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The map label for this gene is moeB [H]

Identifier: 182682228

GI number: 182682228

Start: 1889327

End: 1890466

Strand: Direct

Name: moeB [H]

Synonym: XfasM23_1710

Alternate gene names: 182682228

Gene position: 1889327-1890466 (Clockwise)

Preceding gene: 182682217

Following gene: 182682236

Centisome position: 74.51

GC content: 59.91

Gene sequence:

>1140_bases
ATGAGCATCGCTGAAATCACACCGCATCAGGCACGGTCTCGCGCCGCCAGTGGCGCCGTTTTCATTGATGTACGTCAATC
CTATGAGCGGGTGAGCGGCCAAGCTGAAGGCGCGCTCGGGATCGATCAAGCGACACTGGAAGCGCATAGCAGCACTCATT
TACCCGATACAAACGCGGAGATCGTCCTGATCTGTCAGTCCGGTCAGCGCTCACGGCACACCGGGGAGCGACTGCAAGCA
GCGGGTTATCGGCGGTTGTACTCCGTTGCTGGCGGAACCGATGCCTGGCGCAAGGCCGGTCTGCCATTACTACGCCCTAT
CCTGAGCACTGACGAGCAGGACTTCATGGAGCGTTACGCGCGTCACTTGCGTCTGCCTCACATCGGGCCACATGGCCAGC
AGCGCTTGGCAGAAGCACGTGTGCTGTTGATTGGTGCCGGTGGTCTGGGATCACCCGCCGCGTTCTATTTGACTGCCGCC
GGGGTCGGTCATCTGCGCATCGCCGATCATGACACGGTGGAACGCAGCAATCTGCAACGGCAGATTCTGCACGTGGATGC
AGAATTGGGAGTTCCCAAAGCCGCATCAGCAGCACGGCGCCTGAGTGCCCTGAATCCACGCGTCCAGGTCGAAGCAATGC
AGGTAAGGGCGAATTCCAGCAACATCGAAACACTGTTACAGGACGTCGACGTCGCCATAGACGGTGCCGACAATTTCCCG
GCGCGGTATCTGCTCAACGACGCCTGCGTCAAGATGGGCACTCCTCTGGTCTATGGTGCAGTCCACCAGTTCCAGGGCCA
GGTCAGCGTTTTCGATGCCGGCCGCCAGCGTGGGCAGGCGCCTTGTTATCGCTGTCTGTTTCCGGAACCACCGCACCCAG
AATTCGCACCCAGCTGTAGTGAGGTTGGCGTGCTCGGTGTGTTACCCGGTGTCATCGGGATGCTCCAAGCCACCGAAGCG
CTGAAGCTACTGCTGGATATCGGCAAGCCGCTACGCGGACGTGTGTTGTGTTTCGATGCGCTGGCAATGCAGTTTCGGGA
AATACGTCTGGCCCCAGACCCGACGTGTCCAGTGTGTGCACCAGGACGACCGTTCCCCGGGTACATCGACTATGCCGCAT
TCTGCCGCAATCCACTCTAA

Upstream 100 bases:

>100_bases
AGCATCAGCAATCTGCGCAGCACCGCTCAATCCAACACATTGACGCCTTCAGGAATAGCAACACAGTAACGGCGTACGTG
GATTATTCGATAATGTCACG

Downstream 100 bases:

>100_bases
GCAACCGACTCAGCGCAGTTGATACACCAACGCATGGCACTGCTCTCAACGAGAGCCAAGTCAAATGTGCATTCCATCGG
TAACATCACAATAGGCAGCG

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MSIAEITPHQARSRAASGAVFIDVRQSYERVSGQAEGALGIDQATLEAHSSTHLPDTNAEIVLICQSGQRSRHTGERLQA
AGYRRLYSVAGGTDAWRKAGLPLLRPILSTDEQDFMERYARHLRLPHIGPHGQQRLAEARVLLIGAGGLGSPAAFYLTAA
GVGHLRIADHDTVERSNLQRQILHVDAELGVPKAASAARRLSALNPRVQVEAMQVRANSSNIETLLQDVDVAIDGADNFP
ARYLLNDACVKMGTPLVYGAVHQFQGQVSVFDAGRQRGQAPCYRCLFPEPPHPEFAPSCSEVGVLGVLPGVIGMLQATEA
LKLLLDIGKPLRGRVLCFDALAMQFREIRLAPDPTCPVCAPGRPFPGYIDYAAFCRNPL

Sequences:

>Translated_379_residues
MSIAEITPHQARSRAASGAVFIDVRQSYERVSGQAEGALGIDQATLEAHSSTHLPDTNAEIVLICQSGQRSRHTGERLQA
AGYRRLYSVAGGTDAWRKAGLPLLRPILSTDEQDFMERYARHLRLPHIGPHGQQRLAEARVLLIGAGGLGSPAAFYLTAA
GVGHLRIADHDTVERSNLQRQILHVDAELGVPKAASAARRLSALNPRVQVEAMQVRANSSNIETLLQDVDVAIDGADNFP
ARYLLNDACVKMGTPLVYGAVHQFQGQVSVFDAGRQRGQAPCYRCLFPEPPHPEFAPSCSEVGVLGVLPGVIGMLQATEA
LKLLLDIGKPLRGRVLCFDALAMQFREIRLAPDPTCPVCAPGRPFPGYIDYAAFCRNPL
>Mature_378_residues
SIAEITPHQARSRAASGAVFIDVRQSYERVSGQAEGALGIDQATLEAHSSTHLPDTNAEIVLICQSGQRSRHTGERLQAA
GYRRLYSVAGGTDAWRKAGLPLLRPILSTDEQDFMERYARHLRLPHIGPHGQQRLAEARVLLIGAGGLGSPAAFYLTAAG
VGHLRIADHDTVERSNLQRQILHVDAELGVPKAASAARRLSALNPRVQVEAMQVRANSSNIETLLQDVDVAIDGADNFPA
RYLLNDACVKMGTPLVYGAVHQFQGQVSVFDAGRQRGQAPCYRCLFPEPPHPEFAPSCSEVGVLGVLPGVIGMLQATEAL
KLLLDIGKPLRGRVLCFDALAMQFREIRLAPDPTCPVCAPGRPFPGYIDYAAFCRNPL

Specific function: Involved In The Biosynthesis Of A Demolybdo Cofactor (Molybdopterin), Necessary For Molybdoenzymes. Plays A Role In The Activation Of The Small Subunit Of The Molybdopterin Converting Factor (Moad). [C]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=266, Percent_Identity=45.8646616541353, Blast_Score=184, Evalue=8e-47,
Organism=Homo sapiens, GI4885649, Length=173, Percent_Identity=30.635838150289, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1787048, Length=244, Percent_Identity=43.0327868852459, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI87082356, Length=256, Percent_Identity=41.796875, Blast_Score=175, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17540406, Length=259, Percent_Identity=40.1544401544402, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI193203301, Length=170, Percent_Identity=28.2352941176471, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321903, Length=270, Percent_Identity=34.8148148148148, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6320598, Length=177, Percent_Identity=26.5536723163842, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325323, Length=173, Percent_Identity=28.3236994219653, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24582879, Length=264, Percent_Identity=43.1818181818182, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24660640, Length=172, Percent_Identity=29.0697674418605, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28573937, Length=168, Percent_Identity=29.1666666666667, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI20129973, Length=168, Percent_Identity=31.547619047619, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24641311, Length=250, Percent_Identity=27.6, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 41017; Mature: 40886

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIAEITPHQARSRAASGAVFIDVRQSYERVSGQAEGALGIDQATLEAHSSTHLPDTNAE
CCCCCCCCHHHHHHHCCCCEEEEEHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCCC
IVLICQSGQRSRHTGERLQAAGYRRLYSVAGGTDAWRKAGLPLLRPILSTDEQDFMERYA
EEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHCCCHHHHHHHHH
RHLRLPHIGPHGQQRLAEARVLLIGAGGLGSPAAFYLTAAGVGHLRIADHDTVERSNLQR
HHCCCCCCCCCHHHHHHHCEEEEEECCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHH
QILHVDAELGVPKAASAARRLSALNPRVQVEAMQVRANSSNIETLLQDVDVAIDGADNFP
HHHEEHHHCCCCHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHHCEEEECCCCCC
ARYLLNDACVKMGTPLVYGAVHQFQGQVSVFDAGRQRGQAPCYRCLFPEPPHPEFAPSCS
HHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEHHHHHCCCCCEEEECCCCCCCCCCCCCHH
EVGVLGVLPGVIGMLQATEALKLLLDIGKPLRGRVLCFDALAMQFREIRLAPDPTCPVCA
HCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCC
PGRPFPGYIDYAAFCRNPL
CCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
SIAEITPHQARSRAASGAVFIDVRQSYERVSGQAEGALGIDQATLEAHSSTHLPDTNAE
CCCCCCCHHHHHHHCCCCEEEEEHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCCC
IVLICQSGQRSRHTGERLQAAGYRRLYSVAGGTDAWRKAGLPLLRPILSTDEQDFMERYA
EEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHCCCHHHHHHHHH
RHLRLPHIGPHGQQRLAEARVLLIGAGGLGSPAAFYLTAAGVGHLRIADHDTVERSNLQR
HHCCCCCCCCCHHHHHHHCEEEEEECCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHH
QILHVDAELGVPKAASAARRLSALNPRVQVEAMQVRANSSNIETLLQDVDVAIDGADNFP
HHHEEHHHCCCCHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHHCEEEECCCCCC
ARYLLNDACVKMGTPLVYGAVHQFQGQVSVFDAGRQRGQAPCYRCLFPEPPHPEFAPSCS
HHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEHHHHHCCCCCEEEECCCCCCCCCCCCCHH
EVGVLGVLPGVIGMLQATEALKLLLDIGKPLRGRVLCFDALAMQFREIRLAPDPTCPVCA
HCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCC
PGRPFPGYIDYAAFCRNPL
CCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA