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The map label for this gene is cyoE [H]

Identifier: 182681187

GI number: 182681187

Start: 744626

End: 745531

Strand: Direct

Name: cyoE [H]

Synonym: XfasM23_0630

Alternate gene names: 182681187

Gene position: 744626-745531 (Clockwise)

Preceding gene: 182681186

Following gene: 182681193

Centisome position: 29.37

GC content: 51.32

Gene sequence:

>906_bases
ATGGCGGCTCGGTTGCGGGATTATTGGGATCTGACCAAGCCCAAGGTAGTGGCATTGATTGTGTTCACGGCTTTGGTTGG
GATGTTTCTGGCTATCCCTGGTATGCCCAGTGTTGTGCAGATCCAGAGTGGGGCACTTGGATTTTTAGGCATTTGGTTGG
CGGCGGCGGCCGCGGCGGCAATCAATCAGCTTCTGGATGCCAAAATCGATGCGCAGATGGCACGTACTTCATGGCGTCCG
CTGGTTGTTGGCAAGGTACGCCCTGTGCAGGTGTTGGTTTTTGCGGGGGTGTTGATCACGTTGTCGATGACGATTTTGAC
TCTTTGGGTCAATCTTATTACGGCAGTGCTGACGTTTACTTCGTTGATTGGGTATGCAGTGATTTACACCGTGTATCTTA
AGCGTATGACGTCGCAGAACATTGTGATTGGTGGTTTGGCCGGCGCGATGCCGCCTATGCTGGGCTGGGCTGCGGTCACG
GGGTTGTCGACAGCGGCGGATTGGATTAATGCATCATTGTTGGTAGCCATTATTTTTGTGTGGACGCCGCCGCACTTTTG
GGCATTGGCTATCTTTCGCCGTGCTGATTACGCTAAGGCATCCATTCCGATGTTGCCGGTGACCCATGGGGTGCAACATA
CATCCCGTCAGATCTTGTTGTATACGGTGATTCTGAGTGTGGTAACGCTGCTGCCGGTGGCGACTGGGATGAGCGGGGTA
TTTTATCTGGGGGCTGCTTTGGTGTTGGACGCTGTGTTTCTTTGGTATGCCTGGCGTCTGCTTGATCCACCTGATGAATT
ATTTGCAATGAAAACGTTTGGTTATTCGATCGTGTATTTGATGGCGTTATTCGCGTTTCTGATGTTTGATCATTGGCTGA
GGCTAGCGGATTTTTATTGGAATTAG

Upstream 100 bases:

>100_bases
CGGTTCCTCTGGTGGTGGGGGTGATGCACAACGGCGGCGCGGTGGCATTGCTTTTCGTATTAGTTTCTTTGCTCGCACGG
CTGCGTGCTCCGGAGTGAGT

Downstream 100 bases:

>100_bases
TAATTCAATGTCAGTAGGTGTCCATGGTGCCTGATTCATCATTGGATAAACTTTTGTGTGTTGAATTCAACTCATGATTG
TAATATTCGAAGCTGTTAAT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MAARLRDYWDLTKPKVVALIVFTALVGMFLAIPGMPSVVQIQSGALGFLGIWLAAAAAAAINQLLDAKIDAQMARTSWRP
LVVGKVRPVQVLVFAGVLITLSMTILTLWVNLITAVLTFTSLIGYAVIYTVYLKRMTSQNIVIGGLAGAMPPMLGWAAVT
GLSTAADWINASLLVAIIFVWTPPHFWALAIFRRADYAKASIPMLPVTHGVQHTSRQILLYTVILSVVTLLPVATGMSGV
FYLGAALVLDAVFLWYAWRLLDPPDELFAMKTFGYSIVYLMALFAFLMFDHWLRLADFYWN

Sequences:

>Translated_301_residues
MAARLRDYWDLTKPKVVALIVFTALVGMFLAIPGMPSVVQIQSGALGFLGIWLAAAAAAAINQLLDAKIDAQMARTSWRP
LVVGKVRPVQVLVFAGVLITLSMTILTLWVNLITAVLTFTSLIGYAVIYTVYLKRMTSQNIVIGGLAGAMPPMLGWAAVT
GLSTAADWINASLLVAIIFVWTPPHFWALAIFRRADYAKASIPMLPVTHGVQHTSRQILLYTVILSVVTLLPVATGMSGV
FYLGAALVLDAVFLWYAWRLLDPPDELFAMKTFGYSIVYLMALFAFLMFDHWLRLADFYWN
>Mature_300_residues
AARLRDYWDLTKPKVVALIVFTALVGMFLAIPGMPSVVQIQSGALGFLGIWLAAAAAAAINQLLDAKIDAQMARTSWRPL
VVGKVRPVQVLVFAGVLITLSMTILTLWVNLITAVLTFTSLIGYAVIYTVYLKRMTSQNIVIGGLAGAMPPMLGWAAVTG
LSTAADWINASLLVAIIFVWTPPHFWALAIFRRADYAKASIPMLPVTHGVQHTSRQILLYTVILSVVTLLPVATGMSGVF
YLGAALVLDAVFLWYAWRLLDPPDELFAMKTFGYSIVYLMALFAFLMFDHWLRLADFYWN

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=199, Percent_Identity=37.6884422110553, Blast_Score=112, Evalue=5e-25,
Organism=Escherichia coli, GI1786631, Length=292, Percent_Identity=31.8493150684932, Blast_Score=132, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71998235, Length=270, Percent_Identity=31.1111111111111, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6325085, Length=193, Percent_Identity=33.6787564766839, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI19921064, Length=280, Percent_Identity=32.5, Blast_Score=127, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 33146; Mature: 33015

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARLRDYWDLTKPKVVALIVFTALVGMFLAIPGMPSVVQIQSGALGFLGIWLAAAAAAA
CCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHH
INQLLDAKIDAQMARTSWRPLVVGKVRPVQVLVFAGVLITLSMTILTLWVNLITAVLTFT
HHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLIGYAVIYTVYLKRMTSQNIVIGGLAGAMPPMLGWAAVTGLSTAADWINASLLVAIIFV
HHHHHHHHHHHHHHHHCCCCEEEECHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WTPPHFWALAIFRRADYAKASIPMLPVTHGVQHTSRQILLYTVILSVVTLLPVATGMSGV
HCCHHHHHHHHHHHHCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
FYLGAALVLDAVFLWYAWRLLDPPDELFAMKTFGYSIVYLMALFAFLMFDHWLRLADFYW
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
N
C
>Mature Secondary Structure 
AARLRDYWDLTKPKVVALIVFTALVGMFLAIPGMPSVVQIQSGALGFLGIWLAAAAAAA
CCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHH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C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]