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The map label for this gene is vanR [H]

Identifier: 170757144

GI number: 170757144

Start: 1788325

End: 1789017

Strand: Reverse

Name: vanR [H]

Synonym: CLD_2942

Alternate gene names: 170757144

Gene position: 1789017-1788325 (Counterclockwise)

Preceding gene: 170755985

Following gene: 170755566

Centisome position: 45.2

GC content: 30.45

Gene sequence:

>693_bases
ATGTTTGAATATAAGGTTTTAATAGTTGATGATGAAGATGAAATAAGGGACGCTATAGAAATTTATTTAAGAAATGAAGG
TATAACTGTTTTCAAGGCTAAAGATGGAATAGATGCATTAATGCTTTTAGAAGACCAGGACATCCATCTTATTATAATGG
ATATTATGATGCCTAAAATGGATGGCATTAAGGCAACCTTCAAAATTAGAGAAAATAAAAACATTCCTATAATAATGCTT
TCAGCTAAATCTGAGGATACGGATAAAATATTAGGGCTTAATATAGGGGCAGATGATTATGTTACAAAACCTTTTAATAT
GCTAGAGCTAGTAGCCAGGGTTAAATCTCAGCTTAGAAGATATGTAAATTTAGGAAACTATAAAGAAACTGAAGATAAAG
TTGTAGCGGGTACTCTTGTTTTAGATAAAAAAAGAAAAATAGTAACTGTAGATGAAAAGAAAATAAGACTTACCCCTATC
GAGTATAGAATACTAGAACTTTTGATAGAAAACAAAGGAAGAGTATTTTCTATTGAAGAAATTTATGAAAAGGCTTGGAA
GGAACCCTATTACAATGGTGAAAATACTGTAGCTGTGCATATAAGAAGAATAAGAGAAAAAATTGAAATTAATCCTAGAG
AACCTAGGTACTTGAAGGTGGTGTGGGGAATTGGATATAAAATTCAAGAATAA

Upstream 100 bases:

>100_bases
TTATTATTGTAGAAAAAAACAGTAAGGTTAATTTTGATGACCTATTTAGGAGGTAATAAAAATGTTATAATTTATTCCGT
AAAGAAAGGATGGGACAAGT

Downstream 100 bases:

>100_bases
ATTTATTTATATAATATGTTTCATTGTAGGTATATATATGCTATCTCTTTCAATTTTAACTGGATATGATTTAATAAAAA
ACAGAAAATATCTTGTTAAA

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MFEYKVLIVDDEDEIRDAIEIYLRNEGITVFKAKDGIDALMLLEDQDIHLIIMDIMMPKMDGIKATFKIRENKNIPIIML
SAKSEDTDKILGLNIGADDYVTKPFNMLELVARVKSQLRRYVNLGNYKETEDKVVAGTLVLDKKRKIVTVDEKKIRLTPI
EYRILELLIENKGRVFSIEEIYEKAWKEPYYNGENTVAVHIRRIREKIEINPREPRYLKVVWGIGYKIQE

Sequences:

>Translated_230_residues
MFEYKVLIVDDEDEIRDAIEIYLRNEGITVFKAKDGIDALMLLEDQDIHLIIMDIMMPKMDGIKATFKIRENKNIPIIML
SAKSEDTDKILGLNIGADDYVTKPFNMLELVARVKSQLRRYVNLGNYKETEDKVVAGTLVLDKKRKIVTVDEKKIRLTPI
EYRILELLIENKGRVFSIEEIYEKAWKEPYYNGENTVAVHIRRIREKIEINPREPRYLKVVWGIGYKIQE
>Mature_230_residues
MFEYKVLIVDDEDEIRDAIEIYLRNEGITVFKAKDGIDALMLLEDQDIHLIIMDIMMPKMDGIKATFKIRENKNIPIIML
SAKSEDTDKILGLNIGADDYVTKPFNMLELVARVKSQLRRYVNLGNYKETEDKVVAGTLVLDKKRKIVTVDEKKIRLTPI
EYRILELLIENKGRVFSIEEIYEKAWKEPYYNGENTVAVHIRRIREKIEINPREPRYLKVVWGIGYKIQE

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=35.8407079646018, Blast_Score=150, Evalue=5e-38,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=33.4821428571429, Blast_Score=140, Evalue=5e-35,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=35.2422907488987, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=33.6322869955157, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=32.4561403508772, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=33.4821428571429, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=33.1858407079646, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=34.061135371179, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=31.5555555555556, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1789402, Length=229, Percent_Identity=30.5676855895196, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=29.646017699115, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1787229, Length=213, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=30.6666666666667, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=39.2523364485981, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=26.9565217391304, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790299, Length=117, Percent_Identity=31.6239316239316, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=35.6435643564356, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26979; Mature: 26979

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEYKVLIVDDEDEIRDAIEIYLRNEGITVFKAKDGIDALMLLEDQDIHLIIMDIMMPKM
CCEEEEEEECCHHHHHHHEEEEEECCCEEEEEECCCCEEEEEEECCCCEEEEEEECCCCC
DGIKATFKIRENKNIPIIMLSAKSEDTDKILGLNIGADDYVTKPFNMLELVARVKSQLRR
CCCEEEEEEECCCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
YVNLGNYKETEDKVVAGTLVLDKKRKIVTVDEKKIRLTPIEYRILELLIENKGRVFSIEE
HHCCCCCCCCCCEEEEEEEEEECCCEEEEECCCEEEECHHHHHHHHHHHHCCCCEEEHHH
IYEKAWKEPYYNGENTVAVHIRRIREKIEINPREPRYLKVVWGIGYKIQE
HHHHHHCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCEEEEEEECCEEECC
>Mature Secondary Structure
MFEYKVLIVDDEDEIRDAIEIYLRNEGITVFKAKDGIDALMLLEDQDIHLIIMDIMMPKM
CCEEEEEEECCHHHHHHHEEEEEECCCEEEEEECCCCEEEEEEECCCCEEEEEEECCCCC
DGIKATFKIRENKNIPIIMLSAKSEDTDKILGLNIGADDYVTKPFNMLELVARVKSQLRR
CCCEEEEEEECCCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
YVNLGNYKETEDKVVAGTLVLDKKRKIVTVDEKKIRLTPIEYRILELLIENKGRVFSIEE
HHCCCCCCCCCCEEEEEEEEEECCCEEEEECCCEEEECHHHHHHHHHHHHCCCCEEEHHH
IYEKAWKEPYYNGENTVAVHIRRIREKIEINPREPRYLKVVWGIGYKIQE
HHHHHHCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCEEEEEEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]