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The map label for this gene is adhc1 [H]

Identifier: 182680979

GI number: 182680979

Start: 522272

End: 523330

Strand: Direct

Name: adhc1 [H]

Synonym: XfasM23_0418

Alternate gene names: 182680979

Gene position: 522272-523330 (Clockwise)

Preceding gene: 182680978

Following gene: 182680980

Centisome position: 20.6

GC content: 54.39

Gene sequence:

>1059_bases
ATGAATGTAATGGGCTTCGCTGCCCTATCGGCTACTGGCCCGCTTGAACGGTTCGCTTTCGGACGGAGAGCTCCCAGACC
GGATGACGTCGTCATTGATATCCTTTACTGCGGTGTCTGCCACACTGATCTGCATCTTGCCCGTAACCACAGCGGCTTTA
CTACTTATCCAATCGTGCCCGGCCACGAGATCATCGGTTGTGTACGCGAGATCGGCAAGACAGTCACCCGCTTTAAGCGG
GGCGATCTGGTTGGTGTTGGTTGCATGGTCGATTCTTGCCAGCACTGCCAGCCTTGTCTCAAAGGGTGGGAACAGGACTG
CATTGAAGGTTCGACCTTCACCTATAACAGTATTGATCGGCGGGATGGCAGTATCACCTATGGTGGCTATTCAGATGTCA
TTGTCGTGCGTGATAAGTTCGTGCTGTTGTTGCCTGATGGTCTCGATCCAGCCGGAGCCGCGCCGCTGCTTTGCGCGGGC
ATCACGACATGGTCGCCGCTGCGTCGCTGGAATGTCGGCAAAGACAGCAAGGTTGCGGTGGTCGGTCTTGGCGGCCTCGG
ACACATGGCCTTGAAGCTGGCTAAGGCTCTTGGAGCCGATGTGACGTTGTTCACGCGTTCTTCCGGCAAAGAGGGAGATG
CCTTCCGTCTTGGAGCCGACCGTGTTGTGTTGTCCAGCGATCTGGAGCAGATGAAAGCTGTCTACAGCCGCTTTGACGTT
ATCATTGATACCGCTCCTTATGATCACGACGTCAATCCCTATATGCCCACCCTTGTACTTGAAGGTGTGCTCGTACTCGT
CGGCTATATGGGACCGCTCAGCACGCCTGTGAACGCTGGAGGTGTGGTACGTGGCCGTAGGGCCATTTCGGGTTCGTTCA
TTGGCGGTGTGCCTGAAACCCAGCAAATGCTCGATTTCTGTGGGCAGCACGGCATTGTCTCTGATGTCGAGATCATCCCC
ATCCAGAAAATTAACGAGGCCTATGAGCGTATGTTGAAAAGTGACGTTAAGTATCGTTTCGTCATTGACATGACTTCGCT
GACATCATCAGGAGCTTGA

Upstream 100 bases:

>100_bases
TCTGGTAACGCTTGAGATTCGATTTCGCTATTTCTTTTTCCGGTTGCGCCGGTGTGGTGTGACCGGAAGATCTTTTACGA
AAATTTAAGGAATGTGCGCC

Downstream 100 bases:

>100_bases
AAACATGACCAATATCATCAACCCATCCTGTGTGTAGTGACCAGTCATCTGATCCGCGGCGATAGCGGTGAGCCTACAGG
GTTCGCGATGGTTGAACTCA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Ms-ADHC 1 [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MNVMGFAALSATGPLERFAFGRRAPRPDDVVIDILYCGVCHTDLHLARNHSGFTTYPIVPGHEIIGCVREIGKTVTRFKR
GDLVGVGCMVDSCQHCQPCLKGWEQDCIEGSTFTYNSIDRRDGSITYGGYSDVIVVRDKFVLLLPDGLDPAGAAPLLCAG
ITTWSPLRRWNVGKDSKVAVVGLGGLGHMALKLAKALGADVTLFTRSSGKEGDAFRLGADRVVLSSDLEQMKAVYSRFDV
IIDTAPYDHDVNPYMPTLVLEGVLVLVGYMGPLSTPVNAGGVVRGRRAISGSFIGGVPETQQMLDFCGQHGIVSDVEIIP
IQKINEAYERMLKSDVKYRFVIDMTSLTSSGA

Sequences:

>Translated_352_residues
MNVMGFAALSATGPLERFAFGRRAPRPDDVVIDILYCGVCHTDLHLARNHSGFTTYPIVPGHEIIGCVREIGKTVTRFKR
GDLVGVGCMVDSCQHCQPCLKGWEQDCIEGSTFTYNSIDRRDGSITYGGYSDVIVVRDKFVLLLPDGLDPAGAAPLLCAG
ITTWSPLRRWNVGKDSKVAVVGLGGLGHMALKLAKALGADVTLFTRSSGKEGDAFRLGADRVVLSSDLEQMKAVYSRFDV
IIDTAPYDHDVNPYMPTLVLEGVLVLVGYMGPLSTPVNAGGVVRGRRAISGSFIGGVPETQQMLDFCGQHGIVSDVEIIP
IQKINEAYERMLKSDVKYRFVIDMTSLTSSGA
>Mature_352_residues
MNVMGFAALSATGPLERFAFGRRAPRPDDVVIDILYCGVCHTDLHLARNHSGFTTYPIVPGHEIIGCVREIGKTVTRFKR
GDLVGVGCMVDSCQHCQPCLKGWEQDCIEGSTFTYNSIDRRDGSITYGGYSDVIVVRDKFVLLLPDGLDPAGAAPLLCAG
ITTWSPLRRWNVGKDSKVAVVGLGGLGHMALKLAKALGADVTLFTRSSGKEGDAFRLGADRVVLSSDLEQMKAVYSRFDV
IIDTAPYDHDVNPYMPTLVLEGVLVLVGYMGPLSTPVNAGGVVRGRRAISGSFIGGVPETQQMLDFCGQHGIVSDVEIIP
IQKINEAYERMLKSDVKYRFVIDMTSLTSSGA

Specific function: Prefers aldehydes over alcohols [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786518, Length=349, Percent_Identity=50.1432664756447, Blast_Score=316, Evalue=1e-87,
Organism=Escherichia coli, GI87082401, Length=343, Percent_Identity=35.2769679300292, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI87081918, Length=326, Percent_Identity=29.4478527607362, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788073, Length=289, Percent_Identity=26.2975778546713, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788407, Length=285, Percent_Identity=29.8245614035088, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87082125, Length=183, Percent_Identity=30.6010928961749, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI226510992, Length=265, Percent_Identity=31.3207547169811, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787863, Length=129, Percent_Identity=31.0077519379845, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1788075, Length=182, Percent_Identity=26.9230769230769, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=345, Percent_Identity=24.6376811594203, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17562584, Length=341, Percent_Identity=25.5131964809384, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562582, Length=341, Percent_Identity=26.099706744868, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17562876, Length=261, Percent_Identity=28.735632183908, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=216, Percent_Identity=31.0185185185185, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562878, Length=207, Percent_Identity=30.4347826086957, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71997431, Length=218, Percent_Identity=30.7339449541284, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6323980, Length=333, Percent_Identity=35.4354354354354, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323961, Length=342, Percent_Identity=28.9473684210526, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6319949, Length=335, Percent_Identity=32.8358208955224, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324486, Length=341, Percent_Identity=29.0322580645161, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6323729, Length=331, Percent_Identity=29.0030211480363, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319621, Length=343, Percent_Identity=26.2390670553936, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319258, Length=312, Percent_Identity=24.6794871794872, Blast_Score=73, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=372, Percent_Identity=27.1505376344086, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737897, Length=230, Percent_Identity=30.8695652173913, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.2 [H]

Molecular weight: Translated: 38051; Mature: 38051

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVMGFAALSATGPLERFAFGRRAPRPDDVVIDILYCGVCHTDLHLARNHSGFTTYPIVP
CCCCEEEEECCCCCHHHHHHCCCCCCCCCCEEEEEHHCCHHHHHHHHHCCCCCEEECCCC
GHEIIGCVREIGKTVTRFKRGDLVGVGCMVDSCQHCQPCLKGWEQDCIEGSTFTYNSIDR
CHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCC
RDGSITYGGYSDVIVVRDKFVLLLPDGLDPAGAAPLLCAGITTWSPLRRWNVGKDSKVAV
CCCCEEECCCCCEEEEECCEEEEECCCCCCCCCCCEEHHCCCCCCHHHHCCCCCCCEEEE
VGLGGLGHMALKLAKALGADVTLFTRSSGKEGDAFRLGADRVVLSSDLEQMKAVYSRFDV
EEECCHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHE
IIDTAPYDHDVNPYMPTLVLEGVLVLVGYMGPLSTPVNAGGVVRGRRAISGSFIGGVPET
EEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCHHHCCCCCCCCCCH
QQMLDFCGQHGIVSDVEIIPIQKINEAYERMLKSDVKYRFVIDMTSLTSSGA
HHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHCCCCEEEEEEEEHHCCCCC
>Mature Secondary Structure
MNVMGFAALSATGPLERFAFGRRAPRPDDVVIDILYCGVCHTDLHLARNHSGFTTYPIVP
CCCCEEEEECCCCCHHHHHHCCCCCCCCCCEEEEEHHCCHHHHHHHHHCCCCCEEECCCC
GHEIIGCVREIGKTVTRFKRGDLVGVGCMVDSCQHCQPCLKGWEQDCIEGSTFTYNSIDR
CHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCC
RDGSITYGGYSDVIVVRDKFVLLLPDGLDPAGAAPLLCAGITTWSPLRRWNVGKDSKVAV
CCCCEEECCCCCEEEEECCEEEEECCCCCCCCCCCEEHHCCCCCCHHHHCCCCCCCEEEE
VGLGGLGHMALKLAKALGADVTLFTRSSGKEGDAFRLGADRVVLSSDLEQMKAVYSRFDV
EEECCHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHE
IIDTAPYDHDVNPYMPTLVLEGVLVLVGYMGPLSTPVNAGGVVRGRRAISGSFIGGVPET
EEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCHHHCCCCCCCCCCH
QQMLDFCGQHGIVSDVEIIPIQKINEAYERMLKSDVKYRFVIDMTSLTSSGA
HHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHCCCCEEEEEEEEHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11257547 [H]