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The map label for this gene is ftsI [H]

Identifier: 182682487

GI number: 182682487

Start: 2215309

End: 2217150

Strand: Reverse

Name: ftsI [H]

Synonym: XfasM23_1974

Alternate gene names: 182682487

Gene position: 2217150-2215309 (Counterclockwise)

Preceding gene: 182682488

Following gene: 182682486

Centisome position: 87.44

GC content: 54.13

Gene sequence:

>1842_bases
ATGAAGAACCGTAATAACCGCTTCCGCAGTCATTTCAATTTGCGTGGTCGGTTGTTGCTGGTCGGTACAGCGCTGGGCCT
GTGTTCAATGACGTTGATCGCCAGTGCTGCCTACGTGCAGTTGATTAATAGTGATTTCTATCAGCGTCAGGCCCAAGCGC
GCTACTTGCGTGAGCTACCGATTCCGACCTCGCGTGGAATGATTACAGATCGCAATGGTGAGCCGTTGGCGGTTTCTACG
CCGGTCGAGTCGATTTGGGGAAATCCACAGGAACTATTGCGGAATCCTGATGCCATCTCGAAGTTGGCCAAGGTACTTGA
TGTCCCGATGGAAGAACTGCGTACTCGTTTGTTGCAGAAGGCCGATAAAGAGTTCATGTATTTGAAGCGCCGGATCAATC
CTGACGTTGCACATCACGTTCTTGGGTTGCAAATTCCTGGGGTATTCGCGCAGCGTGAATTCAGGCGTTTCTACCCTCAG
AGTGAGGCAATGGCGCATGTATTGGGTTTTACCAATATTGATGACCGTGGCCAGGAAGGTCTGGAGCTGTCATTTGATGA
TTGGTTGACAGGTAAGCCTGGTAGCAAGCGTGTGGTACGTGATGCGCGTGGCGCGATTGTGGAGAGTGTGGATGCGATCC
GGTCGGCACAGCCGGGTAAGGATTTGGTGTTGACGATTGATCGTCGTATTCAATTTCTTGCTTATAAGGAACTGCGCAAC
GCCATTATTGAAAATCAAGCGGCTGGCGGTTCGATTGTCGTCATGGATGTGAACAATGGCGAGATTTTAGCCATGGTCAA
TTTGCCGACCTACAACCCTAACGCGGTGAACGGGATTAATTCTTCAGCACGGCGTAATCGTGCGGTGACGGATCTGGTTG
AGCCAGGTTCGACGATGAAGCCGTTGACGGTTGCGACCGCGCTGCAAGCGGGTGTGGTGACCCCTGATACGGTCATTGAT
ACCAATCCTGGTTATCTGTCACTGGGACGTTTTACCATCCGCGATGTGCCGCGTAATAACGGTGTGCTCAATGTGACTGG
TGTGATTACGCGCAGTTCCAATATTGGTGCTGCCAAGATCGTCGCCAAGGTGCCGGACAAAACGTTCTACGAATTGGTGC
AAGGTTTTGGTTACGGGACAGCGCCTCATAGCGGTTTTCCTGGTGAATCCAGCGGTGTGTTGCCTTTACCGGCACGTTGG
AGCGGTACTTCCAAGACCACTATGTCTTACGGTTACGGTCTGTCTGTGACGCCGTTGCAAATTGCGCAGGCGTACGCGAC
GTTGGGCAATGGCGGCAAGCTAGTCCCGCCGACGTTTGTGAAAGGCCATCATGCCGAGGCACGTCAAGTCGTTGATGCCA
AGGTTGCACAGCAAGTGATTGGGATGATGGAAACGGTGGTCACACGTGGAGGGGCTAAGGCCGCGGCGATCCTTGGCTAC
CATGTTGCTGGAAAGACGGGCACGGCGCGCAAAACGGGCGCTAATGGCTACGAATCCGGTCATTACAATGCGCTGTTTGC
TGGTTTGGTACCTGCCACGCGCCCGCGTTTCGCCACGGTCATTGTGATCAACGATCCGCAGGGTAAGGCGTATTACGGTG
GCTTGGTATCTGCACCCGTGTTCCATCGGGTGATGGAGGGGGCGCTACGGTTGATGGATGTGCCTCCTGACGACATTCAA
TCATGGTTGGCTGCGCAGGCTGCAGGAAAAACTGGGCGGACGCCACCGCGGCAGGTCGATCCCGATCCGGCATTAGTACC
CGATGCTGCCGATGAGGTCGCCGCTGGTATTCCTACGACGGTGACACCATCGCCGTCTGCGATTCATAGAGATCGCCAAT
GA

Upstream 100 bases:

>100_bases
AGCAAGCGACGTGGGCCGAAGCCAATCGGGTTGATCAGGTTGCACGTGAGCGCTTAGGGATGAGATTCCCGGAAAGCAAA
GAGATCGTTGTGGTGCGTCC

Downstream 100 bases:

>100_bases
GGCGTTCTATGCCATTGGCGCAGCTATTGCCCGATATTCCGCAAGCGCGTGATGTCGTGATCTCTGGTTTGGTGATGGAT
AGCCGTGAGGTGCAGCCGGG

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 613; Mature: 613

Protein sequence:

>613_residues
MKNRNNRFRSHFNLRGRLLLVGTALGLCSMTLIASAAYVQLINSDFYQRQAQARYLRELPIPTSRGMITDRNGEPLAVST
PVESIWGNPQELLRNPDAISKLAKVLDVPMEELRTRLLQKADKEFMYLKRRINPDVAHHVLGLQIPGVFAQREFRRFYPQ
SEAMAHVLGFTNIDDRGQEGLELSFDDWLTGKPGSKRVVRDARGAIVESVDAIRSAQPGKDLVLTIDRRIQFLAYKELRN
AIIENQAAGGSIVVMDVNNGEILAMVNLPTYNPNAVNGINSSARRNRAVTDLVEPGSTMKPLTVATALQAGVVTPDTVID
TNPGYLSLGRFTIRDVPRNNGVLNVTGVITRSSNIGAAKIVAKVPDKTFYELVQGFGYGTAPHSGFPGESSGVLPLPARW
SGTSKTTMSYGYGLSVTPLQIAQAYATLGNGGKLVPPTFVKGHHAEARQVVDAKVAQQVIGMMETVVTRGGAKAAAILGY
HVAGKTGTARKTGANGYESGHYNALFAGLVPATRPRFATVIVINDPQGKAYYGGLVSAPVFHRVMEGALRLMDVPPDDIQ
SWLAAQAAGKTGRTPPRQVDPDPALVPDAADEVAAGIPTTVTPSPSAIHRDRQ

Sequences:

>Translated_613_residues
MKNRNNRFRSHFNLRGRLLLVGTALGLCSMTLIASAAYVQLINSDFYQRQAQARYLRELPIPTSRGMITDRNGEPLAVST
PVESIWGNPQELLRNPDAISKLAKVLDVPMEELRTRLLQKADKEFMYLKRRINPDVAHHVLGLQIPGVFAQREFRRFYPQ
SEAMAHVLGFTNIDDRGQEGLELSFDDWLTGKPGSKRVVRDARGAIVESVDAIRSAQPGKDLVLTIDRRIQFLAYKELRN
AIIENQAAGGSIVVMDVNNGEILAMVNLPTYNPNAVNGINSSARRNRAVTDLVEPGSTMKPLTVATALQAGVVTPDTVID
TNPGYLSLGRFTIRDVPRNNGVLNVTGVITRSSNIGAAKIVAKVPDKTFYELVQGFGYGTAPHSGFPGESSGVLPLPARW
SGTSKTTMSYGYGLSVTPLQIAQAYATLGNGGKLVPPTFVKGHHAEARQVVDAKVAQQVIGMMETVVTRGGAKAAAILGY
HVAGKTGTARKTGANGYESGHYNALFAGLVPATRPRFATVIVINDPQGKAYYGGLVSAPVFHRVMEGALRLMDVPPDDIQ
SWLAAQAAGKTGRTPPRQVDPDPALVPDAADEVAAGIPTTVTPSPSAIHRDRQ
>Mature_613_residues
MKNRNNRFRSHFNLRGRLLLVGTALGLCSMTLIASAAYVQLINSDFYQRQAQARYLRELPIPTSRGMITDRNGEPLAVST
PVESIWGNPQELLRNPDAISKLAKVLDVPMEELRTRLLQKADKEFMYLKRRINPDVAHHVLGLQIPGVFAQREFRRFYPQ
SEAMAHVLGFTNIDDRGQEGLELSFDDWLTGKPGSKRVVRDARGAIVESVDAIRSAQPGKDLVLTIDRRIQFLAYKELRN
AIIENQAAGGSIVVMDVNNGEILAMVNLPTYNPNAVNGINSSARRNRAVTDLVEPGSTMKPLTVATALQAGVVTPDTVID
TNPGYLSLGRFTIRDVPRNNGVLNVTGVITRSSNIGAAKIVAKVPDKTFYELVQGFGYGTAPHSGFPGESSGVLPLPARW
SGTSKTTMSYGYGLSVTPLQIAQAYATLGNGGKLVPPTFVKGHHAEARQVVDAKVAQQVIGMMETVVTRGGAKAAAILGY
HVAGKTGTARKTGANGYESGHYNALFAGLVPATRPRFATVIVINDPQGKAYYGGLVSAPVFHRVMEGALRLMDVPPDDIQ
SWLAAQAAGKTGRTPPRQVDPDPALVPDAADEVAAGIPTTVTPSPSAIHRDRQ

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=581, Percent_Identity=42.6850258175559, Blast_Score=458, Evalue=1e-130,
Organism=Escherichia coli, GI1786854, Length=587, Percent_Identity=25.2129471890971, Blast_Score=142, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 66182; Mature: 66182

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNRNNRFRSHFNLRGRLLLVGTALGLCSMTLIASAAYVQLINSDFYQRQAQARYLRELP
CCCCCCHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IPTSRGMITDRNGEPLAVSTPVESIWGNPQELLRNPDAISKLAKVLDVPMEELRTRLLQK
CCCCCCEEECCCCCCEEEECCHHHHCCCHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHH
ADKEFMYLKRRINPDVAHHVLGLQIPGVFAQREFRRFYPQSEAMAHVLGFTNIDDRGQEG
HHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCC
LELSFDDWLTGKPGSKRVVRDARGAIVESVDAIRSAQPGKDLVLTIDRRIQFLAYKELRN
CEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHH
AIIENQAAGGSIVVMDVNNGEILAMVNLPTYNPNAVNGINSSARRNRAVTDLVEPGSTMK
HHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCHHHHCCCHHHHHCCCCCCC
PLTVATALQAGVVTPDTVIDTNPGYLSLGRFTIRDVPRNNGVLNVTGVITRSSNIGAAKI
CHHHHHHHHCCCCCCCCEEECCCCEEEECCEEEEECCCCCCEEEEEEEEEECCCCCHHHH
VAKVPDKTFYELVQGFGYGTAPHSGFPGESSGVLPLPARWSGTSKTTMSYGYGLSVTPLQ
EEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCHHH
IAQAYATLGNGGKLVPPTFVKGHHAEARQVVDAKVAQQVIGMMETVVTRGGAKAAAILGY
HHHHHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
HVAGKTGTARKTGANGYESGHYNALFAGLVPATRPRFATVIVINDPQGKAYYGGLVSAPV
EECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCCEEECCHHHHHH
FHRVMEGALRLMDVPPDDIQSWLAAQAAGKTGRTPPRQVDPDPALVPDAADEVAAGIPTT
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCC
VTPSPSAIHRDRQ
CCCCCHHHCCCCC
>Mature Secondary Structure
MKNRNNRFRSHFNLRGRLLLVGTALGLCSMTLIASAAYVQLINSDFYQRQAQARYLRELP
CCCCCCHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IPTSRGMITDRNGEPLAVSTPVESIWGNPQELLRNPDAISKLAKVLDVPMEELRTRLLQK
CCCCCCEEECCCCCCEEEECCHHHHCCCHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHH
ADKEFMYLKRRINPDVAHHVLGLQIPGVFAQREFRRFYPQSEAMAHVLGFTNIDDRGQEG
HHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCC
LELSFDDWLTGKPGSKRVVRDARGAIVESVDAIRSAQPGKDLVLTIDRRIQFLAYKELRN
CEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHH
AIIENQAAGGSIVVMDVNNGEILAMVNLPTYNPNAVNGINSSARRNRAVTDLVEPGSTMK
HHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCHHHHCCCHHHHHCCCCCCC
PLTVATALQAGVVTPDTVIDTNPGYLSLGRFTIRDVPRNNGVLNVTGVITRSSNIGAAKI
CHHHHHHHHCCCCCCCCEEECCCCEEEECCEEEEECCCCCCEEEEEEEEEECCCCCHHHH
VAKVPDKTFYELVQGFGYGTAPHSGFPGESSGVLPLPARWSGTSKTTMSYGYGLSVTPLQ
EEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCHHH
IAQAYATLGNGGKLVPPTFVKGHHAEARQVVDAKVAQQVIGMMETVVTRGGAKAAAILGY
HHHHHHHHCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
HVAGKTGTARKTGANGYESGHYNALFAGLVPATRPRFATVIVINDPQGKAYYGGLVSAPV
EECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCCEEECCHHHHHH
FHRVMEGALRLMDVPPDDIQSWLAAQAAGKTGRTPPRQVDPDPALVPDAADEVAAGIPTT
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCC
VTPSPSAIHRDRQ
CCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]