Click here to switch to the map view.

The map label for this gene is add2 [H]

Identifier: 183219465

GI number: 183219465

Start: 38694

End: 40085

Strand: Direct

Name: add2 [H]

Synonym: LEPBI_I0038

Alternate gene names: 183219465

Gene position: 38694-40085 (Clockwise)

Preceding gene: 183219463

Following gene: 183219466

Centisome position: 1.07

GC content: 38.07

Gene sequence:

>1392_bases
TTGTATGCACTTACCAAATTCAGCATTCTTTCCTGGAACATGGAAGTTCCTTTTTCTGAAATCCTAAGCCGTATATCCGT
CATTGACCGTGACATTGCTGAACTCAATCGCTTAAAGAGTCGATTGCCAGCTGACAGGCCCTATTCGCCGACCATCCAAC
TTACCTTCGATAAACAAATCAACACCCTACTTAACGAAAGGGTGTCGCTCATGGAATTGCCTATCCTCCACCCACCGCTT
TGGTTACTGCCCAAAGAAGGAGCGGAAGGTTTAGAGCAAACAACACTACTCAAAGAAAGAAAATCACTGCTTGCAGGAGA
CCTTTCTGTTGCCCATCCAAACGAACAGGATGTCATCAACTTTATCCGAGAAATTCCCAAAACGGAAGTGCATTTGCATT
TAGAAGCCTGTGTAAACAAGGAAACTTTGAAATTCTTATACAAAAAAAATGGGATCGAAGTCACAGATCAGGAATTTGAA
GATAAGTACAATTTCAAAGATTTAAATGGTTTCATCCAAGTTTTCTTTTTTGTCCAAGGTTCAGTCAAAGAAGCATCCGA
CTTAGGTTACTTCATTGATAGTTTAGCAGATTATTTGCGATCCAATCACATTGTGTATTGTGAAGCCTTCTTCGCTCCAT
CAAAGTTCATCCAAAATGGTTTGGATTTTGATGAGATGGTAGAAGTGATGGTGAATCGTATTCGCCAAATTGAAGTGAAA
GATGGAATTTCTATTCGATTGTTAGTAGATGTTTCTCGTTCCTTTGGTCCAGAAAATGCAATGAACAACCTAAAACGTGT
TTTAGGTTTAAAACAGAAAGAAGTGATTGGTATTGGACTTGGTGGTGCGGAATTAATGGGCCCAGCAAAAGACTATGCTG
AAGTTTTTAAAATTGCAAGAGAGTCCGGTTTACGTTGTGTAGCTCACTCTGGTGAAGATGACGGCCCTTGGGCAATATGG
GATGCAGTTAATTTATGTAAGGCGGAAAGAATTGGACATGGCACATCAGCCATCCAAGACCCTGAACTTGTCCGTTACAT
GAAAGAAAACAAAATTCCAATTGAAATCTGTGTCACATCAAATGTTTTCACTGGAAAGTATGTTAGAAAAGAACAAAACC
ATCCAGTTCGATATTACTATGACCAAGGATTGATGCTTTGTATCAACACGGACGATCCTGATATTTTCAACGTAAATTTA
ACGTATGAATACTTTAAGTTGTACCGCTTTTTAGATTTTTCCATTGATGAACTCATTGATTTAGTAAGACAAGGTGTCCT
TTGCACCTTTCATCCAGAAAAAGAAACTCTTTGGAAATCAATGGAAGAAAAAATCGATTTAATTAAACTGAAGTATAACT
TAAATTCTGAAAAACAAGTATTGTCTGTTTAA

Upstream 100 bases:

>100_bases
AATTCGGAAAAAATTTCCAGTCTTTTCCGCTCCCAAACATCCTATCGACGGGAAAATTCAAAGCTAAATAGGGATTTTCA
CCCAAGGTTTAAAAATCTAC

Downstream 100 bases:

>100_bases
TCAGATAGTATAAATTTGATTTTCTTTTGGTGAATTAAAATGTCACATATTTCAATAAGTTTGCTCGTATGGATTCTTTT
TCTTTTTGGATGCCCTCTGT

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MYALTKFSILSWNMEVPFSEILSRISVIDRDIAELNRLKSRLPADRPYSPTIQLTFDKQINTLLNERVSLMELPILHPPL
WLLPKEGAEGLEQTTLLKERKSLLAGDLSVAHPNEQDVINFIREIPKTEVHLHLEACVNKETLKFLYKKNGIEVTDQEFE
DKYNFKDLNGFIQVFFFVQGSVKEASDLGYFIDSLADYLRSNHIVYCEAFFAPSKFIQNGLDFDEMVEVMVNRIRQIEVK
DGISIRLLVDVSRSFGPENAMNNLKRVLGLKQKEVIGIGLGGAELMGPAKDYAEVFKIARESGLRCVAHSGEDDGPWAIW
DAVNLCKAERIGHGTSAIQDPELVRYMKENKIPIEICVTSNVFTGKYVRKEQNHPVRYYYDQGLMLCINTDDPDIFNVNL
TYEYFKLYRFLDFSIDELIDLVRQGVLCTFHPEKETLWKSMEEKIDLIKLKYNLNSEKQVLSV

Sequences:

>Translated_463_residues
MYALTKFSILSWNMEVPFSEILSRISVIDRDIAELNRLKSRLPADRPYSPTIQLTFDKQINTLLNERVSLMELPILHPPL
WLLPKEGAEGLEQTTLLKERKSLLAGDLSVAHPNEQDVINFIREIPKTEVHLHLEACVNKETLKFLYKKNGIEVTDQEFE
DKYNFKDLNGFIQVFFFVQGSVKEASDLGYFIDSLADYLRSNHIVYCEAFFAPSKFIQNGLDFDEMVEVMVNRIRQIEVK
DGISIRLLVDVSRSFGPENAMNNLKRVLGLKQKEVIGIGLGGAELMGPAKDYAEVFKIARESGLRCVAHSGEDDGPWAIW
DAVNLCKAERIGHGTSAIQDPELVRYMKENKIPIEICVTSNVFTGKYVRKEQNHPVRYYYDQGLMLCINTDDPDIFNVNL
TYEYFKLYRFLDFSIDELIDLVRQGVLCTFHPEKETLWKSMEEKIDLIKLKYNLNSEKQVLSV
>Mature_463_residues
MYALTKFSILSWNMEVPFSEILSRISVIDRDIAELNRLKSRLPADRPYSPTIQLTFDKQINTLLNERVSLMELPILHPPL
WLLPKEGAEGLEQTTLLKERKSLLAGDLSVAHPNEQDVINFIREIPKTEVHLHLEACVNKETLKFLYKKNGIEVTDQEFE
DKYNFKDLNGFIQVFFFVQGSVKEASDLGYFIDSLADYLRSNHIVYCEAFFAPSKFIQNGLDFDEMVEVMVNRIRQIEVK
DGISIRLLVDVSRSFGPENAMNNLKRVLGLKQKEVIGIGLGGAELMGPAKDYAEVFKIARESGLRCVAHSGEDDGPWAIW
DAVNLCKAERIGHGTSAIQDPELVRYMKENKIPIEICVTSNVFTGKYVRKEQNHPVRYYYDQGLMLCINTDDPDIFNVNL
TYEYFKLYRFLDFSIDELIDLVRQGVLCTFHPEKETLWKSMEEKIDLIKLKYNLNSEKQVLSV

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family [H]

Homologues:

Organism=Homo sapiens, GI47078295, Length=355, Percent_Identity=23.943661971831, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI61175224, Length=245, Percent_Identity=24.4897959183673, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1787910, Length=291, Percent_Identity=28.8659793814433, Blast_Score=126, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17538512, Length=349, Percent_Identity=24.3553008595989, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32565969, Length=331, Percent_Identity=24.4712990936556, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI115537133, Length=325, Percent_Identity=25.2307692307692, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324188, Length=292, Percent_Identity=25.3424657534247, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24645260, Length=333, Percent_Identity=24.6246246246246, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001365
- InterPro:   IPR006330 [H]

Pfam domain/function: PF00962 A_deaminase [H]

EC number: =3.5.4.4 [H]

Molecular weight: Translated: 53285; Mature: 53285

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYALTKFSILSWNMEVPFSEILSRISVIDRDIAELNRLKSRLPADRPYSPTIQLTFDKQI
CCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECHHH
NTLLNERVSLMELPILHPPLWLLPKEGAEGLEQTTLLKERKSLLAGDLSVAHPNEQDVIN
HHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCEECCCCHHHHHH
FIREIPKTEVHLHLEACVNKETLKFLYKKNGIEVTDQEFEDKYNFKDLNGFIQVFFFVQG
HHHHCCCCEEEEEHHHHCCHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCC
SVKEASDLGYFIDSLADYLRSNHIVYCEAFFAPSKFIQNGLDFDEMVEVMVNRIRQIEVK
CCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHCCCCHHHHHHHHHHHHHEEEEC
DGISIRLLVDVSRSFGPENAMNNLKRVLGLKQKEVIGIGLGGAELMGPAKDYAEVFKIAR
CCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHCCCHHHHHHHHHHHH
ESGLRCVAHSGEDDGPWAIWDAVNLCKAERIGHGTSAIQDPELVRYMKENKIPIEICVTS
HCCCEEEECCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEEEEEC
NVFTGKYVRKEQNHPVRYYYDQGLMLCINTDDPDIFNVNLTYEYFKLYRFLDFSIDELID
CCCCCHHHHHCCCCCEEEEECCCEEEEEECCCCCEEEEEEHHHHHHHHHHHCCCHHHHHH
LVRQGVLCTFHPEKETLWKSMEEKIDLIKLKYNLNSEKQVLSV
HHHCCCEEEECCCHHHHHHHHHHHEEEEEEEECCCCCHHHHCC
>Mature Secondary Structure
MYALTKFSILSWNMEVPFSEILSRISVIDRDIAELNRLKSRLPADRPYSPTIQLTFDKQI
CCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECHHH
NTLLNERVSLMELPILHPPLWLLPKEGAEGLEQTTLLKERKSLLAGDLSVAHPNEQDVIN
HHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCEECCCCHHHHHH
FIREIPKTEVHLHLEACVNKETLKFLYKKNGIEVTDQEFEDKYNFKDLNGFIQVFFFVQG
HHHHCCCCEEEEEHHHHCCHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCC
SVKEASDLGYFIDSLADYLRSNHIVYCEAFFAPSKFIQNGLDFDEMVEVMVNRIRQIEVK
CCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHCCCCHHHHHHHHHHHHHEEEEC
DGISIRLLVDVSRSFGPENAMNNLKRVLGLKQKEVIGIGLGGAELMGPAKDYAEVFKIAR
CCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHCCCHHHHHHHHHHHH
ESGLRCVAHSGEDDGPWAIWDAVNLCKAERIGHGTSAIQDPELVRYMKENKIPIEICVTS
HCCCEEEECCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEEEEEC
NVFTGKYVRKEQNHPVRYYYDQGLMLCINTDDPDIFNVNLTYEYFKLYRFLDFSIDELID
CCCCCHHHHHCCCCCEEEEECCCEEEEEECCCCCEEEEEEHHHHHHHHHHHCCCHHHHHH
LVRQGVLCTFHPEKETLWKSMEEKIDLIKLKYNLNSEKQVLSV
HHHCCCEEEECCCHHHHHHHHHHHEEEEEEEECCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA