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The map label for this gene is trpS

Identifier: 182682261

GI number: 182682261

Start: 1925900

End: 1927207

Strand: Reverse

Name: trpS

Synonym: XfasM23_1743

Alternate gene names: 182682261

Gene position: 1927207-1925900 (Counterclockwise)

Preceding gene: 182682262

Following gene: 182682260

Centisome position: 76.0

GC content: 54.36

Gene sequence:

>1308_bases
ATGAGTATTCGTGTTCTGACTGGTATCACTACTTCCGGGACGCCCCATTTGGGGAATTATGTTGGTGCGATTCGTCCGGC
GATTCGTGCTGCTGGGGCGCCTGGAACTGAAAGTTTTTATTTTTTGGCGGATTTGCACAGTTTGATCAAAGTGCAGGATC
CAGAGCGTACGCAGCGTTCGACGCTGGAGATTGCGGCGACTTGGCTTGCGTGTGGTCTGGATCCGGAAAAGGTGTGGTTG
TATCGGCAGAGTGATGTCCCTGAAATCACAGAGTTGATGTGGTTGCTCACTTGTGTTGCCGGGAAGGGGATTCTTAATCG
TGCGCATGCTTATAAGGCGGTGGTGGATAAGAATCGTAGTCATGGGGATGATGATGATGCAGGGATCACGGCCGGTCTGT
TTATGTATCCGGTGTTGATGGCGGCGGATATTCTTCTTTTTAATGCGCATCAGGTCCCAGTGGGACGCGATCAGATTCAG
CATATCGAGATGGCGCGGGATTTCGCGCAGCGTTTTAATCATATTTACGGTGGGGAGTATTTGGTGCTTCCGGAGGCCGC
TATTGATGAGCAGGTGGCGACGTTGCCGGGTTTGGATGGGCGCAAGATGAGTAAAAGCTATGGCAATACGATGCCGCTGT
TCTGTACGCGGGAGGAGTTAAAGAAGTACGTGTTTTCGATTGTCACCGATTCGCGTGCGCCAGGGGAGCCGAAGGAGGCT
GTTGGTTCGGCAGTGTTCCAGTTGTATCAGGCGTTTGCTGGTGTTGAGGAGTGCAGTATGTTCGCGCAGGCATTGGTTGA
GGGTCTCGGGTGGGGGGAGGCAAAGGTGCGTTTGTTCGAGCGTATTGATGCGGAGGTTGCGCCGCTGCGGGAGCGTTATG
AGGATTTCATGAGGCGTCCGGCGGATATCGAAGCAATGTTGCGTGATAGTGCGGGGCGTTTGCGGGAGAGGGATGCAATC
CCACTTTTGGCACGGTTGCGTGAGGCGGTGGGGTTGCGGAGTTTGTCGCTCTGCATGGTCAGTGCGGTGCCGGTGCCGCA
AGAAAAGGTGGCGTTACCGGTATTGAAGCAATATCGGGAACAGGATGGGCGTTTTTATTTCAAGTTGATTGATGGGCAGG
GGGCGGTGTTGGTGCAGAGTCGGGGGTTTGCTTCGCCGCGTGATGCCGGTCAGTGGATCGCTTTGTTTAAGCAGGTGGTG
TCTGCTGAGGCGTTGGTCTCTCCGATGTTGGAGCCGGTGGCTGATCCTGTTGTTGTGCTCGCTGCGCTGCGTCGGCTGCG
TGAGGCTGGTTTGGATTTATATACTTAA

Upstream 100 bases:

>100_bases
TCTGGGATGGGCTTGCTCTGGAAGGTGGTGATTTTCTGCAGTGCTTTGTATGGCGGGGGTTAGACTTTGAAGCCGTATTT
CATTTCCGATGGGACATTTC

Downstream 100 bases:

>100_bases
TTGCACCAAATTTTATTCAATTCATTTTGATTTGAATGCACTAGATATTTGGTGAGCAATTCTTCCCCATGGAGGTTGCA
ATGAAAGATGTAATGAGTAT

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSIRVLTGITTSGTPHLGNYVGAIRPAIRAAGAPGTESFYFLADLHSLIKVQDPERTQRSTLEIAATWLACGLDPEKVWL
YRQSDVPEITELMWLLTCVAGKGILNRAHAYKAVVDKNRSHGDDDDAGITAGLFMYPVLMAADILLFNAHQVPVGRDQIQ
HIEMARDFAQRFNHIYGGEYLVLPEAAIDEQVATLPGLDGRKMSKSYGNTMPLFCTREELKKYVFSIVTDSRAPGEPKEA
VGSAVFQLYQAFAGVEECSMFAQALVEGLGWGEAKVRLFERIDAEVAPLRERYEDFMRRPADIEAMLRDSAGRLRERDAI
PLLARLREAVGLRSLSLCMVSAVPVPQEKVALPVLKQYREQDGRFYFKLIDGQGAVLVQSRGFASPRDAGQWIALFKQVV
SAEALVSPMLEPVADPVVVLAALRRLREAGLDLYT

Sequences:

>Translated_435_residues
MSIRVLTGITTSGTPHLGNYVGAIRPAIRAAGAPGTESFYFLADLHSLIKVQDPERTQRSTLEIAATWLACGLDPEKVWL
YRQSDVPEITELMWLLTCVAGKGILNRAHAYKAVVDKNRSHGDDDDAGITAGLFMYPVLMAADILLFNAHQVPVGRDQIQ
HIEMARDFAQRFNHIYGGEYLVLPEAAIDEQVATLPGLDGRKMSKSYGNTMPLFCTREELKKYVFSIVTDSRAPGEPKEA
VGSAVFQLYQAFAGVEECSMFAQALVEGLGWGEAKVRLFERIDAEVAPLRERYEDFMRRPADIEAMLRDSAGRLRERDAI
PLLARLREAVGLRSLSLCMVSAVPVPQEKVALPVLKQYREQDGRFYFKLIDGQGAVLVQSRGFASPRDAGQWIALFKQVV
SAEALVSPMLEPVADPVVVLAALRRLREAGLDLYT
>Mature_434_residues
SIRVLTGITTSGTPHLGNYVGAIRPAIRAAGAPGTESFYFLADLHSLIKVQDPERTQRSTLEIAATWLACGLDPEKVWLY
RQSDVPEITELMWLLTCVAGKGILNRAHAYKAVVDKNRSHGDDDDAGITAGLFMYPVLMAADILLFNAHQVPVGRDQIQH
IEMARDFAQRFNHIYGGEYLVLPEAAIDEQVATLPGLDGRKMSKSYGNTMPLFCTREELKKYVFSIVTDSRAPGEPKEAV
GSAVFQLYQAFAGVEECSMFAQALVEGLGWGEAKVRLFERIDAEVAPLRERYEDFMRRPADIEAMLRDSAGRLRERDAIP
LLARLREAVGLRSLSLCMVSAVPVPQEKVALPVLKQYREQDGRFYFKLIDGQGAVLVQSRGFASPRDAGQWIALFKQVVS
AEALVSPMLEPVADPVVVLAALRRLREAGLDLYT

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI7710154, Length=321, Percent_Identity=33.3333333333333, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI41352700, Length=186, Percent_Identity=43.010752688172, Blast_Score=152, Evalue=6e-37,
Organism=Escherichia coli, GI1789786, Length=338, Percent_Identity=34.9112426035503, Blast_Score=164, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI71982800, Length=337, Percent_Identity=28.7833827893175, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71982793, Length=337, Percent_Identity=28.7833827893175, Blast_Score=131, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6320474, Length=348, Percent_Identity=32.183908045977, Blast_Score=147, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24666151, Length=339, Percent_Identity=30.3834808259587, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYW_XYLFT (Q87B10)

Other databases:

- EMBL:   AE009442
- RefSeq:   NP_779841.1
- ProteinModelPortal:   Q87B10
- SMR:   Q87B10
- STRING:   Q87B10
- GeneID:   1142992
- GenomeReviews:   AE009442_GR
- KEGG:   xft:PD1650
- eggNOG:   COG0180
- HOGENOM:   HBG293263
- OMA:   YFIADYH
- ProtClustDB:   PRK12284
- BioCyc:   XFAS183190:PD_1650-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00140_B
- InterPro:   IPR002305
- InterPro:   IPR010879
- InterPro:   IPR014729
- InterPro:   IPR002306
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10055
- PRINTS:   PR01039
- TIGRFAMs:   TIGR00233

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.2

Molecular weight: Translated: 48155; Mature: 48024

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 205-205

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIRVLTGITTSGTPHLGNYVGAIRPAIRAAGAPGTESFYFLADLHSLIKVQDPERTQRS
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHH
TLEIAATWLACGLDPEKVWLYRQSDVPEITELMWLLTCVAGKGILNRAHAYKAVVDKNRS
HHHHHHHHHHHCCCHHHEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
HGDDDDAGITAGLFMYPVLMAADILLFNAHQVPVGRDQIQHIEMARDFAQRFNHIYGGEY
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCE
LVLPEAAIDEQVATLPGLDGRKMSKSYGNTMPLFCTREELKKYVFSIVTDSRAPGEPKEA
EEECCHHHHHHHHHCCCCCCCHHHHHCCCCCCEEECHHHHHHHHHHHHHCCCCCCCHHHH
VGSAVFQLYQAFAGVEECSMFAQALVEGLGWGEAKVRLFERIDAEVAPLRERYEDFMRRP
HHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCC
ADIEAMLRDSAGRLRERDAIPLLARLREAVGLRSLSLCMVSAVPVPQEKVALPVLKQYRE
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHH
QDGRFYFKLIDGQGAVLVQSRGFASPRDAGQWIALFKQVVSAEALVSPMLEPVADPVVVL
CCCCEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALRRLREAGLDLYT
HHHHHHHHCCCCCCC
>Mature Secondary Structure 
SIRVLTGITTSGTPHLGNYVGAIRPAIRAAGAPGTESFYFLADLHSLIKVQDPERTQRS
CEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHH
TLEIAATWLACGLDPEKVWLYRQSDVPEITELMWLLTCVAGKGILNRAHAYKAVVDKNRS
HHHHHHHHHHHCCCHHHEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
HGDDDDAGITAGLFMYPVLMAADILLFNAHQVPVGRDQIQHIEMARDFAQRFNHIYGGEY
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCE
LVLPEAAIDEQVATLPGLDGRKMSKSYGNTMPLFCTREELKKYVFSIVTDSRAPGEPKEA
EEECCHHHHHHHHHCCCCCCCHHHHHCCCCCCEEECHHHHHHHHHHHHHCCCCCCCHHHH
VGSAVFQLYQAFAGVEECSMFAQALVEGLGWGEAKVRLFERIDAEVAPLRERYEDFMRRP
HHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCC
ADIEAMLRDSAGRLRERDAIPLLARLREAVGLRSLSLCMVSAVPVPQEKVALPVLKQYRE
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHH
QDGRFYFKLIDGQGAVLVQSRGFASPRDAGQWIALFKQVVSAEALVSPMLEPVADPVVVL
CCCCEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALRRLREAGLDLYT
HHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12533478