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The map label for this gene is clpP

Identifier: 182681028

GI number: 182681028

Start: 564559

End: 565185

Strand: Direct

Name: clpP

Synonym: XfasM23_0467

Alternate gene names: 182681028

Gene position: 564559-565185 (Clockwise)

Preceding gene: 182681027

Following gene: 182681029

Centisome position: 22.26

GC content: 47.05

Gene sequence:

>627_bases
GTGGATGATGTGACAAAAGCTTTAAATCTAGTGCCGATGGTGGTCGAACAGACTAGCCGGGGGGAGCGTGCTTACGACAT
ATATTCGCGTTTATTAAAGGAACGTCTCATCTTTCTGGTTGGCCCTATTGACGATTACATGGCCAATTTGATAGTAGCGC
AACTCCTTTTCTTGGAAGCGGAAAATCCCGAGAAGGACATTAATATTTACATTAATTCTCCGGGTGGTGTGGTTACTGCA
GGTATGGCCATTTACGACACGATGCAGTACATTAAACCCGCTGTCAGTACTATCTGTGTTGGTCAAGCTGCTTCTATGGG
GGCGTTGTTGCTGGCTTCAGGTGCGTCTGGTAAGCGTTATGCTTTGCCGAACTCGCGTGTGATGATCCATCAACCGTTAG
GTGGTTTCCAGGGGCAAGCTACTGACATAGACATTCATGCGCGTGAGATACTTGCTTTACGTGCACGTCTAAACGAAATA
TTGGCTAAGCATACGGGACAGTCCTTGGAGACTATTGCTCATGACACCGAGCGTGATAACTTTAAAAGTGCTGTTGATGC
CCAAGCTTATGGTTTGGTAGATCAGGTCTTTGGGCAGCGCCAGGAAGAGTTGATCCAGTCTTCTTGA

Upstream 100 bases:

>100_bases
TGAATATAGGCGCTTTTGTTCTACCCAATAACAAAGTTAGTTCCTTGTGTACCTCTGTGTTGAACGTATGGATGTTTAAA
TTAGAGTCGGAGATATCCGC

Downstream 100 bases:

>100_bases
TCTCTCAATGCATCAGTTGGAAAATTTTTAGTTGCAATGGAATCTGTGATGTTGTTCTGCTCATATTGTGGTATTGTCAT
GGGTAAATCTGCATATATAC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MDDVTKALNLVPMVVEQTSRGERAYDIYSRLLKERLIFLVGPIDDYMANLIVAQLLFLEAENPEKDINIYINSPGGVVTA
GMAIYDTMQYIKPAVSTICVGQAASMGALLLASGASGKRYALPNSRVMIHQPLGGFQGQATDIDIHAREILALRARLNEI
LAKHTGQSLETIAHDTERDNFKSAVDAQAYGLVDQVFGQRQEELIQSS

Sequences:

>Translated_208_residues
MDDVTKALNLVPMVVEQTSRGERAYDIYSRLLKERLIFLVGPIDDYMANLIVAQLLFLEAENPEKDINIYINSPGGVVTA
GMAIYDTMQYIKPAVSTICVGQAASMGALLLASGASGKRYALPNSRVMIHQPLGGFQGQATDIDIHAREILALRARLNEI
LAKHTGQSLETIAHDTERDNFKSAVDAQAYGLVDQVFGQRQEELIQSS
>Mature_208_residues
MDDVTKALNLVPMVVEQTSRGERAYDIYSRLLKERLIFLVGPIDDYMANLIVAQLLFLEAENPEKDINIYINSPGGVVTA
GMAIYDTMQYIKPAVSTICVGQAASMGALLLASGASGKRYALPNSRVMIHQPLGGFQGQATDIDIHAREILALRARLNEI
LAKHTGQSLETIAHDTERDNFKSAVDAQAYGLVDQVFGQRQEELIQSS

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=208, Percent_Identity=59.6153846153846, Blast_Score=259, Evalue=2e-69,
Organism=Escherichia coli, GI1786641, Length=199, Percent_Identity=72.8643216080402, Blast_Score=314, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=55.3763440860215, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI20129427, Length=202, Percent_Identity=57.9207920792079, Blast_Score=252, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22795; Mature: 22795

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDVTKALNLVPMVVEQTSRGERAYDIYSRLLKERLIFLVGPIDDYMANLIVAQLLFLEA
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHC
ENPEKDINIYINSPGGVVTAGMAIYDTMQYIKPAVSTICVGQAASMGALLLASGASGKRY
CCCCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEECCCCCCEE
ALPNSRVMIHQPLGGFQGQATDIDIHAREILALRARLNEILAKHTGQSLETIAHDTERDN
ECCCCEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHH
FKSAVDAQAYGLVDQVFGQRQEELIQSS
HHHHHHHHHHHHHHHHHCHHHHHHHHCC
>Mature Secondary Structure
MDDVTKALNLVPMVVEQTSRGERAYDIYSRLLKERLIFLVGPIDDYMANLIVAQLLFLEA
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHC
ENPEKDINIYINSPGGVVTAGMAIYDTMQYIKPAVSTICVGQAASMGALLLASGASGKRY
CCCCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEECCCCCCEE
ALPNSRVMIHQPLGGFQGQATDIDIHAREILALRARLNEILAKHTGQSLETIAHDTERDN
ECCCCEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHH
FKSAVDAQAYGLVDQVFGQRQEELIQSS
HHHHHHHHHHHHHHHHHCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA