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The map label for this gene is degU [H]

Identifier: 182677301

GI number: 182677301

Start: 347183

End: 347872

Strand: Direct

Name: degU [H]

Synonym: Bind_0304

Alternate gene names: 182677301

Gene position: 347183-347872 (Clockwise)

Preceding gene: 182677299

Following gene: 182677302

Centisome position: 8.33

GC content: 56.67

Gene sequence:

>690_bases
ATGGAAAGCTTGAAGGCGCATCAAAAGCCCGTCACGATTCTCATCATCGAGGATCATCCGATCGTTCGTGAGGGTTGCCG
GCGGCTGTTTAGCCGCAGGCCCGATATCGAGACGCATGACGCGGCTTCAGCGGGTGCAGGCCTTGCCTGCAATAAAACCC
TTCGGCCTGATGTCATCATCCTTGATGTGGACCTGCCCGATGCGAGCGGGCTCGACATGATTCCGGCTCTTCTTCAGGAC
AATGACACGGCGCGGATCATCGTCTTCAGTATGTATGAGGCGCGCAATTTCGTGACCCGTGCCCTGGAATTGGGCGCCCG
CGGCTATGTCACGAAGAACGACGATCCCGACATGATCCTCCAGGCCACTGATAAAGTGCTCTCGGGCGCTCTCTATCTCG
GCCAGACGGTCGCGCAAAATCTCGCTCTGGCGCAGATCGAGCCGGCCCAAGATCCGCTGCGTGATCTGAGCGAGCGGGAG
CGTGAAGTGCTCCATTTCATGGGGGAGGGGAAAAGCCTCGGGGAAATCGCGCGGGCTTTGTCGCTCGGCTATAAAACCGT
GGCCAATATTGTTTCCATGCTCAAGCAGAAGCTCGGTGTCACCACCAGTCCGGCTTTGATCAAATTCGCGGTTGAATGTC
GTTCGCATGAAAATCGTTCAAACGAAAATCGCGTGAAACCGGGGTTTTGA

Upstream 100 bases:

>100_bases
AACGGGCCATTTCCCATGACCAATTTGATGCGTTTATAAGGTTTGAGACGCATCGCTCAAGCGTCTGATTGAACGCGCGA
TATTCTCGCGGCGAGGAAGC

Downstream 100 bases:

>100_bases
TCAGGAAGTCTGTTTCTTTCGCGCTTCATCAGAGAATATGAAGTATTAAAGCCGGGAACTTTTCCATATTTCAAGATGAA
ATTTTCTATTTCTCAGGAAG

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MESLKAHQKPVTILIIEDHPIVREGCRRLFSRRPDIETHDAASAGAGLACNKTLRPDVIILDVDLPDASGLDMIPALLQD
NDTARIIVFSMYEARNFVTRALELGARGYVTKNDDPDMILQATDKVLSGALYLGQTVAQNLALAQIEPAQDPLRDLSERE
REVLHFMGEGKSLGEIARALSLGYKTVANIVSMLKQKLGVTTSPALIKFAVECRSHENRSNENRVKPGF

Sequences:

>Translated_229_residues
MESLKAHQKPVTILIIEDHPIVREGCRRLFSRRPDIETHDAASAGAGLACNKTLRPDVIILDVDLPDASGLDMIPALLQD
NDTARIIVFSMYEARNFVTRALELGARGYVTKNDDPDMILQATDKVLSGALYLGQTVAQNLALAQIEPAQDPLRDLSERE
REVLHFMGEGKSLGEIARALSLGYKTVANIVSMLKQKLGVTTSPALIKFAVECRSHENRSNENRVKPGF
>Mature_229_residues
MESLKAHQKPVTILIIEDHPIVREGCRRLFSRRPDIETHDAASAGAGLACNKTLRPDVIILDVDLPDASGLDMIPALLQD
NDTARIIVFSMYEARNFVTRALELGARGYVTKNDDPDMILQATDKVLSGALYLGQTVAQNLALAQIEPAQDPLRDLSERE
REVLHFMGEGKSLGEIARALSLGYKTVANIVSMLKQKLGVTTSPALIKFAVECRSHENRSNENRVKPGF

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=198, Percent_Identity=34.3434343434343, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1788222, Length=204, Percent_Identity=28.4313725490196, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1790102, Length=194, Percent_Identity=35.0515463917526, Blast_Score=94, Evalue=5e-21,
Organism=Escherichia coli, GI1787473, Length=186, Percent_Identity=33.8709677419355, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1786747, Length=207, Percent_Identity=28.5024154589372, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1788712, Length=198, Percent_Identity=27.7777777777778, Blast_Score=81, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 25217; Mature: 25217

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESLKAHQKPVTILIIEDHPIVREGCRRLFSRRPDIETHDAASAGAGLACNKTLRPDVII
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCEEE
LDVDLPDASGLDMIPALLQDNDTARIIVFSMYEARNFVTRALELGARGYVTKNDDPDMIL
EEECCCCCCCHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCEECCCCCHHHH
QATDKVLSGALYLGQTVAQNLALAQIEPAQDPLRDLSEREREVLHFMGEGKSLGEIARAL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
SLGYKTVANIVSMLKQKLGVTTSPALIKFAVECRSHENRSNENRVKPGF
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MESLKAHQKPVTILIIEDHPIVREGCRRLFSRRPDIETHDAASAGAGLACNKTLRPDVII
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCEEE
LDVDLPDASGLDMIPALLQDNDTARIIVFSMYEARNFVTRALELGARGYVTKNDDPDMIL
EEECCCCCCCHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCEECCCCCHHHH
QATDKVLSGALYLGQTVAQNLALAQIEPAQDPLRDLSEREREVLHFMGEGKSLGEIARAL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
SLGYKTVANIVSMLKQKLGVTTSPALIKFAVECRSHENRSNENRVKPGF
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]