Click here to switch to the map view.

The map label for this gene is ung

Identifier: 182682662

GI number: 182682662

Start: 2431769

End: 2432530

Strand: Reverse

Name: ung

Synonym: XfasM23_2152

Alternate gene names: 182682662

Gene position: 2432530-2431769 (Counterclockwise)

Preceding gene: 182682663

Following gene: 182682661

Centisome position: 95.93

GC content: 51.44

Gene sequence:

>762_bases
ATGAACGAGCAAGGTAAGGCCATTAATAGTAGTGCCGAGTCTCGAATTCAGTTGGAATCTTCTTGGAAGGCGCACGTTGG
TAACTGGTTATTGCGTCCGGAAATGCGGGATTTGTCTTCCTTCCTGCGTGCGAGAAAGGTTGCTGGTGTGAGTGTCTACC
CACCAGGATCTCAGATATTTGCGGCGTTCGAAGCGACCCCATTCCAGCGGGTCAAGGCTGTAATCCTTGGTCAAGATCCT
TATCACGGTCAGGGCCAAGCGCATGGTTTGTGTTTTTCAGTGCGGCCGGGTATGCCGTTGCCGCCTTCTTTGTTGAATAT
TTATAAAGAGCTCGAAGAAGATCTTGGGTTGCTCCGCCCTGATCACGGCTGTCTGCTTCCTTGGGCAAAGCGTGGTGTAT
TGCTACTTAATGCGGTACTGACGGTGGAGGATGGTCGTGCAGGTGCGCATCAGGGTAAGGGCTGGGAAGGCTTTACCGAC
CATGTCGTTGATACCTTGAATCGCGAGCGTGAAGGACTTGTATTCATGCTCTGGGGTAGCTATGCCCAAGCCAAGGGTAA
GGCTATTGATACGCGTCGCCACCTTGTACTCAAGGCTCCGCACCCTTCACCTTTGTCAGCGCATCGTGGTTTTCTGGGTT
GCCGTCATTTTTCTCTCTGCAACCAGTACTTGAGCCAACATGGCTTGGGAATGGTGGATTGGAGCTTGCCTCCATGTATT
GCACTGGATGGTGCAATATTAAATGGTAGAATAGCGGTGTAG

Upstream 100 bases:

>100_bases
TGGTGCAGAAGCCGATTGAGGAGCGTTTGCTTGTAACCAAGGTGTTGTTCCAACTGCGCTTGGCGCGTCTTAAAGATGAT
CTAGCGACTATTTGAATAGC

Downstream 100 bases:

>100_bases
TGATTACCGGCCCATGACAATGTTAGGATGCCATTTTAATTTAAATGGAGTTTTTCTAAAGATTTGTTCATTTTAAACGT
ATAGCTGTCACTGTGTGGTT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MNEQGKAINSSAESRIQLESSWKAHVGNWLLRPEMRDLSSFLRARKVAGVSVYPPGSQIFAAFEATPFQRVKAVILGQDP
YHGQGQAHGLCFSVRPGMPLPPSLLNIYKELEEDLGLLRPDHGCLLPWAKRGVLLLNAVLTVEDGRAGAHQGKGWEGFTD
HVVDTLNREREGLVFMLWGSYAQAKGKAIDTRRHLVLKAPHPSPLSAHRGFLGCRHFSLCNQYLSQHGLGMVDWSLPPCI
ALDGAILNGRIAV

Sequences:

>Translated_253_residues
MNEQGKAINSSAESRIQLESSWKAHVGNWLLRPEMRDLSSFLRARKVAGVSVYPPGSQIFAAFEATPFQRVKAVILGQDP
YHGQGQAHGLCFSVRPGMPLPPSLLNIYKELEEDLGLLRPDHGCLLPWAKRGVLLLNAVLTVEDGRAGAHQGKGWEGFTD
HVVDTLNREREGLVFMLWGSYAQAKGKAIDTRRHLVLKAPHPSPLSAHRGFLGCRHFSLCNQYLSQHGLGMVDWSLPPCI
ALDGAILNGRIAV
>Mature_253_residues
MNEQGKAINSSAESRIQLESSWKAHVGNWLLRPEMRDLSSFLRARKVAGVSVYPPGSQIFAAFEATPFQRVKAVILGQDP
YHGQGQAHGLCFSVRPGMPLPPSLLNIYKELEEDLGLLRPDHGCLLPWAKRGVLLLNAVLTVEDGRAGAHQGKGWEGFTD
HVVDTLNREREGLVFMLWGSYAQAKGKAIDTRRHLVLKAPHPSPLSAHRGFLGCRHFSLCNQYLSQHGLGMVDWSLPPCI
ALDGAILNGRIAV

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=215, Percent_Identity=54.4186046511628, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI6224979, Length=217, Percent_Identity=53.9170506912442, Blast_Score=227, Evalue=6e-60,
Organism=Escherichia coli, GI1788934, Length=217, Percent_Identity=55.7603686635945, Blast_Score=251, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI17556304, Length=217, Percent_Identity=46.0829493087558, Blast_Score=207, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6323620, Length=242, Percent_Identity=42.1487603305785, Blast_Score=186, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_XYLF2 (B2IAB2)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830822.1
- ProteinModelPortal:   B2IAB2
- SMR:   B2IAB2
- GeneID:   6202076
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_2152
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- ProtClustDB:   PRK05254
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 27841; Mature: 27841

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 79-79

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEQGKAINSSAESRIQLESSWKAHVGNWLLRPEMRDLSSFLRARKVAGVSVYPPGSQIF
CCCCCCCCCCCCHHEEEECCCCHHHHCCEEECCCHHHHHHHHHHHHHCCEEEECCCHHEE
AAFEATPFQRVKAVILGQDPYHGQGQAHGLCFSVRPGMPLPPSLLNIYKELEEDLGLLRP
EEECCCHHHHEEEEEECCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCC
DHGCLLPWAKRGVLLLNAVLTVEDGRAGAHQGKGWEGFTDHVVDTLNREREGLVFMLWGS
CCCCCCHHHHCCEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECC
YAQAKGKAIDTRRHLVLKAPHPSPLSAHRGFLGCRHFSLCNQYLSQHGLGMVDWSLPPCI
CCHHCCCEECCCCEEEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCE
ALDGAILNGRIAV
EECCEEECCEECC
>Mature Secondary Structure
MNEQGKAINSSAESRIQLESSWKAHVGNWLLRPEMRDLSSFLRARKVAGVSVYPPGSQIF
CCCCCCCCCCCCHHEEEECCCCHHHHCCEEECCCHHHHHHHHHHHHHCCEEEECCCHHEE
AAFEATPFQRVKAVILGQDPYHGQGQAHGLCFSVRPGMPLPPSLLNIYKELEEDLGLLRP
EEECCCHHHHEEEEEECCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCC
DHGCLLPWAKRGVLLLNAVLTVEDGRAGAHQGKGWEGFTDHVVDTLNREREGLVFMLWGS
CCCCCCHHHHCCEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECC
YAQAKGKAIDTRRHLVLKAPHPSPLSAHRGFLGCRHFSLCNQYLSQHGLGMVDWSLPPCI
CCHHCCCEECCCCEEEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCE
ALDGAILNGRIAV
EECCEEECCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA