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The map label for this gene is argH [H]

Identifier: 182680852

GI number: 182680852

Start: 372579

End: 373937

Strand: Direct

Name: argH [H]

Synonym: XfasM23_0289

Alternate gene names: 182680852

Gene position: 372579-373937 (Clockwise)

Preceding gene: 182680851

Following gene: 182680853

Centisome position: 14.69

GC content: 62.55

Gene sequence:

>1359_bases
ATGACCACCCCGGCCTCCCCAATGGACACCACCACCATGCCAAACCTGCTTTGGCACAAACCCGGCGTGGCGATCGACGC
CAGCATCCAAACCTTCCTGGCAGCCGATGATGTCCTTCTGGACCGCGAATTCTTCCTCTACGACATCACAGCCAGCACAG
CCCATGCCCAAGCATTACAGCGCATCGGCCTCCTCACCCCCGACGAACTCGACAACATCCTCCGAGAACTGCAACACCTC
AGCGACGAATACCGCAACGGCACCTTCCTCCTAGATACACAGTACGAAGACGGCCACTCCGCCATTGAATCCCGCTTGAC
CGAACGCCTCGGAGACACCGGCCGCAAAATTCACACCGGCCGCAGCCGCAACGACCAAATCCTAGTCGCCACCCGCCTAT
GGCTGAAAGACCGACTCACCCAACTGAGCACCTTGAACCGTGACATTGCCCACCATGCATTACAGCGTGCTGCTGCCGAA
CAACACCTCCCCATGCCTGGCTACACCCACCTGCAGCGCGCCGTTGTCTCATCGGCCGGCATGTGGTGGGCAGGCTGGGC
TGAATCCTTCATCGACAACGCCCTACGCGCCGCCGATACCCTCGCCCTGATCGACTGCAACCCCCTCGGCACCGCCGCCG
GCTATGGCGTCAACCTCCCCCTGGATCGCCCCCACACCACCACTGCACTGGGCTTTGCACGCCTCCAAGTCAACCCCATC
TGCGCCCAACTTTCTCGCGGCAAATTTGAACTGGCCGCACTCGAAGCACTCGGCAGCGCCACCTTAGACCTCCGCCGTAT
CGCCTGGGATCTCTCCCTATTTACCACCAGCGAATTTGCATTCATCACCCTGCCGCCCGAATACAGCACCGGCAGCTCCA
TCATGCCCAACAAACGCAACCCAGACGTCATCGAACTCATGCGCGCCACCCATGCCAGCGTTGCCGCCGCCCGCACCGAA
ATCGAACAACTCCTCTCCCTCCCGTCCGGCTACCACCGCGACCTTCAGAACAGTAAAGGCGCCATCGTCCGCGGCTTCAA
CCGCGGCCTGGCCGCCTTAGAACTCTTACCCGCACTCCTGTCCCGCCTACAGTGGCGCCCAGACACCCTCCGTGCCGCCA
TTGATCCCGGTATGTATGCCACCGATGCCGCTATTGAAGCCGCAATCGCCGGCATCCCCTTCCGTGACGCCTACCAGATG
GCCGCCAAAACCGCTGACACCGCCGCCCAAGACCGCACCCCAGAAACCAGCCTCACCGCACGCCGCTCCCCCGGCGCTGC
CGCTGATTTATGCCTGGAGACCCTCCGTGCCCGTTGGCACACCTTGACCCAACCCACCTCCGACCCAGACCCGCGGTGA

Upstream 100 bases:

>100_bases
CCGCCACCCAAGCCCTACAGAACCTCAACCGCGCACTTGGCCTGGACGAACTGACCGCCATTCCCTACCAACCTAACCCT
GTCCCATCACCCATTCCATA

Downstream 100 bases:

>100_bases
ACCACCGCCTCCCCGATTCCCATCACCCCCCCCCACACACACCAACCCATCCCCTCCCTGACCCCCCACAGCAACTGCCC
ATGCCTCCCATCTATCCCTG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MTTPASPMDTTTMPNLLWHKPGVAIDASIQTFLAADDVLLDREFFLYDITASTAHAQALQRIGLLTPDELDNILRELQHL
SDEYRNGTFLLDTQYEDGHSAIESRLTERLGDTGRKIHTGRSRNDQILVATRLWLKDRLTQLSTLNRDIAHHALQRAAAE
QHLPMPGYTHLQRAVVSSAGMWWAGWAESFIDNALRAADTLALIDCNPLGTAAGYGVNLPLDRPHTTTALGFARLQVNPI
CAQLSRGKFELAALEALGSATLDLRRIAWDLSLFTTSEFAFITLPPEYSTGSSIMPNKRNPDVIELMRATHASVAAARTE
IEQLLSLPSGYHRDLQNSKGAIVRGFNRGLAALELLPALLSRLQWRPDTLRAAIDPGMYATDAAIEAAIAGIPFRDAYQM
AAKTADTAAQDRTPETSLTARRSPGAAADLCLETLRARWHTLTQPTSDPDPR

Sequences:

>Translated_452_residues
MTTPASPMDTTTMPNLLWHKPGVAIDASIQTFLAADDVLLDREFFLYDITASTAHAQALQRIGLLTPDELDNILRELQHL
SDEYRNGTFLLDTQYEDGHSAIESRLTERLGDTGRKIHTGRSRNDQILVATRLWLKDRLTQLSTLNRDIAHHALQRAAAE
QHLPMPGYTHLQRAVVSSAGMWWAGWAESFIDNALRAADTLALIDCNPLGTAAGYGVNLPLDRPHTTTALGFARLQVNPI
CAQLSRGKFELAALEALGSATLDLRRIAWDLSLFTTSEFAFITLPPEYSTGSSIMPNKRNPDVIELMRATHASVAAARTE
IEQLLSLPSGYHRDLQNSKGAIVRGFNRGLAALELLPALLSRLQWRPDTLRAAIDPGMYATDAAIEAAIAGIPFRDAYQM
AAKTADTAAQDRTPETSLTARRSPGAAADLCLETLRARWHTLTQPTSDPDPR
>Mature_451_residues
TTPASPMDTTTMPNLLWHKPGVAIDASIQTFLAADDVLLDREFFLYDITASTAHAQALQRIGLLTPDELDNILRELQHLS
DEYRNGTFLLDTQYEDGHSAIESRLTERLGDTGRKIHTGRSRNDQILVATRLWLKDRLTQLSTLNRDIAHHALQRAAAEQ
HLPMPGYTHLQRAVVSSAGMWWAGWAESFIDNALRAADTLALIDCNPLGTAAGYGVNLPLDRPHTTTALGFARLQVNPIC
AQLSRGKFELAALEALGSATLDLRRIAWDLSLFTTSEFAFITLPPEYSTGSSIMPNKRNPDVIELMRATHASVAAARTEI
EQLLSLPSGYHRDLQNSKGAIVRGFNRGLAALELLPALLSRLQWRPDTLRAAIDPGMYATDAAIEAAIAGIPFRDAYQMA
AKTADTAAQDRTPETSLTARRSPGAAADLCLETLRARWHTLTQPTSDPDPR

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=381, Percent_Identity=35.9580052493438, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI68303542, Length=381, Percent_Identity=35.9580052493438, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI68303549, Length=381, Percent_Identity=35.4330708661417, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI68303547, Length=380, Percent_Identity=33.9473684210526, Blast_Score=199, Evalue=5e-51,
Organism=Escherichia coli, GI1790398, Length=403, Percent_Identity=33.2506203473945, Blast_Score=193, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6321806, Length=372, Percent_Identity=31.7204301075269, Blast_Score=176, Evalue=6e-45,
Organism=Drosophila melanogaster, GI221473854, Length=373, Percent_Identity=33.5120643431635, Blast_Score=195, Evalue=7e-50,
Organism=Drosophila melanogaster, GI78706858, Length=373, Percent_Identity=33.5120643431635, Blast_Score=195, Evalue=7e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 49659; Mature: 49528

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPASPMDTTTMPNLLWHKPGVAIDASIQTFLAADDVLLDREFFLYDITASTAHAQALQ
CCCCCCCCCCCCCCHHHCCCCCCEEEHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHH
RIGLLTPDELDNILRELQHLSDEYRNGTFLLDTQYEDGHSAIESRLTERLGDTGRKIHTG
HCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECC
RSRNDQILVATRLWLKDRLTQLSTLNRDIAHHALQRAAAEQHLPMPGYTHLQRAVVSSAG
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
MWWAGWAESFIDNALRAADTLALIDCNPLGTAAGYGVNLPLDRPHTTTALGFARLQVNPI
CCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHEEEHEECCHH
CAQLSRGKFELAALEALGSATLDLRRIAWDLSLFTTSEFAFITLPPEYSTGSSIMPNKRN
HHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHHEEEECCEEEEEECCCCCCCCCCCCCCCC
PDVIELMRATHASVAAARTEIEQLLSLPSGYHRDLQNSKGAIVRGFNRGLAALELLPALL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEECHHHHHHHHHHHHHHH
SRLQWRPDTLRAAIDPGMYATDAAIEAAIAGIPFRDAYQMAAKTADTAAQDRTPETSLTA
HHHCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
RRSPGAAADLCLETLRARWHTLTQPTSDPDPR
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TTPASPMDTTTMPNLLWHKPGVAIDASIQTFLAADDVLLDREFFLYDITASTAHAQALQ
CCCCCCCCCCCCCHHHCCCCCCEEEHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHH
RIGLLTPDELDNILRELQHLSDEYRNGTFLLDTQYEDGHSAIESRLTERLGDTGRKIHTG
HCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECC
RSRNDQILVATRLWLKDRLTQLSTLNRDIAHHALQRAAAEQHLPMPGYTHLQRAVVSSAG
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCC
MWWAGWAESFIDNALRAADTLALIDCNPLGTAAGYGVNLPLDRPHTTTALGFARLQVNPI
CCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHEEEHEECCHH
CAQLSRGKFELAALEALGSATLDLRRIAWDLSLFTTSEFAFITLPPEYSTGSSIMPNKRN
HHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHHEEEECCEEEEEECCCCCCCCCCCCCCCC
PDVIELMRATHASVAAARTEIEQLLSLPSGYHRDLQNSKGAIVRGFNRGLAALELLPALL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEECHHHHHHHHHHHHHHH
SRLQWRPDTLRAAIDPGMYATDAAIEAAIAGIPFRDAYQMAAKTADTAAQDRTPETSLTA
HHHCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
RRSPGAAADLCLETLRARWHTLTQPTSDPDPR
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]