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The map label for this gene is guaA

Identifier: 182682053

GI number: 182682053

Start: 1701434

End: 1703002

Strand: Reverse

Name: guaA

Synonym: XfasM23_1531

Alternate gene names: 182682053

Gene position: 1703002-1701434 (Counterclockwise)

Preceding gene: 182682054

Following gene: 182682052

Centisome position: 67.16

GC content: 53.73

Gene sequence:

>1569_bases
ATGACACCGAATATTCATCACGACAAAATTCTTATCCTCGATTTCGGCGCACAGTACACCCAGTTGATTGCCCGTCGTAT
CCGTGAAATTGGTGTCTACTGCGAAGTGTGGCCCTGGGATCACTCCCCTGAAGAGATTCTGAGCTTCGGGGCCAAAGGTA
TCATCCTCTCCGGTGGCCCTGAATCGACCACATCCCCGGGTGCGCCTGCAGCACCGCAGCACGTCTTTGATAGTGACTTA
CCAATCTTCGGTATTTGCTATGGCATGCAAACCATGGCCGTACATCTTGGGGGTGCGACCGAGGCAGCCGACAAACGCGA
GTTTGGTCATGCCTCGGTCCAGGTGATTTACCCGGATACCTTGTTTTCCGGCTTGTCCGATCATCCCTCTGAGTTCCGTC
TGGATGTGTGGATGAGTCATGGTGACCATGTTTCACGCGTCCCGCCCTGCTTCACCATTACAGCCGCCACTGACCGCATC
CCCATTGCGGCGATGAGTCGCGAGGATAAGCGCTGGTATGGCGTGCAATTCCATCCGGAAGTGACCCATACCTTACAGGG
ACAGGCTTTATTGCGCCGTTTTGTGGTTGATATATGTGGCTGTCAGACGTTATGGACCTCCGCTAACATTATTGAAGACC
AAATCGCTCGTGTGCGTGAACGTGTCGGTTGCGATGAAGTCATTCTCGGCCTGTCTGGTGGCGTTGATTCTTCCGTCGTC
GCCGCACTTTTACACAAAGCCATTGGCAGCCAACTGACGTGTGTATTTGTTGATACTGGCATGCTTCGCTGGGGAGAAGG
CGACCAAGTGATGGCCATGTTTGCGGAACATATGGGCGTCAACGTGGTACGTATCAATGCGGCATCGCGTTACTTCGACG
CACTGCAAGGTGTCTACGACCCAGAAGCCAAACGCAAAATCATCGGCAACCTGTTCATCCAGATATTCGAGGAAGAGGCC
AGCAAACGAAAGCAGGCCAAATGGTTGGCCCAAGGCACGATTTATCCTGATGTGATCGAATCGGCCGGCAGCAAAACCGG
CAAAGCCCACGTAATCAAAAGCCATCACAACGTCGGCGGCTTGCCGGAGCAGATGACCCTGGGTATGGTCGAACCATTAC
GTGAATTGTTCAAAGATGAAGTGCGCCGCCTTGGCGTTGCACTGGGCCTGCCCCATGCCATGGTATATCGCCATCCATTC
CCAGGACCTGGCTTGGGCGTGCGTATCCTTGGTGAAGTCAAGCCGGAGTATGCCGAGTTACTGGCCAAGGCTGACTCGAT
TTTTATTGATGAACTTCATCAAGCCGACCTGTACGACAAGGTCAGCCAAGCCTTTGCAGTCTTTCTTCCGGTGAAATCAG
TTGGCGTTGTTGGTGATGCCCGTGCGTACGAATGGGTGATTGCACTGCGCGCGGTTGAGACCGTTGATTTTATGACGGCA
CACTGGGCACCACTGCCGTATGACTTCCTGAGTACCGTCTCCAACCGCATCATCAATGAACTACGCGGCGTGTCCCGCGT
TGTCTACGATATTTCCGGAAAACCGCCAGCCACGATTGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
TTACCTGATGTGCGACTTGCCTGATCTCTTATGTGTCGCGTTACTGAGTTTTTTTTATTGAGCCAGCGCCCACTGCGTTC
CTGTCACTGGACCACCTGCT

Downstream 100 bases:

>100_bases
AATCGTGTCCCTTCTTGCTTAAAGTCCCTTCTTGCTTAAAAAAGAATCAAGACAGCACATGCACATCGTTAACGCACAGG
TGCCTTACGCTGAGCGGTGC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MTPNIHHDKILILDFGAQYTQLIARRIREIGVYCEVWPWDHSPEEILSFGAKGIILSGGPESTTSPGAPAAPQHVFDSDL
PIFGICYGMQTMAVHLGGATEAADKREFGHASVQVIYPDTLFSGLSDHPSEFRLDVWMSHGDHVSRVPPCFTITAATDRI
PIAAMSREDKRWYGVQFHPEVTHTLQGQALLRRFVVDICGCQTLWTSANIIEDQIARVRERVGCDEVILGLSGGVDSSVV
AALLHKAIGSQLTCVFVDTGMLRWGEGDQVMAMFAEHMGVNVVRINAASRYFDALQGVYDPEAKRKIIGNLFIQIFEEEA
SKRKQAKWLAQGTIYPDVIESAGSKTGKAHVIKSHHNVGGLPEQMTLGMVEPLRELFKDEVRRLGVALGLPHAMVYRHPF
PGPGLGVRILGEVKPEYAELLAKADSIFIDELHQADLYDKVSQAFAVFLPVKSVGVVGDARAYEWVIALRAVETVDFMTA
HWAPLPYDFLSTVSNRIINELRGVSRVVYDISGKPPATIEWE

Sequences:

>Translated_522_residues
MTPNIHHDKILILDFGAQYTQLIARRIREIGVYCEVWPWDHSPEEILSFGAKGIILSGGPESTTSPGAPAAPQHVFDSDL
PIFGICYGMQTMAVHLGGATEAADKREFGHASVQVIYPDTLFSGLSDHPSEFRLDVWMSHGDHVSRVPPCFTITAATDRI
PIAAMSREDKRWYGVQFHPEVTHTLQGQALLRRFVVDICGCQTLWTSANIIEDQIARVRERVGCDEVILGLSGGVDSSVV
AALLHKAIGSQLTCVFVDTGMLRWGEGDQVMAMFAEHMGVNVVRINAASRYFDALQGVYDPEAKRKIIGNLFIQIFEEEA
SKRKQAKWLAQGTIYPDVIESAGSKTGKAHVIKSHHNVGGLPEQMTLGMVEPLRELFKDEVRRLGVALGLPHAMVYRHPF
PGPGLGVRILGEVKPEYAELLAKADSIFIDELHQADLYDKVSQAFAVFLPVKSVGVVGDARAYEWVIALRAVETVDFMTA
HWAPLPYDFLSTVSNRIINELRGVSRVVYDISGKPPATIEWE
>Mature_521_residues
TPNIHHDKILILDFGAQYTQLIARRIREIGVYCEVWPWDHSPEEILSFGAKGIILSGGPESTTSPGAPAAPQHVFDSDLP
IFGICYGMQTMAVHLGGATEAADKREFGHASVQVIYPDTLFSGLSDHPSEFRLDVWMSHGDHVSRVPPCFTITAATDRIP
IAAMSREDKRWYGVQFHPEVTHTLQGQALLRRFVVDICGCQTLWTSANIIEDQIARVRERVGCDEVILGLSGGVDSSVVA
ALLHKAIGSQLTCVFVDTGMLRWGEGDQVMAMFAEHMGVNVVRINAASRYFDALQGVYDPEAKRKIIGNLFIQIFEEEAS
KRKQAKWLAQGTIYPDVIESAGSKTGKAHVIKSHHNVGGLPEQMTLGMVEPLRELFKDEVRRLGVALGLPHAMVYRHPFP
GPGLGVRILGEVKPEYAELLAKADSIFIDELHQADLYDKVSQAFAVFLPVKSVGVVGDARAYEWVIALRAVETVDFMTAH
WAPLPYDFLSTVSNRIINELRGVSRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=558, Percent_Identity=35.3046594982079, Blast_Score=294, Evalue=1e-79,
Organism=Escherichia coli, GI1788854, Length=525, Percent_Identity=66.2857142857143, Blast_Score=748, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992710, Length=573, Percent_Identity=35.9511343804538, Blast_Score=305, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI71992717, Length=573, Percent_Identity=35.9511343804538, Blast_Score=305, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI133901714, Length=573, Percent_Identity=35.9511343804538, Blast_Score=305, Evalue=6e-83,
Organism=Saccharomyces cerevisiae, GI6323873, Length=522, Percent_Identity=50.5747126436782, Blast_Score=532, Evalue=1e-152,
Organism=Drosophila melanogaster, GI281365319, Length=561, Percent_Identity=36.541889483066, Blast_Score=305, Evalue=6e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_XYLF2 (B2I6W2)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830213.1
- ProteinModelPortal:   B2I6W2
- SMR:   B2I6W2
- GeneID:   6202580
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1531
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- ProtClustDB:   PRK00074
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 57692; Mature: 57561

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 86-86 ACT_SITE 178-178 ACT_SITE 180-180

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPNIHHDKILILDFGAQYTQLIARRIREIGVYCEVWPWDHSPEEILSFGAKGIILSGGP
CCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCEEEEECCC
ESTTSPGAPAAPQHVFDSDLPIFGICYGMQTMAVHLGGATEAADKREFGHASVQVIYPDT
CCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHEEECCCCCHHHHHHCCCCEEEEEECHH
LFSGLSDHPSEFRLDVWMSHGDHVSRVPPCFTITAATDRIPIAAMSREDKRWYGVQFHPE
HHCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEECCCCCCEEECEEECCC
VTHTLQGQALLRRFVVDICGCQTLWTSANIIEDQIARVRERVGCDEVILGLSGGVDSSVV
HHHHHCHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHH
AALLHKAIGSQLTCVFVDTGMLRWGEGDQVMAMFAEHMGVNVVRINAASRYFDALQGVYD
HHHHHHHHCCCEEEEEEECCCEEECCCCHHHHHHHHHHCCEEEEECCHHHHHHHHHCCCC
PEAKRKIIGNLFIQIFEEEASKRKQAKWLAQGTIYPDVIESAGSKTGKAHVIKSHHNVGG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCEEEEECCCCCCC
LPEQMTLGMVEPLRELFKDEVRRLGVALGLPHAMVYRHPFPGPGLGVRILGEVKPEYAEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCEEEEECCCHHHHHH
LAKADSIFIDELHQADLYDKVSQAFAVFLPVKSVGVVGDARAYEWVIALRAVETVDFMTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
HWAPLPYDFLSTVSNRIINELRGVSRVVYDISGKPPATIEWE
CCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEECC
>Mature Secondary Structure 
TPNIHHDKILILDFGAQYTQLIARRIREIGVYCEVWPWDHSPEEILSFGAKGIILSGGP
CCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCEEEEECCC
ESTTSPGAPAAPQHVFDSDLPIFGICYGMQTMAVHLGGATEAADKREFGHASVQVIYPDT
CCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHEEECCCCCHHHHHHCCCCEEEEEECHH
LFSGLSDHPSEFRLDVWMSHGDHVSRVPPCFTITAATDRIPIAAMSREDKRWYGVQFHPE
HHCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEECCCCCCEEECEEECCC
VTHTLQGQALLRRFVVDICGCQTLWTSANIIEDQIARVRERVGCDEVILGLSGGVDSSVV
HHHHHCHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHH
AALLHKAIGSQLTCVFVDTGMLRWGEGDQVMAMFAEHMGVNVVRINAASRYFDALQGVYD
HHHHHHHHCCCEEEEEEECCCEEECCCCHHHHHHHHHHCCEEEEECCHHHHHHHHHCCCC
PEAKRKIIGNLFIQIFEEEASKRKQAKWLAQGTIYPDVIESAGSKTGKAHVIKSHHNVGG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCEEEEECCCCCCC
LPEQMTLGMVEPLRELFKDEVRRLGVALGLPHAMVYRHPFPGPGLGVRILGEVKPEYAEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCEEEEECCCHHHHHH
LAKADSIFIDELHQADLYDKVSQAFAVFLPVKSVGVVGDARAYEWVIALRAVETVDFMTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
HWAPLPYDFLSTVSNRIINELRGVSRVVYDISGKPPATIEWE
CCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA