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The map label for this gene is rpfC [H]

Identifier: 182680962

GI number: 182680962

Start: 496995

End: 499148

Strand: Direct

Name: rpfC [H]

Synonym: XfasM23_0400

Alternate gene names: 182680962

Gene position: 496995-499148 (Clockwise)

Preceding gene: 182680961

Following gene: 182680964

Centisome position: 19.6

GC content: 51.02

Gene sequence:

>2154_bases
ATGCTAAAGAAAGCTAAATGGATATGCAGTCGGCTATCGCAGCGGCCAGATAGTGAGCATGTACAAAATTTAATCAGATT
TCTTATCGCCTCGCTCTTCATCATCTACTTGAGCGTATGTTGGCATGGCGAAACGGATCTCAATACATCGCGGGTCATCT
GGTTGGTGTTGCTGTCCGATCTTGGCGTGTCGCTGGCGCTGATGCTTGCGATTGTCATGCATCCGCAGATCTCGCACGTG
CGGCGTTGTATTGGCATCATTGCCGACTACACATCACTGACGGTGCTGATGTTGCTGATGGGCGAGGCGGGTTCACCGCT
GTATGTCCTATGTTTGTGGGTAACCATCGGTAATGGCTTACGTTATGGCAGTGTGTATTTGCTGGTCACTACGACCCTTG
GTGCGTTGAGTTTCCTGACGGTGATCCTCGTTTCAGCGTACTGGAAGTCGAATCCGTTTCTGGCTTGGGGATTACTGATT
GGTCTGATTGCCATCCCTTGGTATTTCCAGTCTCTGTTGAAGGCATTGATCCAAGCCCTTAACGATGCACGTCATGCTAA
TGAGGCTAAGAGTCGCTTCTTGGCTAATATGAGCCATGAATTTCGCACGCCGCTGAATGGTTTGTCGGGTATGACGGAGG
TGCTGGCCACAACGCGTTTGGATGCCGAGCAAAGGGAATGCTTGAAAGCGATCCAGGCATCGGTACACAGCGTGTTGTCC
TTGATTGAGGAAGTGCTCGACATCTCAAGAATTGAGGCAGGTAAGATCCGTATCCTCCACGATACTTTCTCCTTGAAGGA
GGTGATTGGCAGTGTCGGTCTGATCCTGCAACCACAGATCCGCAATAAAGCCTTGGAATATCGTGTCGATGTGGGGTTGG
ATGTTCCCGAATGGTTGTTCGGCGATGCTGGCTATGTGCGTCAGGTCTTATTGAACATTGTCGGTAATGCGGTCAAGTTT
ACCGAGCGTGGTCGGATTACATTGTGTGTCAGCGTGTTGAACCGTTCTAGACAGCACAGTGTGGTGTTGCGTTTTGAAGT
TGCAGATACTGGCATTGGTGTGCCATTGGGAATGCGGAATCGGCTTTTCGACGTGTTCGAGCAGGCTGATGTTGGTTTGG
ATCGCCGTTATCAAGGAAGCGGACTGGGTACCACGATTGCCAAGGGTTTAATTGAATTGATGGGTGGAAGCATCGGGTTT
GAGGAGAACGTCCCTTGTGGGAGCTTGTTTTGGTTCGAATTGCCGTTTGAACTTGCCAAGAAACAGGTGGTTGCGCAAGA
GGTATCCGAAGCATCGCAGTGTACCGAACCGAGTAACGTTATCGCATTTTCCAATCCATTCCTACGGCATCGTGCTCGTG
TCAAGAGCATGCGCGTGCTGGTTGCTGATGACCATGAAACTAACCGCATGGTGTTATCCAGAATCCTTGATAAGGCGGGA
CACAAGCTGTTATGCGTGGATGGTGCGGAAGCAGTGTTGGATTGTTTGATCAGTATGGAATTCGATGTTGTGATCATCGA
CCTGCACATGCCTGGAATGAGCGGTTTGGACATGCTCAAACAGTTGCGGGTCATGCAAAGTTCCAGTCTGCCTTATACAC
CGGTGCTTGTGCTGAGTGCCGATGCGACGTCCGATTCGATCCGCTGTTGTGAAGAGGCAGGAGCGCGTGCTTTTCTGTCC
AAACCCGTGCTTGCTACTAAATTGCTGGATGTACTTGCCGAAATTGCTGAAGGGGATGGTGGTGCATTACCTTACGCTGC
ATTATCGCAATCCTCAGTTCAGCAGCATCAGGTGTTCGATCCGGCGGGTTTGGATGATCTGGCTGAGTTGAATATGGACG
ATGATTTCGAAGAGCGGTTCATAGTTCAGTCTTTTCGAGATGCCGAACACTGCCAGCAGACAATGTTGTCTGCCGCTGAA
ACCAACCAGTGGCAGGAGGTGCGGGAAGAAGCGCATGCACTGCGTGGTGTGCTTGGTCATCTTGGTTTAATGCGCGCTTC
GTCGCTGGCGGCAGAGTTGATGCGTATCCCAGATTGGCAGTTGCAATTGGAGTGGTGTGCTCTTGTCCAAATGCTGGATG
AAGCACTGCTGTGTGGTCGTGATGCGCTTGAAGCGCGCCGACAGGAACGCCGGCGCAGTGGGGTTTTACGATGA

Upstream 100 bases:

>100_bases
TTTGATCCACATTGTGTCGACGCTCTCATCAGGGGGCGCGATCAACTACAACGCATTTGCGTTAAGTTCTCCACTGCTTT
GGCCAGGCCGGGAGTGTGGG

Downstream 100 bases:

>100_bases
TCATCAGCACAGCTTTAAGTGCTCAGTTTTTTAGTGCTGTGTTTTTGTGAGTCTGCTGGGCGCGGATCAGGCGCTCCATA
GTTCGGAGTGATTTGTTACT

Product: multi-sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 717; Mature: 717

Protein sequence:

>717_residues
MLKKAKWICSRLSQRPDSEHVQNLIRFLIASLFIIYLSVCWHGETDLNTSRVIWLVLLSDLGVSLALMLAIVMHPQISHV
RRCIGIIADYTSLTVLMLLMGEAGSPLYVLCLWVTIGNGLRYGSVYLLVTTTLGALSFLTVILVSAYWKSNPFLAWGLLI
GLIAIPWYFQSLLKALIQALNDARHANEAKSRFLANMSHEFRTPLNGLSGMTEVLATTRLDAEQRECLKAIQASVHSVLS
LIEEVLDISRIEAGKIRILHDTFSLKEVIGSVGLILQPQIRNKALEYRVDVGLDVPEWLFGDAGYVRQVLLNIVGNAVKF
TERGRITLCVSVLNRSRQHSVVLRFEVADTGIGVPLGMRNRLFDVFEQADVGLDRRYQGSGLGTTIAKGLIELMGGSIGF
EENVPCGSLFWFELPFELAKKQVVAQEVSEASQCTEPSNVIAFSNPFLRHRARVKSMRVLVADDHETNRMVLSRILDKAG
HKLLCVDGAEAVLDCLISMEFDVVIIDLHMPGMSGLDMLKQLRVMQSSSLPYTPVLVLSADATSDSIRCCEEAGARAFLS
KPVLATKLLDVLAEIAEGDGGALPYAALSQSSVQQHQVFDPAGLDDLAELNMDDDFEERFIVQSFRDAEHCQQTMLSAAE
TNQWQEVREEAHALRGVLGHLGLMRASSLAAELMRIPDWQLQLEWCALVQMLDEALLCGRDALEARRQERRRSGVLR

Sequences:

>Translated_717_residues
MLKKAKWICSRLSQRPDSEHVQNLIRFLIASLFIIYLSVCWHGETDLNTSRVIWLVLLSDLGVSLALMLAIVMHPQISHV
RRCIGIIADYTSLTVLMLLMGEAGSPLYVLCLWVTIGNGLRYGSVYLLVTTTLGALSFLTVILVSAYWKSNPFLAWGLLI
GLIAIPWYFQSLLKALIQALNDARHANEAKSRFLANMSHEFRTPLNGLSGMTEVLATTRLDAEQRECLKAIQASVHSVLS
LIEEVLDISRIEAGKIRILHDTFSLKEVIGSVGLILQPQIRNKALEYRVDVGLDVPEWLFGDAGYVRQVLLNIVGNAVKF
TERGRITLCVSVLNRSRQHSVVLRFEVADTGIGVPLGMRNRLFDVFEQADVGLDRRYQGSGLGTTIAKGLIELMGGSIGF
EENVPCGSLFWFELPFELAKKQVVAQEVSEASQCTEPSNVIAFSNPFLRHRARVKSMRVLVADDHETNRMVLSRILDKAG
HKLLCVDGAEAVLDCLISMEFDVVIIDLHMPGMSGLDMLKQLRVMQSSSLPYTPVLVLSADATSDSIRCCEEAGARAFLS
KPVLATKLLDVLAEIAEGDGGALPYAALSQSSVQQHQVFDPAGLDDLAELNMDDDFEERFIVQSFRDAEHCQQTMLSAAE
TNQWQEVREEAHALRGVLGHLGLMRASSLAAELMRIPDWQLQLEWCALVQMLDEALLCGRDALEARRQERRRSGVLR
>Mature_717_residues
MLKKAKWICSRLSQRPDSEHVQNLIRFLIASLFIIYLSVCWHGETDLNTSRVIWLVLLSDLGVSLALMLAIVMHPQISHV
RRCIGIIADYTSLTVLMLLMGEAGSPLYVLCLWVTIGNGLRYGSVYLLVTTTLGALSFLTVILVSAYWKSNPFLAWGLLI
GLIAIPWYFQSLLKALIQALNDARHANEAKSRFLANMSHEFRTPLNGLSGMTEVLATTRLDAEQRECLKAIQASVHSVLS
LIEEVLDISRIEAGKIRILHDTFSLKEVIGSVGLILQPQIRNKALEYRVDVGLDVPEWLFGDAGYVRQVLLNIVGNAVKF
TERGRITLCVSVLNRSRQHSVVLRFEVADTGIGVPLGMRNRLFDVFEQADVGLDRRYQGSGLGTTIAKGLIELMGGSIGF
EENVPCGSLFWFELPFELAKKQVVAQEVSEASQCTEPSNVIAFSNPFLRHRARVKSMRVLVADDHETNRMVLSRILDKAG
HKLLCVDGAEAVLDCLISMEFDVVIIDLHMPGMSGLDMLKQLRVMQSSSLPYTPVLVLSADATSDSIRCCEEAGARAFLS
KPVLATKLLDVLAEIAEGDGGALPYAALSQSSVQQHQVFDPAGLDDLAELNMDDDFEERFIVQSFRDAEHCQQTMLSAAE
TNQWQEVREEAHALRGVLGHLGLMRASSLAAELMRIPDWQLQLEWCALVQMLDEALLCGRDALEARRQERRRSGVLR

Specific function: Involved in the positive regulation of synthesis of extracellular enzymes and polysaccharide, and hence in pathogenicity. Can restore function to the non-pathogenic mutant 8237 [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=268, Percent_Identity=38.0597014925373, Blast_Score=185, Evalue=7e-48,
Organism=Escherichia coli, GI48994928, Length=510, Percent_Identity=25.4901960784314, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI87081816, Length=503, Percent_Identity=26.441351888668, Blast_Score=159, Evalue=8e-40,
Organism=Escherichia coli, GI1788713, Length=406, Percent_Identity=30.5418719211823, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI145693157, Length=244, Percent_Identity=36.0655737704918, Blast_Score=140, Evalue=4e-34,
Organism=Escherichia coli, GI1786912, Length=251, Percent_Identity=29.0836653386454, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1786600, Length=236, Percent_Identity=28.3898305084746, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788279, Length=249, Percent_Identity=27.3092369477912, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082128, Length=230, Percent_Identity=28.695652173913, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786783, Length=330, Percent_Identity=21.8181818181818, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788549, Length=236, Percent_Identity=24.5762711864407, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI1788393, Length=225, Percent_Identity=24.8888888888889, Blast_Score=66, Evalue=9e-12,
Organism=Escherichia coli, GI1788191, Length=129, Percent_Identity=32.5581395348837, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 79667; Mature: 79667

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKAKWICSRLSQRPDSEHVQNLIRFLIASLFIIYLSVCWHGETDLNTSRVIWLVLLSD
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LGVSLALMLAIVMHPQISHVRRCIGIIADYTSLTVLMLLMGEAGSPLYVLCLWVTIGNGL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC
RYGSVYLLVTTTLGALSFLTVILVSAYWKSNPFLAWGLLIGLIAIPWYFQSLLKALIQAL
EECCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NDARHANEAKSRFLANMSHEFRTPLNGLSGMTEVLATTRLDAEQRECLKAIQASVHSVLS
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LIEEVLDISRIEAGKIRILHDTFSLKEVIGSVGLILQPQIRNKALEYRVDVGLDVPEWLF
HHHHHHHHHHCCCCCEEEEECHHHHHHHHHHCCCEECCHHHCCHHHEEEECCCCCHHHHC
GDAGYVRQVLLNIVGNAVKFTERGRITLCVSVLNRSRQHSVVLRFEVADTGIGVPLGMRN
CCHHHHHHHHHHHHCCHHHCCCCCCCEEEHHHHCCCCCCEEEEEEEECCCCCCCCCCHHH
RLFDVFEQADVGLDRRYQGSGLGTTIAKGLIELMGGSIGFEENVPCGSLFWFELPFELAK
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCHHHHH
KQVVAQEVSEASQCTEPSNVIAFSNPFLRHRARVKSMRVLVADDHETNRMVLSRILDKAG
HHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCC
HKLLCVDGAEAVLDCLISMEFDVVIIDLHMPGMSGLDMLKQLRVMQSSSLPYTPVLVLSA
CEEEEECCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEEC
DATSDSIRCCEEAGARAFLSKPVLATKLLDVLAEIAEGDGGALPYAALSQSSVQQHQVFD
CCCCHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
PAGLDDLAELNMDDDFEERFIVQSFRDAEHCQQTMLSAAETNQWQEVREEAHALRGVLGH
CCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLMRASSLAAELMRIPDWQLQLEWCALVQMLDEALLCGRDALEARRQERRRSGVLR
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLKKAKWICSRLSQRPDSEHVQNLIRFLIASLFIIYLSVCWHGETDLNTSRVIWLVLLSD
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LGVSLALMLAIVMHPQISHVRRCIGIIADYTSLTVLMLLMGEAGSPLYVLCLWVTIGNGL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC
RYGSVYLLVTTTLGALSFLTVILVSAYWKSNPFLAWGLLIGLIAIPWYFQSLLKALIQAL
EECCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NDARHANEAKSRFLANMSHEFRTPLNGLSGMTEVLATTRLDAEQRECLKAIQASVHSVLS
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LIEEVLDISRIEAGKIRILHDTFSLKEVIGSVGLILQPQIRNKALEYRVDVGLDVPEWLF
HHHHHHHHHHCCCCCEEEEECHHHHHHHHHHCCCEECCHHHCCHHHEEEECCCCCHHHHC
GDAGYVRQVLLNIVGNAVKFTERGRITLCVSVLNRSRQHSVVLRFEVADTGIGVPLGMRN
CCHHHHHHHHHHHHCCHHHCCCCCCCEEEHHHHCCCCCCEEEEEEEECCCCCCCCCCHHH
RLFDVFEQADVGLDRRYQGSGLGTTIAKGLIELMGGSIGFEENVPCGSLFWFELPFELAK
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCHHHHH
KQVVAQEVSEASQCTEPSNVIAFSNPFLRHRARVKSMRVLVADDHETNRMVLSRILDKAG
HHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCC
HKLLCVDGAEAVLDCLISMEFDVVIIDLHMPGMSGLDMLKQLRVMQSSSLPYTPVLVLSA
CEEEEECCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEEC
DATSDSIRCCEEAGARAFLSKPVLATKLLDVLAEIAEGDGGALPYAALSQSSVQQHQVFD
CCCCHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
PAGLDDLAELNMDDDFEERFIVQSFRDAEHCQQTMLSAAETNQWQEVREEAHALRGVLGH
CCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLMRASSLAAELMRIPDWQLQLEWCALVQMLDEALLCGRDALEARRQERRRSGVLR
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1645442 [H]