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The map label for this gene is guaB [H]

Identifier: 182682054

GI number: 182682054

Start: 1703241

End: 1704698

Strand: Reverse

Name: guaB [H]

Synonym: XfasM23_1532

Alternate gene names: 182682054

Gene position: 1704698-1703241 (Counterclockwise)

Preceding gene: 182682055

Following gene: 182682053

Centisome position: 67.23

GC content: 52.4

Gene sequence:

>1458_bases
ATGCTGCGCATCTTGGCTGAAGCTTTGACTTACGACGATGTTTCACTCGTCCCTTCCCATTCGACCGTCCTGCCCAAGGA
TGTCAAGCTCGAAACCCGGTTGACACGCAATATCAGGCTCAAATTGCCGATCCTTTCAGCGGCGATGGACACCGTCACAG
AAGCTCGTTTGGCGATCGTCATGGCGCAGCTTGGCGGGATTGGCATCATCCACAAAAACCTTACCATCGAACAGCAAGTC
GCTGAGGTCACTAAAGTCAAGAAATACGAATCTGGCGTCATTCGTGATCCGATTACAGTTGATCCAGAGACATCAATTCG
CGATGTGTTAGCACTGACCCGTGCCAAGAACATTTCTGGTGTCCCTGTTGTTGATAAAGGTCAATTAATTGGCCTCGTGA
CTCACCGCGATATGCGCTTTGAAAGGGAGCTTGATGACCCCGTGCGCCATATCATGACTAAAAAAGAAGCCCTGGTGACA
GTCAAAGAAGGGGCCGACTCCCAAGAGGTACTCCAACTGCTGCATAAACATCGCATCGAAAAGATATTGGTTGTGAACGA
TGCTTTTGAACTGCGCGGCCTCATCACTGTTAAAGATATTCAAAAAAAATCCGACTATCCCAACGCAGCCAAAGATGCAG
TGACCCGCTTGCTGGTTGGCGCTGCTGTGGGTGTAGGGGGAGAGACTGAAAAGCGCGTTGAGACATTGGCTACTGCTGGA
GTGGATGTGATCATTGTCGATACTGCGCATGGTTATTCTCAGGGTGTGCTTGATCGTGTGGCTTGGATCAAGCGTTACTT
CCCGCAACTACAAGTGATTGGCGGCAATATTGTGACTGGTGATGCTGCCTTGGCACTGATGGATGTCGGTGCCGATGCAG
TGAAGGTGGGTGTCGGTCCCGGCTCCATTTGTACAACGCGAATGGTGGCAGGTGTTGGTGTGCCGCAGATCACCGCTGTG
CAGATGGTTTCCGACGCGCTGCAAGATCGCATTCCGCTGATTGCTGACGGCGGTATCCGCTATTCCGGTGATATTGGCAA
GGCATTAGCTGCAGGCGCATCAACCGTCATGATCGGTGGTTTGTTTGCAGGGACTGAGGAAGCTCCCGGTGATGTTGAGT
TGTTCCAGGGGCGCACTTACAAAAGCTATCGCGGCATGGGTTCTTTGGCGGCGATGGAAAAGGGCTCCAAAGATCGCTAT
TTCCAGGAAGCGAGCGACGTTGACAAACTGGTCCCGGAAGGCATTGAAGGACGTGTGCCTTACCGTGGTTCAGTCAGTGG
CATCGTGCATCAGCTGATGGGCGGCTTGCGTGCCACCATGGGGTATGTTGGCTGCGCAACAATCGAAGAGATGCGTACCA
AACCCCAGTTTGTGAAAATCACTGGGGCCGGTCAGGTTGAGAGTCACGTTCATGACGTGCAAATCACCAAAGAGCCGCCG
AATTATCGGATGCGCTGA

Upstream 100 bases:

>100_bases
TGCGCACGTTGCAAGGTGTCATTAACATAGGCCCTTAGTGTCGATCCGAGAGATTTCGGCGTAAAATTAAGCATTACCTA
AAACTTTCTCGGATCTGCCG

Downstream 100 bases:

>100_bases
GTCTCAGTGATGCCCCACAGAGCCTCTGCCTGTCTTTCGCGACCTTGTTGGTCGTCATCCGTATCAATCGTTGTGGCATT
TTGTATTGTTGTGTTTTGTG

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MLRILAEALTYDDVSLVPSHSTVLPKDVKLETRLTRNIRLKLPILSAAMDTVTEARLAIVMAQLGGIGIIHKNLTIEQQV
AEVTKVKKYESGVIRDPITVDPETSIRDVLALTRAKNISGVPVVDKGQLIGLVTHRDMRFERELDDPVRHIMTKKEALVT
VKEGADSQEVLQLLHKHRIEKILVVNDAFELRGLITVKDIQKKSDYPNAAKDAVTRLLVGAAVGVGGETEKRVETLATAG
VDVIIVDTAHGYSQGVLDRVAWIKRYFPQLQVIGGNIVTGDAALALMDVGADAVKVGVGPGSICTTRMVAGVGVPQITAV
QMVSDALQDRIPLIADGGIRYSGDIGKALAAGASTVMIGGLFAGTEEAPGDVELFQGRTYKSYRGMGSLAAMEKGSKDRY
FQEASDVDKLVPEGIEGRVPYRGSVSGIVHQLMGGLRATMGYVGCATIEEMRTKPQFVKITGAGQVESHVHDVQITKEPP
NYRMR

Sequences:

>Translated_485_residues
MLRILAEALTYDDVSLVPSHSTVLPKDVKLETRLTRNIRLKLPILSAAMDTVTEARLAIVMAQLGGIGIIHKNLTIEQQV
AEVTKVKKYESGVIRDPITVDPETSIRDVLALTRAKNISGVPVVDKGQLIGLVTHRDMRFERELDDPVRHIMTKKEALVT
VKEGADSQEVLQLLHKHRIEKILVVNDAFELRGLITVKDIQKKSDYPNAAKDAVTRLLVGAAVGVGGETEKRVETLATAG
VDVIIVDTAHGYSQGVLDRVAWIKRYFPQLQVIGGNIVTGDAALALMDVGADAVKVGVGPGSICTTRMVAGVGVPQITAV
QMVSDALQDRIPLIADGGIRYSGDIGKALAAGASTVMIGGLFAGTEEAPGDVELFQGRTYKSYRGMGSLAAMEKGSKDRY
FQEASDVDKLVPEGIEGRVPYRGSVSGIVHQLMGGLRATMGYVGCATIEEMRTKPQFVKITGAGQVESHVHDVQITKEPP
NYRMR
>Mature_485_residues
MLRILAEALTYDDVSLVPSHSTVLPKDVKLETRLTRNIRLKLPILSAAMDTVTEARLAIVMAQLGGIGIIHKNLTIEQQV
AEVTKVKKYESGVIRDPITVDPETSIRDVLALTRAKNISGVPVVDKGQLIGLVTHRDMRFERELDDPVRHIMTKKEALVT
VKEGADSQEVLQLLHKHRIEKILVVNDAFELRGLITVKDIQKKSDYPNAAKDAVTRLLVGAAVGVGGETEKRVETLATAG
VDVIIVDTAHGYSQGVLDRVAWIKRYFPQLQVIGGNIVTGDAALALMDVGADAVKVGVGPGSICTTRMVAGVGVPQITAV
QMVSDALQDRIPLIADGGIRYSGDIGKALAAGASTVMIGGLFAGTEEAPGDVELFQGRTYKSYRGMGSLAAMEKGSKDRY
FQEASDVDKLVPEGIEGRVPYRGSVSGIVHQLMGGLRATMGYVGCATIEEMRTKPQFVKITGAGQVESHVHDVQITKEPP
NYRMR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=482, Percent_Identity=42.5311203319502, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI217035146, Length=480, Percent_Identity=41.875, Blast_Score=342, Evalue=4e-94,
Organism=Homo sapiens, GI156616279, Length=483, Percent_Identity=41.6149068322981, Blast_Score=342, Evalue=6e-94,
Organism=Homo sapiens, GI34328928, Length=480, Percent_Identity=41.875, Blast_Score=342, Evalue=6e-94,
Organism=Homo sapiens, GI34328930, Length=483, Percent_Identity=41.6149068322981, Blast_Score=342, Evalue=7e-94,
Organism=Homo sapiens, GI217035152, Length=476, Percent_Identity=41.3865546218487, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI217035148, Length=480, Percent_Identity=41.0416666666667, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI217035150, Length=480, Percent_Identity=38.75, Blast_Score=301, Evalue=8e-82,
Organism=Homo sapiens, GI50541956, Length=246, Percent_Identity=37.3983739837398, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI50541954, Length=246, Percent_Identity=37.3983739837398, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541952, Length=246, Percent_Identity=37.3983739837398, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI50541948, Length=246, Percent_Identity=37.3983739837398, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI156104880, Length=222, Percent_Identity=40.0900900900901, Blast_Score=162, Evalue=6e-40,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=61.1111111111111, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1786293, Length=255, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71994385, Length=500, Percent_Identity=39, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=41.7061611374408, Blast_Score=279, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17560440, Length=255, Percent_Identity=34.9019607843137, Blast_Score=165, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6323585, Length=487, Percent_Identity=39.4250513347023, Blast_Score=332, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6322012, Length=483, Percent_Identity=38.9233954451346, Blast_Score=329, Evalue=6e-91,
Organism=Saccharomyces cerevisiae, GI6323464, Length=483, Percent_Identity=39.7515527950311, Blast_Score=319, Evalue=6e-88,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=38.7573964497041, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6319353, Length=141, Percent_Identity=37.5886524822695, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24641071, Length=482, Percent_Identity=42.1161825726141, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI24641073, Length=482, Percent_Identity=42.1161825726141, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI28571163, Length=440, Percent_Identity=43.1818181818182, Blast_Score=313, Evalue=2e-85,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52316; Mature: 52316

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRILAEALTYDDVSLVPSHSTVLPKDVKLETRLTRNIRLKLPILSAAMDTVTEARLAIV
CHHHHHHHHCCCCCEECCCCCCCCCCCCEEHEEECCCEEEEEHHHHHHHHHHHHHHHHHH
MAQLGGIGIIHKNLTIEQQVAEVTKVKKYESGVIRDPITVDPETSIRDVLALTRAKNISG
HHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHCCCCCC
VPVVDKGQLIGLVTHRDMRFERELDDPVRHIMTKKEALVTVKEGADSQEVLQLLHKHRIE
CCEECCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHEEEEECCCCHHHHHHHHHHHCCC
KILVVNDAFELRGLITVKDIQKKSDYPNAAKDAVTRLLVGAAVGVGGETEKRVETLATAG
EEEEEECHHHHCEEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
VDVIIVDTAHGYSQGVLDRVAWIKRYFPQLQVIGGNIVTGDAALALMDVGADAVKVGVGP
CEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEECCEEEECCHHEEEECCCCCEEEECCCC
GSICTTRMVAGVGVPQITAVQMVSDALQDRIPLIADGGIRYSGDIGKALAAGASTVMIGG
CCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEECCCEEECCCHHHHHHCCCCEEEEEE
LFAGTEEAPGDVELFQGRTYKSYRGMGSLAAMEKGSKDRYFQEASDVDKLVPEGIEGRVP
EEECCCCCCCCEEEECCCCCHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCC
YRGSVSGIVHQLMGGLRATMGYVGCATIEEMRTKPQFVKITGAGQVESHVHDVQITKEPP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHCCEEEEEECCCC
NYRMR
CCCCC
>Mature Secondary Structure
MLRILAEALTYDDVSLVPSHSTVLPKDVKLETRLTRNIRLKLPILSAAMDTVTEARLAIV
CHHHHHHHHCCCCCEECCCCCCCCCCCCEEHEEECCCEEEEEHHHHHHHHHHHHHHHHHH
MAQLGGIGIIHKNLTIEQQVAEVTKVKKYESGVIRDPITVDPETSIRDVLALTRAKNISG
HHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHCCCCCC
VPVVDKGQLIGLVTHRDMRFERELDDPVRHIMTKKEALVTVKEGADSQEVLQLLHKHRIE
CCEECCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHEEEEECCCCHHHHHHHHHHHCCC
KILVVNDAFELRGLITVKDIQKKSDYPNAAKDAVTRLLVGAAVGVGGETEKRVETLATAG
EEEEEECHHHHCEEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
VDVIIVDTAHGYSQGVLDRVAWIKRYFPQLQVIGGNIVTGDAALALMDVGADAVKVGVGP
CEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEECCEEEECCHHEEEECCCCCEEEECCCC
GSICTTRMVAGVGVPQITAVQMVSDALQDRIPLIADGGIRYSGDIGKALAAGASTVMIGG
CCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEECCCEEECCCHHHHHHCCCCEEEEEE
LFAGTEEAPGDVELFQGRTYKSYRGMGSLAAMEKGSKDRYFQEASDVDKLVPEGIEGRVP
EEECCCCCCCCEEEECCCCCHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCC
YRGSVSGIVHQLMGGLRATMGYVGCATIEEMRTKPQFVKITGAGQVESHVHDVQITKEPP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHCCEEEEEECCCC
NYRMR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA