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The map label for this gene is pyrD

Identifier: 182682570

GI number: 182682570

Start: 2309997

End: 2311052

Strand: Direct

Name: pyrD

Synonym: XfasM23_2058

Alternate gene names: 182682570

Gene position: 2309997-2311052 (Clockwise)

Preceding gene: 182682569

Following gene: 182682571

Centisome position: 91.1

GC content: 55.49

Gene sequence:

>1056_bases
ATGTATTCCCTTTTCCGTCCCCTCCTGTTCACCTGCGACGCAGAGCGTGCCCATGACATCAGCCTGCGCACCTTAGATAT
CGCCTACCACAGTGGAGCATTACCTCTACTGACACGCCACACACGACCTTTACCCACCACAGCCTTCGGTCTGAACTTTC
CCAACCCTGTTGGCTTAGCCGCCGGACTGGACAAAAACGGGACTCACATTGACGCTCTATTCGCCTTAGGCTTTGGCTTT
ATTGAAATCGGTACCACCACCCCACGTCCACAAGCGGGGAATCCCAAGCCTCGCCTTTTCCGCCTGACGCAACAACAAGC
AGTGATTAACCGCATGGGGTTTAACAACCTAGGTGTAGATGCGCTGGTACGTAACGTTGCAGGCGCGCGGCGACGCAACG
GCCCGCTTGGGATCAACATTGGCAAGAACAAAGACACCCCTAACGAACAGGCCAGTAACGACTATCGGTATTGTCTGGAA
CGGGTCTATGCACTGGCAGACTATGTCACTATCAATCTCTCCTCACCAAATACTGCTGGTCTACGAGCGCTGCAAGAGGA
ACAGACATTGCGTCGCTTGATCGGAGAATTACGTGAAACACAAGAAACGCTGGCAGCGAAACACGGCCGGCACGTACCCA
TGCTCATCAAGATGGCACCAGATCTCAGTGACAGCGACATTGATGCAGCAGCACGTGTACTCAACGAGATGAGCGTAGAC
GGAGTGATCGCCACCAATACCACCGTGACGCGCCCGCTCCTAAGACAACATCCGCTGGCAAGCGAAGCGGGGGGGCTGTC
CGGTGCACCCCTCCTGGGACAGTCCACCTTGGTGCTACGTCGGCTACGTACTCACTTACCTGAAACTATTGATCTCATCG
GCGTGGGCGGCATCTGTTGCGGTGCCGATGCCGGCGCCAAAATGGCTGCTGGTGCCAGCCTAGTACAGTGCTACACCGGA
TTGATATTCAAAGGCCCACAGTTGGTTGGAGAATGCGTGGAAGCCATTCGCCGCCGCCTCGAAGCCTCCAGTAGCGGAAG
GGAAAACACTCAATGA

Upstream 100 bases:

>100_bases
AAACAGACAGACCTACATCCTTTGTCAGAGATGGACATACAGCTATCCTATCGGCATAAATACCTGACAGACGCCTTTGC
CGGGCGCTAATTTGAGCAAT

Downstream 100 bases:

>100_bases
GCAGGCAAATCAATACTCCTGACTGGATCCTCCATGCCAACGCGCCTCTGCGTGAGCTGAACACTTTTCATATCCAGGCA
CAAGCGCGCTGGCTACTAGA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MYSLFRPLLFTCDAERAHDISLRTLDIAYHSGALPLLTRHTRPLPTTAFGLNFPNPVGLAAGLDKNGTHIDALFALGFGF
IEIGTTTPRPQAGNPKPRLFRLTQQQAVINRMGFNNLGVDALVRNVAGARRRNGPLGINIGKNKDTPNEQASNDYRYCLE
RVYALADYVTINLSSPNTAGLRALQEEQTLRRLIGELRETQETLAAKHGRHVPMLIKMAPDLSDSDIDAAARVLNEMSVD
GVIATNTTVTRPLLRQHPLASEAGGLSGAPLLGQSTLVLRRLRTHLPETIDLIGVGGICCGADAGAKMAAGASLVQCYTG
LIFKGPQLVGECVEAIRRRLEASSSGRENTQ

Sequences:

>Translated_351_residues
MYSLFRPLLFTCDAERAHDISLRTLDIAYHSGALPLLTRHTRPLPTTAFGLNFPNPVGLAAGLDKNGTHIDALFALGFGF
IEIGTTTPRPQAGNPKPRLFRLTQQQAVINRMGFNNLGVDALVRNVAGARRRNGPLGINIGKNKDTPNEQASNDYRYCLE
RVYALADYVTINLSSPNTAGLRALQEEQTLRRLIGELRETQETLAAKHGRHVPMLIKMAPDLSDSDIDAAARVLNEMSVD
GVIATNTTVTRPLLRQHPLASEAGGLSGAPLLGQSTLVLRRLRTHLPETIDLIGVGGICCGADAGAKMAAGASLVQCYTG
LIFKGPQLVGECVEAIRRRLEASSSGRENTQ
>Mature_351_residues
MYSLFRPLLFTCDAERAHDISLRTLDIAYHSGALPLLTRHTRPLPTTAFGLNFPNPVGLAAGLDKNGTHIDALFALGFGF
IEIGTTTPRPQAGNPKPRLFRLTQQQAVINRMGFNNLGVDALVRNVAGARRRNGPLGINIGKNKDTPNEQASNDYRYCLE
RVYALADYVTINLSSPNTAGLRALQEEQTLRRLIGELRETQETLAAKHGRHVPMLIKMAPDLSDSDIDAAARVLNEMSVD
GVIATNTTVTRPLLRQHPLASEAGGLSGAPLLGQSTLVLRRLRTHLPETIDLIGVGGICCGADAGAKMAAGASLVQCYTG
LIFKGPQLVGECVEAIRRRLEASSSGRENTQ

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=339, Percent_Identity=43.3628318584071, Blast_Score=260, Evalue=2e-69,
Organism=Escherichia coli, GI1787177, Length=335, Percent_Identity=51.3432835820895, Blast_Score=320, Evalue=7e-89,
Organism=Caenorhabditis elegans, GI17509475, Length=342, Percent_Identity=38.8888888888889, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI281361352, Length=349, Percent_Identity=41.5472779369628, Blast_Score=246, Evalue=1e-65,
Organism=Drosophila melanogaster, GI17137316, Length=349, Percent_Identity=41.5472779369628, Blast_Score=246, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_XYLF2 (B2I9T5)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830730.1
- ProteinModelPortal:   B2I9T5
- SMR:   B2I9T5
- GeneID:   6203406
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_2058
- HOGENOM:   HBG351027
- OMA:   SYVTVNI
- ProtClustDB:   PRK05286
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 37878; Mature: 37878

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 175-175

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSLFRPLLFTCDAERAHDISLRTLDIAYHSGALPLLTRHTRPLPTTAFGLNFPNPVGLA
CCHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCHHHHCCCCCCCCCEECCCCCCCCCHH
AGLDKNGTHIDALFALGFGFIEIGTTTPRPQAGNPKPRLFRLTQQQAVINRMGFNNLGVD
CCCCCCCCHHHHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHH
ALVRNVAGARRRNGPLGINIGKNKDTPNEQASNDYRYCLERVYALADYVTINLSSPNTAG
HHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCHHH
LRALQEEQTLRRLIGELRETQETLAAKHGRHVPMLIKMAPDLSDSDIDAAARVLNEMSVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCC
GVIATNTTVTRPLLRQHPLASEAGGLSGAPLLGQSTLVLRRLRTHLPETIDLIGVGGICC
CEEECCCHHHHHHHHHCCCCHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCEEE
GADAGAKMAAGASLVQCYTGLIFKGPQLVGECVEAIRRRLEASSSGRENTQ
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MYSLFRPLLFTCDAERAHDISLRTLDIAYHSGALPLLTRHTRPLPTTAFGLNFPNPVGLA
CCHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCHHHHCCCCCCCCCEECCCCCCCCCHH
AGLDKNGTHIDALFALGFGFIEIGTTTPRPQAGNPKPRLFRLTQQQAVINRMGFNNLGVD
CCCCCCCCHHHHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHH
ALVRNVAGARRRNGPLGINIGKNKDTPNEQASNDYRYCLERVYALADYVTINLSSPNTAG
HHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCHHH
LRALQEEQTLRRLIGELRETQETLAAKHGRHVPMLIKMAPDLSDSDIDAAARVLNEMSVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCC
GVIATNTTVTRPLLRQHPLASEAGGLSGAPLLGQSTLVLRRLRTHLPETIDLIGVGGICC
CEEECCCHHHHHHHHHCCCCHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCEEE
GADAGAKMAAGASLVQCYTGLIFKGPQLVGECVEAIRRRLEASSSGRENTQ
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA