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The map label for this gene is npr

Identifier: 170756071

GI number: 170756071

Start: 1600531

End: 1602252

Strand: Reverse

Name: npr

Synonym: CLD_3108

Alternate gene names: 170756071

Gene position: 1602252-1600531 (Counterclockwise)

Preceding gene: 170756874

Following gene: 170755051

Centisome position: 40.48

GC content: 28.57

Gene sequence:

>1722_bases
ATGAAAAGTAAAAAATTATTAACTATACTTTTAAGTGCTATAATAACAGCTTCATCAATTTCATCAGTTTACGCTGCAGA
ACCCGTAGGAATAAAAAGTAAATACCAACCAAAAACTACCACTATATTTTGGGAAAAAGGTAAACAAAATAATAAGAAAT
CTGTCACTAATATAGCTTCAGAAAAATTCAACAATTTCGAAGAAATAAACCAGTTCTTTCAACAAAATATATCTAGGTTT
GGTTTAAAAAAAGGCTCTCTTAAAAGTACCAAAACTTTAAAGGATGAAAAAGGAAAGATCCACTATCATACAATTTACCA
AGTGGAAGGTATACCTGTATACTATGGAAGGATCGTTTTTACTACTGAAAAAGATTCCACTATAAGTTCTATAAATGGCG
GAGTAGATATTTCCTTTGAAAATGAGAATTGGAAAAACAAAATTAAACTATCAAAGAATGATGCTATGGCAAAAGCTAAA
AATAACATCAAATATGAAGAGTTACATGCTTCAAAGGCAGACTTATATTTATATAATTTTGAAGGAAAGCCTTATGTTGT
TTATTTAGTAGATTTAAGCACAGATGCTGGAGATTGGAATATCTTTGTTAATGCTGAAGATGGTTCTATAGTAAATAAAT
TTAATAATACCCCTACTCTAACTAATACTAGGGATAAGAAATTCACCAGTACTAAAAAAACCAATACTAAAGTTAATAAA
TCAAATAATTTAATTGATGTTCAAGGTAATACCATTAAAGGAAAAGGTAAAAGCTCTTTAAATGGAATAGTAGATATTGA
TCTAACTTATAAAGATGGAAAATATTATTTAAAAAATAGCAACAAAAATATTTATATCTATGATATAAATAATAAATATA
TAGGCTATACTAAATCAGATCTGTTAAGAGCTTCTAGCCTTGTAGAAAATAATAGCAATGAATTTACAAATGATAAACAT
ATAATTGCTGTGGATACTTATATAAACTTAGAGAAAACTTATGATTATTACAAAGATAAATTTAATAGAAATAGTATTGA
TAATAAAGGTATGAAGGTTGAAGCCTTTGTTGATTACAATGCAGTTGGAGATGCTGCTTGGAGTGAAGAATTTAATTCCA
TGTTTTTTGGAAATGGTGATGGAAAAAACTTTGCTCATATGTCAAAGTCTTTAGATATAGTAGGTCATGAATTCAGTCAT
GGTGTAACACATAAAGAATCTAATCTTAAATATGAAAATGAATCTGGAGCTTTAAATGAATCCTTTTCAGATATTATGGG
AGTAGCTATTAAAGGTAAAAACTTTAAACTAGGGGAAGATTCCTGGAAACCAAATACTGAGGAAGCTGCAATAAGAGATA
TGCAATATCCATCTAAAAGAGGACAGCCAGCTCATATGAAAGATTATAGATATATGCCTGCCACTCCGATGGGTGATAAT
GGTGGTGTTCATTTAAATTCAGGTATAATAAATCATGCAGCTTACCTAATTGCAGACGGAATAGAAAAATTAGGGGTAGA
AAATAGTAAAGATATTATGGCAAAATTATTTTATACAGCTAATTGCTATGAATGGGATGAGACAACAAATTTCTCTAAAT
GTAGAAATGACTTAATTAAAGTTACTAAAAACCTTTACGGTGAAAATAGTAAATATGTTCAAATTGTAGAAAATGCTTTT
GACAAAGTTGGAATAACTGCTACACCTCAATTACCATTATAA

Upstream 100 bases:

>100_bases
ACTATATAAAAAACTAAATTTAAATAAATAAGATGATTTCTATTCAAGTAAGAAATCATCTTATTTATATATAATAATTA
TATTGGGGGCTAAAATATTT

Downstream 100 bases:

>100_bases
TAAAATTCTATTAAACCTATAAATATAACTATGTAAAAAACTAAATTTAAATAAATAAGATAATTTCTTATTTGCATAGA
AATCATCTTATTTATATATA

Product: thermolysin metallopeptidase

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 573; Mature: 573

Protein sequence:

>573_residues
MKSKKLLTILLSAIITASSISSVYAAEPVGIKSKYQPKTTTIFWEKGKQNNKKSVTNIASEKFNNFEEINQFFQQNISRF
GLKKGSLKSTKTLKDEKGKIHYHTIYQVEGIPVYYGRIVFTTEKDSTISSINGGVDISFENENWKNKIKLSKNDAMAKAK
NNIKYEELHASKADLYLYNFEGKPYVVYLVDLSTDAGDWNIFVNAEDGSIVNKFNNTPTLTNTRDKKFTSTKKTNTKVNK
SNNLIDVQGNTIKGKGKSSLNGIVDIDLTYKDGKYYLKNSNKNIYIYDINNKYIGYTKSDLLRASSLVENNSNEFTNDKH
IIAVDTYINLEKTYDYYKDKFNRNSIDNKGMKVEAFVDYNAVGDAAWSEEFNSMFFGNGDGKNFAHMSKSLDIVGHEFSH
GVTHKESNLKYENESGALNESFSDIMGVAIKGKNFKLGEDSWKPNTEEAAIRDMQYPSKRGQPAHMKDYRYMPATPMGDN
GGVHLNSGIINHAAYLIADGIEKLGVENSKDIMAKLFYTANCYEWDETTNFSKCRNDLIKVTKNLYGENSKYVQIVENAF
DKVGITATPQLPL

Sequences:

>Translated_573_residues
MKSKKLLTILLSAIITASSISSVYAAEPVGIKSKYQPKTTTIFWEKGKQNNKKSVTNIASEKFNNFEEINQFFQQNISRF
GLKKGSLKSTKTLKDEKGKIHYHTIYQVEGIPVYYGRIVFTTEKDSTISSINGGVDISFENENWKNKIKLSKNDAMAKAK
NNIKYEELHASKADLYLYNFEGKPYVVYLVDLSTDAGDWNIFVNAEDGSIVNKFNNTPTLTNTRDKKFTSTKKTNTKVNK
SNNLIDVQGNTIKGKGKSSLNGIVDIDLTYKDGKYYLKNSNKNIYIYDINNKYIGYTKSDLLRASSLVENNSNEFTNDKH
IIAVDTYINLEKTYDYYKDKFNRNSIDNKGMKVEAFVDYNAVGDAAWSEEFNSMFFGNGDGKNFAHMSKSLDIVGHEFSH
GVTHKESNLKYENESGALNESFSDIMGVAIKGKNFKLGEDSWKPNTEEAAIRDMQYPSKRGQPAHMKDYRYMPATPMGDN
GGVHLNSGIINHAAYLIADGIEKLGVENSKDIMAKLFYTANCYEWDETTNFSKCRNDLIKVTKNLYGENSKYVQIVENAF
DKVGITATPQLPL
>Mature_573_residues
MKSKKLLTILLSAIITASSISSVYAAEPVGIKSKYQPKTTTIFWEKGKQNNKKSVTNIASEKFNNFEEINQFFQQNISRF
GLKKGSLKSTKTLKDEKGKIHYHTIYQVEGIPVYYGRIVFTTEKDSTISSINGGVDISFENENWKNKIKLSKNDAMAKAK
NNIKYEELHASKADLYLYNFEGKPYVVYLVDLSTDAGDWNIFVNAEDGSIVNKFNNTPTLTNTRDKKFTSTKKTNTKVNK
SNNLIDVQGNTIKGKGKSSLNGIVDIDLTYKDGKYYLKNSNKNIYIYDINNKYIGYTKSDLLRASSLVENNSNEFTNDKH
IIAVDTYINLEKTYDYYKDKFNRNSIDNKGMKVEAFVDYNAVGDAAWSEEFNSMFFGNGDGKNFAHMSKSLDIVGHEFSH
GVTHKESNLKYENESGALNESFSDIMGVAIKGKNFKLGEDSWKPNTEEAAIRDMQYPSKRGQPAHMKDYRYMPATPMGDN
GGVHLNSGIINHAAYLIADGIEKLGVENSKDIMAKLFYTANCYEWDETTNFSKCRNDLIKVTKNLYGENSKYVQIVENAF
DKVGITATPQLPL

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 64743; Mature: 64743

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKKLLTILLSAIITASSISSVYAAEPVGIKSKYQPKTTTIFWEKGKQNNKKSVTNIAS
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHH
EKFNNFEEINQFFQQNISRFGLKKGSLKSTKTLKDEKGKIHYHTIYQVEGIPVYYGRIVF
HHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEEECCEEEEEEEEEE
TTEKDSTISSINGGVDISFENENWKNKIKLSKNDAMAKAKNNIKYEELHASKADLYLYNF
EECCCCCHHHCCCCEEEEECCCCCCEEEEECCCHHHHHHHCCCCHHHHCCCCCEEEEEEE
EGKPYVVYLVDLSTDAGDWNIFVNAEDGSIVNKFNNTPTLTNTRDKKFTSTKKTNTKVNK
CCCEEEEEEEEECCCCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEECC
SNNLIDVQGNTIKGKGKSSLNGIVDIDLTYKDGKYYLKNSNKNIYIYDINNKYIGYTKSD
CCCEEEECCCEEECCCCCCCCCEEEEEEEEECCEEEEECCCCEEEEEECCCCEECCCHHH
LLRASSLVENNSNEFTNDKHIIAVDTYINLEKTYDYYKDKFNRNSIDNKGMKVEAFVDYN
HHHHHHHHHCCCCCCCCCCEEEEEEEEEECHHHHHHHHHHCCCCCCCCCCEEEEEEEECC
AVGDAAWSEEFNSMFFGNGDGKNFAHMSKSLDIVGHEFSHGVTHKESNLKYENESGALNE
CCCCCHHHHHHCCEEEECCCCCCHHHHHCCCEEECCHHHCCCCCCCCCCEECCCCCCCCC
SFSDIMGVAIKGKNFKLGEDSWKPNTEEAAIRDMQYPSKRGQPAHMKDYRYMPATPMGDN
CHHHHEEEEEECCCEECCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCEECCCCCCCCC
GGVHLNSGIINHAAYLIADGIEKLGVENSKDIMAKLFYTANCYEWDETTNFSKCRNDLIK
CCEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHEEECCEEECCCCCCHHHHHHHHHH
VTKNLYGENSKYVQIVENAFDKVGITATPQLPL
HHHHHCCCCCCEEEEEHHHHHHCCCEECCCCCC
>Mature Secondary Structure
MKSKKLLTILLSAIITASSISSVYAAEPVGIKSKYQPKTTTIFWEKGKQNNKKSVTNIAS
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHH
EKFNNFEEINQFFQQNISRFGLKKGSLKSTKTLKDEKGKIHYHTIYQVEGIPVYYGRIVF
HHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEEECCEEEEEEEEEE
TTEKDSTISSINGGVDISFENENWKNKIKLSKNDAMAKAKNNIKYEELHASKADLYLYNF
EECCCCCHHHCCCCEEEEECCCCCCEEEEECCCHHHHHHHCCCCHHHHCCCCCEEEEEEE
EGKPYVVYLVDLSTDAGDWNIFVNAEDGSIVNKFNNTPTLTNTRDKKFTSTKKTNTKVNK
CCCEEEEEEEEECCCCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEECC
SNNLIDVQGNTIKGKGKSSLNGIVDIDLTYKDGKYYLKNSNKNIYIYDINNKYIGYTKSD
CCCEEEECCCEEECCCCCCCCCEEEEEEEEECCEEEEECCCCEEEEEECCCCEECCCHHH
LLRASSLVENNSNEFTNDKHIIAVDTYINLEKTYDYYKDKFNRNSIDNKGMKVEAFVDYN
HHHHHHHHHCCCCCCCCCCEEEEEEEEEECHHHHHHHHHHCCCCCCCCCCEEEEEEEECC
AVGDAAWSEEFNSMFFGNGDGKNFAHMSKSLDIVGHEFSHGVTHKESNLKYENESGALNE
CCCCCHHHHHHCCEEEECCCCCCHHHHHCCCEEECCHHHCCCCCCCCCCEECCCCCCCCC
SFSDIMGVAIKGKNFKLGEDSWKPNTEEAAIRDMQYPSKRGQPAHMKDYRYMPATPMGDN
CHHHHEEEEEECCCEECCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCEECCCCCCCCC
GGVHLNSGIINHAAYLIADGIEKLGVENSKDIMAKLFYTANCYEWDETTNFSKCRNDLIK
CCEEECCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHEEECCEEECCCCCCHHHHHHHHHH
VTKNLYGENSKYVQIVENAFDKVGITATPQLPL
HHHHHCCCCCCEEEEEHHHHHHCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7764969 [H]