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The map label for this gene is (mutM1

Identifier: 182680697

GI number: 182680697

Start: 176297

End: 177112

Strand: Direct

Name: (mutM1

Synonym: XfasM23_0126

Alternate gene names: 182680697

Gene position: 176297-177112 (Clockwise)

Preceding gene: 182680696

Following gene: 182680699

Centisome position: 6.95

GC content: 52.08

Gene sequence:

>816_bases
ATGCCTGAACTCCCAGAAGTCGAAACCACATTGCGTGGACTGTTGCCCTATTTGACCAATCAACTGATCTATTCTCTTAC
CCTGCGTAGGCGTACCTTGCGCTGGGATATCCCTTCCCATATCGAAAGTCGTCTCCCAGGCCATCGCATCACTACTGTGT
GTCGTCGGGCCAAATACTTGCTGATCGATACTAATGCAGGGGGAAGTCTCATCATCCACCTTGGCATGTCCGGTACTCTG
CGCTTACTGGCGCCAGAAACGCCTCTACGCCCACACGATCATGTGGACATTATGTTGAATAACCGTCGTGTGCTACGGTT
CAATGACCCTCGCCGCTTCGGATGCTTGCTCTGGCAAGAAGATGGACAAATCCACCCTCTCCTACAGCGCCTCGGCTGCG
AACCACTCTCAGATAGTTTTAATGGTGATTATCTTTATCAGTGCAGCCGTGCTCGCAATGTGTCCGTGAAAACGTTTCTC
ATGGACCAACGCATTGTGGTCGGTGTCGGTAATATCTATGCTGCTGAAAGTTTGTTCCGTGCCGGTATCAGCCCTCTATG
CGAGGCTGACAAAATATCCCTCCAACGCTATCGGCGCTTGGCTGAAGTGGTCAAGGATATCCTCCTATATGCCATCAACC
GTGGAGGAACTACCTTGCGGGATTTCCTCAGTCCCGATGGACGCCCCGGCTACTTCAAGCAGGAATTGTTTGTCTACGGT
CGTCAGCAACAGCCTTGTAAGCAGTGTGGAAGCCTCCTGCGTCAAACCACTATCAGACAGCGAACTACTGTCTGGTGCGG
CCACTGCCAAGGTTGA

Upstream 100 bases:

>100_bases
CCCCTCAAACCCTCATCCTTAGTTGGATGAGGGTTTGTTTCTTTGTGCTGTTTATATCAACACTTGAGGCACACTTGGCT
GATCTTCAGCTCTCTTTCTC

Downstream 100 bases:

>100_bases
AGCATCTGCGTTCCATAGGTGCATCCATGCCTGCTTCCACCAGGTAGCGATGATCATTGTTGGGTGTCGTAGGTGATCAT
CCTTATCCACTACCGAGCCC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MPELPEVETTLRGLLPYLTNQLIYSLTLRRRTLRWDIPSHIESRLPGHRITTVCRRAKYLLIDTNAGGSLIIHLGMSGTL
RLLAPETPLRPHDHVDIMLNNRRVLRFNDPRRFGCLLWQEDGQIHPLLQRLGCEPLSDSFNGDYLYQCSRARNVSVKTFL
MDQRIVVGVGNIYAAESLFRAGISPLCEADKISLQRYRRLAEVVKDILLYAINRGGTTLRDFLSPDGRPGYFKQELFVYG
RQQQPCKQCGSLLRQTTIRQRTTVWCGHCQG

Sequences:

>Translated_271_residues
MPELPEVETTLRGLLPYLTNQLIYSLTLRRRTLRWDIPSHIESRLPGHRITTVCRRAKYLLIDTNAGGSLIIHLGMSGTL
RLLAPETPLRPHDHVDIMLNNRRVLRFNDPRRFGCLLWQEDGQIHPLLQRLGCEPLSDSFNGDYLYQCSRARNVSVKTFL
MDQRIVVGVGNIYAAESLFRAGISPLCEADKISLQRYRRLAEVVKDILLYAINRGGTTLRDFLSPDGRPGYFKQELFVYG
RQQQPCKQCGSLLRQTTIRQRTTVWCGHCQG
>Mature_270_residues
PELPEVETTLRGLLPYLTNQLIYSLTLRRRTLRWDIPSHIESRLPGHRITTVCRRAKYLLIDTNAGGSLIIHLGMSGTLR
LLAPETPLRPHDHVDIMLNNRRVLRFNDPRRFGCLLWQEDGQIHPLLQRLGCEPLSDSFNGDYLYQCSRARNVSVKTFLM
DQRIVVGVGNIYAAESLFRAGISPLCEADKISLQRYRRLAEVVKDILLYAINRGGTTLRDFLSPDGRPGYFKQELFVYGR
QQQPCKQCGSLLRQTTIRQRTTVWCGHCQG

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=270, Percent_Identity=51.1111111111111, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1786932, Length=277, Percent_Identity=24.5487364620939, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_XYLFA (P64154)

Other databases:

- EMBL:   AE003849
- EMBL:   AE003849
- PIR:   G82838
- RefSeq:   NP_297364.1
- RefSeq:   NP_297463.1
- ProteinModelPortal:   P64154
- SMR:   P64154
- GeneID:   1125588
- GeneID:   1125693
- GenomeReviews:   AE003849_GR
- GenomeReviews:   AE003849_GR
- KEGG:   xfa:XF0071
- KEGG:   xfa:XF0170
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- ProtClustDB:   PRK01103
- BioCyc:   XFAS160492:XF0071-MONOMER
- BioCyc:   XFAS160492:XF0170-MONOMER
- BRENDA:   3.2.2.23
- BRENDA:   4.2.99.18
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 31092; Mature: 30960

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 261-261 BINDING 92-92 BINDING 111-111 BINDING 152-152

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETTLRGLLPYLTNQLIYSLTLRRRTLRWDIPSHIESRLPGHRITTVCRRAKYL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHCCCHHHHHHHHHCEEE
LIDTNAGGSLIIHLGMSGTLRLLAPETPLRPHDHVDIMLNNRRVLRFNDPRRFGCLLWQE
EEECCCCCEEEEEECCCCEEEEECCCCCCCCCCCEEEEECCCEEEEECCCCEEEEEEECC
DGQIHPLLQRLGCEPLSDSFNGDYLYQCSRARNVSVKTFLMDQRIVVGVGNIYAAESLFR
CCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCEEEEECCCHHHHHHHHH
AGISPLCEADKISLQRYRRLAEVVKDILLYAINRGGTTLRDFLSPDGRPGYFKQELFVYG
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHHHHEEC
RQQQPCKQCGSLLRQTTIRQRTTVWCGHCQG
CCCCHHHHHHHHHHHHHHHHHHEEEEECCCC
>Mature Secondary Structure 
PELPEVETTLRGLLPYLTNQLIYSLTLRRRTLRWDIPSHIESRLPGHRITTVCRRAKYL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHCCCHHHHHHHHHCEEE
LIDTNAGGSLIIHLGMSGTLRLLAPETPLRPHDHVDIMLNNRRVLRFNDPRRFGCLLWQE
EEECCCCCEEEEEECCCCEEEEECCCCCCCCCCCEEEEECCCEEEEECCCCEEEEEEECC
DGQIHPLLQRLGCEPLSDSFNGDYLYQCSRARNVSVKTFLMDQRIVVGVGNIYAAESLFR
CCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCEEEEECCCHHHHHHHHH
AGISPLCEADKISLQRYRRLAEVVKDILLYAINRGGTTLRDFLSPDGRPGYFKQELFVYG
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHHHHEEC
RQQQPCKQCGSLLRQTTIRQRTTVWCGHCQG
CCCCHHHHHHHHHHHHHHHHHHEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347