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The map label for this gene is nuoD

Identifier: 182680808

GI number: 182680808

Start: 319284

End: 320591

Strand: Direct

Name: nuoD

Synonym: XfasM23_0243

Alternate gene names: 182680808

Gene position: 319284-320591 (Clockwise)

Preceding gene: 182680807

Following gene: 182680809

Centisome position: 12.59

GC content: 52.29

Gene sequence:

>1308_bases
GTGAATCAGATTCGCCAGGCGCCTGCGGCTTCTGCCAGCAATGCTACTGAATCCAAGCAGGAGATTCGTAATTACACGAT
GAACTTCGGTCCACAGCATCCTGCCGCGCATGGGGTGTTGCGTCTGATTCTTGAAATGGACGGGGAGACAGTGGTTCGTG
CGGATCCGCATATCGGTCTGCTGCATCGCGGGACTGAGAAACTTGCTGAGTCCAAGCCGTTTAATCAATCCATCGGTTAC
ATGGATCGCTTGGACTATGTGTCGATGATGTGCAATGAGCACGCTTACGTACGCGCCATTGAGACTTTGATTGGCATCCA
AGCGCCGGAGCGGGCGCAGTACATTCGTACGATGTTCGATGAGATCACGCGTATTCTGAATCATTTGATGTGGCTGGGGT
CCAATGCGTTGGACCTTGGCGCAATGGCTGTGATGTTGTATGCGTTTCGCGAGCGTGAGGAGCTGATGGATGTGTATGAG
GCGATCAGCGGCGCACGCATGCACGCAGCCTACTATCGTCCAGGTGGTGTGTATCGTGATTTGCCGGATACGATGCCCAA
GTACAAGGAATCACGTTGGCACAAGGGCAAGGCGCTGAAGCGTCTGAACGCCGCTCGCGAAGGTTCAATGCTCGATTTTC
TGGAGCACTTCACTGACACGTTCCCGCAGCGTATCGACGAGTATGAGACGTTACTTACTGACAACCGTATCTGGAAGCAA
CGCACCGTTGGTGTGGGTGTGATTGAGCCGGATGTGGCCAAGGCCTGGGGAATGACAGGTGTCATGTTGCGTGGCTCGGG
TATTGCTTGGGATCTGCGCAAGAAGCAGCCTTACGCTAAATATGATGCGGTCGATTTTGATATTCCGCTTGGCACGTGTG
GTGATTGCTATGACCGTTATTTGTGCCGTGTGGCTGAGATGCGTGAGTCGAATCGCATCATCAAACAGTGTGTGCAGTGG
TTGAAGATGAATCCCGGTCAGGTGATGGTTGAAAACTGCAAAGTTGCTCCGCCCAAGCGTGAGAGCATGAAGGACGACAT
GGAGGCATTAATTCACCACTTTAAATTGTTCAGCGAAGGTTATTGTGTTCCTGCCGGTGAAACTTACAGTGCGGTCGAGG
CGCCGAAAGGTGAGTTTGGTTGTTACTTGATCTCCGATGGTGCCAATAAGCCGTTTCGTGTGCATTTGCGTGCTCCAGGA
TTTGCGCACTTGTCCTCAATGGATGCCGTGGTGCGTGGCTATATGTTGGCCGATGTTGTGGCCATGATTGGTACATATGA
TTTAGTGTTTGGTGAGGTCGACCGATGA

Upstream 100 bases:

>100_bases
TCACCTCGGTTGAGCCGCGTGTCAGTGTTCCGCGGGTGATTCGTGATGATCCCCGCTTTGGGGCTGCAGCGGGCGAATCT
ACTCATTCGGAGACTGTTAA

Downstream 100 bases:

>100_bases
AGGCGACAAAGAGTTTTGAACTGGTGCGTGATGTGGATCCCCAGGTGGTATTGGGTGACCGCACGCGGGCTCACATTGAT
CATTGGCTTGCCAAGTTTCC

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MNQIRQAPAASASNATESKQEIRNYTMNFGPQHPAAHGVLRLILEMDGETVVRADPHIGLLHRGTEKLAESKPFNQSIGY
MDRLDYVSMMCNEHAYVRAIETLIGIQAPERAQYIRTMFDEITRILNHLMWLGSNALDLGAMAVMLYAFREREELMDVYE
AISGARMHAAYYRPGGVYRDLPDTMPKYKESRWHKGKALKRLNAAREGSMLDFLEHFTDTFPQRIDEYETLLTDNRIWKQ
RTVGVGVIEPDVAKAWGMTGVMLRGSGIAWDLRKKQPYAKYDAVDFDIPLGTCGDCYDRYLCRVAEMRESNRIIKQCVQW
LKMNPGQVMVENCKVAPPKRESMKDDMEALIHHFKLFSEGYCVPAGETYSAVEAPKGEFGCYLISDGANKPFRVHLRAPG
FAHLSSMDAVVRGYMLADVVAMIGTYDLVFGEVDR

Sequences:

>Translated_435_residues
MNQIRQAPAASASNATESKQEIRNYTMNFGPQHPAAHGVLRLILEMDGETVVRADPHIGLLHRGTEKLAESKPFNQSIGY
MDRLDYVSMMCNEHAYVRAIETLIGIQAPERAQYIRTMFDEITRILNHLMWLGSNALDLGAMAVMLYAFREREELMDVYE
AISGARMHAAYYRPGGVYRDLPDTMPKYKESRWHKGKALKRLNAAREGSMLDFLEHFTDTFPQRIDEYETLLTDNRIWKQ
RTVGVGVIEPDVAKAWGMTGVMLRGSGIAWDLRKKQPYAKYDAVDFDIPLGTCGDCYDRYLCRVAEMRESNRIIKQCVQW
LKMNPGQVMVENCKVAPPKRESMKDDMEALIHHFKLFSEGYCVPAGETYSAVEAPKGEFGCYLISDGANKPFRVHLRAPG
FAHLSSMDAVVRGYMLADVVAMIGTYDLVFGEVDR
>Mature_435_residues
MNQIRQAPAASASNATESKQEIRNYTMNFGPQHPAAHGVLRLILEMDGETVVRADPHIGLLHRGTEKLAESKPFNQSIGY
MDRLDYVSMMCNEHAYVRAIETLIGIQAPERAQYIRTMFDEITRILNHLMWLGSNALDLGAMAVMLYAFREREELMDVYE
AISGARMHAAYYRPGGVYRDLPDTMPKYKESRWHKGKALKRLNAAREGSMLDFLEHFTDTFPQRIDEYETLLTDNRIWKQ
RTVGVGVIEPDVAKAWGMTGVMLRGSGIAWDLRKKQPYAKYDAVDFDIPLGTCGDCYDRYLCRVAEMRESNRIIKQCVQW
LKMNPGQVMVENCKVAPPKRESMKDDMEALIHHFKLFSEGYCVPAGETYSAVEAPKGEFGCYLISDGANKPFRVHLRAPG
FAHLSSMDAVVRGYMLADVVAMIGTYDLVFGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=414, Percent_Identity=57.7294685990338, Blast_Score=496, Evalue=1e-140,
Organism=Homo sapiens, GI260898743, Length=408, Percent_Identity=56.8627450980392, Blast_Score=481, Evalue=1e-136,
Organism=Escherichia coli, GI145693162, Length=410, Percent_Identity=38.5365853658537, Blast_Score=306, Evalue=1e-84,
Organism=Escherichia coli, GI1789076, Length=437, Percent_Identity=26.5446224256293, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788832, Length=408, Percent_Identity=25.4901960784314, Blast_Score=118, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17568379, Length=422, Percent_Identity=52.132701421801, Blast_Score=469, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17555284, Length=417, Percent_Identity=53.2374100719424, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24638644, Length=423, Percent_Identity=57.210401891253, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI221459469, Length=434, Percent_Identity=50.4608294930876, Blast_Score=454, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_XYLF2 (B2I787)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001828968.1
- ProteinModelPortal:   B2I787
- SMR:   B2I787
- GeneID:   6203819
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_0243
- HOGENOM:   HBG459705
- OMA:   MADVITI
- ProtClustDB:   PRK06075
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 49394; Mature: 49394

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQIRQAPAASASNATESKQEIRNYTMNFGPQHPAAHGVLRLILEMDGETVVRADPHIGL
CCCHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCH
LHRGTEKLAESKPFNQSIGYMDRLDYVSMMCNEHAYVRAIETLIGIQAPERAQYIRTMFD
HHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
EITRILNHLMWLGSNALDLGAMAVMLYAFREREELMDVYEAISGARMHAAYYRPGGVYRD
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCC
LPDTMPKYKESRWHKGKALKRLNAAREGSMLDFLEHFTDTFPQRIDEYETLLTDNRIWKQ
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RTVGVGVIEPDVAKAWGMTGVMLRGSGIAWDLRKKQPYAKYDAVDFDIPLGTCGDCYDRY
HCCCCCEECCHHHHHCCCCEEEEECCCCEEECCCCCCCCCCCCEEECCCCCCCHHHHHHH
LCRVAEMRESNRIIKQCVQWLKMNPGQVMVENCKVAPPKRESMKDDMEALIHHFKLFSEG
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCC
YCVPAGETYSAVEAPKGEFGCYLISDGANKPFRVHLRAPGFAHLSSMDAVVRGYMLADVV
CCCCCCCCCHHHCCCCCCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
AMIGTYDLVFGEVDR
HHHHHHHHHHCCCCC
>Mature Secondary Structure
MNQIRQAPAASASNATESKQEIRNYTMNFGPQHPAAHGVLRLILEMDGETVVRADPHIGL
CCCHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCH
LHRGTEKLAESKPFNQSIGYMDRLDYVSMMCNEHAYVRAIETLIGIQAPERAQYIRTMFD
HHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
EITRILNHLMWLGSNALDLGAMAVMLYAFREREELMDVYEAISGARMHAAYYRPGGVYRD
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCC
LPDTMPKYKESRWHKGKALKRLNAAREGSMLDFLEHFTDTFPQRIDEYETLLTDNRIWKQ
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RTVGVGVIEPDVAKAWGMTGVMLRGSGIAWDLRKKQPYAKYDAVDFDIPLGTCGDCYDRY
HCCCCCEECCHHHHHCCCCEEEEECCCCEEECCCCCCCCCCCCEEECCCCCCCHHHHHHH
LCRVAEMRESNRIIKQCVQWLKMNPGQVMVENCKVAPPKRESMKDDMEALIHHFKLFSEG
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCC
YCVPAGETYSAVEAPKGEFGCYLISDGANKPFRVHLRAPGFAHLSSMDAVVRGYMLADVV
CCCCCCCCCHHHCCCCCCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
AMIGTYDLVFGEVDR
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA