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The map label for this gene is yeiR [C]

Identifier: 182681643

GI number: 182681643

Start: 1246336

End: 1247664

Strand: Direct

Name: yeiR [C]

Synonym: XfasM23_1101

Alternate gene names: 182681643

Gene position: 1246336-1247664 (Clockwise)

Preceding gene: 182681642

Following gene: 182681644

Centisome position: 49.15

GC content: 53.5

Gene sequence:

>1329_bases
ATGTCAACGCTGACGCTCCCCTCCGATCTCCGCTTACCTGTCACCGTTTTCTCGGGTTTCCTTGGTGCCGGTAAGACAAC
CCTACTGAATCGCCTCTTGAATAATCGTGATGGTCTGCGTGTGGCAGTGATCGTTAACGACATGAGCGAAGTCAACATTG
ATGCACAGTTGGTACGTGATGGCGGTGCTGCTCTCAGCCGTACCGATGAAACATTGGTTGAATTCAGCAACGGATGTATC
TGCTGCACTCTACGCGATGATTTATCCAAGGAGGTCAAACGTCTTGCGTTGGAGCAACGCTACGATTACCTGTTGATCGA
ATCCACAGGCATTGGCGAGCCAATGCCTGTCGCGGCAACATTTGCTGTGCGGGATGCCGACGGCTTTTGTCTTTCAGATG
TAGCGCGTTTGGATACCATGGTCACGGTCGTTGATGGTAGCCAATTTACTGCGCTATTCAGCTCAATGAATACATTAGCT
GACTTAGGTCAGCAAGCAGATTCCGACGATACTCGCAGCCTTGCCGACCTGCTTGGCCAACAGATCGAGTTTGCTGACAC
CATTGTCATCAGCAAATGTGATCTGATTGATGCGACGCAACTTGCGCGCGTGCGTGCAGTGGTGCGCGGGCTTAACCGTG
ACGCACAGATCATTGAAGCACATCTTGGAGAAGTACCCCTGCCCCAACTCGTTGGTACTGGGCGTTTCGATTTCACTCGC
GCGCAACTTGCGCCAGGTTGGATGCGCGAGCTACGTGGCGAACATACTCCTGAGACCGAAGAGTACGGGATCACCAGCTT
TGTTTACCGCGCGCGCCGTCCATTCCACCCATTACGCTTCAACCATTTGCTTGCTCATGGGTTGTCTGGTGTGATTCGCA
GCAAGGGCTTCTTCTGGTTAGCAAGTCGTATGGATTGGGTTGGCGAATTATCCAGCGTTGGTAGTGCCACGCGCACTCAA
GCAGCCGGGTTTTGGTATGCCGCACGGCACCGTGTCGACGTACATGAGGAAAATATGCCACCGCAGATTGGCATCGCCCC
ACTGCCCTACACCGAACTAGGTTGGCAACGTCAACAGAATGATTGTTGGACCGCACCATTGCCTGCGCCGCATGAGGTGA
GCGATCCTGGCGAATATGTGGCGATGCAGCGTCTATGGCATCCACAATGGGGCGACCGCCGACAAGAATTGGCGGTCATT
GGGTTGGATATGGATAAGGATGTTGCACGTAATGAATTAGATGCTTGCCTGCTCAGCAACGAAGAGCTGAGGATGGGGCC
AATGTATTGGAGCGCACTACCAGATCCATTCCCACAGTGGCGCCGCTGA

Upstream 100 bases:

>100_bases
ATAAAGTATCAAATTCCTTGGCTAGCCCGCCAAGCATCCCAGATATCGACAAGATCAGACTTGTAAATCGACAACTACAT
AACAAAGGTGATGGTTTGCT

Downstream 100 bases:

>100_bases
ATATTACGTTGTCCGTTAGGTCCGCCTGATAATGCAGTCCATGAAACACTCCTTATGCTGTAATAGTGTCGTAACAGTGC
ACTCACCCTGACCTGGGCTA

Product: cobalamin synthesis protein P47K

Products: NA

Alternate protein names: P47K [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MSTLTLPSDLRLPVTVFSGFLGAGKTTLLNRLLNNRDGLRVAVIVNDMSEVNIDAQLVRDGGAALSRTDETLVEFSNGCI
CCTLRDDLSKEVKRLALEQRYDYLLIESTGIGEPMPVAATFAVRDADGFCLSDVARLDTMVTVVDGSQFTALFSSMNTLA
DLGQQADSDDTRSLADLLGQQIEFADTIVISKCDLIDATQLARVRAVVRGLNRDAQIIEAHLGEVPLPQLVGTGRFDFTR
AQLAPGWMRELRGEHTPETEEYGITSFVYRARRPFHPLRFNHLLAHGLSGVIRSKGFFWLASRMDWVGELSSVGSATRTQ
AAGFWYAARHRVDVHEENMPPQIGIAPLPYTELGWQRQQNDCWTAPLPAPHEVSDPGEYVAMQRLWHPQWGDRRQELAVI
GLDMDKDVARNELDACLLSNEELRMGPMYWSALPDPFPQWRR

Sequences:

>Translated_442_residues
MSTLTLPSDLRLPVTVFSGFLGAGKTTLLNRLLNNRDGLRVAVIVNDMSEVNIDAQLVRDGGAALSRTDETLVEFSNGCI
CCTLRDDLSKEVKRLALEQRYDYLLIESTGIGEPMPVAATFAVRDADGFCLSDVARLDTMVTVVDGSQFTALFSSMNTLA
DLGQQADSDDTRSLADLLGQQIEFADTIVISKCDLIDATQLARVRAVVRGLNRDAQIIEAHLGEVPLPQLVGTGRFDFTR
AQLAPGWMRELRGEHTPETEEYGITSFVYRARRPFHPLRFNHLLAHGLSGVIRSKGFFWLASRMDWVGELSSVGSATRTQ
AAGFWYAARHRVDVHEENMPPQIGIAPLPYTELGWQRQQNDCWTAPLPAPHEVSDPGEYVAMQRLWHPQWGDRRQELAVI
GLDMDKDVARNELDACLLSNEELRMGPMYWSALPDPFPQWRR
>Mature_441_residues
STLTLPSDLRLPVTVFSGFLGAGKTTLLNRLLNNRDGLRVAVIVNDMSEVNIDAQLVRDGGAALSRTDETLVEFSNGCIC
CTLRDDLSKEVKRLALEQRYDYLLIESTGIGEPMPVAATFAVRDADGFCLSDVARLDTMVTVVDGSQFTALFSSMNTLAD
LGQQADSDDTRSLADLLGQQIEFADTIVISKCDLIDATQLARVRAVVRGLNRDAQIIEAHLGEVPLPQLVGTGRFDFTRA
QLAPGWMRELRGEHTPETEEYGITSFVYRARRPFHPLRFNHLLAHGLSGVIRSKGFFWLASRMDWVGELSSVGSATRTQA
AGFWYAARHRVDVHEENMPPQIGIAPLPYTELGWQRQQNDCWTAPLPAPHEVSDPGEYVAMQRLWHPQWGDRRQELAVIG
LDMDKDVARNELDACLLSNEELRMGPMYWSALPDPFPQWRR

Specific function: The presence of P47K is critical for the expression of the nitrile hydratase genes. May stabilize or activate the nitrile hydratase proteins [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=260, Percent_Identity=31.5384615384615, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI126722884, Length=260, Percent_Identity=31.1538461538462, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI223941779, Length=213, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI148727351, Length=260, Percent_Identity=30.7692307692308, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI146231952, Length=260, Percent_Identity=30.7692307692308, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI223941776, Length=249, Percent_Identity=30.5220883534137, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI119120938, Length=137, Percent_Identity=37.2262773722628, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI87082430, Length=298, Percent_Identity=25.503355704698, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788499, Length=105, Percent_Identity=37.1428571428571, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324356, Length=238, Percent_Identity=25.6302521008403, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 49359; Mature: 49227

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLTLPSDLRLPVTVFSGFLGAGKTTLLNRLLNNRDGLRVAVIVNDMSEVNIDAQLVRD
CCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEECHHHCCCCCEEEEC
GGAALSRTDETLVEFSNGCICCTLRDDLSKEVKRLALEQRYDYLLIESTGIGEPMPVAAT
CCCHHHCCHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEE
FAVRDADGFCLSDVARLDTMVTVVDGSQFTALFSSMNTLADLGQQADSDDTRSLADLLGQ
EEEECCCCCHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
QIEFADTIVISKCDLIDATQLARVRAVVRGLNRDAQIIEAHLGEVPLPQLVGTGRFDFTR
HHHHHHEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHCCCCCCCHH
AQLAPGWMRELRGEHTPETEEYGITSFVYRARRPFHPLRFNHLLAHGLSGVIRSKGFFWL
HHCCHHHHHHHCCCCCCCHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEE
ASRMDWVGELSSVGSATRTQAAGFWYAARHRVDVHEENMPPQIGIAPLPYTELGWQRQQN
HHHHHHHHHHHHCCCHHHHHHCCEEHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCC
DCWTAPLPAPHEVSDPGEYVAMQRLWHPQWGDRRQELAVIGLDMDKDVARNELDACLLSN
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCC
EELRMGPMYWSALPDPFPQWRR
CCCEECCCHHHCCCCCCHHCCC
>Mature Secondary Structure 
STLTLPSDLRLPVTVFSGFLGAGKTTLLNRLLNNRDGLRVAVIVNDMSEVNIDAQLVRD
CCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEECHHHCCCCCEEEEC
GGAALSRTDETLVEFSNGCICCTLRDDLSKEVKRLALEQRYDYLLIESTGIGEPMPVAAT
CCCHHHCCHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEE
FAVRDADGFCLSDVARLDTMVTVVDGSQFTALFSSMNTLADLGQQADSDDTRSLADLLGQ
EEEECCCCCHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
QIEFADTIVISKCDLIDATQLARVRAVVRGLNRDAQIIEAHLGEVPLPQLVGTGRFDFTR
HHHHHHEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHCCCCCCCHH
AQLAPGWMRELRGEHTPETEEYGITSFVYRARRPFHPLRFNHLLAHGLSGVIRSKGFFWL
HHCCHHHHHHHCCCCCCCHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEE
ASRMDWVGELSSVGSATRTQAAGFWYAARHRVDVHEENMPPQIGIAPLPYTELGWQRQQN
HHHHHHHHHHHHCCCHHHHHHCCEEHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCC
DCWTAPLPAPHEVSDPGEYVAMQRLWHPQWGDRRQELAVIGLDMDKDVARNELDACLLSN
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCC
EELRMGPMYWSALPDPFPQWRR
CCCEECCCHHHCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2013568 [H]