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The map label for this gene is echA8 [H]

Identifier: 183219479

GI number: 183219479

Start: 51508

End: 52290

Strand: Reverse

Name: echA8 [H]

Synonym: LEPBI_I0052

Alternate gene names: 183219479

Gene position: 52290-51508 (Counterclockwise)

Preceding gene: 183219480

Following gene: 183219478

Centisome position: 1.45

GC content: 38.31

Gene sequence:

>783_bases
ATGAACTACAAAAGAGAAGTAATCGATTTACCTAATGGAAAAGGAGAAATCATTCGTTTTCAAATGAATGAACAAAACTC
ACTGACTGGCCAAAACATGAGAGACCTTGGTGAGATCTTAAAAGAAATCAAGGATGACCCTACCAAACGAGGTGTCATCT
TAGGAACAGACAATCCAAAATTTTTCTGTAACGGATTGGATGCAGAAAACCTTCTTTCTACACCGAAAGACAAACTCATT
GAAGAAGTAGGCGGTATTGTCATTCTCTTTGGAGAACTTGTGAAATTTGATAAACCTCTCATCACAGAAGTGACTGGTTA
TGCGATGGGTGGTGGTGCCGTGATCACTGTTGCATCCGATTTCAAATTCATGTTAGATGGGAAATGTCGAATTGGTTTTA
CAGAGGTAAATGTTGGACTCCCACTTCCTGGAAGTTTTATCGATCGGATCAAAATGTGTGTTGAACCAAGGTATTGGGCA
GAAGTTTGTTTAGAAGGTACAATCTATAAAGCTCCTGAAGCGAAAAAAATTGGTCTCATTGATGAAATTGCTTCCACACC
TGAAGAAGTAAGAAAACTCTCAGTAAAAAAATTAGAAACACTTTCCAAGGTACCTTCCTCCGCTTACCGTGCGACAAAAA
ACACCTTAAACGCTTCACTCCTTCGAAATTTGGAACAGTATAAAATCGACACGACCAAATCATTCGAACAACCAGGTGTT
GTTGATAATTTACTCGAAGCAATGACGGCTTTAAAAGAAAAAAGAAGACCTGTTTTCCAATAA

Upstream 100 bases:

>100_bases
AAGAGATAGAATCATAATCTTCCAATCAAAATACAGTATCCATCCAAGCGAAAAATAACAAATTCAAACCGATAGAAATT
TAAACCAAAAGAAGTAACCT

Downstream 100 bases:

>100_bases
CTTTTCTTCATTTAAATTCAGGGGATAAGAATTCTATTCCCTGAATTCTTATAAGTCTTTTCACCATAATTGCCGAAAAT
TATAGTGAAATCTGATGTTG

Product: putative enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MNYKREVIDLPNGKGEIIRFQMNEQNSLTGQNMRDLGEILKEIKDDPTKRGVILGTDNPKFFCNGLDAENLLSTPKDKLI
EEVGGIVILFGELVKFDKPLITEVTGYAMGGGAVITVASDFKFMLDGKCRIGFTEVNVGLPLPGSFIDRIKMCVEPRYWA
EVCLEGTIYKAPEAKKIGLIDEIASTPEEVRKLSVKKLETLSKVPSSAYRATKNTLNASLLRNLEQYKIDTTKSFEQPGV
VDNLLEAMTALKEKRRPVFQ

Sequences:

>Translated_260_residues
MNYKREVIDLPNGKGEIIRFQMNEQNSLTGQNMRDLGEILKEIKDDPTKRGVILGTDNPKFFCNGLDAENLLSTPKDKLI
EEVGGIVILFGELVKFDKPLITEVTGYAMGGGAVITVASDFKFMLDGKCRIGFTEVNVGLPLPGSFIDRIKMCVEPRYWA
EVCLEGTIYKAPEAKKIGLIDEIASTPEEVRKLSVKKLETLSKVPSSAYRATKNTLNASLLRNLEQYKIDTTKSFEQPGV
VDNLLEAMTALKEKRRPVFQ
>Mature_260_residues
MNYKREVIDLPNGKGEIIRFQMNEQNSLTGQNMRDLGEILKEIKDDPTKRGVILGTDNPKFFCNGLDAENLLSTPKDKLI
EEVGGIVILFGELVKFDKPLITEVTGYAMGGGAVITVASDFKFMLDGKCRIGFTEVNVGLPLPGSFIDRIKMCVEPRYWA
EVCLEGTIYKAPEAKKIGLIDEIASTPEEVRKLSVKKLETLSKVPSSAYRATKNTLNASLLRNLEQYKIDTTKSFEQPGV
VDNLLEAMTALKEKRRPVFQ

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI62530384, Length=217, Percent_Identity=23.963133640553, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI221142681, Length=252, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17554946, Length=236, Percent_Identity=26.271186440678, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24583165, Length=252, Percent_Identity=26.984126984127, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI20129971, Length=235, Percent_Identity=25.9574468085106, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24653477, Length=235, Percent_Identity=25.9574468085106, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24653139, Length=244, Percent_Identity=24.5901639344262, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19921018, Length=231, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 28995; Mature: 28995

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYKREVIDLPNGKGEIIRFQMNEQNSLTGQNMRDLGEILKEIKDDPTKRGVILGTDNPK
CCCCCCEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCC
FFCNGLDAENLLSTPKDKLIEEVGGIVILFGELVKFDKPLITEVTGYAMGGGAVITVASD
EEECCCCHHHHHCCCHHHHHHHHCCEEEEHHHHHHCCCCHHHHHHCEEECCCEEEEEECC
FKFMLDGKCRIGFTEVNVGLPLPGSFIDRIKMCVEPRYWAEVCLEGTIYKAPEAKKIGLI
CEEEECCCEEEEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHCCCEECCCCCCCCCHH
DEIASTPEEVRKLSVKKLETLSKVPSSAYRATKNTLNASLLRNLEQYKIDTTKSFEQPGV
HHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
VDNLLEAMTALKEKRRPVFQ
HHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNYKREVIDLPNGKGEIIRFQMNEQNSLTGQNMRDLGEILKEIKDDPTKRGVILGTDNPK
CCCCCCEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCC
FFCNGLDAENLLSTPKDKLIEEVGGIVILFGELVKFDKPLITEVTGYAMGGGAVITVASD
EEECCCCHHHHHCCCHHHHHHHHCCEEEEHHHHHHCCCCHHHHHHCEEECCCEEEEEECC
FKFMLDGKCRIGFTEVNVGLPLPGSFIDRIKMCVEPRYWAEVCLEGTIYKAPEAKKIGLI
CEEEECCCEEEEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHCCCEECCCCCCCCCHH
DEIASTPEEVRKLSVKKLETLSKVPSSAYRATKNTLNASLLRNLEQYKIDTTKSFEQPGV
HHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
VDNLLEAMTALKEKRRPVFQ
HHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]