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The map label for this gene is lysA [H]

Identifier: 182680964

GI number: 182680964

Start: 500323

End: 502929

Strand: Direct

Name: lysA [H]

Synonym: XfasM23_0402

Alternate gene names: 182680964

Gene position: 500323-502929 (Clockwise)

Preceding gene: 182680962

Following gene: 182680965

Centisome position: 19.73

GC content: 54.43

Gene sequence:

>2607_bases
ATGTCCGCTTCCCCTACAGCCGAGCGCTGGATCGTTCTAAAATTTGGTGGTACTTCCGTATCGCGTCGTCATCGCTGGGA
CACCATTGCGATGGTGGTGAGGAAGCGCCTTGAAGAGCATGGAACACGTGTACTGATCGTGGTTTCGGCGCTGTCTGGCG
TGACCAATGAACTGACGGCGATTGCTCAAGGTGTTGTGGACAGTGCCAAGCGCGTCACTGCATTGGAGCAGCGTCATCGC
GATTTTTTGGTTGAGCTTGGGTTAGATGCGCAAGCTGTGCTCGGCACGCGTTTCGCCATGTTGTCGGATCTTCTGCAAGA
TGCGCGTGCGGTGACGCGGTCACTGGACTGGCAGGCTGAGTTGTTAGGGCAAGGTGAACTGTTGTCTTCCACACTCGGTG
CGGCCTACCTGGGTGCTTCGGGTATTGATATCGGTTGGATGGATGCACGTGACTGGCTGACCGCTTTACCACCACAGCCC
AACCAGAGTGAATGGTCGCAACGTCTTTCTGTCTCCTGTCAATGGAAGTCTGATGTGGAGTGGCGTACACGTTTCGATGC
CCAACGTGCTCAGGTATTGATCACTCAAGGGTTTATCTCACGTCATCAAGATGGTGGTACCGCCATCCTGGGACGTGGTG
GTTCGGACACGTCAGCAGCATATTTTGGTGCGCTACTTGGTGCGGCGTGTGTTGAGATCTGGACTGATGTACCAGGGATG
TTCAGTGCGAACCCGAAGGAGGTCCCTGATGCGCGTTTGCTGACGCGCCTGGATTACTACGAGGCACAGGAGATCGCCAC
AACTGGCGCGAAGGTGTTGCATCCGCGTTCGATCAAACCATGCCGTGATACTGGCGTGCCGATGCTGATTCTAGATACTG
AGCGGCCCGATGTGTTGGGGACCCGTATTGATGCTGAAGTTGAGCCGGTGCTTGGAGTCAAGGCGATTAGCCGTCGTGAT
GGCATTGTATTAGTGTCGATGGAAGGGATCGGCATGTGGCAGCAGGTGGGTTTTCTTGCTGACGTATTTACATTGTTCAA
GAAACACGGATTGTCGGTGGACCTCATCGGATCGGCAGAAACCAATGTTACTGTGTCCTTGGACCCCTCCGAGAACCTGG
TTAACACCGACGTACTGACTGCATTGTCAACCGATTTATCACAGATCTGCAAAGTCAAAATTATTGTGCCTTGCGCTGCG
ATCACTTTGGTCGGGCGTGGTATGCGTTCCCTGCTGCATAAACTCTCTGAGGTATGGGCTACGTTCGGTAAAGAACGTGT
CCACATGATCTCGCAGTCTTCCAATGATCTTAATCTCACCTTTGTGATTGATGAGACTGATGCGGACGGATTATTGGCGG
TGCTGCATTTCAAATTGATCGAAAGTGGTGCAATGCCTGTCCAAGATCGTGCCGTGTTTGGTTCGCCTTGGCGCGAGATC
ATCGGGCACGTACGTACGCGGGTCATGCCTTGGTGGCACAGTGCCCGCATGCGTTTACTGGCCATGAGAGATGAAGAGGG
CATTGGTCCTTGCTACGTCTACCATTTGCCGACAGTGCGCGAACGTGCGCGGCAATTGAATGCAGTAGCTGCCGTGGATC
AGTGCTACTACGCCATCAAGGCCAACCCGCATCCGGCCATTCTCCGTACCCTGATTGAAGAAGGCTTTGGACTAGAGTGC
GTGTCATTGGGTGAATTGCGTCACGTGTTTGAAGTGGTGCCACACTTGGTTCCGTCGCGTGTGTTATTCACTCCAAGTTT
CGCCTCACGTGTGGAGTACGAGCAGGCATTCTTACTAGGTGTCAATGTGACCTTGGACAATGTCGAGGCCTTGCGCTTAT
GGCCGGAGGTATTCCGTGAACGGACGTTATGGTTACGTATCGATTTGGGTTACGGCGATGGACATCACGAGAAGGTCACC
ACCGGTGGTAAGACATCTAAATTTGGCCTTTCGGTCACGCGGATTGATGAATTTATCGATGTTGCCAAGACACTGAACAT
AACCGTGACCGGCCTGCATGCCCATCTTGGCAGTGGCGTGGAGAGCGGCAACCATTGGTCTCGCATGTACGATGAGTTGG
CTGGTTTTGCCTCCCGCATCGGGAGTGTGTCTACCCTGGATATCGGCGGCGGCTTACCGATCCCGTACCGGCCTGATGAT
GAACCATTTGACGTGGGGGCGTGGGGAGCAAGTTTGGCTGAAGTCAAAGCCTTGCATCCCAAATTTCAATTGGTGATTGA
GCCGGGCCGCTTCCTTGTAGCCGAAGCGGGCGTGCTCTTGACCAGGGTCACCCAAGTGATTGAAAAAGATGACATCCTTC
GGGTTGGCCTGGAGGCTGGCATGCATACCCTGATTCGTCCGGCCCTTTACGATGCCTGGCACGGCGTGGAGAACCTCACC
CGCTTGGATGAGACACCCCATGTACTGTGCGATGTCGTGGGTCCTATTTGCGAGTCATCCGACGTGTTTGGCCGTCGCCG
TCACCTTCCAGCCGCCACCGCCTCCGGTGATTTAATGTTGATTGCAGATGCTGGCGCCTATGGTTTCTCGATGGCCAGCA
CTTACAATCTGCGCGGCCTGCCGGCCGAGGTCGTGCTTGATGCCTGA

Upstream 100 bases:

>100_bases
CAGGAATAGGGCGGTCATCAATCGTTAGATTGGCAGTAGAATTCCCAGAAATGCCACGTACCGTAAATGGCTTTACTCTT
GAGTGAAAACAGTAACGCTA

Downstream 100 bases:

>100_bases
GTGGTGTTGTGGTCCGGTTGTAACGACAATCATGCAGGTTGTGCATCCTGTTACATGCGGACTGTTGACCTGTCCGTTCA
GGGATTTTTCATGACGTCCA

Product: bifunctional aspartate kinase/diaminopimelate decarboxylase protein

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 868; Mature: 867

Protein sequence:

>868_residues
MSASPTAERWIVLKFGGTSVSRRHRWDTIAMVVRKRLEEHGTRVLIVVSALSGVTNELTAIAQGVVDSAKRVTALEQRHR
DFLVELGLDAQAVLGTRFAMLSDLLQDARAVTRSLDWQAELLGQGELLSSTLGAAYLGASGIDIGWMDARDWLTALPPQP
NQSEWSQRLSVSCQWKSDVEWRTRFDAQRAQVLITQGFISRHQDGGTAILGRGGSDTSAAYFGALLGAACVEIWTDVPGM
FSANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDTGVPMLILDTERPDVLGTRIDAEVEPVLGVKAISRRD
GIVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAETNVTVSLDPSENLVNTDVLTALSTDLSQICKVKIIVPCAA
ITLVGRGMRSLLHKLSEVWATFGKERVHMISQSSNDLNLTFVIDETDADGLLAVLHFKLIESGAMPVQDRAVFGSPWREI
IGHVRTRVMPWWHSARMRLLAMRDEEGIGPCYVYHLPTVRERARQLNAVAAVDQCYYAIKANPHPAILRTLIEEGFGLEC
VSLGELRHVFEVVPHLVPSRVLFTPSFASRVEYEQAFLLGVNVTLDNVEALRLWPEVFRERTLWLRIDLGYGDGHHEKVT
TGGKTSKFGLSVTRIDEFIDVAKTLNITVTGLHAHLGSGVESGNHWSRMYDELAGFASRIGSVSTLDIGGGLPIPYRPDD
EPFDVGAWGASLAEVKALHPKFQLVIEPGRFLVAEAGVLLTRVTQVIEKDDILRVGLEAGMHTLIRPALYDAWHGVENLT
RLDETPHVLCDVVGPICESSDVFGRRRHLPAATASGDLMLIADAGAYGFSMASTYNLRGLPAEVVLDA

Sequences:

>Translated_868_residues
MSASPTAERWIVLKFGGTSVSRRHRWDTIAMVVRKRLEEHGTRVLIVVSALSGVTNELTAIAQGVVDSAKRVTALEQRHR
DFLVELGLDAQAVLGTRFAMLSDLLQDARAVTRSLDWQAELLGQGELLSSTLGAAYLGASGIDIGWMDARDWLTALPPQP
NQSEWSQRLSVSCQWKSDVEWRTRFDAQRAQVLITQGFISRHQDGGTAILGRGGSDTSAAYFGALLGAACVEIWTDVPGM
FSANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDTGVPMLILDTERPDVLGTRIDAEVEPVLGVKAISRRD
GIVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAETNVTVSLDPSENLVNTDVLTALSTDLSQICKVKIIVPCAA
ITLVGRGMRSLLHKLSEVWATFGKERVHMISQSSNDLNLTFVIDETDADGLLAVLHFKLIESGAMPVQDRAVFGSPWREI
IGHVRTRVMPWWHSARMRLLAMRDEEGIGPCYVYHLPTVRERARQLNAVAAVDQCYYAIKANPHPAILRTLIEEGFGLEC
VSLGELRHVFEVVPHLVPSRVLFTPSFASRVEYEQAFLLGVNVTLDNVEALRLWPEVFRERTLWLRIDLGYGDGHHEKVT
TGGKTSKFGLSVTRIDEFIDVAKTLNITVTGLHAHLGSGVESGNHWSRMYDELAGFASRIGSVSTLDIGGGLPIPYRPDD
EPFDVGAWGASLAEVKALHPKFQLVIEPGRFLVAEAGVLLTRVTQVIEKDDILRVGLEAGMHTLIRPALYDAWHGVENLT
RLDETPHVLCDVVGPICESSDVFGRRRHLPAATASGDLMLIADAGAYGFSMASTYNLRGLPAEVVLDA
>Mature_867_residues
SASPTAERWIVLKFGGTSVSRRHRWDTIAMVVRKRLEEHGTRVLIVVSALSGVTNELTAIAQGVVDSAKRVTALEQRHRD
FLVELGLDAQAVLGTRFAMLSDLLQDARAVTRSLDWQAELLGQGELLSSTLGAAYLGASGIDIGWMDARDWLTALPPQPN
QSEWSQRLSVSCQWKSDVEWRTRFDAQRAQVLITQGFISRHQDGGTAILGRGGSDTSAAYFGALLGAACVEIWTDVPGMF
SANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDTGVPMLILDTERPDVLGTRIDAEVEPVLGVKAISRRDG
IVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAETNVTVSLDPSENLVNTDVLTALSTDLSQICKVKIIVPCAAI
TLVGRGMRSLLHKLSEVWATFGKERVHMISQSSNDLNLTFVIDETDADGLLAVLHFKLIESGAMPVQDRAVFGSPWREII
GHVRTRVMPWWHSARMRLLAMRDEEGIGPCYVYHLPTVRERARQLNAVAAVDQCYYAIKANPHPAILRTLIEEGFGLECV
SLGELRHVFEVVPHLVPSRVLFTPSFASRVEYEQAFLLGVNVTLDNVEALRLWPEVFRERTLWLRIDLGYGDGHHEKVTT
GGKTSKFGLSVTRIDEFIDVAKTLNITVTGLHAHLGSGVESGNHWSRMYDELAGFASRIGSVSTLDIGGGLPIPYRPDDE
PFDVGAWGASLAEVKALHPKFQLVIEPGRFLVAEAGVLLTRVTQVIEKDDILRVGLEAGMHTLIRPALYDAWHGVENLTR
LDETPHVLCDVVGPICESSDVFGRRRHLPAATASGDLMLIADAGAYGFSMASTYNLRGLPAEVVLDA

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=351, Percent_Identity=25.9259259259259, Blast_Score=76, Evalue=2e-13,
Organism=Escherichia coli, GI1789203, Length=380, Percent_Identity=34.2105263157895, Blast_Score=194, Evalue=2e-50,
Organism=Escherichia coli, GI1786183, Length=477, Percent_Identity=30.398322851153, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1790455, Length=457, Percent_Identity=29.9781181619256, Blast_Score=171, Evalue=2e-43,
Organism=Escherichia coli, GI1790376, Length=320, Percent_Identity=30.9375, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320893, Length=508, Percent_Identity=24.4094488188976, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322664, Length=366, Percent_Identity=22.9508196721311, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24586472, Length=356, Percent_Identity=28.6516853932584, Blast_Score=97, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 95285; Mature: 95154

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00324 ASPARTOKINASE ; PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASPTAERWIVLKFGGTSVSRRHRWDTIAMVVRKRLEEHGTRVLIVVSALSGVTNELTA
CCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHCCHHHHHHH
IAQGVVDSAKRVTALEQRHRDFLVELGLDAQAVLGTRFAMLSDLLQDARAVTRSLDWQAE
HHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LLGQGELLSSTLGAAYLGASGIDIGWMDARDWLTALPPQPNQSEWSQRLSVSCQWKSDVE
HCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHCEEEEEECCCCC
WRTRFDAQRAQVLITQGFISRHQDGGTAILGRGGSDTSAAYFGALLGAACVEIWTDVPGM
HHHHHCHHHHHEEEEHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCC
FSANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDTGVPMLILDTERPDVLG
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHCCCCEEEEECCCCCCCC
TRIDAEVEPVLGVKAISRRDGIVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAE
CCCCCCCCCHHCHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCC
TNVTVSLDPSENLVNTDVLTALSTDLSQICKVKIIVPCAAITLVGRGMRSLLHKLSEVWA
CEEEEEECCCCCCCCHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
TFGKERVHMISQSSNDLNLTFVIDETDADGLLAVLHFKLIESGAMPVQDRAVFGSPWREI
HHCHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
IGHVRTRVMPWWHSARMRLLAMRDEEGIGPCYVYHLPTVRERARQLNAVAAVDQCYYAIK
HHHHHHHCCCCHHHHHEEEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHEEEEE
ANPHPAILRTLIEEGFGLECVSLGELRHVFEVVPHLVPSRVLFTPSFASRVEYEQAFLLG
CCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCEEEEEE
VNVTLDNVEALRLWPEVFRERTLWLRIDLGYGDGHHEKVTTGGKTSKFGLSVTRIDEFID
EEEEECCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEECCCCCCCCCCCHHHHHHHHH
VAKTLNITVTGLHAHLGSGVESGNHWSRMYDELAGFASRIGSVSTLDIGGGLPIPYRPDD
HHHHEEEEEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCC
EPFDVGAWGASLAEVKALHPKFQLVIEPGRFLVAEAGVLLTRVTQVIEKDDILRVGLEAG
CCCCCCCCCHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHCCHHHHHHHHH
MHTLIRPALYDAWHGVENLTRLDETPHVLCDVVGPICESSDVFGRRRHLPAATASGDLML
HHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCEEE
IADAGAYGFSMASTYNLRGLPAEVVLDA
EEECCCCCEECCCCCCCCCCCCEEEECC
>Mature Secondary Structure 
SASPTAERWIVLKFGGTSVSRRHRWDTIAMVVRKRLEEHGTRVLIVVSALSGVTNELTA
CCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEHHCCHHHHHHH
IAQGVVDSAKRVTALEQRHRDFLVELGLDAQAVLGTRFAMLSDLLQDARAVTRSLDWQAE
HHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LLGQGELLSSTLGAAYLGASGIDIGWMDARDWLTALPPQPNQSEWSQRLSVSCQWKSDVE
HCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHCEEEEEECCCCC
WRTRFDAQRAQVLITQGFISRHQDGGTAILGRGGSDTSAAYFGALLGAACVEIWTDVPGM
HHHHHCHHHHHEEEEHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCC
FSANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDTGVPMLILDTERPDVLG
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCHHHCCCCEEEEECCCCCCCC
TRIDAEVEPVLGVKAISRRDGIVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAE
CCCCCCCCCHHCHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCC
TNVTVSLDPSENLVNTDVLTALSTDLSQICKVKIIVPCAAITLVGRGMRSLLHKLSEVWA
CEEEEEECCCCCCCCHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
TFGKERVHMISQSSNDLNLTFVIDETDADGLLAVLHFKLIESGAMPVQDRAVFGSPWREI
HHCHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
IGHVRTRVMPWWHSARMRLLAMRDEEGIGPCYVYHLPTVRERARQLNAVAAVDQCYYAIK
HHHHHHHCCCCHHHHHEEEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHEEEEE
ANPHPAILRTLIEEGFGLECVSLGELRHVFEVVPHLVPSRVLFTPSFASRVEYEQAFLLG
CCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCEEEEEE
VNVTLDNVEALRLWPEVFRERTLWLRIDLGYGDGHHEKVTTGGKTSKFGLSVTRIDEFID
EEEEECCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEECCCCCCCCCCCHHHHHHHHH
VAKTLNITVTGLHAHLGSGVESGNHWSRMYDELAGFASRIGSVSTLDIGGGLPIPYRPDD
HHHHEEEEEEEEHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCC
EPFDVGAWGASLAEVKALHPKFQLVIEPGRFLVAEAGVLLTRVTQVIEKDDILRVGLEAG
CCCCCCCCCHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHCCHHHHHHHHH
MHTLIRPALYDAWHGVENLTRLDETPHVLCDVVGPICESSDVFGRRRHLPAATASGDLML
HHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCEEE
IADAGAYGFSMASTYNLRGLPAEVVLDA
EEECCCCCEECCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]