Click here to switch to the map view.

The map label for this gene is pcoA [H]

Identifier: 182677312

GI number: 182677312

Start: 359916

End: 361274

Strand: Direct

Name: pcoA [H]

Synonym: Bind_0315

Alternate gene names: 182677312

Gene position: 359916-361274 (Clockwise)

Preceding gene: 182677311

Following gene: 182677313

Centisome position: 8.63

GC content: 61.3

Gene sequence:

>1359_bases
ATGGCAGAGACTAAAGGGGTTTCCCGTCGGCATGTTCTTGGCGGTGGCGGGCTCGTCCTGGCCTCGGCCGCGATGATCGG
GAGCCGCGCCGAGGCGGCAAGCCTGCCCGAGGCACCGATCATGCGCGAGACAACAATGCAGCCCCCGCTCCATCCCGCGA
GCGGGCCGGATTATCATCCGGTCGTCACGCTGAATGGCTGGAGCCTGCCCTTCCGCATGAATGGCGATTGGAAGGAATTT
CACCTTCTCGCCGAGCCGGTCGTGCGGGAAATGGCCCCTGGCATGAAGGCCAATCTCTGGGGCTATAACGGCCAGAGCCC
GGGTCCGACCATCGAGGCGGTCGAGGGCGACAAGGTTCGCATCTTTGTGACCAATCATCTGCCCGAGGCGACGAGCGTGC
ATTGGCATGGCATCGAACTGCCAAGTGGCATGGATGGTGTCGCGGGCCTCACCCAGCCCGGCATTCCGCCGGGCAAGACC
TTCGCCTATGAATTCGTGCTGCCGCGCTCCGGTACCTTCATGTATCACCCGCATGCGGATGAAATGGTCCAGATGGCGAT
GGGCATGATGGGTTCTTTCGTCGTGCATCCGCGCGATCCCGATTTCCGCCGCGTTGATCGCGATTTCATTTTCCTCCTGT
CGACCTATGCGGTCGATCCCGGCAGTTATACGCCGCGCGTCAATGAAATGACTGATTTCAGCCTGTGGACGTTCAATTCG
CGCGTCTTTCCAGGCATTGATCCCTTGCCTGTGCGGCAGGGCGATCAAGTGCGCATCCGCATCGGCAATCTCTCCATGAC
CAATCATCCGATCCACATTCACGGGACGCATTTCCGCGTCACCGGTACGGATGGCGGCTGGGTCGATCCTGCCGCCTCCT
GGCCCGAGGTCACGGTCGATATGGCGGTTGGGCAGATGCGGGCAATCGAATTTTCAGCGGACAATCCCGGCGATTGGGCG
ATGCATTGCCATAAGTCGCATCATACGATGAATCCGATGGGCCATCAGGTCCGTACTTACATTGGCGTCGATCTGAAACA
GACGGCCAAGGCCCTGCGCAAATTGGCGCCCGATTACATGCCGATGGGCTCAACCGGCGGTGGTTCCATGGCCGAGATGG
AAATGCCCCTGCCACGCAATACACTGCCGATGATGACGGGCGATGGCCCCTTCGGTTCGGTCGAGATGGGCGGCATGTTT
ACCACCATCAAGATCCGGCCGGATCTCGCCCCTGGCGATTATCGCGATCCCGGCTGGTATCGGCACCCGCAAGGCACTGT
CGCCTATGAATGGCGCGGTGACGCTCCCGCCACTCCTCCCACCATGCCGCCCCGCCACGGCGGACATACCAAGCGTTGA

Upstream 100 bases:

>100_bases
ATCTCGCAGCGGCGACTTATGGCGGCGGCTTTGGGGGCGGTGGTCCCTCCAGCGTGGCGACGAGCAGCACAGCTGCGGCA
AATTGAGAGAGGAGCCTCCC

Downstream 100 bases:

>100_bases
CACTCCTCCTCGACAAACCAGGGCAATGATCATGTCTCTCCGTCTTCTTTTTACCTCCGCCGCAATCGCTTGTCTGGTAT
TTGCCGCCCCCGCTTCCTGC

Product: multicopper oxidase type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MAETKGVSRRHVLGGGGLVLASAAMIGSRAEAASLPEAPIMRETTMQPPLHPASGPDYHPVVTLNGWSLPFRMNGDWKEF
HLLAEPVVREMAPGMKANLWGYNGQSPGPTIEAVEGDKVRIFVTNHLPEATSVHWHGIELPSGMDGVAGLTQPGIPPGKT
FAYEFVLPRSGTFMYHPHADEMVQMAMGMMGSFVVHPRDPDFRRVDRDFIFLLSTYAVDPGSYTPRVNEMTDFSLWTFNS
RVFPGIDPLPVRQGDQVRIRIGNLSMTNHPIHIHGTHFRVTGTDGGWVDPAASWPEVTVDMAVGQMRAIEFSADNPGDWA
MHCHKSHHTMNPMGHQVRTYIGVDLKQTAKALRKLAPDYMPMGSTGGGSMAEMEMPLPRNTLPMMTGDGPFGSVEMGGMF
TTIKIRPDLAPGDYRDPGWYRHPQGTVAYEWRGDAPATPPTMPPRHGGHTKR

Sequences:

>Translated_452_residues
MAETKGVSRRHVLGGGGLVLASAAMIGSRAEAASLPEAPIMRETTMQPPLHPASGPDYHPVVTLNGWSLPFRMNGDWKEF
HLLAEPVVREMAPGMKANLWGYNGQSPGPTIEAVEGDKVRIFVTNHLPEATSVHWHGIELPSGMDGVAGLTQPGIPPGKT
FAYEFVLPRSGTFMYHPHADEMVQMAMGMMGSFVVHPRDPDFRRVDRDFIFLLSTYAVDPGSYTPRVNEMTDFSLWTFNS
RVFPGIDPLPVRQGDQVRIRIGNLSMTNHPIHIHGTHFRVTGTDGGWVDPAASWPEVTVDMAVGQMRAIEFSADNPGDWA
MHCHKSHHTMNPMGHQVRTYIGVDLKQTAKALRKLAPDYMPMGSTGGGSMAEMEMPLPRNTLPMMTGDGPFGSVEMGGMF
TTIKIRPDLAPGDYRDPGWYRHPQGTVAYEWRGDAPATPPTMPPRHGGHTKR
>Mature_451_residues
AETKGVSRRHVLGGGGLVLASAAMIGSRAEAASLPEAPIMRETTMQPPLHPASGPDYHPVVTLNGWSLPFRMNGDWKEFH
LLAEPVVREMAPGMKANLWGYNGQSPGPTIEAVEGDKVRIFVTNHLPEATSVHWHGIELPSGMDGVAGLTQPGIPPGKTF
AYEFVLPRSGTFMYHPHADEMVQMAMGMMGSFVVHPRDPDFRRVDRDFIFLLSTYAVDPGSYTPRVNEMTDFSLWTFNSR
VFPGIDPLPVRQGDQVRIRIGNLSMTNHPIHIHGTHFRVTGTDGGWVDPAASWPEVTVDMAVGQMRAIEFSADNPGDWAM
HCHKSHHTMNPMGHQVRTYIGVDLKQTAKALRKLAPDYMPMGSTGGGSMAEMEMPLPRNTLPMMTGDGPFGSVEMGGMFT
TIKIRPDLAPGDYRDPGWYRHPQGTVAYEWRGDAPATPPTMPPRHGGHTKR

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=105, Percent_Identity=36.1904761904762, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321067, Length=123, Percent_Identity=37.3983739837398, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323703, Length=104, Percent_Identity=41.3461538461538, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI28574104, Length=108, Percent_Identity=38.8888888888889, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24650186, Length=95, Percent_Identity=41.0526315789474, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI18859919, Length=108, Percent_Identity=38.8888888888889, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 49686; Mature: 49555

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.9 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.7 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETKGVSRRHVLGGGGLVLASAAMIGSRAEAASLPEAPIMRETTMQPPLHPASGPDYHP
CCCCCCCCCEEEECCCCHHHHHHHHHCCCCHHHCCCCCCCCHHCCCCCCCCCCCCCCCCE
VVTLNGWSLPFRMNGDWKEFHLLAEPVVREMAPGMKANLWGYNGQSPGPTIEAVEGDKVR
EEEECCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEECCCEEE
IFVTNHLPEATSVHWHGIELPSGMDGVAGLTQPGIPPGKTFAYEFVLPRSGTFMYHPHAD
EEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEECCCHH
EMVQMAMGMMGSFVVHPRDPDFRRVDRDFIFLLSTYAVDPGSYTPRVNEMTDFSLWTFNS
HHHHHHHHHHCCEEECCCCCCHHHHCHHEEEEEEEEEECCCCCCCCCCCCCCEEEEEECC
RVFPGIDPLPVRQGDQVRIRIGNLSMTNHPIHIHGTHFRVTGTDGGWVDPAASWPEVTVD
EECCCCCCCCCCCCCEEEEEECCEEECCCCEEEECEEEEEECCCCCCCCCCCCCCCEEEE
MAVGQMRAIEFSADNPGDWAMHCHKSHHTMNPMGHQVRTYIGVDLKQTAKALRKLAPDYM
EECCCEEEEEECCCCCCCCEEEEECCCCCCCCCCHHEEEEECCCHHHHHHHHHHHCCCCC
PMGSTGGGSMAEMEMPLPRNTLPMMTGDGPFGSVEMGGMFTTIKIRPDLAPGDYRDPGWY
CCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCEEECCEEEEEEEECCCCCCCCCCCCCE
RHPQGTVAYEWRGDAPATPPTMPPRHGGHTKR
ECCCCCEEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AETKGVSRRHVLGGGGLVLASAAMIGSRAEAASLPEAPIMRETTMQPPLHPASGPDYHP
CCCCCCCCEEEECCCCHHHHHHHHHCCCCHHHCCCCCCCCHHCCCCCCCCCCCCCCCCE
VVTLNGWSLPFRMNGDWKEFHLLAEPVVREMAPGMKANLWGYNGQSPGPTIEAVEGDKVR
EEEECCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEECCCEEE
IFVTNHLPEATSVHWHGIELPSGMDGVAGLTQPGIPPGKTFAYEFVLPRSGTFMYHPHAD
EEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEECCCHH
EMVQMAMGMMGSFVVHPRDPDFRRVDRDFIFLLSTYAVDPGSYTPRVNEMTDFSLWTFNS
HHHHHHHHHHCCEEECCCCCCHHHHCHHEEEEEEEEEECCCCCCCCCCCCCCEEEEEECC
RVFPGIDPLPVRQGDQVRIRIGNLSMTNHPIHIHGTHFRVTGTDGGWVDPAASWPEVTVD
EECCCCCCCCCCCCCEEEEEECCEEECCCCEEEECEEEEEECCCCCCCCCCCCCCCEEEE
MAVGQMRAIEFSADNPGDWAMHCHKSHHTMNPMGHQVRTYIGVDLKQTAKALRKLAPDYM
EECCCEEEEEECCCCCCCCEEEEECCCCCCCCCCHHEEEEECCCHHHHHHHHHHHCCCCC
PMGSTGGGSMAEMEMPLPRNTLPMMTGDGPFGSVEMGGMFTTIKIRPDLAPGDYRDPGWY
CCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCEEECCEEEEEEEECCCCCCCCCCCCCE
RHPQGTVAYEWRGDAPATPPTMPPRHGGHTKR
ECCCCCEEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]