIVVTHAATEGEF
QKSLMEIDTMTNIIKQKTVAIRLLENL
>Mature_427_residues
MKEVRIGLLGAGVVGTSLLQLLDKNREKIQRQYGINLQLTAIATRSPGKLQGKTNVPVSDDVLSVTKRSDIDMIVELMGG
TDTAYTAVRSALEHGKTVITANKALLSEKGRELYAIAETSGVEIGYEAAVAGSIPIIRTLRDGLASCEFEVICGILNGTT
NFILTKMEQESWDYATALKKAQELGFAEADPTFDVEGIDAGHKISLLASLAFRESVSFQTVSVKGISELQSMDIQAALSL
GYRIKLLGISKRSSAGILTKVHPTLVPLDHPLANVMNESNAVFYKTKEADSGMITGKGAGGLPTASAVLSDIIYYASRLG
SQNIAKENNLFPEGKRFPEPENLVRYYLRFSTVDKPGVLAEISQVLGRHNISIASVQQKESTSEPVSVIVVTHAATEGEF
QKSLMEIDTMTNIIKQKTVAIRLLENL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322599, Length=266, Percent_Identity=27.8195488721804, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46119; Mature: 46119

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEVRIGLLGAGVVGTSLLQLLDKNREKIQRQYGINLQLTAIATRSPGKLQGKTNVPVSD
CCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCC
DVLSVTKRSDIDMIVELMGGTDTAYTAVRSALEHGKTVITANKALLSEKGRELYAIAETS
HHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECHHHHHHCCCEEEEEEECC
GVEIGYEAAVAGSIPIIRTLRDGLASCEFEVICGILNGTTNFILTKMEQESWDYATALKK
CCEECCHHEECCCCHHHHHHHHHHHCCCHHHEEEHHCCCCEEEEEECCHHCCHHHHHHHH
AQELGFAEADPTFDVEGIDAGHKISLLASLAFRESVSFQTVSVKGISELQSMDIQAALSL
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCC
GYRIKLLGISKRSSAGILTKVHPTLVPLDHPLANVMNESNAVFYKTKEADSGMITGKGAG
CEEEEEEEECCCCCCCCEEECCCCEECCCCHHHHHHCCCCEEEEEECCCCCCEEECCCCC
GLPTASAVLSDIIYYASRLGSQNIAKENNLFPEGKRFPEPENLVRYYLRFSTVDKPGVLA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHH
EISQVLGRHNISIASVQQKESTSEPVSVIVVTHAATEGEFQKSLMEIDTMTNIIKQKTVA
HHHHHHCCCCCEEEEEHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
IRLLENL
HHHHHCC
>Mature Secondary Structure
MKEVRIGLLGAGVVGTSLLQLLDKNREKIQRQYGINLQLTAIATRSPGKLQGKTNVPVSD
CCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCC
DVLSVTKRSDIDMIVELMGGTDTAYTAVRSALEHGKTVITANKALLSEKGRELYAIAETS
HHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECHHHHHHCCCEEEEEEECC
GVEIGYEAAVAGSIPIIRTLRDGLASCEFEVICGILNGTTNFILTKMEQESWDYATALKK
CCEECCHHEECCCCHHHHHHHHHHHCCCHHHEEEHHCCCCEEEEEECCHHCCHHHHHHHH
AQELGFAEADPTFDVEGIDAGHKISLLASLAFRESVSFQTVSVKGISELQSMDIQAALSL
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCC
GYRIKLLGISKRSSAGILTKVHPTLVPLDHPLANVMNESNAVFYKTKEADSGMITGKGAG
CEEEEEEEECCCCCCCCEEECCCCEECCCCHHHHHHCCCCEEEEEECCCCCCEEECCCCC
GLPTASAVLSDIIYYASRLGSQNIAKENNLFPEGKRFPEPENLVRYYLRFSTVDKPGVLA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHH
EISQVLGRHNISIASVQQKESTSEPVSVIVVTHAATEGEFQKSLMEIDTMTNIIKQKTVA
HHHHHHCCCCCEEEEEHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
IRLLENL
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]