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The map label for this gene is tdcB [H]

Identifier: 182681652

GI number: 182681652

Start: 1257850

End: 1258902

Strand: Direct

Name: tdcB [H]

Synonym: XfasM23_1110

Alternate gene names: 182681652

Gene position: 1257850-1258902 (Clockwise)

Preceding gene: 182681651

Following gene: 182681653

Centisome position: 49.61

GC content: 54.89

Gene sequence:

>1053_bases
ATGGATATACCTGATGTAGGGCACACAGTTGTCAAGCAACCCAATGCAAGTAACGTCAATACCGTGAGTGTGGCCGATGT
GTTGGCTGCACAAGCCCGCTTACGTCGTTATCTAATGCCTACTCCAATTCACTATGCCGAGCGTTTCGGAGTGATGCTGA
AGTTAGAAAATCTGCAACGCACCGGATCCTATAAAGTGCGCGGCGCACTGAACGCAATGTTAGTTGCGCTGGAACGCGGC
GATAACCGCCCTGTCATTTGCGCATCAGCCGGTAACCACGCCCAAGGCGTAGCTTGGTCAGCTTACCGGCTTGGTATACA
AGCAATCACTGTCATGCCTCACGGTGCTCCGGCCACAAAGGTTGCAGGTGTTTCACATTGGGGGGCAACGGTACGCCAAC
ACGGCCAAAGCTATGACGAGGCCTATACGTTCGCATGTGAGTTGGCTGAGCAAAACGATTACCGCTTTCTATCAGCATTC
GATGATCCGGATGTGATTGCCGGTCAGGGAACTGTTGGCATAGAGATCACCGCGCATGAACCGGATGTAGTCATTGTGCC
GATCGGCGGCGGCGGCCTTGCTTCAGGCATTGCTTTGGTGCTGCGCTCGCAGGGAGTACGTGTCATTGGCGCTCAGGTCG
AGGGCGTGGATGCGATGGCGCGTGCAATCCGTGGCGACACACGCGAGATCGCTCCAGTTTCGACCTTAGCTGACGGGGTG
AAAGTCAAGATTCCTGGTTTCATTACCCGCCATCTGTGTGCCAACTTGTTAGACGATGTAGTAATCGTGCGTGAGGCTGA
ACTGCGCGAAACATTGGTGCGTTTAGTATTGGAAGAACACCTGATCGCCGAAGGGGCAGGCGCACTGGCATTGGCCGCTG
GCCGCCGCGTTGCAGGTAAGCGCAAGTGTGCAGTGGTCTCCGGAGGTAATATTGACGCTGCAGTACTGGCCAAACTGTTG
TCCGAAGTAAGACCACGGCCACCCCGCAAACCACGTAGGCGTAGTGCAGATCGCCCCAACAATTGCGGCAATTTACCGCT
CCCTTTTAACTGA

Upstream 100 bases:

>100_bases
GATATACCACGCGCAATACTACCGCTGGATTTTCTTAGCGGGCACGAGTCAGCATGGCATGCCATCAGGATGTGTGCAGA
TCATCAGGAAGTATAGCTAT

Downstream 100 bases:

>100_bases
TTCCACCCCATATCCACGCCTGCCAATAGCACTGCTGTAGAGGAGTATTCACTGGTGAACACGAGCATATCCAGCCAGCC
GCCCTGTATCCGGATTTTTG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MDIPDVGHTVVKQPNASNVNTVSVADVLAAQARLRRYLMPTPIHYAERFGVMLKLENLQRTGSYKVRGALNAMLVALERG
DNRPVICASAGNHAQGVAWSAYRLGIQAITVMPHGAPATKVAGVSHWGATVRQHGQSYDEAYTFACELAEQNDYRFLSAF
DDPDVIAGQGTVGIEITAHEPDVVIVPIGGGGLASGIALVLRSQGVRVIGAQVEGVDAMARAIRGDTREIAPVSTLADGV
KVKIPGFITRHLCANLLDDVVIVREAELRETLVRLVLEEHLIAEGAGALALAAGRRVAGKRKCAVVSGGNIDAAVLAKLL
SEVRPRPPRKPRRRSADRPNNCGNLPLPFN

Sequences:

>Translated_350_residues
MDIPDVGHTVVKQPNASNVNTVSVADVLAAQARLRRYLMPTPIHYAERFGVMLKLENLQRTGSYKVRGALNAMLVALERG
DNRPVICASAGNHAQGVAWSAYRLGIQAITVMPHGAPATKVAGVSHWGATVRQHGQSYDEAYTFACELAEQNDYRFLSAF
DDPDVIAGQGTVGIEITAHEPDVVIVPIGGGGLASGIALVLRSQGVRVIGAQVEGVDAMARAIRGDTREIAPVSTLADGV
KVKIPGFITRHLCANLLDDVVIVREAELRETLVRLVLEEHLIAEGAGALALAAGRRVAGKRKCAVVSGGNIDAAVLAKLL
SEVRPRPPRKPRRRSADRPNNCGNLPLPFN
>Mature_350_residues
MDIPDVGHTVVKQPNASNVNTVSVADVLAAQARLRRYLMPTPIHYAERFGVMLKLENLQRTGSYKVRGALNAMLVALERG
DNRPVICASAGNHAQGVAWSAYRLGIQAITVMPHGAPATKVAGVSHWGATVRQHGQSYDEAYTFACELAEQNDYRFLSAF
DDPDVIAGQGTVGIEITAHEPDVVIVPIGGGGLASGIALVLRSQGVRVIGAQVEGVDAMARAIRGDTREIAPVSTLADGV
KVKIPGFITRHLCANLLDDVVIVREAELRETLVRLVLEEHLIAEGAGALALAAGRRVAGKRKCAVVSGGNIDAAVLAKLL
SEVRPRPPRKPRRRSADRPNNCGNLPLPFN

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=315, Percent_Identity=33.015873015873, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1789505, Length=315, Percent_Identity=40, Blast_Score=181, Evalue=5e-47,
Organism=Escherichia coli, GI1790207, Length=289, Percent_Identity=35.9861591695502, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71991565, Length=317, Percent_Identity=33.4384858044164, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17508781, Length=318, Percent_Identity=29.559748427673, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17537387, Length=282, Percent_Identity=32.6241134751773, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322631, Length=314, Percent_Identity=33.4394904458599, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6320930, Length=255, Percent_Identity=36.4705882352941, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21355833, Length=322, Percent_Identity=34.472049689441, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24645328, Length=220, Percent_Identity=34.5454545454545, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 37306; Mature: 37306

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIPDVGHTVVKQPNASNVNTVSVADVLAAQARLRRYLMPTPIHYAERFGVMLKLENLQR
CCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEEEECHHC
TGSYKVRGALNAMLVALERGDNRPVICASAGNHAQGVAWSAYRLGIQAITVMPHGAPATK
CCCEEEHHHHHHHEEEEECCCCCCEEEECCCCCCCCCEEHHHHCCEEEEEEECCCCCCHH
VAGVSHWGATVRQHGQSYDEAYTFACELAEQNDYRFLSAFDDPDVIAGQGTVGIEITAHE
CCCCHHHHHHHHHHCCCHHHHHEEEEEECCCCCEEEEEECCCCCEEECCCEEEEEEEECC
PDVVIVPIGGGGLASGIALVLRSQGVRVIGAQVEGVDAMARAIRGDTREIAPVSTLADGV
CCEEEEECCCCHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHCCCCCCCCCHHHHCCCC
KVKIPGFITRHLCANLLDDVVIVREAELRETLVRLVLEEHLIAEGAGALALAAGRRVAGK
EEEECHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCC
RKCAVVSGGNIDAAVLAKLLSEVRPRPPRKPRRRSADRPNNCGNLPLPFN
CEEEEEECCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDIPDVGHTVVKQPNASNVNTVSVADVLAAQARLRRYLMPTPIHYAERFGVMLKLENLQR
CCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEEEECHHC
TGSYKVRGALNAMLVALERGDNRPVICASAGNHAQGVAWSAYRLGIQAITVMPHGAPATK
CCCEEEHHHHHHHEEEEECCCCCCEEEECCCCCCCCCEEHHHHCCEEEEEEECCCCCCHH
VAGVSHWGATVRQHGQSYDEAYTFACELAEQNDYRFLSAFDDPDVIAGQGTVGIEITAHE
CCCCHHHHHHHHHHCCCHHHHHEEEEEECCCCCEEEEEECCCCCEEECCCEEEEEEEECC
PDVVIVPIGGGGLASGIALVLRSQGVRVIGAQVEGVDAMARAIRGDTREIAPVSTLADGV
CCEEEEECCCCHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHCCCCCCCCCHHHHCCCC
KVKIPGFITRHLCANLLDDVVIVREAELRETLVRLVLEEHLIAEGAGALALAAGRRVAGK
EEEECHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCC
RKCAVVSGGNIDAAVLAKLLSEVRPRPPRKPRRRSADRPNNCGNLPLPFN
CEEEEEECCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]