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The map label for this gene is ptxR [H]

Identifier: 182677612

GI number: 182677612

Start: 699934

End: 700839

Strand: Direct

Name: ptxR [H]

Synonym: Bind_0619

Alternate gene names: 182677612

Gene position: 699934-700839 (Clockwise)

Preceding gene: 182677605

Following gene: 182677618

Centisome position: 16.78

GC content: 54.19

Gene sequence:

>906_bases
ATGAGCGATTTCGATTGGAATAGTTTGCGCTCCTTTCTGGCTGTCGCCCGAACCGGGCGATTGACGACCGCTGCACGCAC
ACTTGGGGTCGATCATACGACACTCAGCCGTCGTATCGCCGGATTGGAAGAGGCCCTCAAAGTCAAATTGTTCGAGCGTC
ATCCCTCTGGCTATCGATTGACGAATGCAGGAGACCGGTTGCTGCTTTCAGCCGAAACGATGGAAAGCATCGCCTTGACC
ACGCAGAGTCAGATCGGGGGAGAAGATCTGGCCGTGACAGGTGCTGTGCGAATCGGCGCGCCGGAAGGGTTCGGCAGCAA
TTTTCTGGCATCCCGCATTGCCGCTCTCTGCCATCAACATCCGCAATTGGAGATTCAACTCGTGGCCATGCCACGTTTGT
TCAGCCTGTCGAAACGCGAGGCCGATATAGCAATCAGTCTCGCTCCCCCACGTGAAGGCCGGCTCGTGGCGCGTAAACTC
ACTGATTACCGGCTACGGCTTTATGCGGCACCGGCCTATTTGGCGACACTGCCCCCTATAAAGTCTATTGAAGATCTACG
GGACTGCCGGTTCATCGGCTATATCGATGATTTGATTTATAGCCAGGAACTCGATTATCTGGGAGAAATCGCCAGTTTTT
TGTCGCCCCAACTCAAGAGCGCAAATCTGATCGCCCAACTCAATGCGGCTATTACAGGAACGGGGATTTGTGTGTTACCG
GACTTCATCGCTCGCGGCTGTGAAGGACTCGTCCCTGTTCTCCCCAGTCAAGTCAGTCTGATGCGCTCGTTCTGGCTGGT
TACCCATGCCGATTTGCGTGGCTTGGCCCGGATTAAAACGGTTTCCGCCTTCATTAGCAACGAAGTCAAAACTGCTCAGG
CATTGTTCAAGCCGTGTGATGATTGA

Upstream 100 bases:

>100_bases
TCGGGTGGCTTTGATGCATTATCTTTATATTGGTGATATTCCACGGCAATACGATTTTCCTCAAACCTATTGTGCGTCAA
TCCACATACCGGAGTTCCAG

Downstream 100 bases:

>100_bases
AATGGATCATGGAAGTTTTCTCGGCAGATCGCACATGATCTTCAATTTGTTTCGTAGCGTACGCGCGAAAAACTTGTGTT
TTACAAGTCTTTCCGAAATT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MSDFDWNSLRSFLAVARTGRLTTAARTLGVDHTTLSRRIAGLEEALKVKLFERHPSGYRLTNAGDRLLLSAETMESIALT
TQSQIGGEDLAVTGAVRIGAPEGFGSNFLASRIAALCHQHPQLEIQLVAMPRLFSLSKREADIAISLAPPREGRLVARKL
TDYRLRLYAAPAYLATLPPIKSIEDLRDCRFIGYIDDLIYSQELDYLGEIASFLSPQLKSANLIAQLNAAITGTGICVLP
DFIARGCEGLVPVLPSQVSLMRSFWLVTHADLRGLARIKTVSAFISNEVKTAQALFKPCDD

Sequences:

>Translated_301_residues
MSDFDWNSLRSFLAVARTGRLTTAARTLGVDHTTLSRRIAGLEEALKVKLFERHPSGYRLTNAGDRLLLSAETMESIALT
TQSQIGGEDLAVTGAVRIGAPEGFGSNFLASRIAALCHQHPQLEIQLVAMPRLFSLSKREADIAISLAPPREGRLVARKL
TDYRLRLYAAPAYLATLPPIKSIEDLRDCRFIGYIDDLIYSQELDYLGEIASFLSPQLKSANLIAQLNAAITGTGICVLP
DFIARGCEGLVPVLPSQVSLMRSFWLVTHADLRGLARIKTVSAFISNEVKTAQALFKPCDD
>Mature_300_residues
SDFDWNSLRSFLAVARTGRLTTAARTLGVDHTTLSRRIAGLEEALKVKLFERHPSGYRLTNAGDRLLLSAETMESIALTT
QSQIGGEDLAVTGAVRIGAPEGFGSNFLASRIAALCHQHPQLEIQLVAMPRLFSLSKREADIAISLAPPREGRLVARKLT
DYRLRLYAAPAYLATLPPIKSIEDLRDCRFIGYIDDLIYSQELDYLGEIASFLSPQLKSANLIAQLNAAITGTGICVLPD
FIARGCEGLVPVLPSQVSLMRSFWLVTHADLRGLARIKTVSAFISNEVKTAQALFKPCDD

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786401, Length=292, Percent_Identity=26.3698630136986, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1789440, Length=306, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081978, Length=181, Percent_Identity=32.0441988950276, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787601, Length=284, Percent_Identity=23.2394366197183, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI157672245, Length=251, Percent_Identity=29.0836653386454, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789173, Length=297, Percent_Identity=25.2525252525253, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32942; Mature: 32811

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFDWNSLRSFLAVARTGRLTTAARTLGVDHTTLSRRIAGLEEALKVKLFERHPSGYRL
CCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
TNAGDRLLLSAETMESIALTTQSQIGGEDLAVTGAVRIGAPEGFGSNFLASRIAALCHQH
CCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHCC
PQLEIQLVAMPRLFSLSKREADIAISLAPPREGRLVARKLTDYRLRLYAAPAYLATLPPI
CCEEEEEEECCHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHEEEEEECCHHHHHCCCH
KSIEDLRDCRFIGYIDDLIYSQELDYLGEIASFLSPQLKSANLIAQLNAAITGTGICVLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEH
DFIARGCEGLVPVLPSQVSLMRSFWLVTHADLRGLARIKTVSAFISNEVKTAQALFKPCD
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
D
C
>Mature Secondary Structure 
SDFDWNSLRSFLAVARTGRLTTAARTLGVDHTTLSRRIAGLEEALKVKLFERHPSGYRL
CCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
TNAGDRLLLSAETMESIALTTQSQIGGEDLAVTGAVRIGAPEGFGSNFLASRIAALCHQH
CCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHCC
PQLEIQLVAMPRLFSLSKREADIAISLAPPREGRLVARKLTDYRLRLYAAPAYLATLPPI
CCEEEEEEECCHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHEEEEEECCHHHHHCCCH
KSIEDLRDCRFIGYIDDLIYSQELDYLGEIASFLSPQLKSANLIAQLNAAITGTGICVLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEH
DFIARGCEGLVPVLPSQVSLMRSFWLVTHADLRGLARIKTVSAFISNEVKTAQALFKPCD
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]