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The map label for this gene is cysG

Identifier: 182682454

GI number: 182682454

Start: 2171663

End: 2173099

Strand: Direct

Name: cysG

Synonym: XfasM23_1941

Alternate gene names: 182682454

Gene position: 2171663-2173099 (Clockwise)

Preceding gene: 182682451

Following gene: 182682455

Centisome position: 85.64

GC content: 61.17

Gene sequence:

>1437_bases
GTGACTGCCAACGTTCTGTTCCCCTTATTTGCCAACCTACACGACCGCGCCGTCCTGGTGGTCGGCGGCGGTAAGGTTGC
AGAACGCAAGACAGAGGCATTACTCAAAGTGGGCGCCTTGCCGATTATCGGCGCCCCCTCTCTGACCGCATCGTTACAGC
GCTGGGCCGAAACCGGTCGCATCACGTGGCGGCAAGGGACGTTTGAAAACAGCTGGCTGCAAGAAGATATTTGGTTGGTC
ATCGCCGCCACCGATCAACCCGAGGTGAACCACGCCGCGGCGCGCGCAGCACATGCGCAACGGTTATTCGTCAACGTGGT
CGACGACATTGCACTCTCCAACGTGCAGGTCCCGGCCGTGGTCGAACGCGGCCCGTTGCGGATCGCGATTTCTAGCGGCG
GTGGCGCACCGATGGTGGCACGCTATCTGCGACAACAACTGGAAAGCCTCATTGACGATAGTTGGGGACGACTGACCACA
CTGTTCGCGCAACGCCGCGACACTATCCGCGCCCGCTATCCAAACATAGAAGCACGCCGCCGCTTCTTTGAAACCCAACT
CGCCGGCCCACTCCAACGATTGCTACGCAAGCAACGCCACGCAGAGGCCGAAGCAGTGCTGGAAGCAGCACTCGCCAAGA
CTCCCCCCACGGAGTCCGGCAGCGTCACCCTGGTGGGCGCTGGCGCCGGCGACGCCGGGCTACTGACCTTAAATGCACTG
CGCGCCTTGAATGAAGCCGACATCATCCTCTACGACCGCCTGGTCAGCGACACCGTGTTACAGATGGCACGGCGCGATGC
GGAGCAGATCGAAGTAGGCAAATCCGCAACGGGCCACAGTGTGCGCCAAGAAGACATTCACACCCTGATGCTGCAACACG
CCCGTGCTGGTCAGCGTGTCGTACGGCTGAAAGGTGGCGATCCATTCGTCTTCGGTCGTGGTGGCGAGGAACTGGAATTC
TTACGTACCCACGGCATCCCCTATGAGGTCATCCCCGGAATCACCGCCGCCCTTGCCTGTGCCGCCTATGCGGGTATCCC
CTTGACCCACCGCGACCACGCCCAATCGCTATGCCTGATCACCGCCCATTGCCAATCCTCCCTAGATACCCTGAACTGGG
CTGCACTGGCACAAGAACGTCAAACGCTGGCGTTCTACATGGGCGTGGCGGGACTACCCACCATACAGCAACGCCTGTGT
GAGGCTGGACGGACCGAAACAACGCCTTTTGCACTGATCGAAAATGGCGCACGCGCGCAACAGCGGGTGCTCACAGGAAC
GCTGAAAACACTCGCGCACACCGCACAGACATACGCCGTGCGTCCCCCCGCACTGCTGATCCTCGGCGAAGTCACCGCGC
TGGCCGAACACCTGCATTGGTTCGGCACCACACCATTATCTGCCCCATGCCCCCCACGCACGCATCCTATAAGCTGA

Upstream 100 bases:

>100_bases
GAACTTAATAACTAACGGCTATTTTCCAACTGCCTGAAGTCATTTCCTGAGATTATCAACCAGGCACTACGGTCATGACC
CCCGACCTCAACTCACTATC

Downstream 100 bases:

>100_bases
TTCAAAGACACACGTATCTGTGTGTACATCCTCCCCGATTACTTCCACAGAGACCTTCATGACTATCTACAACACTATCC
TGGACACGATTGGCCACACA

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MTANVLFPLFANLHDRAVLVVGGGKVAERKTEALLKVGALPIIGAPSLTASLQRWAETGRITWRQGTFENSWLQEDIWLV
IAATDQPEVNHAAARAAHAQRLFVNVVDDIALSNVQVPAVVERGPLRIAISSGGGAPMVARYLRQQLESLIDDSWGRLTT
LFAQRRDTIRARYPNIEARRRFFETQLAGPLQRLLRKQRHAEAEAVLEAALAKTPPTESGSVTLVGAGAGDAGLLTLNAL
RALNEADIILYDRLVSDTVLQMARRDAEQIEVGKSATGHSVRQEDIHTLMLQHARAGQRVVRLKGGDPFVFGRGGEELEF
LRTHGIPYEVIPGITAALACAAYAGIPLTHRDHAQSLCLITAHCQSSLDTLNWAALAQERQTLAFYMGVAGLPTIQQRLC
EAGRTETTPFALIENGARAQQRVLTGTLKTLAHTAQTYAVRPPALLILGEVTALAEHLHWFGTTPLSAPCPPRTHPIS

Sequences:

>Translated_478_residues
MTANVLFPLFANLHDRAVLVVGGGKVAERKTEALLKVGALPIIGAPSLTASLQRWAETGRITWRQGTFENSWLQEDIWLV
IAATDQPEVNHAAARAAHAQRLFVNVVDDIALSNVQVPAVVERGPLRIAISSGGGAPMVARYLRQQLESLIDDSWGRLTT
LFAQRRDTIRARYPNIEARRRFFETQLAGPLQRLLRKQRHAEAEAVLEAALAKTPPTESGSVTLVGAGAGDAGLLTLNAL
RALNEADIILYDRLVSDTVLQMARRDAEQIEVGKSATGHSVRQEDIHTLMLQHARAGQRVVRLKGGDPFVFGRGGEELEF
LRTHGIPYEVIPGITAALACAAYAGIPLTHRDHAQSLCLITAHCQSSLDTLNWAALAQERQTLAFYMGVAGLPTIQQRLC
EAGRTETTPFALIENGARAQQRVLTGTLKTLAHTAQTYAVRPPALLILGEVTALAEHLHWFGTTPLSAPCPPRTHPIS
>Mature_477_residues
TANVLFPLFANLHDRAVLVVGGGKVAERKTEALLKVGALPIIGAPSLTASLQRWAETGRITWRQGTFENSWLQEDIWLVI
AATDQPEVNHAAARAAHAQRLFVNVVDDIALSNVQVPAVVERGPLRIAISSGGGAPMVARYLRQQLESLIDDSWGRLTTL
FAQRRDTIRARYPNIEARRRFFETQLAGPLQRLLRKQRHAEAEAVLEAALAKTPPTESGSVTLVGAGAGDAGLLTLNALR
ALNEADIILYDRLVSDTVLQMARRDAEQIEVGKSATGHSVRQEDIHTLMLQHARAGQRVVRLKGGDPFVFGRGGEELEFL
RTHGIPYEVIPGITAALACAAYAGIPLTHRDHAQSLCLITAHCQSSLDTLNWAALAQERQTLAFYMGVAGLPTIQQRLCE
AGRTETTPFALIENGARAQQRVLTGTLKTLAHTAQTYAVRPPALLILGEVTALAEHLHWFGTTPLSAPCPPRTHPIS

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family

Homologues:

Organism=Escherichia coli, GI1789768, Length=457, Percent_Identity=45.7330415754923, Blast_Score=400, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6322922, Length=243, Percent_Identity=34.9794238683128, Blast_Score=137, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYSG_XYLF2 (B2I985)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830614.1
- ProteinModelPortal:   B2I985
- SMR:   B2I985
- GeneID:   6203265
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1941
- HOGENOM:   HBG730212
- OMA:   MCRRDAE
- ProtClustDB:   CLSK881271
- GO:   GO:0005488
- HAMAP:   MF_01646
- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043
- Gene3D:   G3DSA:3.40.1010.10
- Gene3D:   G3DSA:3.30.950.10
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.8.210
- TIGRFAMs:   TIGR01469
- TIGRFAMs:   TIGR01470

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase; SSF53790 Cor/por_Metransf

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4

Molecular weight: Translated: 51958; Mature: 51827

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS00839 SUMT_1; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTANVLFPLFANLHDRAVLVVGGGKVAERKTEALLKVGALPIIGAPSLTASLQRWAETGR
CCCCCHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHCCC
ITWRQGTFENSWLQEDIWLVIAATDQPEVNHAAARAAHAQRLFVNVVDDIALSNVQVPAV
EEEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
VERGPLRIAISSGGGAPMVARYLRQQLESLIDDSWGRLTTLFAQRRDTIRARYPNIEARR
ECCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
RFFETQLAGPLQRLLRKQRHAEAEAVLEAALAKTPPTESGSVTLVGAGAGDAGLLTLNAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHH
RALNEADIILYDRLVSDTVLQMARRDAEQIEVGKSATGHSVRQEDIHTLMLQHARAGQRV
HHCCCCCEEEHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEE
VRLKGGDPFVFGRGGEELEFLRTHGIPYEVIPGITAALACAAYAGIPLTHRDHAQSLCLI
EEEECCCEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHEEEE
TAHCQSSLDTLNWAALAQERQTLAFYMGVAGLPTIQQRLCEAGRTETTPFALIENGARAQ
EHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCEECCCHHHH
QRVLTGTLKTLAHTAQTYAVRPPALLILGEVTALAEHLHWFGTTPLSAPCPPRTHPIS
HHHHHHHHHHHHHHHHHEEECCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TANVLFPLFANLHDRAVLVVGGGKVAERKTEALLKVGALPIIGAPSLTASLQRWAETGR
CCCCHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHCCC
ITWRQGTFENSWLQEDIWLVIAATDQPEVNHAAARAAHAQRLFVNVVDDIALSNVQVPAV
EEEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
VERGPLRIAISSGGGAPMVARYLRQQLESLIDDSWGRLTTLFAQRRDTIRARYPNIEARR
ECCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
RFFETQLAGPLQRLLRKQRHAEAEAVLEAALAKTPPTESGSVTLVGAGAGDAGLLTLNAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHH
RALNEADIILYDRLVSDTVLQMARRDAEQIEVGKSATGHSVRQEDIHTLMLQHARAGQRV
HHCCCCCEEEHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEE
VRLKGGDPFVFGRGGEELEFLRTHGIPYEVIPGITAALACAAYAGIPLTHRDHAQSLCLI
EEEECCCEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHEEEE
TAHCQSSLDTLNWAALAQERQTLAFYMGVAGLPTIQQRLCEAGRTETTPFALIENGARAQ
EHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCEECCCHHHH
QRVLTGTLKTLAHTAQTYAVRPPALLILGEVTALAEHLHWFGTTPLSAPCPPRTHPIS
HHHHHHHHHHHHHHHHHEEECCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA