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The map label for this gene is lpxD [H]

Identifier: 182682385

GI number: 182682385

Start: 2077607

End: 2078251

Strand: Reverse

Name: lpxD [H]

Synonym: XfasM23_1871

Alternate gene names: 182682385

Gene position: 2078251-2077607 (Counterclockwise)

Preceding gene: 182682386

Following gene: 182682379

Centisome position: 81.96

GC content: 47.29

Gene sequence:

>645_bases
ATGAAAAATACTTTCAATTACGTATTTTCCAATGGGCAACCAGCTACAGCCGCACTGGATTGGATCAATCCAGATGGAAG
TAAAGGCGGTATCGTCGCTGCCAACGCCAATATCAATCCGTCTGTGGTGATTGATAGAACTTCCGTGGTTGATGTGAATG
TCACCATCGGGGCCGGCACGGTGATCGGTGGAAAAACCAAGATTGGCAGAAATTCGGTGATCGGCACAAAAGTCACTATT
ACTTGTAATGCTGATATCGGTAATAACGTCTGCATTGGTAAAGAATCAAAAATTAATAATAAAGTCCGGATTGAGGATCA
CGCCGTGATTGGTGAGTCGGTCAGCATTGGCTATAACACGCACCTAGGCCAGTCGGTCAGTATTAGCTATAACGTGCACT
TAGGTCAGTCGATCAGCATTGGCCATAAAGCGCACCTAGGGGAGTCGGTCAGTGTTGATGATAACGTGCACATAGGCGAG
TCAGTCAGTATTGGCGATCATGTGCATCTAGGTGAGTCAGTCAGTATTGCCAAATTGGCGTGCATCGCTCGTCATGCGAG
CATTAGTCATAGAGCATGTATCGGCGAGTCGGTAAGGGTTGTGGAATTTGCACGCATCGCTCCTGGTGCCATCGTCAGTC
AATGA

Upstream 100 bases:

>100_bases
TTCGCAATAAGGTCCGGATTGAAAATCACGCTGTCATTGGTGAGTTGGTAATAAGCATTGCCAAATATCCATGCACCGTT
GCTACAGCGGTGGGTGCAGT

Downstream 100 bases:

>100_bases
GCGACATATCTATTTTTAAGAGATATTCCAAGAGTCATTTTCCCTCCCCAGGTCTGAGGAGTCGTCTGTGGAGTCGGGGG
GCTTTCTTGGGTTGCTTTTT

Product: UDP-3-O-(3-hydroxymyristoyl)-like protein

Products: UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine; [Acyl-Carrier Protein]. [C]

Alternate protein names: NA

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MKNTFNYVFSNGQPATAALDWINPDGSKGGIVAANANINPSVVIDRTSVVDVNVTIGAGTVIGGKTKIGRNSVIGTKVTI
TCNADIGNNVCIGKESKINNKVRIEDHAVIGESVSIGYNTHLGQSVSISYNVHLGQSISIGHKAHLGESVSVDDNVHIGE
SVSIGDHVHLGESVSIAKLACIARHASISHRACIGESVRVVEFARIAPGAIVSQ

Sequences:

>Translated_214_residues
MKNTFNYVFSNGQPATAALDWINPDGSKGGIVAANANINPSVVIDRTSVVDVNVTIGAGTVIGGKTKIGRNSVIGTKVTI
TCNADIGNNVCIGKESKINNKVRIEDHAVIGESVSIGYNTHLGQSVSISYNVHLGQSISIGHKAHLGESVSVDDNVHIGE
SVSIGDHVHLGESVSIAKLACIARHASISHRACIGESVRVVEFARIAPGAIVSQ
>Mature_214_residues
MKNTFNYVFSNGQPATAALDWINPDGSKGGIVAANANINPSVVIDRTSVVDVNVTIGAGTVIGGKTKIGRNSVIGTKVTI
TCNADIGNNVCIGKESKINNKVRIEDHAVIGESVSIGYNTHLGQSVSISYNVHLGQSISIGHKAHLGESVSVDDNVHIGE
SVSIGDHVHLGESVSIAKLACIARHASISHRACIGESVRVVEFARIAPGAIVSQ

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.- [C]

Molecular weight: Translated: 22238; Mature: 22238

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTFNYVFSNGQPATAALDWINPDGSKGGIVAANANINPSVVIDRTSVVDVNVTIGAGT
CCCCEEEEEECCCCCEEEEEEECCCCCCCCEEEECCCCCCEEEEECCEEEEEEEEECCCE
VIGGKTKIGRNSVIGTKVTITCNADIGNNVCIGKESKINNKVRIEDHAVIGESVSIGYNT
EECCCCCCCCCCEEEEEEEEEECCCCCCCEEECCCCCCCCEEEEEEEEEECCEEEECCCC
HLGQSVSISYNVHLGQSISIGHKAHLGESVSVDDNVHIGESVSIGDHVHLGESVSIAKLA
CCCCEEEEEEEEEECCEECCCCHHCCCCCCCCCCCEEECCEECCCCEEECCCCCCHHHHE
CIARHASISHRACIGESVRVVEFARIAPGAIVSQ
EHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCC
>Mature Secondary Structure
MKNTFNYVFSNGQPATAALDWINPDGSKGGIVAANANINPSVVIDRTSVVDVNVTIGAGT
CCCCEEEEEECCCCCEEEEEEECCCCCCCCEEEECCCCCCEEEEECCEEEEEEEEECCCE
VIGGKTKIGRNSVIGTKVTITCNADIGNNVCIGKESKINNKVRIEDHAVIGESVSIGYNT
EECCCCCCCCCCEEEEEEEEEECCCCCCCEEECCCCCCCCEEEEEEEEEECCEEEECCCC
HLGQSVSISYNVHLGQSISIGHKAHLGESVSVDDNVHIGESVSIGDHVHLGESVSIAKLA
CCCCEEEEEEEEEECCEECCCCHHCCCCCCCCCCCEEECCEECCCCEEECCCCCCHHHHE
CIARHASISHRACIGESVRVVEFARIAPGAIVSQ
EHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine; (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine + (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] = UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine + [Acyl-Carrier Protein]. [C]

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA