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The map label for this gene is adk

Identifier: 182680781

GI number: 182680781

Start: 283967

End: 284530

Strand: Direct

Name: adk

Synonym: XfasM23_0210

Alternate gene names: 182680781

Gene position: 283967-284530 (Clockwise)

Preceding gene: 182680777

Following gene: 182680782

Centisome position: 11.2

GC content: 53.9

Gene sequence:

>564_bases
ATGCGATTGGTTCTATTGGGACCACCTGGTTCAGGTAAAGGCACTCAGGCGGCGCAAATGCAGGAAACATTACAGATTCC
GCATATTTCCACTGGTGACCTGTTGCGCAGTGAAGTGGTTGCTGGGACTCCTCTTGGCCTACAGGCCAAGCAAGTCATGG
CACAAGGTGATTTGGTTTCCGATGCGATTTTGCTTGGCATGCTTGAGTCACGTTTGAGCCATACGGATGTAGTAAAAGGC
TTCATCCTTGATGGCTATCCGCGCAATCTGTCTCAGGCCGCTGCGCTGGATGGGTTGTTAGCCAAGTTCGGGCATCCTTT
AAATGCTGTGGTGCAGCTTGAGGTACCCACCGATGTGTTGGTGGAACGTATTGCTGGCCGTGCTCAGGCGGAAGGCCGTG
AGGATGACACTCCTGATGCGGTGCGTAAGCGTTTGCAGGTCTATAACGATTCAACCGCGCCGGTCATCGGTTTCTATCAG
CAGCGCGGCATCTTGTTGCGCGTGGATGGTGTGGGACGTTTGGATGAGGTTTCCCAGCGTATTGCGGTTGCGCTGGGTTG
CTGA

Upstream 100 bases:

>100_bases
CTTGGATGCGTTAAGCTGCGCGGCATCATGGTGCGGTGTAGGCAGAGGGTCGAAGTGTAACCCCGCTTGCCGTTGTTTTT
TTTCTATATGGAGTGAATTA

Downstream 100 bases:

>100_bases
AGTCGGTTCACGTGACTTTAGGATGTTGGAGAAGAGGTGCGGTATCAATGACGCTCTGACATGATGCCACTTGGGTTCAG
AGGTCCTCTTTACTTATCTG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MRLVLLGPPGSGKGTQAAQMQETLQIPHISTGDLLRSEVVAGTPLGLQAKQVMAQGDLVSDAILLGMLESRLSHTDVVKG
FILDGYPRNLSQAAALDGLLAKFGHPLNAVVQLEVPTDVLVERIAGRAQAEGREDDTPDAVRKRLQVYNDSTAPVIGFYQ
QRGILLRVDGVGRLDEVSQRIAVALGC

Sequences:

>Translated_187_residues
MRLVLLGPPGSGKGTQAAQMQETLQIPHISTGDLLRSEVVAGTPLGLQAKQVMAQGDLVSDAILLGMLESRLSHTDVVKG
FILDGYPRNLSQAAALDGLLAKFGHPLNAVVQLEVPTDVLVERIAGRAQAEGREDDTPDAVRKRLQVYNDSTAPVIGFYQ
QRGILLRVDGVGRLDEVSQRIAVALGC
>Mature_187_residues
MRLVLLGPPGSGKGTQAAQMQETLQIPHISTGDLLRSEVVAGTPLGLQAKQVMAQGDLVSDAILLGMLESRLSHTDVVKG
FILDGYPRNLSQAAALDGLLAKFGHPLNAVVQLEVPTDVLVERIAGRAQAEGREDDTPDAVRKRLQVYNDSTAPVIGFYQ
QRGILLRVDGVGRLDEVSQRIAVALGC

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=213, Percent_Identity=35.6807511737089, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI7524346, Length=213, Percent_Identity=35.6807511737089, Blast_Score=134, Evalue=3e-32,
Organism=Homo sapiens, GI4502011, Length=184, Percent_Identity=34.7826086956522, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI19923437, Length=198, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI310110345, Length=198, Percent_Identity=32.8282828282828, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI53832003, Length=198, Percent_Identity=32.8282828282828, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI8051579, Length=198, Percent_Identity=32.8282828282828, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI53832001, Length=198, Percent_Identity=32.8282828282828, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI28144899, Length=184, Percent_Identity=30.4347826086957, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI28144897, Length=184, Percent_Identity=30.4347826086957, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI7706497, Length=180, Percent_Identity=28.8888888888889, Blast_Score=94, Evalue=6e-20,
Organism=Homo sapiens, GI22749187, Length=127, Percent_Identity=36.2204724409449, Blast_Score=74, Evalue=6e-14,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=36.697247706422, Blast_Score=135, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17552384, Length=208, Percent_Identity=35.5769230769231, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17567503, Length=177, Percent_Identity=36.7231638418079, Blast_Score=124, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17550688, Length=182, Percent_Identity=34.6153846153846, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17533833, Length=172, Percent_Identity=35.4651162790698, Blast_Score=107, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17537943, Length=199, Percent_Identity=29.6482412060301, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=197, Percent_Identity=42.1319796954315, Blast_Score=155, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=33.8461538461538, Blast_Score=107, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322828, Length=173, Percent_Identity=32.3699421965318, Blast_Score=104, Evalue=7e-24,
Organism=Drosophila melanogaster, GI22026816, Length=205, Percent_Identity=38.5365853658537, Blast_Score=146, Evalue=8e-36,
Organism=Drosophila melanogaster, GI17737899, Length=197, Percent_Identity=35.0253807106599, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24645822, Length=197, Percent_Identity=35.0253807106599, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24663208, Length=188, Percent_Identity=33.5106382978723, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17647141, Length=188, Percent_Identity=33.5106382978723, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI221459597, Length=191, Percent_Identity=32.4607329842932, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21356893, Length=191, Percent_Identity=32.4607329842932, Blast_Score=100, Evalue=4e-22,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_XYLF2 (B2I757)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001828941.1
- ProteinModelPortal:   B2I757
- SMR:   B2I757
- GeneID:   6204096
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_0210
- HOGENOM:   HBG630208
- OMA:   EINQPLE
- ProtClustDB:   PRK00279
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 19943; Mature: 19943

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVLLGPPGSGKGTQAAQMQETLQIPHISTGDLLRSEVVAGTPLGLQAKQVMAQGDLVS
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCHHH
DAILLGMLESRLSHTDVVKGFILDGYPRNLSQAAALDGLLAKFGHPLNAVVQLEVPTDVL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHH
VERIAGRAQAEGREDDTPDAVRKRLQVYNDSTAPVIGFYQQRGILLRVDGVGRLDEVSQR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEHHHHCCEEEEECCCCCHHHHHHH
IAVALGC
HHHHCCC
>Mature Secondary Structure
MRLVLLGPPGSGKGTQAAQMQETLQIPHISTGDLLRSEVVAGTPLGLQAKQVMAQGDLVS
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCHHH
DAILLGMLESRLSHTDVVKGFILDGYPRNLSQAAALDGLLAKFGHPLNAVVQLEVPTDVL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHH
VERIAGRAQAEGREDDTPDAVRKRLQVYNDSTAPVIGFYQQRGILLRVDGVGRLDEVSQR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEHHHHCCEEEEECCCCCHHHHHHH
IAVALGC
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA