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The map label for this gene is dctA2 [H]

Identifier: 182682125

GI number: 182682125

Start: 1778358

End: 1779671

Strand: Direct

Name: dctA2 [H]

Synonym: XfasM23_1603

Alternate gene names: 182682125

Gene position: 1778358-1779671 (Clockwise)

Preceding gene: 182682112

Following gene: 182682126

Centisome position: 70.13

GC content: 54.34

Gene sequence:

>1314_bases
ATGAAGTTGATCTCGGGTTGGTTACGGATTCCGTTCTGGCAACGCGTGGTCGCGGGTTTTGTACTCGGGGCTCTAGTTGG
TTGGGTGATGGGACCGGCCGCCAAAACTTGGTTTGGACCATTGGGCACACTGTATGTCACGTTGATCAAGATGATCGCAA
TACCGCTGGTGTTCTTCGCGGTGATTAACGCGATTGCGGCGCTGCACGGACAACGATCGGTCGCCATGTTGGGCGGACGC
ACGTTTCTGTGGTTTATCGTCACCGCAGCCTTGGCGGTGTGTGTGGGATTGGGTGTGGGTACGTTGCTGAAACCCGGTAA
TGGTGACTTCACTGTGAGTGTGGATGCGGCATGGGCGCCACCAGATGTACCGAGTCCGGTGCATGTGTTGCTGGATGTGG
TGCCATCCAATCCGTTTTATGCATTGACCGGCATCGGGACTCGCAGTAATAACACGGGGGAAACGACGTTGGCGGCCGGA
CGTGGCTCAATTCTTCCAGTAATCTTTTTCGCAGCGCTGTTGGGCTTGGCCATTGTCAAGCTTGGGGAACGCGTGACGGA
GGTACGCAAGCTGATCGGGCAGATGAGCGAGATCATGATCCAAATCACTCGCTTTGTGCTGGAGATGACACCACTGGGGA
CCTTTGGATTAATCGCTGCGTTGGTCGGGAGCTATGGTTTTCAGAAGTTGCTGCCTTTCGGTCACTTTGTATTGGCACTT
TATTTGGCATGTGCGTTACACATTGTGGTGGTGTACAGCGGGCTTCTGCTGGCACATGGTTTGAGTCCATTGAAGTTTTT
CAGGGGTGTCGCGCCAGGGATGCAGGTCGCTTTTGTGAGTTCTTCCAGCTTTGCTGCGATGCCAGTGGCGTTACGCGCGA
TTACGCACAATCTGGGGGTTAACAAGGACTACGCTGCATTTGCTGTGCCGCTGGGTAGTAGCATCAAGATGGACGGTTGC
GGGGCGATCTTTCCAGCGTTGTGTGCGGTGTTCATCGCTCAGTACACCGGGGTGCCGCTGACCGCGAATCAATATTTCGT
CATTTTTATCGCATCGGTACTCGGCAGTTTTGGCACGGCCGGGGTGCCAGGTACGGCGGTGGTGATGGCAACCGTGGTGC
TGAGTGCAGCTCATTTGCCGCTGGAGGTAATTGGTTATCTGTATGCCATTGATCGCGTGTTAGACATGATGCGCACTATG
ACAAACGTCACCGGACAGATGTTGGTGCCGGTGCTGGTGGCAAAAGAAACGGGATTACTGAATACAACGGTTTACGAGGC
AGCGTCCAGTAACGTTGGAATTGGGACATCCTGA

Upstream 100 bases:

>100_bases
AGACGATAAAGTCACATAGATGACAGTGTTCAACTGTGGTTTCATATACGAATAACACAAGGGCTATTGTCTGTTCCCCC
ATTTTGGACACTCTTTCATT

Downstream 100 bases:

>100_bases
TTGTGTCCAAGAAAATGCGACGCGAGCGGTGCTCAGTCAGATTGCGTCGCACTGCGGTGCTCCATATTTATACAGGCTTG
CTTAAGACATCAGCTGCAAA

Product: sodium:dicarboxylate symporter

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MKLISGWLRIPFWQRVVAGFVLGALVGWVMGPAAKTWFGPLGTLYVTLIKMIAIPLVFFAVINAIAALHGQRSVAMLGGR
TFLWFIVTAALAVCVGLGVGTLLKPGNGDFTVSVDAAWAPPDVPSPVHVLLDVVPSNPFYALTGIGTRSNNTGETTLAAG
RGSILPVIFFAALLGLAIVKLGERVTEVRKLIGQMSEIMIQITRFVLEMTPLGTFGLIAALVGSYGFQKLLPFGHFVLAL
YLACALHIVVVYSGLLLAHGLSPLKFFRGVAPGMQVAFVSSSSFAAMPVALRAITHNLGVNKDYAAFAVPLGSSIKMDGC
GAIFPALCAVFIAQYTGVPLTANQYFVIFIASVLGSFGTAGVPGTAVVMATVVLSAAHLPLEVIGYLYAIDRVLDMMRTM
TNVTGQMLVPVLVAKETGLLNTTVYEAASSNVGIGTS

Sequences:

>Translated_437_residues
MKLISGWLRIPFWQRVVAGFVLGALVGWVMGPAAKTWFGPLGTLYVTLIKMIAIPLVFFAVINAIAALHGQRSVAMLGGR
TFLWFIVTAALAVCVGLGVGTLLKPGNGDFTVSVDAAWAPPDVPSPVHVLLDVVPSNPFYALTGIGTRSNNTGETTLAAG
RGSILPVIFFAALLGLAIVKLGERVTEVRKLIGQMSEIMIQITRFVLEMTPLGTFGLIAALVGSYGFQKLLPFGHFVLAL
YLACALHIVVVYSGLLLAHGLSPLKFFRGVAPGMQVAFVSSSSFAAMPVALRAITHNLGVNKDYAAFAVPLGSSIKMDGC
GAIFPALCAVFIAQYTGVPLTANQYFVIFIASVLGSFGTAGVPGTAVVMATVVLSAAHLPLEVIGYLYAIDRVLDMMRTM
TNVTGQMLVPVLVAKETGLLNTTVYEAASSNVGIGTS
>Mature_437_residues
MKLISGWLRIPFWQRVVAGFVLGALVGWVMGPAAKTWFGPLGTLYVTLIKMIAIPLVFFAVINAIAALHGQRSVAMLGGR
TFLWFIVTAALAVCVGLGVGTLLKPGNGDFTVSVDAAWAPPDVPSPVHVLLDVVPSNPFYALTGIGTRSNNTGETTLAAG
RGSILPVIFFAALLGLAIVKLGERVTEVRKLIGQMSEIMIQITRFVLEMTPLGTFGLIAALVGSYGFQKLLPFGHFVLAL
YLACALHIVVVYSGLLLAHGLSPLKFFRGVAPGMQVAFVSSSSFAAMPVALRAITHNLGVNKDYAAFAVPLGSSIKMDGC
GAIFPALCAVFIAQYTGVPLTANQYFVIFIASVLGSFGTAGVPGTAVVMATVVLSAAHLPLEVIGYLYAIDRVLDMMRTM
TNVTGQMLVPVLVAKETGLLNTTVYEAASSNVGIGTS

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI66773030, Length=444, Percent_Identity=27.4774774774775, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI21314632, Length=407, Percent_Identity=28.009828009828, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI40254478, Length=411, Percent_Identity=25.0608272506083, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI169790839, Length=470, Percent_Identity=25.9574468085106, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI194239697, Length=459, Percent_Identity=24.400871459695, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI5032093, Length=374, Percent_Identity=28.0748663101604, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI4827012, Length=246, Percent_Identity=30.4878048780488, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI223468564, Length=249, Percent_Identity=28.9156626506024, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI223468566, Length=249, Percent_Identity=28.9156626506024, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI301601644, Length=151, Percent_Identity=33.7748344370861, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI262359914, Length=381, Percent_Identity=24.6719160104987, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1789947, Length=428, Percent_Identity=28.0373831775701, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1788024, Length=404, Percent_Identity=33.1683168316832, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1790514, Length=421, Percent_Identity=28.2660332541568, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1789473, Length=390, Percent_Identity=23.3333333333333, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71983106, Length=437, Percent_Identity=27.4599542334096, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71983099, Length=437, Percent_Identity=27.4599542334096, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17537407, Length=451, Percent_Identity=25.9423503325942, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI193206505, Length=398, Percent_Identity=28.1407035175879, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI71996953, Length=442, Percent_Identity=25.3393665158371, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI193206654, Length=422, Percent_Identity=25.3554502369668, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17541374, Length=401, Percent_Identity=23.1920199501247, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24583025, Length=428, Percent_Identity=25.7009345794392, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI17137668, Length=428, Percent_Identity=25.7009345794392, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24583023, Length=428, Percent_Identity=25.7009345794392, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI281360481, Length=440, Percent_Identity=25.9090909090909, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI281360483, Length=440, Percent_Identity=25.9090909090909, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17137666, Length=440, Percent_Identity=25.9090909090909, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45922; Mature: 45922

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLISGWLRIPFWQRVVAGFVLGALVGWVMGPAAKTWFGPLGTLYVTLIKMIAIPLVFFA
CCCHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHHHHHHHHHHHHH
VINAIAALHGQRSVAMLGGRTFLWFIVTAALAVCVGLGVGTLLKPGNGDFTVSVDAAWAP
HHHHHHHHHCCCCEEHHCCHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCEEEEEECCCCC
PDVPSPVHVLLDVVPSNPFYALTGIGTRSNNTGETTLAAGRGSILPVIFFAALLGLAIVK
CCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHH
LGERVTEVRKLIGQMSEIMIQITRFVLEMTPLGTFGLIAALVGSYGFQKLLPFGHFVLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHH
YLACALHIVVVYSGLLLAHGLSPLKFFRGVAPGMQVAFVSSSSFAAMPVALRAITHNLGV
HHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
NKDYAAFAVPLGSSIKMDGCGAIFPALCAVFIAQYTGVPLTANQYFVIFIASVLGSFGTA
CCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCC
GVPGTAVVMATVVLSAAHLPLEVIGYLYAIDRVLDMMRTMTNVTGQMLVPVLVAKETGLL
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
NTTVYEAASSNVGIGTS
HHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKLISGWLRIPFWQRVVAGFVLGALVGWVMGPAAKTWFGPLGTLYVTLIKMIAIPLVFFA
CCCHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHHHHHHHHHHHHH
VINAIAALHGQRSVAMLGGRTFLWFIVTAALAVCVGLGVGTLLKPGNGDFTVSVDAAWAP
HHHHHHHHHCCCCEEHHCCHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCEEEEEECCCCC
PDVPSPVHVLLDVVPSNPFYALTGIGTRSNNTGETTLAAGRGSILPVIFFAALLGLAIVK
CCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHH
LGERVTEVRKLIGQMSEIMIQITRFVLEMTPLGTFGLIAALVGSYGFQKLLPFGHFVLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHH
YLACALHIVVVYSGLLLAHGLSPLKFFRGVAPGMQVAFVSSSSFAAMPVALRAITHNLGV
HHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
NKDYAAFAVPLGSSIKMDGCGAIFPALCAVFIAQYTGVPLTANQYFVIFIASVLGSFGTA
CCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCC
GVPGTAVVMATVVLSAAHLPLEVIGYLYAIDRVLDMMRTMTNVTGQMLVPVLVAKETGLL
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
NTTVYEAASSNVGIGTS
HHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA