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The map label for this gene is accC [H]

Identifier: 182680606

GI number: 182680606

Start: 44975

End: 46342

Strand: Direct

Name: accC [H]

Synonym: XfasM23_0034

Alternate gene names: 182680606

Gene position: 44975-46342 (Clockwise)

Preceding gene: 182680605

Following gene: 182680608

Centisome position: 1.77

GC content: 54.09

Gene sequence:

>1368_bases
ATGTTAGACAAAGTCGTTATTGCCAACCGTGGTGAGATCGCGTTGCGTATTCTTCGCGCATGCCACACGTTGGGTATCCG
CACGGTTGCGGTGCACTCTACCGTTGATCGTAATCTGAAGCATGTCGCGATGGCTGATGAGTCGGTGTGTATTGGTCCTG
CACCATCGGCGGAGAGTTATCTCAATATTCCGGCGCTGATTGCCGCCGCTGAGGTCACGGATGCTCAGGCCATCCACCCT
GGCTATGGTTTTTTGTCGGAAAACGCTAGTTTTGCTGAACGTGTGGAACAGTCGGGCTTCATTTTCATTGGGCCACGGGC
AGAGACGATTCGTTTAATGGGCGACAAGGTGCAGGCTATCCATGCGATGAAAGCGGCTGGTGTGCCGTGTGTCCCTGGTT
CGGATGGTCCATTGGGTGATGACATTGTCGCTAACGTCAAAATTGCACGTGAGATCGGTTATCCGGTCATCATTAAGGCT
TCCGGCGGAGGCGGTGGACGCGGGATGCGTGTGGTACATACCGAGGCCGGTTTAGAGGCGGCTATCGAGACCACGCAGTG
TGAAGCTAAAGCCGCTTTTGGCAATGGCCAGGTGTATATGGAAAAGTTTCTGGAGAATCCGCGTCACGTGGAGATTCAGG
TGCTCGCCGATGGTCAGGGGAACGCGATCCATTTGGGGGAGCGGGATTGTTCGATGCAACGCCGCCATCAGAAGGTGGTG
GAGGAAGCCCCCGCACCCGGTATCACTGAGGCGCTGCGCAATGAAATCGGTCAGGTGTGTGTAGATGCCTGTATTCGTAT
CGGTTACCGCGGTGCTGGGACGTTTGAATTTCTGTTCGAGAATGGTCGTTTTTACTTCATCGAGATGAATACGCGCATCC
AGGTAGAGCATCCGGTGACGGAGCGTATCACTGGTATTGACTTGGTATGCGAGCAGTTGCGTATTGCCGCTGGTCAGCCA
TTGAGTATCAAGCAGAGCGATGTGGTGTTGCGTGGCCATGCGATCGAATGCCGTATCAATGCTGAGGATGCGGAGACGTT
CTTGCCCAATCCGGGTTTGATTACTGCGTTCCATCCACCAGGTGGTCCGGGTGTGCGTATGGATACGCATATCTACAGTG
GTTACAAGGTGCCGCCGAACTATGATTCGATGATCGGCAAGCTTATCGTGCATGGTCCGGACCGTGAGACGGCGATTGCG
CGCATGCATTTGGCGCTGAGCGAAATGGTCGTGGATGGGATCAAGACCAATATCCCATTGCAGCAGCGCATTATGTGCGA
TAAGGGTTTCCAGTCCGGTGGACAGAACATCCATTATTTGGAGAAGTGTTTGGCGGAGCGTAAGAACCAAACGATCGGGC
GGACCTGA

Upstream 100 bases:

>100_bases
TCAGCCGGTTGAGTTTGACCAACCGCTGTTTGTGATCCGCTGAGCCATACATCAGGCGTTGGCCGTTGCCTTAAGGACGC
CGTACTTCGGAACCTTTCTC

Downstream 100 bases:

>100_bases
GAAGCAGCGGTGATCGCGCGGGATGCACGCCGCAGAAATTCGATGCGGAAACGGGCTTTAGAATGAATGGAGCACTTCCC
CGGCATCGTATTGATGTCGG

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MLDKVVIANRGEIALRILRACHTLGIRTVAVHSTVDRNLKHVAMADESVCIGPAPSAESYLNIPALIAAAEVTDAQAIHP
GYGFLSENASFAERVEQSGFIFIGPRAETIRLMGDKVQAIHAMKAAGVPCVPGSDGPLGDDIVANVKIAREIGYPVIIKA
SGGGGGRGMRVVHTEAGLEAAIETTQCEAKAAFGNGQVYMEKFLENPRHVEIQVLADGQGNAIHLGERDCSMQRRHQKVV
EEAPAPGITEALRNEIGQVCVDACIRIGYRGAGTFEFLFENGRFYFIEMNTRIQVEHPVTERITGIDLVCEQLRIAAGQP
LSIKQSDVVLRGHAIECRINAEDAETFLPNPGLITAFHPPGGPGVRMDTHIYSGYKVPPNYDSMIGKLIVHGPDRETAIA
RMHLALSEMVVDGIKTNIPLQQRIMCDKGFQSGGQNIHYLEKCLAERKNQTIGRT

Sequences:

>Translated_455_residues
MLDKVVIANRGEIALRILRACHTLGIRTVAVHSTVDRNLKHVAMADESVCIGPAPSAESYLNIPALIAAAEVTDAQAIHP
GYGFLSENASFAERVEQSGFIFIGPRAETIRLMGDKVQAIHAMKAAGVPCVPGSDGPLGDDIVANVKIAREIGYPVIIKA
SGGGGGRGMRVVHTEAGLEAAIETTQCEAKAAFGNGQVYMEKFLENPRHVEIQVLADGQGNAIHLGERDCSMQRRHQKVV
EEAPAPGITEALRNEIGQVCVDACIRIGYRGAGTFEFLFENGRFYFIEMNTRIQVEHPVTERITGIDLVCEQLRIAAGQP
LSIKQSDVVLRGHAIECRINAEDAETFLPNPGLITAFHPPGGPGVRMDTHIYSGYKVPPNYDSMIGKLIVHGPDRETAIA
RMHLALSEMVVDGIKTNIPLQQRIMCDKGFQSGGQNIHYLEKCLAERKNQTIGRT
>Mature_455_residues
MLDKVVIANRGEIALRILRACHTLGIRTVAVHSTVDRNLKHVAMADESVCIGPAPSAESYLNIPALIAAAEVTDAQAIHP
GYGFLSENASFAERVEQSGFIFIGPRAETIRLMGDKVQAIHAMKAAGVPCVPGSDGPLGDDIVANVKIAREIGYPVIIKA
SGGGGGRGMRVVHTEAGLEAAIETTQCEAKAAFGNGQVYMEKFLENPRHVEIQVLADGQGNAIHLGERDCSMQRRHQKVV
EEAPAPGITEALRNEIGQVCVDACIRIGYRGAGTFEFLFENGRFYFIEMNTRIQVEHPVTERITGIDLVCEQLRIAAGQP
LSIKQSDVVLRGHAIECRINAEDAETFLPNPGLITAFHPPGGPGVRMDTHIYSGYKVPPNYDSMIGKLIVHGPDRETAIA
RMHLALSEMVVDGIKTNIPLQQRIMCDKGFQSGGQNIHYLEKCLAERKNQTIGRT

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=48.6363636363636, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=48.3069977426637, Blast_Score=407, Evalue=1e-114,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=48.3069977426637, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=48.3069977426637, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=46.3251670378619, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=46.3251670378619, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=46.3251670378619, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI38679960, Length=514, Percent_Identity=30.5447470817121, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI38679977, Length=514, Percent_Identity=30.5447470817121, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI38679967, Length=514, Percent_Identity=30.5447470817121, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI38679971, Length=514, Percent_Identity=30.5447470817121, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI38679974, Length=514, Percent_Identity=30.5447470817121, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI134142062, Length=516, Percent_Identity=29.8449612403101, Blast_Score=222, Evalue=7e-58,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=77.027027027027, Blast_Score=678, Evalue=0.0,
Organism=Escherichia coli, GI1786216, Length=189, Percent_Identity=25.3968253968254, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17567343, Length=449, Percent_Identity=47.8841870824053, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71987519, Length=436, Percent_Identity=49.0825688073394, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=43.0803571428571, Blast_Score=343, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI133931226, Length=500, Percent_Identity=28, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI71997168, Length=522, Percent_Identity=28.3524904214559, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71997163, Length=522, Percent_Identity=28.3524904214559, Blast_Score=183, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6319685, Length=433, Percent_Identity=43.4180138568129, Blast_Score=357, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=44.6428571428571, Blast_Score=344, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=45.3125, Blast_Score=333, Evalue=4e-92,
Organism=Saccharomyces cerevisiae, GI6324343, Length=536, Percent_Identity=29.6641791044776, Blast_Score=226, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6323863, Length=465, Percent_Identity=32.4731182795699, Blast_Score=213, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24652212, Length=445, Percent_Identity=47.6404494382022, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652210, Length=445, Percent_Identity=47.6404494382022, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652214, Length=445, Percent_Identity=47.6404494382022, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI19921944, Length=445, Percent_Identity=47.6404494382022, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652216, Length=445, Percent_Identity=47.6404494382022, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI281363050, Length=445, Percent_Identity=47.6404494382022, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652224, Length=445, Percent_Identity=47.6404494382022, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652222, Length=445, Percent_Identity=47.6404494382022, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652220, Length=445, Percent_Identity=47.6404494382022, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652218, Length=445, Percent_Identity=47.6404494382022, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24651757, Length=441, Percent_Identity=45.8049886621315, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24651759, Length=402, Percent_Identity=45.5223880597015, Blast_Score=341, Evalue=5e-94,
Organism=Drosophila melanogaster, GI161076409, Length=514, Percent_Identity=29.3774319066148, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI161076407, Length=514, Percent_Identity=29.3774319066148, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24586460, Length=514, Percent_Identity=29.3774319066148, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24586458, Length=514, Percent_Identity=29.3774319066148, Blast_Score=211, Evalue=8e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49338; Mature: 49338

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKVVIANRGEIALRILRACHTLGIRTVAVHSTVDRNLKHVAMADESVCIGPAPSAESY
CCCCEEEECCCHHHHHHHHHHHHCCCEEEEEECHHHCCCEEEEECCCCEEECCCCCCCHH
LNIPALIAAAEVTDAQAIHPGYGFLSENASFAERVEQSGFIFIGPRAETIRLMGDKVQAI
CCCHHHEEEHHCCCCCEECCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEHHHHHHHH
HAMKAAGVPCVPGSDGPLGDDIVANVKIAREIGYPVIIKASGGGGGRGMRVVHTEAGLEA
HHHHHCCCCCCCCCCCCCCCCHHEEEEEHHHCCCCEEEEECCCCCCCCEEEEEECCCCHH
AIETTQCEAKAAFGNGQVYMEKFLENPRHVEIQVLADGQGNAIHLGERDCSMQRRHQKVV
HHHHHHCCEEEECCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGITEALRNEIGQVCVDACIRIGYRGAGTFEFLFENGRFYFIEMNTRIQVEHPVT
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
ERITGIDLVCEQLRIAAGQPLSIKQSDVVLRGHAIECRINAEDAETFLPNPGLITAFHPP
HHHCCHHHHHHHHHHHCCCCCCCCCCCEEEECEEEEEEEECCCHHHCCCCCCEEEEECCC
GGPGVRMDTHIYSGYKVPPNYDSMIGKLIVHGPDRETAIARMHLALSEMVVDGIKTNIPL
CCCCCEEEEEEECCCCCCCCHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCH
QQRIMCDKGFQSGGQNIHYLEKCLAERKNQTIGRT
HHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLDKVVIANRGEIALRILRACHTLGIRTVAVHSTVDRNLKHVAMADESVCIGPAPSAESY
CCCCEEEECCCHHHHHHHHHHHHCCCEEEEEECHHHCCCEEEEECCCCEEECCCCCCCHH
LNIPALIAAAEVTDAQAIHPGYGFLSENASFAERVEQSGFIFIGPRAETIRLMGDKVQAI
CCCHHHEEEHHCCCCCEECCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEHHHHHHHH
HAMKAAGVPCVPGSDGPLGDDIVANVKIAREIGYPVIIKASGGGGGRGMRVVHTEAGLEA
HHHHHCCCCCCCCCCCCCCCCHHEEEEEHHHCCCCEEEEECCCCCCCCEEEEEECCCCHH
AIETTQCEAKAAFGNGQVYMEKFLENPRHVEIQVLADGQGNAIHLGERDCSMQRRHQKVV
HHHHHHCCEEEECCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGITEALRNEIGQVCVDACIRIGYRGAGTFEFLFENGRFYFIEMNTRIQVEHPVT
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
ERITGIDLVCEQLRIAAGQPLSIKQSDVVLRGHAIECRINAEDAETFLPNPGLITAFHPP
HHHCCHHHHHHHHHHHCCCCCCCCCCCEEEECEEEEEEEECCCHHHCCCCCCEEEEECCC
GGPGVRMDTHIYSGYKVPPNYDSMIGKLIVHGPDRETAIARMHLALSEMVVDGIKTNIPL
CCCCCEEEEEEECCCCCCCCHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCH
QQRIMCDKGFQSGGQNIHYLEKCLAERKNQTIGRT
HHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]