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The map label for this gene is uvrC

Identifier: 182681939

GI number: 182681939

Start: 1567624

End: 1569489

Strand: Direct

Name: uvrC

Synonym: XfasM23_1410

Alternate gene names: 182681939

Gene position: 1567624-1569489 (Clockwise)

Preceding gene: 182681937

Following gene: 182681940

Centisome position: 61.82

GC content: 55.25

Gene sequence:

>1866_bases
ATGACGGATAACGCACCAATCACATTTGATGGAAAAAGGTTCGCCGCACATCTGAGTACGGCGCCTGGCGTCTATCGTAT
GTACGCTGCTGACGACACGTTGTTATACGTTGGCAAAGCAGGGGCGCTGCGCAAACGCGTTGCCAGCTATTTCAATGGCA
CTCCAAAAAATACCCGGCTGACCGCCATGCTCGCCCAGGTGGTACGCATGGACGTCACCATCACGCGCAACGAAGCCGAA
GCCCTGCTGCTGGAGAACCAGCTCATTAAATCACTGACTCCGCGCTATAACGTCTTGCTGCGAGACGACAAGAGTTATCC
ATACGTACTGCTGACACGTGAGGCATGGCCACGCATTGCACTACATCGCGGCCCACAGATCGTTCCAGGCCGCTACTTCG
GCCCCTATCCTGGGGTGACCGCGGTACGCGACATGCTGAATCTCATACACAAACTATTCAAACTACGCAGTTGTGAAGAC
AGTGTGTTCCGCAACCGTTCGCGACCATGCCTGCAATATCAAATTGGACGTTGCAGTGCACCATGTGTCAACGTGGTCAC
ACACGATAATTACACTGAGGCAGTACACCGTGTGACGCTGTTTCTTGAAGGGAAAAGCGATCTGCTTGCAGAAGAGTTGA
TACAAGCAATGCAAGTTGCCAGTGAACATCTGGAATTCGAGCAGGCCGCGCGGTTGCGCGACCTGCTCACCTCATTACGC
AGCATGCAAAATCGGCAATACGTGGACGGACGCGCCGCAGATTTAGATGTGCTGGCCTGCGCGGCTCTATCCGGTCACGC
CTGCGTACTGCTGCTCAGTTTCCGTGATGGCCGCAATCTTGGCACACGTATGTTCTTTCCCAAGACAAATGGTGAAGAAC
GCACCGCTGAGATACTCAGTGCCTTTGTCTCTCAATACTACGCGGAGTACCCACCTCCACCGGAGATCCTGCTGGACCAA
GAAATCCCCGATCACACACTCCTGGAAGCCGCATTCAGTCGTTCCAGCGCACATAAAATCAGCCTACGCTGGAACGTCCG
TGGTGAGCGTGCCGGTTACGTCGAGTTAGCCGTACGTAACGCTCAAGTAGCCTTATCCACCGAACTCACCAGCCAACGTG
CCCAGCGGGTACGTAGTGAAGCAGTACGTCAACTGCTCGGTCTGGAGGGGCCGATTAAGCGTGTAGAATGCTTCGACATT
AGTCACACGATGGGTGAGGCCACGGTTGCCTCCTGTGTGGTGTTTGATGCTGTTGGTCCGGTACGTTCCCAGTATCGGCG
TTACAACATCACTGGCATTACCCCTGGTGACGACTATGCAGCAATGCGTCAGGCCATCGAGAGGCGCTTCCGCCGTGCGG
TTGAAGAAGACAAACAGGGAGAACGACCGGACGTGCTATTCATTGACGGTGGTGCTGGCCAGTTGGCACAAGCCAAGATG
GCACTCAACGCTGTTGGGGTGGAAAGCGTGCTGCTGGTCGGCGTGTCCAAGGGCGAAGAGCGCCGTGCAGGACACGAGAC
GCTGATTATGCTGGATGGACAGGAGCTGCATCCTGGAGCAGCTTCACCCGCGTTGCAGTTCATCCAGCAGGTGCGTGACG
AGGCACACCGATTTGCAATCACTGGACACCGCGCACGTCGGCAAAAAACGCGGATGACCAGTAAATTAGAAGACATTCCT
GGAATCGGCTCACGCCGCCGCGCCAATCTTCTCAAGCATTTTGGTGGACTGGCGGGAGTCAAAGCTGCTGGCCAAACCGA
GATTGCCAGGGTGGAAGGCATCAGTACTGCGCTGGCAGCCAAGATTTACGCCAGCCTGCATGGACTATCGAAAAATGATG
CAGCAAATGCGTCGAGGGTGTCATGA

Upstream 100 bases:

>100_bases
CACACTTGGCTGGCGCTTCCTCAGTGAATCGCGTTAGCCTCAACGGCTTTGGTGCTGTCAATCGGCAAGGGCGAAGCAAT
GTGTGCAACATCATTGGAAT

Downstream 100 bases:

>100_bases
AATTGACCGTCCCCACTTGGTTAACGCTGCTACGGATCGTGATGATCCCTGTGCTCATTGTGGTGTTCTATCTACCTTAT
CAATGGAGCAATATTGTCGC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 621; Mature: 620

Protein sequence:

>621_residues
MTDNAPITFDGKRFAAHLSTAPGVYRMYAADDTLLYVGKAGALRKRVASYFNGTPKNTRLTAMLAQVVRMDVTITRNEAE
ALLLENQLIKSLTPRYNVLLRDDKSYPYVLLTREAWPRIALHRGPQIVPGRYFGPYPGVTAVRDMLNLIHKLFKLRSCED
SVFRNRSRPCLQYQIGRCSAPCVNVVTHDNYTEAVHRVTLFLEGKSDLLAEELIQAMQVASEHLEFEQAARLRDLLTSLR
SMQNRQYVDGRAADLDVLACAALSGHACVLLLSFRDGRNLGTRMFFPKTNGEERTAEILSAFVSQYYAEYPPPPEILLDQ
EIPDHTLLEAAFSRSSAHKISLRWNVRGERAGYVELAVRNAQVALSTELTSQRAQRVRSEAVRQLLGLEGPIKRVECFDI
SHTMGEATVASCVVFDAVGPVRSQYRRYNITGITPGDDYAAMRQAIERRFRRAVEEDKQGERPDVLFIDGGAGQLAQAKM
ALNAVGVESVLLVGVSKGEERRAGHETLIMLDGQELHPGAASPALQFIQQVRDEAHRFAITGHRARRQKTRMTSKLEDIP
GIGSRRRANLLKHFGGLAGVKAAGQTEIARVEGISTALAAKIYASLHGLSKNDAANASRVS

Sequences:

>Translated_621_residues
MTDNAPITFDGKRFAAHLSTAPGVYRMYAADDTLLYVGKAGALRKRVASYFNGTPKNTRLTAMLAQVVRMDVTITRNEAE
ALLLENQLIKSLTPRYNVLLRDDKSYPYVLLTREAWPRIALHRGPQIVPGRYFGPYPGVTAVRDMLNLIHKLFKLRSCED
SVFRNRSRPCLQYQIGRCSAPCVNVVTHDNYTEAVHRVTLFLEGKSDLLAEELIQAMQVASEHLEFEQAARLRDLLTSLR
SMQNRQYVDGRAADLDVLACAALSGHACVLLLSFRDGRNLGTRMFFPKTNGEERTAEILSAFVSQYYAEYPPPPEILLDQ
EIPDHTLLEAAFSRSSAHKISLRWNVRGERAGYVELAVRNAQVALSTELTSQRAQRVRSEAVRQLLGLEGPIKRVECFDI
SHTMGEATVASCVVFDAVGPVRSQYRRYNITGITPGDDYAAMRQAIERRFRRAVEEDKQGERPDVLFIDGGAGQLAQAKM
ALNAVGVESVLLVGVSKGEERRAGHETLIMLDGQELHPGAASPALQFIQQVRDEAHRFAITGHRARRQKTRMTSKLEDIP
GIGSRRRANLLKHFGGLAGVKAAGQTEIARVEGISTALAAKIYASLHGLSKNDAANASRVS
>Mature_620_residues
TDNAPITFDGKRFAAHLSTAPGVYRMYAADDTLLYVGKAGALRKRVASYFNGTPKNTRLTAMLAQVVRMDVTITRNEAEA
LLLENQLIKSLTPRYNVLLRDDKSYPYVLLTREAWPRIALHRGPQIVPGRYFGPYPGVTAVRDMLNLIHKLFKLRSCEDS
VFRNRSRPCLQYQIGRCSAPCVNVVTHDNYTEAVHRVTLFLEGKSDLLAEELIQAMQVASEHLEFEQAARLRDLLTSLRS
MQNRQYVDGRAADLDVLACAALSGHACVLLLSFRDGRNLGTRMFFPKTNGEERTAEILSAFVSQYYAEYPPPPEILLDQE
IPDHTLLEAAFSRSSAHKISLRWNVRGERAGYVELAVRNAQVALSTELTSQRAQRVRSEAVRQLLGLEGPIKRVECFDIS
HTMGEATVASCVVFDAVGPVRSQYRRYNITGITPGDDYAAMRQAIERRFRRAVEEDKQGERPDVLFIDGGAGQLAQAKMA
LNAVGVESVLLVGVSKGEERRAGHETLIMLDGQELHPGAASPALQFIQQVRDEAHRFAITGHRARRQKTRMTSKLEDIPG
IGSRRRANLLKHFGGLAGVKAAGQTEIARVEGISTALAAKIYASLHGLSKNDAANASRVS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=608, Percent_Identity=49.671052631579, Blast_Score=586, Evalue=1e-168,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_XYLF2 (B2I637)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830099.1
- GeneID:   6202358
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1410
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 68898; Mature: 68767

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDNAPITFDGKRFAAHLSTAPGVYRMYAADDTLLYVGKAGALRKRVASYFNGTPKNTRL
CCCCCCEEECCHHHHHHHCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHCCCCCCHHH
TAMLAQVVRMDVTITRNEAEALLLENQLIKSLTPRYNVLLRDDKSYPYVLLTREAWPRIA
HHHHHHHHHHCEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCHH
LHRGPQIVPGRYFGPYPGVTAVRDMLNLIHKLFKLRSCEDSVFRNRSRPCLQYQIGRCSA
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCEECCCCCC
PCVNVVTHDNYTEAVHRVTLFLEGKSDLLAEELIQAMQVASEHLEFEQAARLRDLLTSLR
CEEEEEECCCHHHHHEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMQNRQYVDGRAADLDVLACAALSGHACVLLLSFRDGRNLGTRMFFPKTNGEERTAEILS
HHCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEECCCCCHHHHHHHHH
AFVSQYYAEYPPPPEILLDQEIPDHTLLEAAFSRSSAHKISLRWNVRGERAGYVELAVRN
HHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCEEEEEEEC
AQVALSTELTSQRAQRVRSEAVRQLLGLEGPIKRVECFDISHTMGEATVASCVVFDAVGP
CEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHCHHHHHHHHHHHHHHH
VRSQYRRYNITGITPGDDYAAMRQAIERRFRRAVEEDKQGERPDVLFIDGGAGQLAQAKM
HHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHH
ALNAVGVESVLLVGVSKGEERRAGHETLIMLDGQELHPGAASPALQFIQQVRDEAHRFAI
HHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHEEE
TGHRARRQKTRMTSKLEDIPGIGSRRRANLLKHFGGLAGVKAAGQTEIARVEGISTALAA
ECHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHH
KIYASLHGLSKNDAANASRVS
HHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDNAPITFDGKRFAAHLSTAPGVYRMYAADDTLLYVGKAGALRKRVASYFNGTPKNTRL
CCCCCEEECCHHHHHHHCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHCCCCCCHHH
TAMLAQVVRMDVTITRNEAEALLLENQLIKSLTPRYNVLLRDDKSYPYVLLTREAWPRIA
HHHHHHHHHHCEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCHH
LHRGPQIVPGRYFGPYPGVTAVRDMLNLIHKLFKLRSCEDSVFRNRSRPCLQYQIGRCSA
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCEECCCCCC
PCVNVVTHDNYTEAVHRVTLFLEGKSDLLAEELIQAMQVASEHLEFEQAARLRDLLTSLR
CEEEEEECCCHHHHHEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMQNRQYVDGRAADLDVLACAALSGHACVLLLSFRDGRNLGTRMFFPKTNGEERTAEILS
HHCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEECCCCCHHHHHHHHH
AFVSQYYAEYPPPPEILLDQEIPDHTLLEAAFSRSSAHKISLRWNVRGERAGYVELAVRN
HHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCEEEEEEEC
AQVALSTELTSQRAQRVRSEAVRQLLGLEGPIKRVECFDISHTMGEATVASCVVFDAVGP
CEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHCHHHHHHHHHHHHHHH
VRSQYRRYNITGITPGDDYAAMRQAIERRFRRAVEEDKQGERPDVLFIDGGAGQLAQAKM
HHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHH
ALNAVGVESVLLVGVSKGEERRAGHETLIMLDGQELHPGAASPALQFIQQVRDEAHRFAI
HHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHEEE
TGHRARRQKTRMTSKLEDIPGIGSRRRANLLKHFGGLAGVKAAGQTEIARVEGISTALAA
ECHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHH
KIYASLHGLSKNDAANASRVS
HHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA