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The map label for this gene is serA [H]

Identifier: 182681872

GI number: 182681872

Start: 1478363

End: 1479604

Strand: Direct

Name: serA [H]

Synonym: XfasM23_1340

Alternate gene names: 182681872

Gene position: 1478363-1479604 (Clockwise)

Preceding gene: 182681870

Following gene: 182681873

Centisome position: 58.3

GC content: 54.35

Gene sequence:

>1242_bases
ATGCCACCGACGAAAACTTCTTTTCCCAAACAAGACATCCGAATTTTGCTGCTAGAAGGGGTCAGTCACAGCGGGATCGA
AACGTTCCGTGCGGCGGGTTACTCGCAGATCAAGATCCATACGACATCGCTGCCGGAAGAGGCTCTGCAAGCAGAGATTG
CGGAAGCGCACATCATCGGTATTCGCTCGCGCACTCAATTGAATGCAGCGGTGCTAGGGCATGCCAAACGTCTGATGGCC
ATAGGTTGTTTCTGCATCGGGACGAATCAGGTGGACTTGGATACGGCGGAATTGAGCGGGATCCCCGTGTTCAACGCGCC
ATATTCCAATACGCGTAGTGTGGCTGAGCTGATCATTGCGGAAGCAATTTTGTTGCTACGCAGGATCCCGCAGAAAAATG
CCGAATGCCATCGTGGGGGCTGGTCCAAATCTGCCATCAATAGTCATGAAGCACGCGGTAAGGTGTTGGGCATCGTGGGA
TACGGTCACATCGGTACGCAAGTCAGTGTGCTGGCGGAGGCGATGGGGATGCAGGTGATTTTCTACGATATTGAATCCAA
GCTCTCTTTGGGCAATGCGCGTCCAGCGGCAAGCTTGGATGAGTTGCTCGGCATTGCCGACGTAGTGACGCTGCATGTAC
CGGAAACGGCAGCGACCAAGAATATGCTTGGTCATGCAGAATTGGCACGAATGAAACCGGGGGCGCATTTGATTAATGCA
TCGCGCGGTACGGTTGTGGAGATTGACGCGCTGGATGCGGCTCTGGTGTCGGGGCATCTGGGCGGGGCGGCAGTGGATGT
ATTCCCAAGCGAACCCAAGGGCAATAGTGATCCGTTCATCTCGCCATTGAGCAGGCACGACAATGTGATTTTGACGCCAC
ATATTGGGGGCAGCACGCTAGAAGCGCAGGACAATATTGGGATTGAGGTGGCAGCCAAATTGATCCGTTATAGCGATAAC
GGCAGCACGCTATCGGCGGTGAATTTCCCTGAAGTCAGTTTGCCGGAGCACGTGGGGAGTATGCGTTTGCTGCATATCCA
CCGTAATGTGCCCGGGGTGCTGTCGCATATCAACGAGCTGTTCTCGCGTCACAACGTCAATATTGATGGTCAGTTCCTGC
GTACCGATGCCACGTTGGGCTATGTGGTCATTGATATCGGTGCCAGTCAGACGCAGGCTCTGGCATTAAAAGAGGCATTG
ACGCAGGTTCCCGGAACGCTGCGTACCCGTCTGCTGTACTGA

Upstream 100 bases:

>100_bases
GGGTTTGTCACGCTGACAGGAGTGGTTCCGCGCAATCTGCACAAACAGAAAGATTCATCTGGCATAGTCGCGGTTTCATT
TCACTCTCATTGATCCGGTT

Downstream 100 bases:

>100_bases
GACTAAGTTGTAATACTGCTTGTGTTGTTCCACACCTATTGGCAAGGTAAGCATCGCCTGACGTTGGTTATCTACTGCCA
ATTTTAAGATTTATGACTCA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MPPTKTSFPKQDIRILLLEGVSHSGIETFRAAGYSQIKIHTTSLPEEALQAEIAEAHIIGIRSRTQLNAAVLGHAKRLMA
IGCFCIGTNQVDLDTAELSGIPVFNAPYSNTRSVAELIIAEAILLLRRIPQKNAECHRGGWSKSAINSHEARGKVLGIVG
YGHIGTQVSVLAEAMGMQVIFYDIESKLSLGNARPAASLDELLGIADVVTLHVPETAATKNMLGHAELARMKPGAHLINA
SRGTVVEIDALDAALVSGHLGGAAVDVFPSEPKGNSDPFISPLSRHDNVILTPHIGGSTLEAQDNIGIEVAAKLIRYSDN
GSTLSAVNFPEVSLPEHVGSMRLLHIHRNVPGVLSHINELFSRHNVNIDGQFLRTDATLGYVVIDIGASQTQALALKEAL
TQVPGTLRTRLLY

Sequences:

>Translated_413_residues
MPPTKTSFPKQDIRILLLEGVSHSGIETFRAAGYSQIKIHTTSLPEEALQAEIAEAHIIGIRSRTQLNAAVLGHAKRLMA
IGCFCIGTNQVDLDTAELSGIPVFNAPYSNTRSVAELIIAEAILLLRRIPQKNAECHRGGWSKSAINSHEARGKVLGIVG
YGHIGTQVSVLAEAMGMQVIFYDIESKLSLGNARPAASLDELLGIADVVTLHVPETAATKNMLGHAELARMKPGAHLINA
SRGTVVEIDALDAALVSGHLGGAAVDVFPSEPKGNSDPFISPLSRHDNVILTPHIGGSTLEAQDNIGIEVAAKLIRYSDN
GSTLSAVNFPEVSLPEHVGSMRLLHIHRNVPGVLSHINELFSRHNVNIDGQFLRTDATLGYVVIDIGASQTQALALKEAL
TQVPGTLRTRLLY
>Mature_412_residues
PPTKTSFPKQDIRILLLEGVSHSGIETFRAAGYSQIKIHTTSLPEEALQAEIAEAHIIGIRSRTQLNAAVLGHAKRLMAI
GCFCIGTNQVDLDTAELSGIPVFNAPYSNTRSVAELIIAEAILLLRRIPQKNAECHRGGWSKSAINSHEARGKVLGIVGY
GHIGTQVSVLAEAMGMQVIFYDIESKLSLGNARPAASLDELLGIADVVTLHVPETAATKNMLGHAELARMKPGAHLINAS
RGTVVEIDALDAALVSGHLGGAAVDVFPSEPKGNSDPFISPLSRHDNVILTPHIGGSTLEAQDNIGIEVAAKLIRYSDNG
STLSAVNFPEVSLPEHVGSMRLLHIHRNVPGVLSHINELFSRHNVNIDGQFLRTDATLGYVVIDIGASQTQALALKEALT
QVPGTLRTRLLY

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=292, Percent_Identity=35.2739726027397, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI61743967, Length=283, Percent_Identity=30.3886925795053, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4557497, Length=283, Percent_Identity=30.3886925795053, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI145580578, Length=293, Percent_Identity=32.0819112627986, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4557499, Length=293, Percent_Identity=32.0819112627986, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI145580575, Length=293, Percent_Identity=32.0819112627986, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI6912396, Length=279, Percent_Identity=26.8817204301075, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1789279, Length=409, Percent_Identity=61.8581907090465, Blast_Score=511, Evalue=1e-146,
Organism=Escherichia coli, GI87082289, Length=247, Percent_Identity=31.9838056680162, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787645, Length=232, Percent_Identity=29.7413793103448, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788660, Length=257, Percent_Identity=31.5175097276265, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87081824, Length=194, Percent_Identity=26.8041237113402, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=323, Percent_Identity=31.5789473684211, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI25147481, Length=252, Percent_Identity=31.3492063492063, Blast_Score=98, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6320925, Length=425, Percent_Identity=48.9411764705882, Blast_Score=401, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6322116, Length=425, Percent_Identity=48.4705882352941, Blast_Score=397, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6324964, Length=239, Percent_Identity=27.1966527196653, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324055, Length=227, Percent_Identity=25.5506607929515, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=152, Percent_Identity=32.8947368421053, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324980, Length=182, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19921140, Length=306, Percent_Identity=30.718954248366, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI28574286, Length=260, Percent_Identity=28.8461538461538, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28571528, Length=332, Percent_Identity=26.5060240963855, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24646446, Length=221, Percent_Identity=32.1266968325792, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24646448, Length=221, Percent_Identity=32.1266968325792, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24646452, Length=221, Percent_Identity=32.1266968325792, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24646450, Length=221, Percent_Identity=32.1266968325792, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI62472511, Length=221, Percent_Identity=32.1266968325792, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45551003, Length=262, Percent_Identity=25.9541984732824, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI28574284, Length=262, Percent_Identity=25.9541984732824, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI45552429, Length=262, Percent_Identity=25.9541984732824, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24585514, Length=262, Percent_Identity=25.9541984732824, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28574282, Length=262, Percent_Identity=25.9541984732824, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24585516, Length=301, Percent_Identity=24.2524916943522, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44156; Mature: 44025

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPTKTSFPKQDIRILLLEGVSHSGIETFRAAGYSQIKIHTTSLPEEALQAEIAEAHIIG
CCCCCCCCCCCCEEEEEEECCCCCCHHHHHHCCCEEEEEEECCCCHHHHHHHHHHEEEEE
IRSRTQLNAAVLGHAKRLMAIGCFCIGTNQVDLDTAELSGIPVFNAPYSNTRSVAELIIA
ECCCCHHHHHHHHHHHHHHHEEEEEEECCEEECCHHHHCCCEEECCCCCCHHHHHHHHHH
EAILLLRRIPQKNAECHRGGWSKSAINSHEARGKVLGIVGYGHIGTQVSVLAEAMGMQVI
HHHHHHHHCCCCCCCHHCCCCCCHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCEEE
FYDIESKLSLGNARPAASLDELLGIADVVTLHVPETAATKNMLGHAELARMKPGAHLINA
EEECCCHHCCCCCCCCCCHHHHHHHHHEEEEECCCHHHHHHHHCHHHHHHCCCCCEEEEC
SRGTVVEIDALDAALVSGHLGGAAVDVFPSEPKGNSDPFISPLSRHDNVILTPHIGGSTL
CCCCEEEEECHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEE
EAQDNIGIEVAAKLIRYSDNGSTLSAVNFPEVSLPEHVGSMRLLHIHRNVPGVLSHINEL
CCCCCCCHHHHHHHHEECCCCCEEEEECCCCCCCHHHHCCEEEEEEECCCCHHHHHHHHH
FSRHNVNIDGQFLRTDATLGYVVIDIGASQTQALALKEALTQVPGTLRTRLLY
HHHCCCCCCCEEEEECCCEEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHCCC
>Mature Secondary Structure 
PPTKTSFPKQDIRILLLEGVSHSGIETFRAAGYSQIKIHTTSLPEEALQAEIAEAHIIG
CCCCCCCCCCCEEEEEEECCCCCCHHHHHHCCCEEEEEEECCCCHHHHHHHHHHEEEEE
IRSRTQLNAAVLGHAKRLMAIGCFCIGTNQVDLDTAELSGIPVFNAPYSNTRSVAELIIA
ECCCCHHHHHHHHHHHHHHHEEEEEEECCEEECCHHHHCCCEEECCCCCCHHHHHHHHHH
EAILLLRRIPQKNAECHRGGWSKSAINSHEARGKVLGIVGYGHIGTQVSVLAEAMGMQVI
HHHHHHHHCCCCCCCHHCCCCCCHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCEEE
FYDIESKLSLGNARPAASLDELLGIADVVTLHVPETAATKNMLGHAELARMKPGAHLINA
EEECCCHHCCCCCCCCCCHHHHHHHHHEEEEECCCHHHHHHHHCHHHHHHCCCCCEEEEC
SRGTVVEIDALDAALVSGHLGGAAVDVFPSEPKGNSDPFISPLSRHDNVILTPHIGGSTL
CCCCEEEEECHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEE
EAQDNIGIEVAAKLIRYSDNGSTLSAVNFPEVSLPEHVGSMRLLHIHRNVPGVLSHINEL
CCCCCCCHHHHHHHHEECCCCCEEEEECCCCCCCHHHHCCEEEEEEECCCCHHHHHHHHH
FSRHNVNIDGQFLRTDATLGYVVIDIGASQTQALALKEALTQVPGTLRTRLLY
HHHCCCCCCCEEEEECCCEEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]