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The map label for this gene is cpx [H]

Identifier: 170756350

GI number: 170756350

Start: 396049

End: 397350

Strand: Direct

Name: cpx [H]

Synonym: CLD_0437

Alternate gene names: 170756350

Gene position: 396049-397350 (Clockwise)

Preceding gene: 170754224

Following gene: 170755314

Centisome position: 10.01

GC content: 32.8

Gene sequence:

>1302_bases
ATGAAAAAAAATGAGACGGATATTCAGTTAATGTATGGGGTTAATGATAAGCCAAAAATATTAATGCAAATTTTATTAGG
ATTGCAGCATATTTTTGCGGCTTTTGGTGGAATAATTGTTGTTCCAATTGTTATTTCAGCAGCCTTAGGCTTTGATGCTA
AAATTTCAACTGCATTAATTAGTAGTGCAATTTTAGCGGCAGGGGTGGCTACTTTCATTCAGTCAAGAGGAATAGGTCCT
ATTGGAGCACGTGTTGCCTGCATTATGGGAACTGATTTTACATTTGTTGCACCAGCAATTGCTGTTGGTGGAAAGTTTGG
ATTATCAGGAATTTTTGGTGCAACAATTTTAGGTGCTGGTATAGTAATTATTTTAAGTTTTTTTGTTAAGCCACTAATGA
AACTATTTCCACCTATTGTGACAGGAACAGTTGTGAGTTTAATTGGGTTAACATTATTACCAGTTTCAATAGATTGGGCA
GCAGGTGGTGTTGGATCAGCTAATTATGGAAGTTTAAAAAATATTTCTATTGCTTTATTTATAATGATAGTTACATTATT
ACTAAATCATTATGGAAAAGGATTAGTAAGTAGTGCTTCAATCTTAATAGGTATGGTTGTTGGATATATAATTTGTATTC
CATTAGGAATGGTTGATTTTTCATCAGTAAGCCAAGCTAGTTGGGTATCATTACCTAAAATTTTTGGCTATGGTATAACT
TTTAACTTACAGGTTTTATTACCTTTTATTCCTGCATATTTTGTTACTATCATTGGAACTGTTGGATGTCTTAAAGCCAT
TACTGAAGTTTCTGGAATTAAAGAAGATGAAAAACCTATTACAGCAGGAGTCTTATCTGATGGTGTAGGAAGTATGTTAG
CAGGGGTTTTTGGTGCCTTACCCAATACATCATTTAGTCAAAATATTGGATTAATTCCTCTAACAAAAGTAGCTAGCCGT
TATGTAACAATGATGGCTGGAATACTATTAGTTATTTTAGGATTGTTTCCTAAATTTGCTGCACTAATCAACATAATGCC
ACAGCCGGTACTTGGTGGTGTAGGAATTGTTATGTTTGGAACAGTTGCTGCAGCAGGAATTCAAACTTTAAGTAGTGTAA
AGTTAAATAATAGAAATATGTTAATAATTGCTACATCCATTGGCTTAGGATTAGGAGTTACCTTCCGTCCGGAATTTATT
GCTCAATTACCAGAATCCTTAAAAATGATTTTTTCATCAGGAATTTCAACTGGAACAATTGTAGCTTTATTATTAAATGT
AATATTAAAAGAAAAAGAATAA

Upstream 100 bases:

>100_bases
TTATCTCCTATATAGGTGGATTCTTATTTATGTACCTTAAGATGCTGTATGATAAATAAATATTTAGAGCATTAATAAAG
TTAGGGAGGAGAGTAGTAAA

Downstream 100 bases:

>100_bases
GGAATTTTACGGGGTGATATAAGTGGAAAAATTACAAAATCGTATTTTACAAGAAGGGCATGCATTATCTGAAACTGTAT
TAAAGGTGGATTCTTTTTTA

Product: xanthine/uracil permease family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MKKNETDIQLMYGVNDKPKILMQILLGLQHIFAAFGGIIVVPIVISAALGFDAKISTALISSAILAAGVATFIQSRGIGP
IGARVACIMGTDFTFVAPAIAVGGKFGLSGIFGATILGAGIVIILSFFVKPLMKLFPPIVTGTVVSLIGLTLLPVSIDWA
AGGVGSANYGSLKNISIALFIMIVTLLLNHYGKGLVSSASILIGMVVGYIICIPLGMVDFSSVSQASWVSLPKIFGYGIT
FNLQVLLPFIPAYFVTIIGTVGCLKAITEVSGIKEDEKPITAGVLSDGVGSMLAGVFGALPNTSFSQNIGLIPLTKVASR
YVTMMAGILLVILGLFPKFAALINIMPQPVLGGVGIVMFGTVAAAGIQTLSSVKLNNRNMLIIATSIGLGLGVTFRPEFI
AQLPESLKMIFSSGISTGTIVALLLNVILKEKE

Sequences:

>Translated_433_residues
MKKNETDIQLMYGVNDKPKILMQILLGLQHIFAAFGGIIVVPIVISAALGFDAKISTALISSAILAAGVATFIQSRGIGP
IGARVACIMGTDFTFVAPAIAVGGKFGLSGIFGATILGAGIVIILSFFVKPLMKLFPPIVTGTVVSLIGLTLLPVSIDWA
AGGVGSANYGSLKNISIALFIMIVTLLLNHYGKGLVSSASILIGMVVGYIICIPLGMVDFSSVSQASWVSLPKIFGYGIT
FNLQVLLPFIPAYFVTIIGTVGCLKAITEVSGIKEDEKPITAGVLSDGVGSMLAGVFGALPNTSFSQNIGLIPLTKVASR
YVTMMAGILLVILGLFPKFAALINIMPQPVLGGVGIVMFGTVAAAGIQTLSSVKLNNRNMLIIATSIGLGLGVTFRPEFI
AQLPESLKMIFSSGISTGTIVALLLNVILKEKE
>Mature_433_residues
MKKNETDIQLMYGVNDKPKILMQILLGLQHIFAAFGGIIVVPIVISAALGFDAKISTALISSAILAAGVATFIQSRGIGP
IGARVACIMGTDFTFVAPAIAVGGKFGLSGIFGATILGAGIVIILSFFVKPLMKLFPPIVTGTVVSLIGLTLLPVSIDWA
AGGVGSANYGSLKNISIALFIMIVTLLLNHYGKGLVSSASILIGMVVGYIICIPLGMVDFSSVSQASWVSLPKIFGYGIT
FNLQVLLPFIPAYFVTIIGTVGCLKAITEVSGIKEDEKPITAGVLSDGVGSMLAGVFGALPNTSFSQNIGLIPLTKVASR
YVTMMAGILLVILGLFPKFAALINIMPQPVLGGVGIVMFGTVAAAGIQTLSSVKLNNRNMLIIATSIGLGLGVTFRPEFI
AQLPESLKMIFSSGISTGTIVALLLNVILKEKE

Specific function: Unknown

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=468, Percent_Identity=25.8547008547009, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI44680143, Length=472, Percent_Identity=25.4237288135593, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI44680148, Length=500, Percent_Identity=25, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI40316845, Length=500, Percent_Identity=25, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI87082181, Length=414, Percent_Identity=39.6135265700483, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI1790087, Length=452, Percent_Identity=34.7345132743363, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI87082178, Length=442, Percent_Identity=34.1628959276018, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI1788843, Length=394, Percent_Identity=29.9492385786802, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI87081818, Length=449, Percent_Identity=28.5077951002227, Blast_Score=135, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17558856, Length=471, Percent_Identity=25.2653927813163, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17541904, Length=455, Percent_Identity=25.0549450549451, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17542262, Length=445, Percent_Identity=24.7191011235955, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71993493, Length=443, Percent_Identity=23.7020316027088, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI193206893, Length=458, Percent_Identity=24.6724890829694, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17542260, Length=109, Percent_Identity=37.6146788990826, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356175, Length=434, Percent_Identity=25.3456221198157, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44980; Mature: 44980

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNETDIQLMYGVNDKPKILMQILLGLQHIFAAFGGIIVVPIVISAALGFDAKISTALI
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SSAILAAGVATFIQSRGIGPIGARVACIMGTDFTFVAPAIAVGGKFGLSGIFGATILGAG
HHHHHHHHHHHHHHHCCCCCHHHHEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IVIILSFFVKPLMKLFPPIVTGTVVSLIGLTLLPVSIDWAAGGVGSANYGSLKNISIALF
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCCHHHHHHHH
IMIVTLLLNHYGKGLVSSASILIGMVVGYIICIPLGMVDFSSVSQASWVSLPKIFGYGIT
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHCCCCE
FNLQVLLPFIPAYFVTIIGTVGCLKAITEVSGIKEDEKPITAGVLSDGVGSMLAGVFGAL
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHCC
PNTSFSQNIGLIPLTKVASRYVTMMAGILLVILGLFPKFAALINIMPQPVLGGVGIVMFG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCHHHHHHHH
TVAAAGIQTLSSVKLNNRNMLIIATSIGLGLGVTFRPEFIAQLPESLKMIFSSGISTGTI
HHHHHHHHHHHHHEECCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
VALLLNVILKEKE
HHHHHHHHHCCCC
>Mature Secondary Structure
MKKNETDIQLMYGVNDKPKILMQILLGLQHIFAAFGGIIVVPIVISAALGFDAKISTALI
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SSAILAAGVATFIQSRGIGPIGARVACIMGTDFTFVAPAIAVGGKFGLSGIFGATILGAG
HHHHHHHHHHHHHHHCCCCCHHHHEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IVIILSFFVKPLMKLFPPIVTGTVVSLIGLTLLPVSIDWAAGGVGSANYGSLKNISIALF
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCCHHHHHHHH
IMIVTLLLNHYGKGLVSSASILIGMVVGYIICIPLGMVDFSSVSQASWVSLPKIFGYGIT
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHCCCCE
FNLQVLLPFIPAYFVTIIGTVGCLKAITEVSGIKEDEKPITAGVLSDGVGSMLAGVFGAL
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHCC
PNTSFSQNIGLIPLTKVASRYVTMMAGILLVILGLFPKFAALINIMPQPVLGGVGIVMFG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCHHHHHHHH
TVAAAGIQTLSSVKLNNRNMLIIATSIGLGLGVTFRPEFIAQLPESLKMIFSSGISTGTI
HHHHHHHHHHHHHEECCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
VALLLNVILKEKE
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11792842; 8162194 [H]