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The map label for this gene is lpxB

Identifier: 182680880

GI number: 182680880

Start: 414013

End: 415170

Strand: Reverse

Name: lpxB

Synonym: XfasM23_0318

Alternate gene names: 182680880

Gene position: 415170-414013 (Counterclockwise)

Preceding gene: 182680881

Following gene: 182680879

Centisome position: 16.37

GC content: 54.23

Gene sequence:

>1158_bases
ATGATCCAAGCGCCCCGCATCGCAATCATCGCGGGTGAAGCATCAGGTGACCACCTTGGCGCTGGATTAATCCAACAACT
GCGCTTGCACTTCGCTACCGCAGAATTCATCGGCATCGGCGGGGACATGATGCGCTCGGCGGGCTGCCAGACTTGGTTTG
ACACAAGCGAACTCGCGGTTATGGGCCTGACCGAAGTACTACGGCATCTACCACGTCTTTTAAAGATACGTCGCGAATTC
TGCAAACGCGCACTAGCTTGGCATCCGGACGTATTGATCGGTATTGACGCACCAGACTTCAACCTTACAGTAGAACGCTG
GTTCAAACAGCGTCACATCCGCACCGTTCATTACGTCAGTCCCTCGATATGGGCTTGGCGTGAAAAACGTGCCGCGAAAA
TTGGTGCCAGCGTCGACCGCGTCCTCTGTCTCTTCCCAATGGAACCACCTATTTACGCACGCTACGGCATTGATGCACGC
TTTGTCGGCCATCCAATGGCCGATGAGATTCCCTATCAAACCGACCGTGCCACAGCGCGAACTGCATTGGGCCTGCCCCT
CCTCAGCCCAGTGCTTGCAGTCCTTCCAGGCAGCCGCCATAGCGAAATTAGCCAACTTGGCAACACCTTCTTAGAAGCCG
CCGGACAATTGTCTGAACATCTACCAGGGCTACATGTCGTCATCCCAGCTGCAAACACACAATGCAAACCACTGCTAGCC
GAACAACTCTCGCGCTCCACCTTACCCGTCATGCACTCACACCTACTGGATAGTAGCGCTCGTACTGCAATGTTGGCCGC
AGACGTGGTCCTGGTGGCCTCTGGTACAGCGACCCTCGAAGCCATGCTGCTCAAACGCCCAATGGTCGTCGCTTACAAAG
TCGCACCACTCACCTATCGCATTGTCAAAACACTGAAACTACTAAAAATCAATCGTTTTGCCCTGCCCAACATCCTCGCA
GGAGAAGACCTTGTACCGGAACTGATACAGAAGGATTGCACCGCACCGGCCCTCTGCGCAGCACTGCTAGACTGCTTCAA
ACATCCCCAGAAAGTCACCGCACTACAAAACCGTTATCTGCAATTACACACACAACTACGCCGCAACGCATCGACACGCG
CAGCCGAAGCAATCGCCGAACTATTACAACAGAGATAG

Upstream 100 bases:

>100_bases
GCGCAAAGGCCGCTACTACGATGAGCTCAACCTCAAAGCAGAAGATACCCACCGATACCCCGTTACCGCACACCAAACTG
ACTTACCACGGCACCTTGAC

Downstream 100 bases:

>100_bases
ACTGCAACACTCGGGGACACTGCACCACGAATCAGCACCACACACAGCAGGTAACAATGGTCTCCAAGTTTGATACACAA
CATCTCCTCAATAGCAACAC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MIQAPRIAIIAGEASGDHLGAGLIQQLRLHFATAEFIGIGGDMMRSAGCQTWFDTSELAVMGLTEVLRHLPRLLKIRREF
CKRALAWHPDVLIGIDAPDFNLTVERWFKQRHIRTVHYVSPSIWAWREKRAAKIGASVDRVLCLFPMEPPIYARYGIDAR
FVGHPMADEIPYQTDRATARTALGLPLLSPVLAVLPGSRHSEISQLGNTFLEAAGQLSEHLPGLHVVIPAANTQCKPLLA
EQLSRSTLPVMHSHLLDSSARTAMLAADVVLVASGTATLEAMLLKRPMVVAYKVAPLTYRIVKTLKLLKINRFALPNILA
GEDLVPELIQKDCTAPALCAALLDCFKHPQKVTALQNRYLQLHTQLRRNASTRAAEAIAELLQQR

Sequences:

>Translated_385_residues
MIQAPRIAIIAGEASGDHLGAGLIQQLRLHFATAEFIGIGGDMMRSAGCQTWFDTSELAVMGLTEVLRHLPRLLKIRREF
CKRALAWHPDVLIGIDAPDFNLTVERWFKQRHIRTVHYVSPSIWAWREKRAAKIGASVDRVLCLFPMEPPIYARYGIDAR
FVGHPMADEIPYQTDRATARTALGLPLLSPVLAVLPGSRHSEISQLGNTFLEAAGQLSEHLPGLHVVIPAANTQCKPLLA
EQLSRSTLPVMHSHLLDSSARTAMLAADVVLVASGTATLEAMLLKRPMVVAYKVAPLTYRIVKTLKLLKINRFALPNILA
GEDLVPELIQKDCTAPALCAALLDCFKHPQKVTALQNRYLQLHTQLRRNASTRAAEAIAELLQQR
>Mature_385_residues
MIQAPRIAIIAGEASGDHLGAGLIQQLRLHFATAEFIGIGGDMMRSAGCQTWFDTSELAVMGLTEVLRHLPRLLKIRREF
CKRALAWHPDVLIGIDAPDFNLTVERWFKQRHIRTVHYVSPSIWAWREKRAAKIGASVDRVLCLFPMEPPIYARYGIDAR
FVGHPMADEIPYQTDRATARTALGLPLLSPVLAVLPGSRHSEISQLGNTFLEAAGQLSEHLPGLHVVIPAANTQCKPLLA
EQLSRSTLPVMHSHLLDSSARTAMLAADVVLVASGTATLEAMLLKRPMVVAYKVAPLTYRIVKTLKLLKINRFALPNILA
GEDLVPELIQKDCTAPALCAALLDCFKHPQKVTALQNRYLQLHTQLRRNASTRAAEAIAELLQQR

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=377, Percent_Identity=45.8885941644562, Blast_Score=333, Evalue=8e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_XYLF2 (B2I7N8)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001829040.1
- ProteinModelPortal:   B2I7N8
- GeneID:   6204147
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_0318
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- ProtClustDB:   PRK00025
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 42557; Mature: 42557

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQAPRIAIIAGEASGDHLGAGLIQQLRLHFATAEFIGIGGDMMRSAGCQTWFDTSELAV
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHH
MGLTEVLRHLPRLLKIRREFCKRALAWHPDVLIGIDAPDFNLTVERWFKQRHIRTVHYVS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCEEEECC
PSIWAWREKRAAKIGASVDRVLCLFPMEPPIYARYGIDARFVGHPMADEIPYQTDRATAR
CCHHHHHHHHHHHHCCCHHHEEEEECCCCCCEEECCCCEEECCCCCCCCCCCCCCHHHHH
TALGLPLLSPVLAVLPGSRHSEISQLGNTFLEAAGQLSEHLPGLHVVIPAANTQCKPLLA
HHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHH
EQLSRSTLPVMHSHLLDSSARTAMLAADVVLVASGTATLEAMLLKRPMVVAYKVAPLTYR
HHHCCCHHHHHHHHHHCCCHHHHHHHHHHHEEECCHHHHHHHHHHCCCEEEEEECHHHHH
IVKTLKLLKINRFALPNILAGEDLVPELIQKDCTAPALCAALLDCFKHPQKVTALQNRYL
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
QLHTQLRRNASTRAAEAIAELLQQR
HHHHHHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIQAPRIAIIAGEASGDHLGAGLIQQLRLHFATAEFIGIGGDMMRSAGCQTWFDTSELAV
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHH
MGLTEVLRHLPRLLKIRREFCKRALAWHPDVLIGIDAPDFNLTVERWFKQRHIRTVHYVS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCEEEECC
PSIWAWREKRAAKIGASVDRVLCLFPMEPPIYARYGIDARFVGHPMADEIPYQTDRATAR
CCHHHHHHHHHHHHCCCHHHEEEEECCCCCCEEECCCCEEECCCCCCCCCCCCCCHHHHH
TALGLPLLSPVLAVLPGSRHSEISQLGNTFLEAAGQLSEHLPGLHVVIPAANTQCKPLLA
HHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHH
EQLSRSTLPVMHSHLLDSSARTAMLAADVVLVASGTATLEAMLLKRPMVVAYKVAPLTYR
HHHCCCHHHHHHHHHHCCCHHHHHHHHHHHEEECCHHHHHHHHHHCCCEEEEEECHHHHH
IVKTLKLLKINRFALPNILAGEDLVPELIQKDCTAPALCAALLDCFKHPQKVTALQNRYL
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
QLHTQLRRNASTRAAEAIAELLQQR
HHHHHHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA