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The map label for this gene is sdhA

Identifier: 182680906

GI number: 182680906

Start: 441426

End: 443216

Strand: Direct

Name: sdhA

Synonym: XfasM23_0344

Alternate gene names: 182680906

Gene position: 441426-443216 (Clockwise)

Preceding gene: 182680905

Following gene: 182680907

Centisome position: 17.41

GC content: 52.04

Gene sequence:

>1791_bases
ATGTCCGCTTATACAATTACCGAACACAAATATGACATGGTTGTCGTTGGTGCTGGCGGTGCTGGTCTACGTGCCACGTT
CGGTTTGGCTCATAAAGGCTTACAGACTGTCTGTCTGACAAAAGTATTCCCGACGCGTTCGCATACCGTCGCTGCGCAAG
GTGGTATCTCCGCTGCGCTTGGTAACATGGGGGAGGATGATTGGCGTTACCATTTTTATGACACCATCAAAGGGTCAGAC
TGGCTGGGTGACCAGGATGCGATTGAGTACATGTGCCGTGAGGCAATCCCGGCTGTGATCGAACTAGAACACTATGGTGT
TCCGTTCTCTCGTACTGCACAAGGCAAGATTTACCAGCGGCCATTTGGTGGGATGACGACACGTTACGGTGAGGGGCCGC
GGGCAGAGCGTACCTGCGCTGCAGCTGATCGAACCGGCCATGCGATGTTACATACCTTGTACCAGCAAGCATTGGCGCAC
GACGCGCGTTTCATGATTGAGTACTTTGCACTTGATCTGATCTTCGACAGCGAGGGTTTGTGTCGTGGCGTGTTGGCGTT
GGACATGGCCGAGGGATCCTTGCACCTGTTTCGTGCCCATGGAGTCGTGTTGGCGACCGGTGGCTACGGTCGCACGTACT
TCAGTGCAACTTCTGCTCATACCTGTACTGGTGACGGTGGTGGCTTGGTGATGCGTGCCGGTTTACCGATGCAGGATATG
GAGTTTGTGCAGTTCCATCCCACAGGAATCTATGGGGCTGGCTGCCTCATCACCGAAGGAGTGCGTGGTGAGGGAGGAAT
CTTGCGTAACTCTAACGGGGAGCGCTTCATGGAGCGCTATGCACCTCACTACAAGGATCTGGCCTCTCGTGATGTGGTGA
GTCGCTCAATGATTATTGAGATCAGGGAGGGGCGCGGCGTTGGTGAACACAAAGACCATATATTGCTTGATTTGACTCAC
TTGGGTCCGAGCATGATCCAAGAAAAATTGCCTGGCATTGCCGAGAGTGCGCGTATCTTCGCTGGCGTGGATGTGACCAA
GCAGCCGATTCCAGTGCTGCCAACAGTGCATTACAACATGGGTGGTATTCCAACCAATTACCATGGCGAAGTGGTGCGTA
AAGTTGGTAATGATCCTGATGCAGTGGTGCCGGGGCTATATGCGGTTGGTGAAGCGGCCTGTGTATCGGTGCACGGTGCC
AATCGTTTGGGATCGAATTCGTTGCTTGATTTGGTGGTATTCGGTCGTGCGGTTGCCAATCGTTGTTCCGAAACAATCAA
ACCAAATCAGCCGCATAAGGTATTGCCCTCGGATAGTTGCGACAAGGCACTGGGCTTGCTTGATAAACTTCGCCATGCTG
ATGGTTCCACGCCGACAGCGGTGATTCGTGACACGATGCAACGTACCATGCAATCTGATGCTTCGGTGTTTCGTACGAGT
AAGACCTTGCAAGAAGGGTGCGAAAAGATGAATGAAATCTTTGCCTTGTTTGATGACGTCAAGGTTTCTGATCGTTCACT
TGTTTGGAATTCGGATTTGATAGAAACCTACGAGCTCCACAATTTGCTGTTAAACGCACTGGCTACGATTAACTCGGCTG
AACAGCGCAAAGAGAGCCGTGGTGCTCATGCGCATGAAGATTATCCAGATCGCGATGACGAGAATTGGTTGAAACACACA
TTGGTCAGTGTCGACGAAAAGGGCTCATGCAGTTTTGACTACCGCCCTGTGCACATGTACACGCTCAGCAAAGACGTGGA
TGTGATACCTCCTAAGCCGCGCGTCTATTGA

Upstream 100 bases:

>100_bases
GCTTTGACACTCCAGACGATGGTGAGATTTATCGCTGTCCTTGGCGCGGTCGCCAGCGTTTTTGCGGTCGTTCGTATCGC
GCTTGGGAACTGATAATTCG

Downstream 100 bases:

>100_bases
CCTAGCTGGATATAAATGTCATGGCAGAGTTCACTCTCCCTAAGAATTCGAAGATCGGTAAGGGGACGCATTTCCCCGCC
AAAAGCGGTACTAAAAATGC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 596; Mature: 595

Protein sequence:

>596_residues
MSAYTITEHKYDMVVVGAGGAGLRATFGLAHKGLQTVCLTKVFPTRSHTVAAQGGISAALGNMGEDDWRYHFYDTIKGSD
WLGDQDAIEYMCREAIPAVIELEHYGVPFSRTAQGKIYQRPFGGMTTRYGEGPRAERTCAAADRTGHAMLHTLYQQALAH
DARFMIEYFALDLIFDSEGLCRGVLALDMAEGSLHLFRAHGVVLATGGYGRTYFSATSAHTCTGDGGGLVMRAGLPMQDM
EFVQFHPTGIYGAGCLITEGVRGEGGILRNSNGERFMERYAPHYKDLASRDVVSRSMIIEIREGRGVGEHKDHILLDLTH
LGPSMIQEKLPGIAESARIFAGVDVTKQPIPVLPTVHYNMGGIPTNYHGEVVRKVGNDPDAVVPGLYAVGEAACVSVHGA
NRLGSNSLLDLVVFGRAVANRCSETIKPNQPHKVLPSDSCDKALGLLDKLRHADGSTPTAVIRDTMQRTMQSDASVFRTS
KTLQEGCEKMNEIFALFDDVKVSDRSLVWNSDLIETYELHNLLLNALATINSAEQRKESRGAHAHEDYPDRDDENWLKHT
LVSVDEKGSCSFDYRPVHMYTLSKDVDVIPPKPRVY

Sequences:

>Translated_596_residues
MSAYTITEHKYDMVVVGAGGAGLRATFGLAHKGLQTVCLTKVFPTRSHTVAAQGGISAALGNMGEDDWRYHFYDTIKGSD
WLGDQDAIEYMCREAIPAVIELEHYGVPFSRTAQGKIYQRPFGGMTTRYGEGPRAERTCAAADRTGHAMLHTLYQQALAH
DARFMIEYFALDLIFDSEGLCRGVLALDMAEGSLHLFRAHGVVLATGGYGRTYFSATSAHTCTGDGGGLVMRAGLPMQDM
EFVQFHPTGIYGAGCLITEGVRGEGGILRNSNGERFMERYAPHYKDLASRDVVSRSMIIEIREGRGVGEHKDHILLDLTH
LGPSMIQEKLPGIAESARIFAGVDVTKQPIPVLPTVHYNMGGIPTNYHGEVVRKVGNDPDAVVPGLYAVGEAACVSVHGA
NRLGSNSLLDLVVFGRAVANRCSETIKPNQPHKVLPSDSCDKALGLLDKLRHADGSTPTAVIRDTMQRTMQSDASVFRTS
KTLQEGCEKMNEIFALFDDVKVSDRSLVWNSDLIETYELHNLLLNALATINSAEQRKESRGAHAHEDYPDRDDENWLKHT
LVSVDEKGSCSFDYRPVHMYTLSKDVDVIPPKPRVY
>Mature_595_residues
SAYTITEHKYDMVVVGAGGAGLRATFGLAHKGLQTVCLTKVFPTRSHTVAAQGGISAALGNMGEDDWRYHFYDTIKGSDW
LGDQDAIEYMCREAIPAVIELEHYGVPFSRTAQGKIYQRPFGGMTTRYGEGPRAERTCAAADRTGHAMLHTLYQQALAHD
ARFMIEYFALDLIFDSEGLCRGVLALDMAEGSLHLFRAHGVVLATGGYGRTYFSATSAHTCTGDGGGLVMRAGLPMQDME
FVQFHPTGIYGAGCLITEGVRGEGGILRNSNGERFMERYAPHYKDLASRDVVSRSMIIEIREGRGVGEHKDHILLDLTHL
GPSMIQEKLPGIAESARIFAGVDVTKQPIPVLPTVHYNMGGIPTNYHGEVVRKVGNDPDAVVPGLYAVGEAACVSVHGAN
RLGSNSLLDLVVFGRAVANRCSETIKPNQPHKVLPSDSCDKALGLLDKLRHADGSTPTAVIRDTMQRTMQSDASVFRTSK
TLQEGCEKMNEIFALFDDVKVSDRSLVWNSDLIETYELHNLLLNALATINSAEQRKESRGAHAHEDYPDRDDENWLKHTL
VSVDEKGSCSFDYRPVHMYTLSKDVDVIPPKPRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=614, Percent_Identity=61.2377850162867, Blast_Score=727, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=588, Percent_Identity=52.2108843537415, Blast_Score=545, Evalue=1e-156,
Organism=Escherichia coli, GI1790597, Length=575, Percent_Identity=41.5652173913044, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1788928, Length=563, Percent_Identity=31.2611012433393, Blast_Score=211, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17550100, Length=619, Percent_Identity=59.7738287560582, Blast_Score=714, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=615, Percent_Identity=58.3739837398374, Blast_Score=691, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=598, Percent_Identity=64.0468227424749, Blast_Score=768, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=602, Percent_Identity=63.6212624584718, Blast_Score=750, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320788, Length=484, Percent_Identity=26.4462809917355, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17137288, Length=611, Percent_Identity=62.847790507365, Blast_Score=759, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=611, Percent_Identity=62.847790507365, Blast_Score=759, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=611, Percent_Identity=62.847790507365, Blast_Score=759, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=613, Percent_Identity=56.7699836867863, Blast_Score=682, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65409; Mature: 65278

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAYTITEHKYDMVVVGAGGAGLRATFGLAHKGLQTVCLTKVFPTRSHTVAAQGGISAAL
CCCEEEECCCEEEEEEECCCCCHHHHHHHHHHCHHHHHHHHCCCCCCCEEEECCCHHHHH
GNMGEDDWRYHFYDTIKGSDWLGDQDAIEYMCREAIPAVIELEHYGVPFSRTAQGKIYQR
CCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEC
PFGGMTTRYGEGPRAERTCAAADRTGHAMLHTLYQQALAHDARFMIEYFALDLIFDSEGL
CCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCH
CRGVLALDMAEGSLHLFRAHGVVLATGGYGRTYFSATSAHTCTGDGGGLVMRAGLPMQDM
HHHHHEEEECCCCEEEEEECCEEEEECCCCCEEEECCCCCEECCCCCCEEEECCCCCCCC
EFVQFHPTGIYGAGCLITEGVRGEGGILRNSNGERFMERYAPHYKDLASRDVVSRSMIIE
CEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCHHHHHHHHHHHHHEEEEE
IREGRGVGEHKDHILLDLTHLGPSMIQEKLPGIAESARIFAGVDVTKQPIPVLPTVHYNM
EECCCCCCCCCCEEEEEEHHCCHHHHHHHCCCCHHCCEEEECCCCCCCCCCCCCEEECCC
GGIPTNYHGEVVRKVGNDPDAVVPGLYAVGEAACVSVHGANRLGSNSLLDLVVFGRAVAN
CCCCCCCCHHHHHHCCCCCCHHCCCHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHH
RCSETIKPNQPHKVLPSDSCDKALGLLDKLRHADGSTPTAVIRDTMQRTMQSDASVFRTS
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KTLQEGCEKMNEIFALFDDVKVSDRSLVWNSDLIETYELHNLLLNALATINSAEQRKESR
HHHHHHHHHHHHHHHHHHCCEECCCEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHC
GAHAHEDYPDRDDENWLKHTLVSVDEKGSCSFDYRPVHMYTLSKDVDVIPPKPRVY
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SAYTITEHKYDMVVVGAGGAGLRATFGLAHKGLQTVCLTKVFPTRSHTVAAQGGISAAL
CCEEEECCCEEEEEEECCCCCHHHHHHHHHHCHHHHHHHHCCCCCCCEEEECCCHHHHH
GNMGEDDWRYHFYDTIKGSDWLGDQDAIEYMCREAIPAVIELEHYGVPFSRTAQGKIYQR
CCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEC
PFGGMTTRYGEGPRAERTCAAADRTGHAMLHTLYQQALAHDARFMIEYFALDLIFDSEGL
CCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCH
CRGVLALDMAEGSLHLFRAHGVVLATGGYGRTYFSATSAHTCTGDGGGLVMRAGLPMQDM
HHHHHEEEECCCCEEEEEECCEEEEECCCCCEEEECCCCCEECCCCCCEEEECCCCCCCC
EFVQFHPTGIYGAGCLITEGVRGEGGILRNSNGERFMERYAPHYKDLASRDVVSRSMIIE
CEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCHHHHHHHHHHHHHEEEEE
IREGRGVGEHKDHILLDLTHLGPSMIQEKLPGIAESARIFAGVDVTKQPIPVLPTVHYNM
EECCCCCCCCCCEEEEEEHHCCHHHHHHHCCCCHHCCEEEECCCCCCCCCCCCCEEECCC
GGIPTNYHGEVVRKVGNDPDAVVPGLYAVGEAACVSVHGANRLGSNSLLDLVVFGRAVAN
CCCCCCCCHHHHHHCCCCCCHHCCCHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHH
RCSETIKPNQPHKVLPSDSCDKALGLLDKLRHADGSTPTAVIRDTMQRTMQSDASVFRTS
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KTLQEGCEKMNEIFALFDDVKVSDRSLVWNSDLIETYELHNLLLNALATINSAEQRKESR
HHHHHHHHHHHHHHHHHHCCEECCCEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHHC
GAHAHEDYPDRDDENWLKHTLVSVDEKGSCSFDYRPVHMYTLSKDVDVIPPKPRVY
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA