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The map label for this gene is cysM [C]

Identifier: 182680661

GI number: 182680661

Start: 125407

End: 126564

Strand: Reverse

Name: cysM [C]

Synonym: XfasM23_0090

Alternate gene names: 182680661

Gene position: 126564-125407 (Counterclockwise)

Preceding gene: 182680665

Following gene: 182680660

Centisome position: 4.99

GC content: 56.3

Gene sequence:

>1158_bases
GTGCAAGGTGGCTATGGGAGAATCGACGCTTTCTATCACTGTTGCTCTTTTATGTCGCAGCGCGAGTGGGTCGCATCCTC
CATCTGTAAGATCGAAGCTGATTTTAATCGCTCCGTTGACACCCATCTCATCCCGTTGCAGTTGCCTGGTTTCCCGGACA
TTGATTTCTATCTCAAAGACGAATCGATCCACCCCACTGGAAGCCTTAAGCATCGATTGGCACGTTCGTTGTTCTTGTAC
GCTCTGGTCAATGGTTGGCTGTCTCCAGGGCGGCCGGTGATTGAAGCATCCAGCGGTTCAACGGCTGTCTCAGAGGCTTA
CTTCGCGAGGCTGTTGGGGCTTCCTTTTATCGCGGTGATCCCAACCTCGACCTCACCGGAGAAGGTGGCTGCGATCGAGT
TTCACGGGGGGCGCTGTCACGCGGTCGAACGGGCGTGTGATCTGCATGATGCTGCACATCAGTTGGCGCGTGAGACAGGG
GGCCATTTCATGGACCAGTTCACTTACGCAGAACGTGCAACTGATTGGCGCGCCAATAACAATATTGCTGAGTCGATCTT
TAAGCAGATGGCCGATGAGCCACACCCAATTCCCGCCTGGATTGTGTGTAGTCCGGGGACGGGAGGCACTGCTGCAACGC
TCGGCCGCTATGTGCGCTACCGGCGTCACGTCACTCGCATCCTGTGCGCTGATCCGGAGATTTCGGTGTTCTTCGATCAC
TACCGCGCTGCCTGCAAGGGAAGCGATCATAGGAACAGCGTCACTGACACGGGGGGATCTCGGATGGAAGGGATCGGCCG
ACCACGCTTAGAACCAAGTTTCATCCACAATTGTATCGACGCGATGATTAAGGTGCCCGACGCGCTGAGTCTGGCGGCAA
TGCGCTATATCAGCGCTCGCTTAGGTCGACGTGTGGGCGGCTCCACTGGAACCAATATGGTGGGTGTGCTGCAAACCGCA
GCACGCATGCGGGCTGAAGGCATGAAGGGTTCGATCGTCACCATTCTGTGTGATGGAGGTGAACGTTACGCGCATAGTTA
CTATTCTCCAGCGTGGTACGCGGCACATGGCATTGATGTGTCGGACAGTGACGCGGTGATCGCTGCTGTCGTGGCAGGTG
ATACGTTGCCGCTGCTTCCTTGCGCGGCTCTGGAATGA

Upstream 100 bases:

>100_bases
GGCGAATGGTGCAAGGCGGCACGCGCTGACCTACAGATGCAAATGGGTGGGTCATAAAAAAGCCGAACACGTCGCGAAAC
ACTCAATGGGTGCTCAGAGG

Downstream 100 bases:

>100_bases
CACCATAATCGGTAGGCATCTCCGCATTTGGCTGCATTCCCAAGACACAGAAGACACACATGAGTAACCCACTCCTCGAT
TTCTCAGACCTTCCTCGCTT

Product: pyridoxal-5'-phosphate-dependent protein subunit beta

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MQGGYGRIDAFYHCCSFMSQREWVASSICKIEADFNRSVDTHLIPLQLPGFPDIDFYLKDESIHPTGSLKHRLARSLFLY
ALVNGWLSPGRPVIEASSGSTAVSEAYFARLLGLPFIAVIPTSTSPEKVAAIEFHGGRCHAVERACDLHDAAHQLARETG
GHFMDQFTYAERATDWRANNNIAESIFKQMADEPHPIPAWIVCSPGTGGTAATLGRYVRYRRHVTRILCADPEISVFFDH
YRAACKGSDHRNSVTDTGGSRMEGIGRPRLEPSFIHNCIDAMIKVPDALSLAAMRYISARLGRRVGGSTGTNMVGVLQTA
ARMRAEGMKGSIVTILCDGGERYAHSYYSPAWYAAHGIDVSDSDAVIAAVVAGDTLPLLPCAALE

Sequences:

>Translated_385_residues
MQGGYGRIDAFYHCCSFMSQREWVASSICKIEADFNRSVDTHLIPLQLPGFPDIDFYLKDESIHPTGSLKHRLARSLFLY
ALVNGWLSPGRPVIEASSGSTAVSEAYFARLLGLPFIAVIPTSTSPEKVAAIEFHGGRCHAVERACDLHDAAHQLARETG
GHFMDQFTYAERATDWRANNNIAESIFKQMADEPHPIPAWIVCSPGTGGTAATLGRYVRYRRHVTRILCADPEISVFFDH
YRAACKGSDHRNSVTDTGGSRMEGIGRPRLEPSFIHNCIDAMIKVPDALSLAAMRYISARLGRRVGGSTGTNMVGVLQTA
ARMRAEGMKGSIVTILCDGGERYAHSYYSPAWYAAHGIDVSDSDAVIAAVVAGDTLPLLPCAALE
>Mature_385_residues
MQGGYGRIDAFYHCCSFMSQREWVASSICKIEADFNRSVDTHLIPLQLPGFPDIDFYLKDESIHPTGSLKHRLARSLFLY
ALVNGWLSPGRPVIEASSGSTAVSEAYFARLLGLPFIAVIPTSTSPEKVAAIEFHGGRCHAVERACDLHDAAHQLARETG
GHFMDQFTYAERATDWRANNNIAESIFKQMADEPHPIPAWIVCSPGTGGTAATLGRYVRYRRHVTRILCADPEISVFFDH
YRAACKGSDHRNSVTDTGGSRMEGIGRPRLEPSFIHNCIDAMIKVPDALSLAAMRYISARLGRRVGGSTGTNMVGVLQTA
ARMRAEGMKGSIVTILCDGGERYAHSYYSPAWYAAHGIDVSDSDAVIAAVVAGDTLPLLPCAALE

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Escherichia coli, GI2367138, Length=312, Percent_Identity=26.6025641025641, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71996324, Length=365, Percent_Identity=34.2465753424658, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17539800, Length=357, Percent_Identity=31.3725490196078, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17539640, Length=359, Percent_Identity=28.133704735376, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6321449, Length=347, Percent_Identity=27.0893371757925, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24643623, Length=309, Percent_Identity=29.4498381877023, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI20129101, Length=309, Percent_Identity=29.4498381877023, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 41996; Mature: 41996

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGGYGRIDAFYHCCSFMSQREWVASSICKIEADFNRSVDTHLIPLQLPGFPDIDFYLKD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEEEECCCCCCCEEEEEC
ESIHPTGSLKHRLARSLFLYALVNGWLSPGRPVIEASSGSTAVSEAYFARLLGLPFIAVI
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEE
PTSTSPEKVAAIEFHGGRCHAVERACDLHDAAHQLARETGGHFMDQFTYAERATDWRANN
ECCCCCCEEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC
NIAESIFKQMADEPHPIPAWIVCSPGTGGTAATLGRYVRYRRHVTRILCADPEISVFFDH
HHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
YRAACKGSDHRNSVTDTGGSRMEGIGRPRLEPSFIHNCIDAMIKVPDALSLAAMRYISAR
HHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LGRRVGGSTGTNMVGVLQTAARMRAEGMKGSIVTILCDGGERYAHSYYSPAWYAAHGIDV
HHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHCCCCCCEEECCCCC
SDSDAVIAAVVAGDTLPLLPCAALE
CCCCCEEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MQGGYGRIDAFYHCCSFMSQREWVASSICKIEADFNRSVDTHLIPLQLPGFPDIDFYLKD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEEEECCCCCCCEEEEEC
ESIHPTGSLKHRLARSLFLYALVNGWLSPGRPVIEASSGSTAVSEAYFARLLGLPFIAVI
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEE
PTSTSPEKVAAIEFHGGRCHAVERACDLHDAAHQLARETGGHFMDQFTYAERATDWRANN
ECCCCCCEEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC
NIAESIFKQMADEPHPIPAWIVCSPGTGGTAATLGRYVRYRRHVTRILCADPEISVFFDH
HHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
YRAACKGSDHRNSVTDTGGSRMEGIGRPRLEPSFIHNCIDAMIKVPDALSLAAMRYISAR
HHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LGRRVGGSTGTNMVGVLQTAARMRAEGMKGSIVTILCDGGERYAHSYYSPAWYAAHGIDV
HHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHCCCCCCEEECCCCC
SDSDAVIAAVVAGDTLPLLPCAALE
CCCCCEEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]