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The map label for this gene is argM [C]

Identifier: 182677118

GI number: 182677118

Start: 133040

End: 134305

Strand: Direct

Name: argM [C]

Synonym: Bind_0117

Alternate gene names: 182677118

Gene position: 133040-134305 (Clockwise)

Preceding gene: 182677117

Following gene: 182677123

Centisome position: 3.19

GC content: 55.13

Gene sequence:

>1266_bases
ATGGATTCGCAACAAATAGGGGAAGCCTATCGTCAGCGTCACTGGCGCTTTCTTGCCGATCTTCAGAAAAAGGCGGGAAT
GGAATTTGTCGTGGGGCGACGCGAAGGGTCCCATATCTGGAATGTCGAGAATTCACGGCGCCTTCTCGATTGCGGCAATA
GCGGGGGCGTTCATTCTCTTGGACATTGCAATCCGGAAATACGACAGCTGATTGCTGAGAGTTTGGAAACGCTCGATGCG
GGCATGTGGGTGATGCCAACCGAAGAAGCATTGGCGTTCCAGGACACAGTCAATCGTGCGGATTCGCCCATTCCGGACTG
CCGGACTGTTCTGACGTTGAGTGCCTCGGACGCCATGGATGCCACGATCATGTGGTCGTTTCGCGTCACCGGCCGCAAGA
AGGTGCTGGCGTTCAAGCATGGCTATCATGGCCATAGTGGTTTTGCCGCGCTGGCGACGGGATCAGAGGCCGAGGGGCTT
TTGTCGCATTATTCTCTTCCGGGCGATTATAGCCTGTTTTTTGAGGATTATGGCGATCTCGACGCGATCGAAAGAACGAT
CGATGCGTCCTGTGCGGCCATCATCATGGAGCCTATGAATTATGAAACCTTCGAGCCCGCGCCTGATGGTTTTCTGGAAG
GTGTCCAGGCTTTGTGCCGCCGCCATTCGACGCTTTTGATTCTTGATGAGACACGGTCGGGCCTTGGCCGTTCCGGCCGG
CTTTGGATGAGCGGCTTTTATGATATCCAACCCGACATCATCATATCCGGAAAAGGATTGGGCGGAGGCTATTATCCCGT
CGGCGCCTTGATCGCTCGATCAGATATTTATGATCTCTGCATGAATAGTGGCCATTGGGGCTATATGGCGAGTCTTGCCG
GCAGCCCCATTGGCGCACGGATCGCCATGAAGGTTCTGGATATTGTGCGGCGTCCGGAACTTGTCGCGAATGTCCACCTC
TTGGAGAGAGATCTCACCACGCTTTTTTTGGCGCTCAGCGCGAACTTTCCAGATCTCTATCGACCAGCCTGGGTCAGGGG
AGGGATTGCCGCTCTCGGCCTTCAGGATGCGCAATTCGCCTCGATGATCCAGCTTGAACTGTTTAGGCGTGGCGTGCTTT
GCCACAGCACCTCGCTCATTACGCCTTCCGTTGTCAAATTCTTCCCGTGCTTGACCAGCACACCCTCAATCGTCGAAGAG
CTTGGCGGTGCGCTCGAGGATTGCGCGCAATCCTTCCGCAAGCAGGAAAGGGTTTCAACCTCGTAG

Upstream 100 bases:

>100_bases
CGCCTCGGCGATGATGGTTTGCATCCTCAAAGCCGCCGCCATGGAATGAGAGGGCTTTGTCGTTGGCCAGCGCCTCCCCG
CCACATCCAGGATCATCTCG

Downstream 100 bases:

>100_bases
GGACAGAGTTCGGAGCAGATCGGATATCTCCGATCTGCTCTCCTTAAAGAACAATTGTTTTGGACCCCGCCTCAGAATGA
CATACCTCAGAATGACATGA

Product: class III aminotransferase

Products: N-acetyl-L-glutamate 5-semialdehyde; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MDSQQIGEAYRQRHWRFLADLQKKAGMEFVVGRREGSHIWNVENSRRLLDCGNSGGVHSLGHCNPEIRQLIAESLETLDA
GMWVMPTEEALAFQDTVNRADSPIPDCRTVLTLSASDAMDATIMWSFRVTGRKKVLAFKHGYHGHSGFAALATGSEAEGL
LSHYSLPGDYSLFFEDYGDLDAIERTIDASCAAIIMEPMNYETFEPAPDGFLEGVQALCRRHSTLLILDETRSGLGRSGR
LWMSGFYDIQPDIIISGKGLGGGYYPVGALIARSDIYDLCMNSGHWGYMASLAGSPIGARIAMKVLDIVRRPELVANVHL
LERDLTTLFLALSANFPDLYRPAWVRGGIAALGLQDAQFASMIQLELFRRGVLCHSTSLITPSVVKFFPCLTSTPSIVEE
LGGALEDCAQSFRKQERVSTS

Sequences:

>Translated_421_residues
MDSQQIGEAYRQRHWRFLADLQKKAGMEFVVGRREGSHIWNVENSRRLLDCGNSGGVHSLGHCNPEIRQLIAESLETLDA
GMWVMPTEEALAFQDTVNRADSPIPDCRTVLTLSASDAMDATIMWSFRVTGRKKVLAFKHGYHGHSGFAALATGSEAEGL
LSHYSLPGDYSLFFEDYGDLDAIERTIDASCAAIIMEPMNYETFEPAPDGFLEGVQALCRRHSTLLILDETRSGLGRSGR
LWMSGFYDIQPDIIISGKGLGGGYYPVGALIARSDIYDLCMNSGHWGYMASLAGSPIGARIAMKVLDIVRRPELVANVHL
LERDLTTLFLALSANFPDLYRPAWVRGGIAALGLQDAQFASMIQLELFRRGVLCHSTSLITPSVVKFFPCLTSTPSIVEE
LGGALEDCAQSFRKQERVSTS
>Mature_421_residues
MDSQQIGEAYRQRHWRFLADLQKKAGMEFVVGRREGSHIWNVENSRRLLDCGNSGGVHSLGHCNPEIRQLIAESLETLDA
GMWVMPTEEALAFQDTVNRADSPIPDCRTVLTLSASDAMDATIMWSFRVTGRKKVLAFKHGYHGHSGFAALATGSEAEGL
LSHYSLPGDYSLFFEDYGDLDAIERTIDASCAAIIMEPMNYETFEPAPDGFLEGVQALCRRHSTLLILDETRSGLGRSGR
LWMSGFYDIQPDIIISGKGLGGGYYPVGALIARSDIYDLCMNSGHWGYMASLAGSPIGARIAMKVLDIVRRPELVANVHL
LERDLTTLFLALSANFPDLYRPAWVRGGIAALGLQDAQFASMIQLELFRRGVLCHSTSLITPSVVKFFPCLTSTPSIVEE
LGGALEDCAQSFRKQERVSTS

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=376, Percent_Identity=27.1276595744681, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI284507298, Length=275, Percent_Identity=29.4545454545455, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI37574042, Length=320, Percent_Identity=25.625, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI226442709, Length=303, Percent_Identity=24.7524752475248, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI226442705, Length=265, Percent_Identity=26.0377358490566, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788044, Length=297, Percent_Identity=30.3030303030303, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1789759, Length=302, Percent_Identity=26.8211920529801, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789016, Length=368, Percent_Identity=26.0869565217391, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI145693181, Length=363, Percent_Identity=26.1707988980716, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786349, Length=316, Percent_Identity=29.4303797468354, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787560, Length=408, Percent_Identity=25.4901960784314, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1786991, Length=315, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25144271, Length=412, Percent_Identity=25.2427184466019, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI25144274, Length=242, Percent_Identity=29.7520661157025, Blast_Score=111, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6323470, Length=330, Percent_Identity=26.0606060606061, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324432, Length=404, Percent_Identity=22.2772277227723, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21357415, Length=311, Percent_Identity=27.0096463022508, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21356575, Length=322, Percent_Identity=26.3975155279503, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.11

Molecular weight: Translated: 46351; Mature: 46351

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSQQIGEAYRQRHWRFLADLQKKAGMEFVVGRREGSHIWNVENSRRLLDCGNSGGVHSL
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCCCCEEEECCCCCCCCCC
GHCNPEIRQLIAESLETLDAGMWVMPTEEALAFQDTVNRADSPIPDCRTVLTLSASDAMD
CCCCHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCC
ATIMWSFRVTGRKKVLAFKHGYHGHSGFAALATGSEAEGLLSHYSLPGDYSLFFEDYGDL
EEEEEEEEECCCEEEEEEECCCCCCCCEEEEECCCCHHHHHHHCCCCCCEEEEECCCCCH
DAIERTIDASCAAIIMEPMNYETFEPAPDGFLEGVQALCRRHSTLLILDETRSGLGRSGR
HHHHHHHHHHHHEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
LWMSGFYDIQPDIIISGKGLGGGYYPVGALIARSDIYDLCMNSGHWGYMASLAGSPIGAR
EEECCCEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHH
IAMKVLDIVRRPELVANVHLLERDLTTLFLALSANFPDLYRPAWVRGGIAALGLQDAQFA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHCCCCCEECCCHHHHH
SMIQLELFRRGVLCHSTSLITPSVVKFFPCLTSTPSIVEELGGALEDCAQSFRKQERVST
HHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHCCC
S
C
>Mature Secondary Structure
MDSQQIGEAYRQRHWRFLADLQKKAGMEFVVGRREGSHIWNVENSRRLLDCGNSGGVHSL
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCCCCEEEECCCCCCCCCC
GHCNPEIRQLIAESLETLDAGMWVMPTEEALAFQDTVNRADSPIPDCRTVLTLSASDAMD
CCCCHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCC
ATIMWSFRVTGRKKVLAFKHGYHGHSGFAALATGSEAEGLLSHYSLPGDYSLFFEDYGDL
EEEEEEEEECCCEEEEEEECCCCCCCCEEEEECCCCHHHHHHHCCCCCCEEEEECCCCCH
DAIERTIDASCAAIIMEPMNYETFEPAPDGFLEGVQALCRRHSTLLILDETRSGLGRSGR
HHHHHHHHHHHHEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
LWMSGFYDIQPDIIISGKGLGGGYYPVGALIARSDIYDLCMNSGHWGYMASLAGSPIGAR
EEECCCEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHH
IAMKVLDIVRRPELVANVHLLERDLTTLFLALSANFPDLYRPAWVRGGIAALGLQDAQFA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHCCCCCEECCCHHHHH
SMIQLELFRRGVLCHSTSLITPSVVKFFPCLTSTPSIVEELGGALEDCAQSFRKQERVST
HHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N2-acetyl-L-ornithine; 2-oxoglutarate

Specific reaction: N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]