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The map label for this gene is glmS [H]

Identifier: 182680674

GI number: 182680674

Start: 139406

End: 141235

Strand: Direct

Name: glmS [H]

Synonym: XfasM23_0103

Alternate gene names: 182680674

Gene position: 139406-141235 (Clockwise)

Preceding gene: 182680673

Following gene: 182680675

Centisome position: 5.5

GC content: 53.55

Gene sequence:

>1830_bases
ATGTGCGGTATTGTCGGTGCTATTGCTGGCCGTGACGTGGTTCCTGTGTTGATTGAGGGCCTCAAGCGGTTGGAATATCG
AGGGTATGATTCTTCCGGTATCGCGGTGCTTGAGAGCGGGTCAATCCGGCGGGTGCGTCGTACTGGGCGGGTTGCTGAAA
TGGCTGTCGCCGCAACGCAAGAGGGATTTACAGCATCGCTTGGTATCGGTCATACGCGTTGGGCAACGCATGGGGGAGTG
ACCGAGGCCAATGCGCATCCACATGTGAGCCACGGTGTTGTGTTGGTGCACAACGGGATCATTGAGAATTACGAGGTGCA
GCGCGAGCGTCTGTCTGCCTTTGGCTATGTCTTCCAGTCGCAGACGGATACGGAAGTCATTGCGCATCTGATTCATTACT
ACATGCAGCAAGGTGGTGATCTTCTGGGGGCGTTGCAGTGTGCGGTCAAGGCGCTGACGGGGATCTATGCGTTGGCGGTG
ATGAGTCAGGCTGAACCAGGGCGTTTTGTCTGCGCTCGGATGGGGTGCCCGTTATTGATTGGTATAGGGGATGGTGAGAG
TTTTGTTGCTTCTGACATCTCTGCGCTCATCCAAGCAACACGTCAGGTGATTTTTTTGGAGGATGGCGATACTGCGGAGA
TTCGCCGTGATGGAATCAGTATTTTCAATGCGGAACAGTGTCCAGTGGAACGTTCATTGCATCTGTCGAATGTGTCGCTG
TCTTCGTTGGAATTGGGGGAGTTCCGTCATTTCATGCAGAAGGAGATTCATGAGCAACCTCGGGTGCTTGCCGATACGAT
GGAGGCGGCGATTGATGCGGCTGGATTTCCACCCATGTTGTTCGGTGCGCAGGCCGAGTCGGTGTTCCGTGGCATTACGG
GTATCCAGATTTTGGCGTGTGGCACCAGTTACTACGCTGGTTTGACCGCGCGTTATTGGATTGAGGCGATTGCTGGTTTG
CCATGTCAGGTGGAGATTGCTAGTGAGTACCGTTACCGTAAGGCGTATGTCAATCCACAGCATTTGGTGGTCACGATTTC
CCAGTCTGGGGAGACGCTGGATACATTGGAGGCGTTGAAGTACGCCAAAGCATTAGGTCACCGTCATACGCTGTCGATTT
GTAATGCTCCTGACAGTGCGATTCCGCGGATCAGTGAGTTGATTTGCTATACCCGTGCAGGCCCAGAGATTGGTGTGGCT
TCGACGAAGGCATTCACCACTCAGCTGGTGGTGCTGTTCCAGTTGGCTGTGGCATTGGGGGTGTTGCGTGGGGCTGTTGA
TGCCGAGGGTGAAGCGGCGTATTTGGAGCAATTGCGCCAATTGCCTTGCAGCGTACAGCAAGCACTCAATCTGGAACCGC
AGATTGCTGGGTGGGCGGAGTGTTTTTCGTCGCGTCATCATGCGTTGTTTCTTGGTCGCGGTTTGCATTATCCGATTGCG
TTAGAAGGTGCGCTCAAACTGAAGGAAATCTCTTATATCCATGCTGAGGCATATCCGGCGGGTGAGTTGAAGCATGGGCC
ACTTGCGTTAGTGGATGCTGATATGCCGGTCGTGGTGATTGCACCGAACGATAGTCTGTTGGAAAAGGTGAAGTCCAATA
TGCAGGAAGTGCGCGCGCGCGGTGGGGAGCTGTTTGTGTTTGCTGATCAGGACAGTCACTTTAGTGAATCGGAAGGTTTG
CATGTGATTCGTACGCTGCGCCACACGGGGGTATTGTCGCCGTTAGTACACACGATTCCTGTGCAGTTGTTGGCTTATCA
CACTGCGTTGGTACGTGGTACTGATGTGGATAAGCCACGTAATCTGGCGAAGAGTGTCACGGTGGAATAA

Upstream 100 bases:

>100_bases
GTGAGCAGGTTGCGCGCTTTTTTGTAGGTCGCTGTCAGAGGGTGCGGAGGTTAAGGGGCGACATCGTTACAATGTCTGCT
TTACATTCTGTGGCTGTCTT

Downstream 100 bases:

>100_bases
TCCTGGTTGGTTTTTATTGAACGCTCAAAAACGCGGAGATTCAGAGGTTCTTTGACCGTAACGGGTCACGACGCGCGGTA
TGACAGATGTTTATATTGGT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MCGIVGAIAGRDVVPVLIEGLKRLEYRGYDSSGIAVLESGSIRRVRRTGRVAEMAVAATQEGFTASLGIGHTRWATHGGV
TEANAHPHVSHGVVLVHNGIIENYEVQRERLSAFGYVFQSQTDTEVIAHLIHYYMQQGGDLLGALQCAVKALTGIYALAV
MSQAEPGRFVCARMGCPLLIGIGDGESFVASDISALIQATRQVIFLEDGDTAEIRRDGISIFNAEQCPVERSLHLSNVSL
SSLELGEFRHFMQKEIHEQPRVLADTMEAAIDAAGFPPMLFGAQAESVFRGITGIQILACGTSYYAGLTARYWIEAIAGL
PCQVEIASEYRYRKAYVNPQHLVVTISQSGETLDTLEALKYAKALGHRHTLSICNAPDSAIPRISELICYTRAGPEIGVA
STKAFTTQLVVLFQLAVALGVLRGAVDAEGEAAYLEQLRQLPCSVQQALNLEPQIAGWAECFSSRHHALFLGRGLHYPIA
LEGALKLKEISYIHAEAYPAGELKHGPLALVDADMPVVVIAPNDSLLEKVKSNMQEVRARGGELFVFADQDSHFSESEGL
HVIRTLRHTGVLSPLVHTIPVQLLAYHTALVRGTDVDKPRNLAKSVTVE

Sequences:

>Translated_609_residues
MCGIVGAIAGRDVVPVLIEGLKRLEYRGYDSSGIAVLESGSIRRVRRTGRVAEMAVAATQEGFTASLGIGHTRWATHGGV
TEANAHPHVSHGVVLVHNGIIENYEVQRERLSAFGYVFQSQTDTEVIAHLIHYYMQQGGDLLGALQCAVKALTGIYALAV
MSQAEPGRFVCARMGCPLLIGIGDGESFVASDISALIQATRQVIFLEDGDTAEIRRDGISIFNAEQCPVERSLHLSNVSL
SSLELGEFRHFMQKEIHEQPRVLADTMEAAIDAAGFPPMLFGAQAESVFRGITGIQILACGTSYYAGLTARYWIEAIAGL
PCQVEIASEYRYRKAYVNPQHLVVTISQSGETLDTLEALKYAKALGHRHTLSICNAPDSAIPRISELICYTRAGPEIGVA
STKAFTTQLVVLFQLAVALGVLRGAVDAEGEAAYLEQLRQLPCSVQQALNLEPQIAGWAECFSSRHHALFLGRGLHYPIA
LEGALKLKEISYIHAEAYPAGELKHGPLALVDADMPVVVIAPNDSLLEKVKSNMQEVRARGGELFVFADQDSHFSESEGL
HVIRTLRHTGVLSPLVHTIPVQLLAYHTALVRGTDVDKPRNLAKSVTVE
>Mature_609_residues
MCGIVGAIAGRDVVPVLIEGLKRLEYRGYDSSGIAVLESGSIRRVRRTGRVAEMAVAATQEGFTASLGIGHTRWATHGGV
TEANAHPHVSHGVVLVHNGIIENYEVQRERLSAFGYVFQSQTDTEVIAHLIHYYMQQGGDLLGALQCAVKALTGIYALAV
MSQAEPGRFVCARMGCPLLIGIGDGESFVASDISALIQATRQVIFLEDGDTAEIRRDGISIFNAEQCPVERSLHLSNVSL
SSLELGEFRHFMQKEIHEQPRVLADTMEAAIDAAGFPPMLFGAQAESVFRGITGIQILACGTSYYAGLTARYWIEAIAGL
PCQVEIASEYRYRKAYVNPQHLVVTISQSGETLDTLEALKYAKALGHRHTLSICNAPDSAIPRISELICYTRAGPEIGVA
STKAFTTQLVVLFQLAVALGVLRGAVDAEGEAAYLEQLRQLPCSVQQALNLEPQIAGWAECFSSRHHALFLGRGLHYPIA
LEGALKLKEISYIHAEAYPAGELKHGPLALVDADMPVVVIAPNDSLLEKVKSNMQEVRARGGELFVFADQDSHFSESEGL
HVIRTLRHTGVLSPLVHTIPVQLLAYHTALVRGTDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=684, Percent_Identity=35.672514619883, Blast_Score=378, Evalue=1e-104,
Organism=Homo sapiens, GI205277386, Length=689, Percent_Identity=35.8490566037736, Blast_Score=375, Evalue=1e-104,
Organism=Escherichia coli, GI1790167, Length=610, Percent_Identity=55.2459016393443, Blast_Score=676, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=176, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17539970, Length=431, Percent_Identity=38.0510440835267, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17532897, Length=434, Percent_Identity=37.5576036866359, Blast_Score=270, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17532899, Length=434, Percent_Identity=37.5576036866359, Blast_Score=270, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6322745, Length=434, Percent_Identity=39.4009216589862, Blast_Score=280, Evalue=7e-76,
Organism=Saccharomyces cerevisiae, GI6323731, Length=434, Percent_Identity=29.7235023041475, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=38.5365853658537, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI21357745, Length=686, Percent_Identity=37.7551020408163, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI28573187, Length=141, Percent_Identity=34.0425531914894, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66031; Mature: 66031

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAIAGRDVVPVLIEGLKRLEYRGYDSSGIAVLESGSIRRVRRTGRVAEMAVAATQ
CCCCCHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHCCCHHHHHHHHHC
EGFTASLGIGHTRWATHGGVTEANAHPHVSHGVVLVHNGIIENYEVQRERLSAFGYVFQS
CCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCC
QTDTEVIAHLIHYYMQQGGDLLGALQCAVKALTGIYALAVMSQAEPGRFVCARMGCPLLI
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEE
GIGDGESFVASDISALIQATRQVIFLEDGDTAEIRRDGISIFNAEQCPVERSLHLSNVSL
EECCCCHHHHHHHHHHHHHCCEEEEEECCCHHHHHHCCCCEECCCCCCCHHCEEECCCCC
SSLELGEFRHFMQKEIHEQPRVLADTMEAAIDAAGFPPMLFGAQAESVFRGITGIQILAC
CCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHCCCCEEEEEE
GTSYYAGLTARYWIEAIAGLPCQVEIASEYRYRKAYVNPQHLVVTISQSGETLDTLEALK
CCHHHHCHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHH
YAKALGHRHTLSICNAPDSAIPRISELICYTRAGPEIGVASTKAFTTQLVVLFQLAVALG
HHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VLRGAVDAEGEAAYLEQLRQLPCSVQQALNLEPQIAGWAECFSSRHHALFLGRGLHYPIA
HHHHCCCCCCCHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHCCCCCEEEEECCCCCCEE
LEGALKLKEISYIHAEAYPAGELKHGPLALVDADMPVVVIAPNDSLLEKVKSNMQEVRAR
ECCCEEHHHHHEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
GGELFVFADQDSHFSESEGLHVIRTLRHTGVLSPLVHTIPVQLLAYHTALVRGTDVDKPR
CCEEEEEECCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
NLAKSVTVE
HHHHHCCCC
>Mature Secondary Structure
MCGIVGAIAGRDVVPVLIEGLKRLEYRGYDSSGIAVLESGSIRRVRRTGRVAEMAVAATQ
CCCCCHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHCCCHHHHHHHHHC
EGFTASLGIGHTRWATHGGVTEANAHPHVSHGVVLVHNGIIENYEVQRERLSAFGYVFQS
CCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCC
QTDTEVIAHLIHYYMQQGGDLLGALQCAVKALTGIYALAVMSQAEPGRFVCARMGCPLLI
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEE
GIGDGESFVASDISALIQATRQVIFLEDGDTAEIRRDGISIFNAEQCPVERSLHLSNVSL
EECCCCHHHHHHHHHHHHHCCEEEEEECCCHHHHHHCCCCEECCCCCCCHHCEEECCCCC
SSLELGEFRHFMQKEIHEQPRVLADTMEAAIDAAGFPPMLFGAQAESVFRGITGIQILAC
CCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHCCCCEEEEEE
GTSYYAGLTARYWIEAIAGLPCQVEIASEYRYRKAYVNPQHLVVTISQSGETLDTLEALK
CCHHHHCHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHH
YAKALGHRHTLSICNAPDSAIPRISELICYTRAGPEIGVASTKAFTTQLVVLFQLAVALG
HHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
VLRGAVDAEGEAAYLEQLRQLPCSVQQALNLEPQIAGWAECFSSRHHALFLGRGLHYPIA
HHHHCCCCCCCHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHCCCCCEEEEECCCCCCEE
LEGALKLKEISYIHAEAYPAGELKHGPLALVDADMPVVVIAPNDSLLEKVKSNMQEVRAR
ECCCEEHHHHHEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
GGELFVFADQDSHFSESEGLHVIRTLRHTGVLSPLVHTIPVQLLAYHTALVRGTDVDKPR
CCEEEEEECCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
NLAKSVTVE
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]