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The map label for this gene is accB [H]

Identifier: 182680605

GI number: 182680605

Start: 44432

End: 44917

Strand: Direct

Name: accB [H]

Synonym: XfasM23_0033

Alternate gene names: 182680605

Gene position: 44432-44917 (Clockwise)

Preceding gene: 182680604

Following gene: 182680606

Centisome position: 1.75

GC content: 53.7

Gene sequence:

>486_bases
ATGGATCTCCGAAAAATCAAGAAACTCATCGACCTGTTAGAAGAATCGAATCTTTCCGAGATCGAGATTAAAGAAGGCGA
AGAGAGTGTACGTTTGGCGCGTACCTCCAACGCCGGTATGAATATAATGGCACCAACGATGCCGTGGGTACCGTCTGTAG
CAAATGTACCGGCGGCACCGGCGATGCCGATGATTTCGCCCACAGATGCTTCTACCGGCGGTATCCCTAAAGATGATGGG
GCGCTTCCGCAGGGGCATGTGCTGCGCGCACCGATGGTCGGCACGTTTTATACCTCACCGGCGCCGGATAAGCCGGTGTT
TGTGAGTGTTGGTCAAACGATTAAGCAAGGTGACACCCTGGCCATCATTGAGGCAATGAAAATGTTTAACCCGATTGAGG
CCGATGTCGCCGGCACGGTCGTGGCGATTCTTGGCGAGAACGGTCAGCCGGTTGAGTTTGACCAACCGCTGTTTGTGATC
CGCTGA

Upstream 100 bases:

>100_bases
TGGAGGGAGTGATTGCCAGACTTGGTTCTGACGTCTGAGTCGGCGATCAGCGCTCCGTATCCTTACTGTTTTTCTATTCT
GTATTACCAATGAGGCCGTT

Downstream 100 bases:

>100_bases
GCCATACATCAGGCGTTGGCCGTTGCCTTAAGGACGCCGTACTTCGGAACCTTTCTCATGTTAGACAAAGTCGTTATTGC
CAACCGTGGTGAGATCGCGT

Product: acetyl-CoA carboxylase biotin carboxyl carrier protein subunit

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MDLRKIKKLIDLLEESNLSEIEIKEGEESVRLARTSNAGMNIMAPTMPWVPSVANVPAAPAMPMISPTDASTGGIPKDDG
ALPQGHVLRAPMVGTFYTSPAPDKPVFVSVGQTIKQGDTLAIIEAMKMFNPIEADVAGTVVAILGENGQPVEFDQPLFVI
R

Sequences:

>Translated_161_residues
MDLRKIKKLIDLLEESNLSEIEIKEGEESVRLARTSNAGMNIMAPTMPWVPSVANVPAAPAMPMISPTDASTGGIPKDDG
ALPQGHVLRAPMVGTFYTSPAPDKPVFVSVGQTIKQGDTLAIIEAMKMFNPIEADVAGTVVAILGENGQPVEFDQPLFVI
R
>Mature_161_residues
MDLRKIKKLIDLLEESNLSEIEIKEGEESVRLARTSNAGMNIMAPTMPWVPSVANVPAAPAMPMISPTDASTGGIPKDDG
ALPQGHVLRAPMVGTFYTSPAPDKPVFVSVGQTIKQGDTLAIIEAMKMFNPIEADVAGTVVAILGENGQPVEFDQPLFVI
R

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=165, Percent_Identity=50.9090909090909, Blast_Score=155, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: NA

Molecular weight: Translated: 17182; Mature: 17182

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRKIKKLIDLLEESNLSEIEIKEGEESVRLARTSNAGMNIMAPTMPWVPSVANVPAAP
CCHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCCCCEEECCCCCCCCCCCCCCCCC
AMPMISPTDASTGGIPKDDGALPQGHVLRAPMVGTFYTSPAPDKPVFVSVGQTIKQGDTL
CCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCCCEEEECCCHHHCCCCH
AIIEAMKMFNPIEADVAGTVVAILGENGQPVEFDQPLFVIR
HHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEC
>Mature Secondary Structure
MDLRKIKKLIDLLEESNLSEIEIKEGEESVRLARTSNAGMNIMAPTMPWVPSVANVPAAP
CCHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCCCCEEECCCCCCCCCCCCCCCCC
AMPMISPTDASTGGIPKDDGALPQGHVLRAPMVGTFYTSPAPDKPVFVSVGQTIKQGDTL
CCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCCCEEEECCCHHHCCCCH
AIIEAMKMFNPIEADVAGTVVAILGENGQPVEFDQPLFVIR
HHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]