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The map label for this gene is acn [H]

Identifier: 182681092

GI number: 182681092

Start: 632652

End: 633461

Strand: Direct

Name: acn [H]

Synonym: XfasM23_0534

Alternate gene names: 182681092

Gene position: 632652-633461 (Clockwise)

Preceding gene: 182681091

Following gene: 182681093

Centisome position: 24.95

GC content: 60.25

Gene sequence:

>810_bases
ATGGGGCACCCCGGGAGTACGTACATCCGTCGGCCCCCTTATTGGGAAGGGGTCTTAGCCGGTGCGCGCACCTTGCGCGG
GTTACGGCCGTTGGCGGTGTTGGGCGATAACATCACCACCGATCATCTGTCTCCGTCGAATGCCATCCTGCCCAATAGTG
CGGCTGGAGAGTATCTGGCCCGCATGGGGGTGCCCCAAGAGGACTTTAATAGTTATGCAACCCGCCGCGGCGACCATTTG
ACCGCCCAGCGCGCCACCTTCGCTAATCCGATGCTGTTAAACGAGTTGGTGCGTGATGCTGATGGCAAGGTGCGTCAAGG
GTCGCTGACCCGGCTTGAGCCGGATGGCACCGTGATGCGGATGTGGGAAGCCATAGAAATCTACATGCAGCGCAGCCAAC
CTTTGATCATCATTGCTGGTGCGGATTATGGGCAGGGATCCTCCCGTGACTGGGCGGCCAAGGGCGTGCGTCTGGCTGGC
GTGGAGGCGATTGTGGCCGAAGGGTTCGAGCGTATCCACCGCACCAATGTCATTGGCATGGGCGTGTTACCGCTGACGTT
TCACCCTGGTACCACCCGCATCACGTTGCGCATTGATGGCACGGAGTTGTTTGATGTATGCGGCGTGCCGAGTGTGGGTG
CGGTGTTGATCCTGCGTATACAGCGCCGTGATGGCAGCGTCGCGGAAGTGCCGGTCACATGTCGGCTCGATACCGCTGAG
GAGCTGTCAATTTATGCGGCCGGTGGCGTGTTGCAGCGTGTTGCGCAAGAGATGCTTGCGACCACCTCAGGCACCTCACA
ACGCGTTTGA

Upstream 100 bases:

>100_bases
TGGTGCGTCGCAGCGTTCACCCGGAGCAATTCCGTCATGTGTACATGCCGCTGTTGCAAGCGTCTAGACAGCGGCGTGAA
TGCGTCCCGCCGTTATACGC

Downstream 100 bases:

>100_bases
TATAAGCGGTGTCCTGTTGTTGTTCACCGCGTAGGAAATCCCTTTGTGATATGACAGCGTGATGGTGCTTGGTGTGTCTA
TGATTTAACGCGTATCCCAT

Product: aconitate hydratase

Products: NA

Alternate protein names: Aconitase; Citrate hydro-lyase; IP210; Major iron-containing protein; MICP [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MGHPGSTYIRRPPYWEGVLAGARTLRGLRPLAVLGDNITTDHLSPSNAILPNSAAGEYLARMGVPQEDFNSYATRRGDHL
TAQRATFANPMLLNELVRDADGKVRQGSLTRLEPDGTVMRMWEAIEIYMQRSQPLIIIAGADYGQGSSRDWAAKGVRLAG
VEAIVAEGFERIHRTNVIGMGVLPLTFHPGTTRITLRIDGTELFDVCGVPSVGAVLILRIQRRDGSVAEVPVTCRLDTAE
ELSIYAAGGVLQRVAQEMLATTSGTSQRV

Sequences:

>Translated_269_residues
MGHPGSTYIRRPPYWEGVLAGARTLRGLRPLAVLGDNITTDHLSPSNAILPNSAAGEYLARMGVPQEDFNSYATRRGDHL
TAQRATFANPMLLNELVRDADGKVRQGSLTRLEPDGTVMRMWEAIEIYMQRSQPLIIIAGADYGQGSSRDWAAKGVRLAG
VEAIVAEGFERIHRTNVIGMGVLPLTFHPGTTRITLRIDGTELFDVCGVPSVGAVLILRIQRRDGSVAEVPVTCRLDTAE
ELSIYAAGGVLQRVAQEMLATTSGTSQRV
>Mature_268_residues
GHPGSTYIRRPPYWEGVLAGARTLRGLRPLAVLGDNITTDHLSPSNAILPNSAAGEYLARMGVPQEDFNSYATRRGDHLT
AQRATFANPMLLNELVRDADGKVRQGSLTRLEPDGTVMRMWEAIEIYMQRSQPLIIIAGADYGQGSSRDWAAKGVRLAGV
EAIVAEGFERIHRTNVIGMGVLPLTFHPGTTRITLRIDGTELFDVCGVPSVGAVLILRIQRRDGSVAEVPVTCRLDTAEE
LSIYAAGGVLQRVAQEMLATTSGTSQRV

Specific function: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate [H]

COG id: COG1048

COG function: function code C; Aconitase A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aconitase/IPM isomerase family [H]

Homologues:

Organism=Homo sapiens, GI8659555, Length=256, Percent_Identity=37.890625, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI41352693, Length=255, Percent_Identity=38.8235294117647, Blast_Score=176, Evalue=2e-44,
Organism=Escherichia coli, GI1787531, Length=259, Percent_Identity=46.7181467181467, Blast_Score=227, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI17568399, Length=258, Percent_Identity=39.922480620155, Blast_Score=184, Evalue=3e-47,
Organism=Drosophila melanogaster, GI17137564, Length=258, Percent_Identity=41.8604651162791, Blast_Score=199, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24645686, Length=259, Percent_Identity=40.5405405405405, Blast_Score=197, Evalue=7e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015931
- InterPro:   IPR015937
- InterPro:   IPR001030
- InterPro:   IPR015928
- InterPro:   IPR006249
- InterPro:   IPR015934
- InterPro:   IPR015932
- InterPro:   IPR018136
- InterPro:   IPR000573 [H]

Pfam domain/function: PF00330 Aconitase; PF00694 Aconitase_C [H]

EC number: =4.2.1.3 [H]

Molecular weight: Translated: 29179; Mature: 29048

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHPGSTYIRRPPYWEGVLAGARTLRGLRPLAVLGDNITTDHLSPSNAILPNSAAGEYLA
CCCCCCCCEECCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHH
RMGVPQEDFNSYATRRGDHLTAQRATFANPMLLNELVRDADGKVRQGSLTRLEPDGTVMR
HCCCCHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHCCCCCEECCCCEEECCCCHHHH
MWEAIEIYMQRSQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNVIGM
HHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHCCEEEHHHHHHHHHHHHHHHHCCEEEE
GVLPLTFHPGTTRITLRIDGTELFDVCGVPSVGAVLILRIQRRDGSVAEVPVTCRLDTAE
CEEEEEECCCCEEEEEEECCCHHHHHCCCCCCCEEEEEEEECCCCCEEEEEEEEEECCHH
ELSIYAAGGVLQRVAQEMLATTSGTSQRV
HEEEEECCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GHPGSTYIRRPPYWEGVLAGARTLRGLRPLAVLGDNITTDHLSPSNAILPNSAAGEYLA
CCCCCCCEECCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHH
RMGVPQEDFNSYATRRGDHLTAQRATFANPMLLNELVRDADGKVRQGSLTRLEPDGTVMR
HCCCCHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHCCCCCEECCCCEEECCCCHHHH
MWEAIEIYMQRSQPLIIIAGADYGQGSSRDWAAKGVRLAGVEAIVAEGFERIHRTNVIGM
HHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHCCEEEHHHHHHHHHHHHHHHHCCEEEE
GVLPLTFHPGTTRITLRIDGTELFDVCGVPSVGAVLILRIQRRDGSVAEVPVTCRLDTAE
CEEEEEECCCCEEEEEEECCCHHHHHCCCCCCCEEEEEEEECCCCCEEEEEEEEEECCHH
ELSIYAAGGVLQRVAQEMLATTSGTSQRV
HEEEEECCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8366052 [H]