Click here to switch to the map view.

The map label for this gene is gyrA1 [H]

Identifier: 183219433

GI number: 183219433

Start: 6272

End: 8803

Strand: Direct

Name: gyrA1 [H]

Synonym: LEPBI_I0006

Alternate gene names: 183219433

Gene position: 6272-8803 (Clockwise)

Preceding gene: 183219432

Following gene: 183219434

Centisome position: 0.17

GC content: 40.17

Gene sequence:

>2532_bases
ATGACCGAACAAAACGGCCAAGAAAACGAATCAAACAAAACCTTAGCACTCAATTTATCCGGTAGACCAGACGTAGCCGG
TGCTTTAAAAGCTGGTGTCAGGGTCATTCCGGTTGAAATTGAAGACCAAATGAAGGAAGCTTACCTTGATTATGCGATGA
GTGTCATCGTGGGTCGAGCACTTCCTGATGTGCGAGATGGTTTAAAACCAGTCCATAGACGTGTCCTCCATGCGATGAAC
GAAAGAGCCTGGAGATCTGACAGACCTTACGTCAAGTCGGCAAAGATTGTTGGGGAAGTGATTGGTAACTATCACCCTCA
TGGTGACTCTGCAGTATATGAAACAATGGTTCGTATGGCGCAAACTTTTTCCATGCGAGAGACATTGATTGATGGCCAAG
GTAACTTTGGATCTGTCGATGGTGACAATGCGGCGGCATATCGGTATACAGAAGCTCGTCTGACAAAACTTGCAGAAGAA
CTTCTCAAAGACATCGAAAAAAACACAGTAAGTTTTTCCCCTAACTTTGATGATACGAGACAACAACCTGATGTTTTACC
TGCTAATTTTCCAAATATTTTAGTCAATGGTTCCACAGGGATTGCGGTCGGAATGGCAACAAACATTCCTCCTCACAACT
TAAAAGAAGCGGTGAATGCAGTCATCGCCCTGATACAAAATCCGGATATCACTCTTCCTGAATTAATGAAAATTTTACCT
GGTCCAGATTTTCCAACAGGTGGAACCATCATTGGTGGAGAAGGACTTTACCAAGCATATGCAACGGGTAAAGGATCCAT
TCGTATTCGATCGAAAGTTGATATCATCGAAAATAACAAAGGTCGCGAGATCATTGTCATTCATGAAATTCCATACCAAG
TGAACAAAAAAAACATGTTGGAAAAGATTGGAGATTTGGTGAATGAAAAAATCATCGAAGGTATCTCTGAAATTTTAGAT
TTGTCGGATCGAAAAGGGATCCGAGTTGAGATCCATGTTAAAAAAGATGCAAACGCACAAGTGATTTTAAACCAACTTTT
TAAACTGACCCAACTGCAAGTCAGTTATGGAATCACCATGCTTGCGATTTTGGACAACCGTCCAAAAATCTTTTCACTCA
AAGAAATTTTAAAATCTTACGCAGAACATAGGCGAGAAGTTGTTGTCAAACGGACTGAGTTTGATTTAGACAAGGCGCAA
AAACGTGCACATATCTTAGAAGGTTTAAGGATTGCTCTCGAAAATATCGATGAAGTGATTCGTATTATCCGGGCTTCTAA
AGATGTAAGAGAAGCGCAAAGTTCCCTTATGGCAACGTTTTCTTTGTCAGAATTGCAAGCTGATGCCATTCTTGAAATGC
GACTACAAAGATTAACTTCTTTGGAAGTCCAAAAGATCATCGATGAATTGGAGCAGGTTCGAATATTGATCGCTGATCTT
GAAGATATTCTATCAAAACCTGATCGAGTGAAATCAATCATTTGTGATGAACTTGGGAAAGTATCTCAATCTTTTGGAAA
TACTCGCACAACAGAAATTAGTTTAGAATCGCTCGAGTCTTCCACGTTTAACGCAGAAGATTTGATTGCCGATGAAGAAG
TGGTTGTCCAACTTTCCGAAGACATGTTCATCAAACGGCTTCCTATGGATACCTTCCGTCGCCAAAAACGAGGTGGAAAG
GGAGTTCAAGGGATCTCGACCAAACGAGAAGACTTTGTCAAAAAACTAAGTAGTGCCATGACTCATGATAACTTGATGCT
TTTTTCCAATAAAGGCCGAGCATTCCTACTAAAAGTATATGAGTTACCGATTGCGACAAAAGAAGCACGTGGAAAATCAC
TAAAAGCAGTTATTAATTTGAATGATGATGAAATCATCACTTCATTGTTTACCTTTAGAAACTTTGATGAGTCGTATCTC
CTTATGGTAACGAGAGAAGGTTTTGTGAAAAAAATCCAATTGGATGAGTTCACAAACACAAAAAAATCGGGAATCATTGC
GATTGGTCTCAGAGATGGAGATGAACTCATTGATGTAATTGCCAATCCAAATAACTACGATGTATTCATTGGTAGTAAAA
ATGGTCTGGCGATTCGTATGAACCTGAATGAACTGAGATCACAGGGACGTACAGCTTCTGGTGTCACGGCAATGAAATTG
GAAGATGATGATTCCATTGCTGGCATTACAAAAGTAGAACCTAATACTAATTTGTTTTGTATTTCCGAAAATGGATTTGG
AAAACGAACTGACTTTGAAGAGTTTTCCACCAAAGGTCGAGGTGGGAAAGGGATGACATATCTTAAGATCGGTGAAAAGA
ATGGACGTGCTGTTGGTATCTCTTCTGTGAAAGAAGAAGACGAACTACTTGTCATCACTCAATCCGGTATGGCAATTCGA
GTGGAAGTTAAAACCATTTCGATGGTAGGAAGGTCAGCAATGGGTGTCAAAGTAGTGAATACGAAAGACGAAGACTTTGT
GAAAGATTTTGCCGTCGTTCGAGAATCGGATTCGGACTCCGCTGAGTCTTAA

Upstream 100 bases:

>100_bases
ATCCTAATGGGTGATGAAGTGTCTCCTCGTCGTCGTTTCATTGAAGCGAATTCTTACAAAGTAGCAAATTTAGATCTTTA
ATCGGAATTAGGAAAATCAA

Downstream 100 bases:

>100_bases
TTAGGAAATCAAAATGGTAAGGGTAGGAAATGTAATCATCGAAGGAGACGTTGCCTTGTCTCCGATGGCTGGAATTTCTG
ATAGCCCTTACCGCCAGATC

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 843; Mature: 842

Protein sequence:

>843_residues
MTEQNGQENESNKTLALNLSGRPDVAGALKAGVRVIPVEIEDQMKEAYLDYAMSVIVGRALPDVRDGLKPVHRRVLHAMN
ERAWRSDRPYVKSAKIVGEVIGNYHPHGDSAVYETMVRMAQTFSMRETLIDGQGNFGSVDGDNAAAYRYTEARLTKLAEE
LLKDIEKNTVSFSPNFDDTRQQPDVLPANFPNILVNGSTGIAVGMATNIPPHNLKEAVNAVIALIQNPDITLPELMKILP
GPDFPTGGTIIGGEGLYQAYATGKGSIRIRSKVDIIENNKGREIIVIHEIPYQVNKKNMLEKIGDLVNEKIIEGISEILD
LSDRKGIRVEIHVKKDANAQVILNQLFKLTQLQVSYGITMLAILDNRPKIFSLKEILKSYAEHRREVVVKRTEFDLDKAQ
KRAHILEGLRIALENIDEVIRIIRASKDVREAQSSLMATFSLSELQADAILEMRLQRLTSLEVQKIIDELEQVRILIADL
EDILSKPDRVKSIICDELGKVSQSFGNTRTTEISLESLESSTFNAEDLIADEEVVVQLSEDMFIKRLPMDTFRRQKRGGK
GVQGISTKREDFVKKLSSAMTHDNLMLFSNKGRAFLLKVYELPIATKEARGKSLKAVINLNDDEIITSLFTFRNFDESYL
LMVTREGFVKKIQLDEFTNTKKSGIIAIGLRDGDELIDVIANPNNYDVFIGSKNGLAIRMNLNELRSQGRTASGVTAMKL
EDDDSIAGITKVEPNTNLFCISENGFGKRTDFEEFSTKGRGGKGMTYLKIGEKNGRAVGISSVKEEDELLVITQSGMAIR
VEVKTISMVGRSAMGVKVVNTKDEDFVKDFAVVRESDSDSAES

Sequences:

>Translated_843_residues
MTEQNGQENESNKTLALNLSGRPDVAGALKAGVRVIPVEIEDQMKEAYLDYAMSVIVGRALPDVRDGLKPVHRRVLHAMN
ERAWRSDRPYVKSAKIVGEVIGNYHPHGDSAVYETMVRMAQTFSMRETLIDGQGNFGSVDGDNAAAYRYTEARLTKLAEE
LLKDIEKNTVSFSPNFDDTRQQPDVLPANFPNILVNGSTGIAVGMATNIPPHNLKEAVNAVIALIQNPDITLPELMKILP
GPDFPTGGTIIGGEGLYQAYATGKGSIRIRSKVDIIENNKGREIIVIHEIPYQVNKKNMLEKIGDLVNEKIIEGISEILD
LSDRKGIRVEIHVKKDANAQVILNQLFKLTQLQVSYGITMLAILDNRPKIFSLKEILKSYAEHRREVVVKRTEFDLDKAQ
KRAHILEGLRIALENIDEVIRIIRASKDVREAQSSLMATFSLSELQADAILEMRLQRLTSLEVQKIIDELEQVRILIADL
EDILSKPDRVKSIICDELGKVSQSFGNTRTTEISLESLESSTFNAEDLIADEEVVVQLSEDMFIKRLPMDTFRRQKRGGK
GVQGISTKREDFVKKLSSAMTHDNLMLFSNKGRAFLLKVYELPIATKEARGKSLKAVINLNDDEIITSLFTFRNFDESYL
LMVTREGFVKKIQLDEFTNTKKSGIIAIGLRDGDELIDVIANPNNYDVFIGSKNGLAIRMNLNELRSQGRTASGVTAMKL
EDDDSIAGITKVEPNTNLFCISENGFGKRTDFEEFSTKGRGGKGMTYLKIGEKNGRAVGISSVKEEDELLVITQSGMAIR
VEVKTISMVGRSAMGVKVVNTKDEDFVKDFAVVRESDSDSAES
>Mature_842_residues
TEQNGQENESNKTLALNLSGRPDVAGALKAGVRVIPVEIEDQMKEAYLDYAMSVIVGRALPDVRDGLKPVHRRVLHAMNE
RAWRSDRPYVKSAKIVGEVIGNYHPHGDSAVYETMVRMAQTFSMRETLIDGQGNFGSVDGDNAAAYRYTEARLTKLAEEL
LKDIEKNTVSFSPNFDDTRQQPDVLPANFPNILVNGSTGIAVGMATNIPPHNLKEAVNAVIALIQNPDITLPELMKILPG
PDFPTGGTIIGGEGLYQAYATGKGSIRIRSKVDIIENNKGREIIVIHEIPYQVNKKNMLEKIGDLVNEKIIEGISEILDL
SDRKGIRVEIHVKKDANAQVILNQLFKLTQLQVSYGITMLAILDNRPKIFSLKEILKSYAEHRREVVVKRTEFDLDKAQK
RAHILEGLRIALENIDEVIRIIRASKDVREAQSSLMATFSLSELQADAILEMRLQRLTSLEVQKIIDELEQVRILIADLE
DILSKPDRVKSIICDELGKVSQSFGNTRTTEISLESLESSTFNAEDLIADEEVVVQLSEDMFIKRLPMDTFRRQKRGGKG
VQGISTKREDFVKKLSSAMTHDNLMLFSNKGRAFLLKVYELPIATKEARGKSLKAVINLNDDEIITSLFTFRNFDESYLL
MVTREGFVKKIQLDEFTNTKKSGIIAIGLRDGDELIDVIANPNNYDVFIGSKNGLAIRMNLNELRSQGRTASGVTAMKLE
DDDSIAGITKVEPNTNLFCISENGFGKRTDFEEFSTKGRGGKGMTYLKIGEKNGRAVGISSVKEEDELLVITQSGMAIRV
EVKTISMVGRSAMGVKVVNTKDEDFVKDFAVVRESDSDSAES

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=349, Percent_Identity=25.7879656160458, Blast_Score=90, Evalue=8e-18,
Organism=Homo sapiens, GI19913406, Length=183, Percent_Identity=32.2404371584699, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1788562, Length=830, Percent_Identity=46.3855421686747, Blast_Score=746, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=650, Percent_Identity=36.3076923076923, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17535065, Length=173, Percent_Identity=34.1040462427746, Blast_Score=84, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI212645657, Length=372, Percent_Identity=25.8064516129032, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI115534553, Length=169, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=176, Percent_Identity=31.25, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17136538, Length=353, Percent_Identity=24.0793201133144, Blast_Score=76, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 93820; Mature: 93689

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQNGQENESNKTLALNLSGRPDVAGALKAGVRVIPVEIEDQMKEAYLDYAMSVIVGRA
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHC
LPDVRDGLKPVHRRVLHAMNERAWRSDRPYVKSAKIVGEVIGNYHPHGDSAVYETMVRMA
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
QTFSMRETLIDGQGNFGSVDGDNAAAYRYTEARLTKLAEELLKDIEKNTVSFSPNFDDTR
HHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCEEEECCCCCCCC
QQPDVLPANFPNILVNGSTGIAVGMATNIPPHNLKEAVNAVIALIQNPDITLPELMKILP
CCCCCCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCC
GPDFPTGGTIIGGEGLYQAYATGKGSIRIRSKVDIIENNKGREIIVIHEIPYQVNKKNML
CCCCCCCCEEECCCCHHHHHCCCCCCEEEEEEEEEEECCCCCEEEEEECCCCCCCHHHHH
EKIGDLVNEKIIEGISEILDLSDRKGIRVEIHVKKDANAQVILNQLFKLTQLQVSYGITM
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCEEE
LAILDNRPKIFSLKEILKSYAEHRREVVVKRTEFDLDKAQKRAHILEGLRIALENIDEVI
EEEECCCCCEEHHHHHHHHHHHHHHHEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
RIIRASKDVREAQSSLMATFSLSELQADAILEMRLQRLTSLEVQKIIDELEQVRILIADL
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDILSKPDRVKSIICDELGKVSQSFGNTRTTEISLESLESSTFNAEDLIADEEVVVQLSE
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCHHHHCCCCHHHEEEHH
DMFIKRLPMDTFRRQKRGGKGVQGISTKREDFVKKLSSAMTHDNLMLFSNKGRAFLLKVY
HHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEE
ELPIATKEARGKSLKAVINLNDDEIITSLFTFRNFDESYLLMVTREGFVKKIQLDEFTNT
ECCCCCHHCCCCCEEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEHHHHCCC
KKSGIIAIGLRDGDELIDVIANPNNYDVFIGSKNGLAIRMNLNELRSQGRTASGVTAMKL
CCCCEEEEEECCCHHHHHHHCCCCCEEEEEECCCCEEEEEEHHHHHHCCCCCCCEEEEEE
EDDDSIAGITKVEPNTNLFCISENGFGKRTDFEEFSTKGRGGKGMTYLKIGEKNGRAVGI
CCCCCCCCEEEECCCCCEEEEECCCCCCCCCHHHHHCCCCCCCCEEEEEEECCCCCEEEC
SSVKEEDELLVITQSGMAIRVEVKTISMVGRSAMGVKVVNTKDEDFVKDFAVVRESDSDS
CCCCCCCCEEEEEECCCEEEEEEEEEEHHCCCCCCEEEECCCCHHHHHHHHHHCCCCCCC
AES
CCC
>Mature Secondary Structure 
TEQNGQENESNKTLALNLSGRPDVAGALKAGVRVIPVEIEDQMKEAYLDYAMSVIVGRA
CCCCCCCCCCCCEEEEEECCCCCHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHC
LPDVRDGLKPVHRRVLHAMNERAWRSDRPYVKSAKIVGEVIGNYHPHGDSAVYETMVRMA
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
QTFSMRETLIDGQGNFGSVDGDNAAAYRYTEARLTKLAEELLKDIEKNTVSFSPNFDDTR
HHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCEEEECCCCCCCC
QQPDVLPANFPNILVNGSTGIAVGMATNIPPHNLKEAVNAVIALIQNPDITLPELMKILP
CCCCCCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCC
GPDFPTGGTIIGGEGLYQAYATGKGSIRIRSKVDIIENNKGREIIVIHEIPYQVNKKNML
CCCCCCCCEEECCCCHHHHHCCCCCCEEEEEEEEEEECCCCCEEEEEECCCCCCCHHHHH
EKIGDLVNEKIIEGISEILDLSDRKGIRVEIHVKKDANAQVILNQLFKLTQLQVSYGITM
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCEEE
LAILDNRPKIFSLKEILKSYAEHRREVVVKRTEFDLDKAQKRAHILEGLRIALENIDEVI
EEEECCCCCEEHHHHHHHHHHHHHHHEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
RIIRASKDVREAQSSLMATFSLSELQADAILEMRLQRLTSLEVQKIIDELEQVRILIADL
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDILSKPDRVKSIICDELGKVSQSFGNTRTTEISLESLESSTFNAEDLIADEEVVVQLSE
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCHHHHCCCCHHHEEEHH
DMFIKRLPMDTFRRQKRGGKGVQGISTKREDFVKKLSSAMTHDNLMLFSNKGRAFLLKVY
HHHHHHCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEE
ELPIATKEARGKSLKAVINLNDDEIITSLFTFRNFDESYLLMVTREGFVKKIQLDEFTNT
ECCCCCHHCCCCCEEEEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEHHHHCCC
KKSGIIAIGLRDGDELIDVIANPNNYDVFIGSKNGLAIRMNLNELRSQGRTASGVTAMKL
CCCCEEEEEECCCHHHHHHHCCCCCEEEEEECCCCEEEEEEHHHHHHCCCCCCCEEEEEE
EDDDSIAGITKVEPNTNLFCISENGFGKRTDFEEFSTKGRGGKGMTYLKIGEKNGRAVGI
CCCCCCCCEEEECCCCCEEEEECCCCCCCCCHHHHHCCCCCCCCEEEEEEECCCCCEEEC
SSVKEEDELLVITQSGMAIRVEVKTISMVGRSAMGVKVVNTKDEDFVKDFAVVRESDSDS
CCCCCCCCEEEEEECCCEEEEEEEEEEHHCCCCCCEEEECCCCHHHHHHHHHHCCCCCCC
AES
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]