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The map label for this gene is map [H]

Identifier: 182680649

GI number: 182680649

Start: 107111

End: 107890

Strand: Direct

Name: map [H]

Synonym: XfasM23_0078

Alternate gene names: 182680649

Gene position: 107111-107890 (Clockwise)

Preceding gene: 182680648

Following gene: 182680650

Centisome position: 4.22

GC content: 53.33

Gene sequence:

>780_bases
ATGGTGGCTGTTAACCTGAAAACCAAAGAAGAGATTGAACAAATGCGCATCGCTGGCCGCTTGGCTGCTACGGTGCTTGA
TGTGGTCGCGCCATACGTGAAGCCGGGTGTGACTACCGCAGAACTCGACCAGATCTGCCACAACTATATTGTGACGGTAC
AGGGCGCGATTCCGGCTAACCTTGGCTATCGCGGCTTTCCTAAGACGATATGCACTTCGGTCAATAATGTCATTTGCCAT
GGTATTCCTAGCGATGCCAAGGTCCTGAAAGACGGCGACATCATCAATATCGACGTGACTGTCATCAAGGACGGTTGGCA
TGGCGATACAAGTCGCATGTATTACGTCGGTAACCCCTCGGTGATGGCGCGCCGACTCGTGGAAACCACTTACGAGGCAA
TGTGGCGTGGCATCCGTGCCGTTAAACCTGGTGCGACGCTTGGTGACATTGGCCACGCCATTCAAACCTACGCCGAAAAC
GAACGCTTTAGCGTTGTCCGCGAATACTGTGGTCACGGTATCGGCAAGGTCTACCACGACAATCCGCAGGTACTACATTA
CGGCCGTCCTGGCGAGGGACTGGTGCTGGAATCAGGAATGACCTTCACGATCGAGCCAATGATCAATGAAGGAACCCGCC
ACCATAAGGTATTGCCCGATGGCTGGACCGTGGTTACCAAGGATCGCAAACTGTCAGCGCAGTGGGAACATATGATTGCA
GTCACTGAAGACGGCGTGGATGTGTTGACCCTATCGCCTAACGACATCGGCAGTACATAA

Upstream 100 bases:

>100_bases
GCTGGATAGTTTTTGCATTTTGATCGTTTCAGGGCACCCCATCGTTGTAACGAATAACTAGTCAGAGAAAACCTTTAGAT
TCAGGATCGGCGATAATCCC

Downstream 100 bases:

>100_bases
ACCTACCTGCTGTTCCACGTGCCCGCGTTTGTGGCAGACGGTGATGGTGGTTGAGCGATCTGCTTGGCAAGAGTCGGTTG
AGATTGATCTCCAGTGAGCG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MVAVNLKTKEEIEQMRIAGRLAATVLDVVAPYVKPGVTTAELDQICHNYIVTVQGAIPANLGYRGFPKTICTSVNNVICH
GIPSDAKVLKDGDIINIDVTVIKDGWHGDTSRMYYVGNPSVMARRLVETTYEAMWRGIRAVKPGATLGDIGHAIQTYAEN
ERFSVVREYCGHGIGKVYHDNPQVLHYGRPGEGLVLESGMTFTIEPMINEGTRHHKVLPDGWTVVTKDRKLSAQWEHMIA
VTEDGVDVLTLSPNDIGST

Sequences:

>Translated_259_residues
MVAVNLKTKEEIEQMRIAGRLAATVLDVVAPYVKPGVTTAELDQICHNYIVTVQGAIPANLGYRGFPKTICTSVNNVICH
GIPSDAKVLKDGDIINIDVTVIKDGWHGDTSRMYYVGNPSVMARRLVETTYEAMWRGIRAVKPGATLGDIGHAIQTYAEN
ERFSVVREYCGHGIGKVYHDNPQVLHYGRPGEGLVLESGMTFTIEPMINEGTRHHKVLPDGWTVVTKDRKLSAQWEHMIA
VTEDGVDVLTLSPNDIGST
>Mature_259_residues
MVAVNLKTKEEIEQMRIAGRLAATVLDVVAPYVKPGVTTAELDQICHNYIVTVQGAIPANLGYRGFPKTICTSVNNVICH
GIPSDAKVLKDGDIINIDVTVIKDGWHGDTSRMYYVGNPSVMARRLVETTYEAMWRGIRAVKPGATLGDIGHAIQTYAEN
ERFSVVREYCGHGIGKVYHDNPQVLHYGRPGEGLVLESGMTFTIEPMINEGTRHHKVLPDGWTVVTKDRKLSAQWEHMIA
VTEDGVDVLTLSPNDIGST

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=247, Percent_Identity=48.9878542510121, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI40385867, Length=253, Percent_Identity=42.6877470355731, Blast_Score=211, Evalue=6e-55,
Organism=Escherichia coli, GI1786364, Length=254, Percent_Identity=59.8425196850394, Blast_Score=337, Evalue=5e-94,
Organism=Caenorhabditis elegans, GI71996291, Length=248, Percent_Identity=43.9516129032258, Blast_Score=216, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6323273, Length=243, Percent_Identity=48.559670781893, Blast_Score=237, Evalue=1e-63,
Organism=Drosophila melanogaster, GI21355531, Length=241, Percent_Identity=48.1327800829876, Blast_Score=224, Evalue=4e-59,
Organism=Drosophila melanogaster, GI24583427, Length=247, Percent_Identity=42.914979757085, Blast_Score=204, Evalue=6e-53,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28468; Mature: 28468

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAVNLKTKEEIEQMRIAGRLAATVLDVVAPYVKPGVTTAELDQICHNYIVTVQGAIPAN
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEEECCCCCC
LGYRGFPKTICTSVNNVICHGIPSDAKVLKDGDIINIDVTVIKDGWHGDTSRMYYVGNPS
CCCCCCCHHHHHHHCCEEEECCCCCCEEECCCCEEEEEEEEEECCCCCCCCEEEEECCHH
VMARRLVETTYEAMWRGIRAVKPGATLGDIGHAIQTYAENERFSVVREYCGHGIGKVYHD
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEECC
NPQVLHYGRPGEGLVLESGMTFTIEPMINEGTRHHKVLPDGWTVVTKDRKLSAQWEHMIA
CCCEEEECCCCCCEEEECCCEEEEEECCCCCCCCCEECCCCCEEEEECCCCCCCEEEEEE
VTEDGVDVLTLSPNDIGST
EECCCCEEEEECCCCCCCC
>Mature Secondary Structure
MVAVNLKTKEEIEQMRIAGRLAATVLDVVAPYVKPGVTTAELDQICHNYIVTVQGAIPAN
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEEECCCCCC
LGYRGFPKTICTSVNNVICHGIPSDAKVLKDGDIINIDVTVIKDGWHGDTSRMYYVGNPS
CCCCCCCHHHHHHHCCEEEECCCCCCEEECCCCEEEEEEEEEECCCCCCCCEEEEECCHH
VMARRLVETTYEAMWRGIRAVKPGATLGDIGHAIQTYAENERFSVVREYCGHGIGKVYHD
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEECC
NPQVLHYGRPGEGLVLESGMTFTIEPMINEGTRHHKVLPDGWTVVTKDRKLSAQWEHMIA
CCCEEEECCCCCCEEEECCCEEEEEECCCCCCCCCEECCCCCEEEEECCCCCCCEEEEEE
VTEDGVDVLTLSPNDIGST
EECCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]