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The map label for this gene is nuoH

Identifier: 182680812

GI number: 182680812

Start: 324682

End: 325773

Strand: Direct

Name: nuoH

Synonym: XfasM23_0247

Alternate gene names: 182680812

Gene position: 324682-325773 (Clockwise)

Preceding gene: 182680811

Following gene: 182680813

Centisome position: 12.8

GC content: 48.72

Gene sequence:

>1092_bases
ATGAATACATGGTTCTTGAATGTGGTTGATCCGTTGCACCAATGGTTTCTCGGGTTTGGAGACATTGGTGTCGTGTTGTG
GACCGTCTTGAAGATACTCATGATCGCTATCCCATTAATTGTGTCGGTGGCGTTCTATGTGGTGTGGGAACGCAAACTGA
TCGGTTGGATGCATGTGCGTCATGGGCCGATGTATGTCGGCATGGGTCTCTTTCAAGCTTTCGCGGACGTTTTCAAACTT
CTGTTTAAAGAGGTTCTATATCCTAGCAAGGCGCATAAGGCGATTTTTGTGATCGCGCCGTTGTTGACGTTAGCGCCCTC
ATTCGCCGCTTGGGCCGTTGTGCCCTTTGATACAAAATTAGTGTTGTCTAACGCCAATGTGGGCTTGTTGTATTTGTTGG
CGATGACTTCGCTGGGTGTCTACGGCATCATTTTGGCCGGTTGGGCCTCTAATTCGAAGTATGCCTTCCTGGGGGCAATG
CGTTCAGCGGCTCAGGTCGTCAGCTACGAAATTGCGATGGGCTTTGCTTTGGTCGGTGTGATGATTGCTGCGGGCAGTCT
CAATCTGTCTCAGATTGTGATGGCGCAGGCGGGCAGTTCTGGTTTCTTTGATTGGTTTTTGATTCCGTTATTCCCCTTGT
TTATTGTGTATTGGGTATCTGGTGTGGCTGAAACGAATCGTTCTCCGTTTGATGTTGTGGAGGGTGAGTCTGAAATTGTC
GCCGGACATATGGTGGAATATTCCGGCAGTGTATTTGCGCTTTTTTTCTTGGCCGAATACGCCAATATGATTTTGGTCAG
TTTCTTGATTTCGATTTTTTTCCTGGGCGGTTGGTTGAGTCCAATCCAGGGATGGGTGAGTGGTCAGGTTTCACCGTTGA
TTGATTGGGTGTGGAACGGTGGTTGGCCGTGGTTGCTGCTTAAGGTCTTGTTTTTTGCCAGCGCCTATATTTGGTTCCGT
GCGAGTTTCCCCCGCTATCGTTACGACCAGATTATGCGTTTGGGGTGGAAGGTGTTTATCCCACTGACGATTGTGTGGAT
CGCAGTGACGGCATTAATGGTGTTTTCCGGTGTGATTCAAAAGGGCGTGTAA

Upstream 100 bases:

>100_bases
TGGTGTTAGACACGCGTGTCGCCTTGGGTACGGTCTGGATCGAAACGGGTCACGGTGCCACCGCACCAATCGGTGCTGGT
CGCGTCACGATGGTGGCTGT

Downstream 100 bases:

>100_bases
GTGATGAACAGAGTGATGCATTACTTCAAGAGCCTGCTGTTACTTGAACTGTTGGCTGGATTGTGGCTGACGTTGAAATA
CACCTTCAGGCCGAAATACA

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MNTWFLNVVDPLHQWFLGFGDIGVVLWTVLKILMIAIPLIVSVAFYVVWERKLIGWMHVRHGPMYVGMGLFQAFADVFKL
LFKEVLYPSKAHKAIFVIAPLLTLAPSFAAWAVVPFDTKLVLSNANVGLLYLLAMTSLGVYGIILAGWASNSKYAFLGAM
RSAAQVVSYEIAMGFALVGVMIAAGSLNLSQIVMAQAGSSGFFDWFLIPLFPLFIVYWVSGVAETNRSPFDVVEGESEIV
AGHMVEYSGSVFALFFLAEYANMILVSFLISIFFLGGWLSPIQGWVSGQVSPLIDWVWNGGWPWLLLKVLFFASAYIWFR
ASFPRYRYDQIMRLGWKVFIPLTIVWIAVTALMVFSGVIQKGV

Sequences:

>Translated_363_residues
MNTWFLNVVDPLHQWFLGFGDIGVVLWTVLKILMIAIPLIVSVAFYVVWERKLIGWMHVRHGPMYVGMGLFQAFADVFKL
LFKEVLYPSKAHKAIFVIAPLLTLAPSFAAWAVVPFDTKLVLSNANVGLLYLLAMTSLGVYGIILAGWASNSKYAFLGAM
RSAAQVVSYEIAMGFALVGVMIAAGSLNLSQIVMAQAGSSGFFDWFLIPLFPLFIVYWVSGVAETNRSPFDVVEGESEIV
AGHMVEYSGSVFALFFLAEYANMILVSFLISIFFLGGWLSPIQGWVSGQVSPLIDWVWNGGWPWLLLKVLFFASAYIWFR
ASFPRYRYDQIMRLGWKVFIPLTIVWIAVTALMVFSGVIQKGV
>Mature_363_residues
MNTWFLNVVDPLHQWFLGFGDIGVVLWTVLKILMIAIPLIVSVAFYVVWERKLIGWMHVRHGPMYVGMGLFQAFADVFKL
LFKEVLYPSKAHKAIFVIAPLLTLAPSFAAWAVVPFDTKLVLSNANVGLLYLLAMTSLGVYGIILAGWASNSKYAFLGAM
RSAAQVVSYEIAMGFALVGVMIAAGSLNLSQIVMAQAGSSGFFDWFLIPLFPLFIVYWVSGVAETNRSPFDVVEGESEIV
AGHMVEYSGSVFALFFLAEYANMILVSFLISIFFLGGWLSPIQGWVSGQVSPLIDWVWNGGWPWLLLKVLFFASAYIWFR
ASFPRYRYDQIMRLGWKVFIPLTIVWIAVTALMVFSGVIQKGV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=304, Percent_Identity=39.4736842105263, Blast_Score=227, Evalue=1e-59,
Organism=Escherichia coli, GI1788618, Length=331, Percent_Identity=39.8791540785499, Blast_Score=239, Evalue=3e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_XYLF2 (B2I791)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001828972.1
- GeneID:   6203887
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_0247
- HOGENOM:   HBG727670
- OMA:   SSHKAMF
- ProtClustDB:   PRK06076
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 40525; Mature: 40525

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1293b684)-; HASH(0x40737f18)-; HASH(0x4074fbc4)-; HASH(0x1323a518)-; HASH(0x11cee340)-; HASH(0x12805278)-; HASH(0x132aaa54)-; HASH(0x134b8078)-; HASH(0x135e77f8)-; HASH(0x12f48d1c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTWFLNVVDPLHQWFLGFGDIGVVLWTVLKILMIAIPLIVSVAFYVVWERKLIGWMHVR
CCEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HGPMYVGMGLFQAFADVFKLLFKEVLYPSKAHKAIFVIAPLLTLAPSFAAWAVVPFDTKL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHEEEEECCCEE
VLSNANVGLLYLLAMTSLGVYGIILAGWASNSKYAFLGAMRSAAQVVSYEIAMGFALVGV
EEECCCHHHHHHHHHHHCCHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MIAAGSLNLSQIVMAQAGSSGFFDWFLIPLFPLFIVYWVSGVAETNRSPFDVVEGESEIV
HHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
AGHMVEYSGSVFALFFLAEYANMILVSFLISIFFLGGWLSPIQGWVSGQVSPLIDWVWNG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
GWPWLLLKVLFFASAYIWFRASFPRYRYDQIMRLGWKVFIPLTIVWIAVTALMVFSGVIQ
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGV
HCH
>Mature Secondary Structure
MNTWFLNVVDPLHQWFLGFGDIGVVLWTVLKILMIAIPLIVSVAFYVVWERKLIGWMHVR
CCEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
HGPMYVGMGLFQAFADVFKLLFKEVLYPSKAHKAIFVIAPLLTLAPSFAAWAVVPFDTKL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHEEEEECCCEE
VLSNANVGLLYLLAMTSLGVYGIILAGWASNSKYAFLGAMRSAAQVVSYEIAMGFALVGV
EEECCCHHHHHHHHHHHCCHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MIAAGSLNLSQIVMAQAGSSGFFDWFLIPLFPLFIVYWVSGVAETNRSPFDVVEGESEIV
HHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
AGHMVEYSGSVFALFFLAEYANMILVSFLISIFFLGGWLSPIQGWVSGQVSPLIDWVWNG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
GWPWLLLKVLFFASAYIWFRASFPRYRYDQIMRLGWKVFIPLTIVWIAVTALMVFSGVIQ
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGV
HCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA