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The map label for this gene is npr

Identifier: 170754349

GI number: 170754349

Start: 1604275

End: 1606068

Strand: Reverse

Name: npr

Synonym: CLD_3106

Alternate gene names: 170754349

Gene position: 1606068-1604275 (Counterclockwise)

Preceding gene: 170755979

Following gene: 170756874

Centisome position: 40.58

GC content: 30.66

Gene sequence:

>1794_bases
ATGAAAAGTAAAAAATTATTAGCTACAGTGTTAAGTGCTATAATCACTTTTTCAGCAGTTTCAGCAGTTTCAGCAGTTTC
AGCTGCACCTGTAGGAAAAGAAAGTAAAAGTGACCCAAAGACCACAACAATATCTTGGGACAAAAGTGAACAAAATGCTA
AAAAGGCTACTACAGACATAAAGCAAAAGAAATTTAACAATGCTCAAGAAATAACTAAATTCTTTGAGAAAAACATATCT
AAATTCGGGGTAAAAAAAGGTACTCTTAAGAGTACTAAAACTTTAAAAGATGACAAAGGTAAAACTCACTATCATACAAT
TTATGAAGTAGAAGGTATACCTGTATACTATGGAAGAATTGTCTTTACAACTGAAAAAGACTCAACTATGGATTCTATAA
ATGGTAGAGTTGATACTGTTTTTGAAAATGGAAATTGGAAAAACAAAATCAAACTATCAAAAGAAGATGCCATAGCAAAA
GCTAAAGCTGATATTAAAAATGAAAAATCCAACAAGGAAAAGGCTGAGTTATATCTGTATAATTTCGAGGGCAAACCTTA
TGTAGTTTATTTAGTAAATTCAATTACAAATAGCGGTAATTGGGATATTTTTGTTAATGCTGAAGATGGTTCTATAGTAA
ATAAATTTAATAATACCCCTACTCTACTTGATACTAAAGCTGAGAAATTACCCAATGCTAAAAAAATTAAAGATGAAGCT
GAAAAAAATGAAGCTAAAAAGGCTAATAATATGAATAATATAATTGATGTACAAGGTCAAAGCGTTAAAGGATTAGGAAG
AACTAGCTTAGATGGACTAGTAAATATTGATCTAACTTATGGCTATGGAAGATATTATTTAAAAGATAATAATAGAAAAA
TTTATATATATGATTTAAAAAATCAAGTTAATGATACTGACTTAGAAAATTATTTGACTTGGTACCCTGGGAACCACAAT
GAAGCGCTAATGGGTAGATCTGAATTAGTATCTAATTCCAATAATAATTTTGTAGATAATGATAAAGTTAACTCTGTAGA
TGCTTATGTAAATATGGGTAAGTCTTATGATTATTATAAAAATAAACTATCTAGAAATAGTATTGATAATAAAGGTATGG
ATGTTAAGGGATTTGTTCATGTAGGCAAAGATTATGGTAACGCCTTTTGGTATGGAGAATACGATAGTATGTTCTTTGGC
GATGGTAACGGACTATACTTCTCTTCTCTTGCTAAAGCTTTAGATGTTGTAGGCCACGAACTAAGTCATGGTGTTACTAA
TAAACAATCCGATCTTAAATATGAAAAGGAATCTGGTGCTTTAAACGAATCCTTCTCAGATATTATGGGAACAGCTATTG
AGGGTAAAAATTTTGAAATAGGTGAAGACTGCTGGATACCTAGTGATAGATATGGAGAGATAATGAGAGATATGAAGGAT
CCATCTAGAGGAAATCAACCAGCTCATATGAAAGATTTTAGAGATCTTCCTGTTGATGAAGATCATGATTGGGGTGGGGT
TCATACAAATTCAGGTATAATAAACCATGCTGCTTATTTAATTGCAGATGGATTTGAAAAAATGGGTGAAAAAGATAGTA
AAGATATTATGGCAAAAATATTTTATATAGCTAACTGCTATTACTGGGATCAAATAACAGATTTTGCCAAATGCAGAAAT
GATGTAGTTAAAGTTGCTAAAGATCTTTACGGTGACAATAGTAAAGAAGTTCAAATTGTAAAAAATGCTTTTGACCAAGT
TGGAATAACTGCTACACCTCAATTGCCATTATAA

Upstream 100 bases:

>100_bases
ATAAATATATCTATATAAAATTATAAACCTATTGATATTTTGCTATATAAATATCAATAGGTTTATAAGTAAAAATATAT
TAACTGGGGGTTATTTATTC

Downstream 100 bases:

>100_bases
TCAAATATACTTTGATTATAAAATATATTTATAAAACTATATAATTTTAGCATTTTACTTTATAAACATTAATAGGTTTA
TAAGTAAAAATATATTAAAT

Product: thermolysin metallopeptidase

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 597; Mature: 597

Protein sequence:

>597_residues
MKSKKLLATVLSAIITFSAVSAVSAVSAAPVGKESKSDPKTTTISWDKSEQNAKKATTDIKQKKFNNAQEITKFFEKNIS
KFGVKKGTLKSTKTLKDDKGKTHYHTIYEVEGIPVYYGRIVFTTEKDSTMDSINGRVDTVFENGNWKNKIKLSKEDAIAK
AKADIKNEKSNKEKAELYLYNFEGKPYVVYLVNSITNSGNWDIFVNAEDGSIVNKFNNTPTLLDTKAEKLPNAKKIKDEA
EKNEAKKANNMNNIIDVQGQSVKGLGRTSLDGLVNIDLTYGYGRYYLKDNNRKIYIYDLKNQVNDTDLENYLTWYPGNHN
EALMGRSELVSNSNNNFVDNDKVNSVDAYVNMGKSYDYYKNKLSRNSIDNKGMDVKGFVHVGKDYGNAFWYGEYDSMFFG
DGNGLYFSSLAKALDVVGHELSHGVTNKQSDLKYEKESGALNESFSDIMGTAIEGKNFEIGEDCWIPSDRYGEIMRDMKD
PSRGNQPAHMKDFRDLPVDEDHDWGGVHTNSGIINHAAYLIADGFEKMGEKDSKDIMAKIFYIANCYYWDQITDFAKCRN
DVVKVAKDLYGDNSKEVQIVKNAFDQVGITATPQLPL

Sequences:

>Translated_597_residues
MKSKKLLATVLSAIITFSAVSAVSAVSAAPVGKESKSDPKTTTISWDKSEQNAKKATTDIKQKKFNNAQEITKFFEKNIS
KFGVKKGTLKSTKTLKDDKGKTHYHTIYEVEGIPVYYGRIVFTTEKDSTMDSINGRVDTVFENGNWKNKIKLSKEDAIAK
AKADIKNEKSNKEKAELYLYNFEGKPYVVYLVNSITNSGNWDIFVNAEDGSIVNKFNNTPTLLDTKAEKLPNAKKIKDEA
EKNEAKKANNMNNIIDVQGQSVKGLGRTSLDGLVNIDLTYGYGRYYLKDNNRKIYIYDLKNQVNDTDLENYLTWYPGNHN
EALMGRSELVSNSNNNFVDNDKVNSVDAYVNMGKSYDYYKNKLSRNSIDNKGMDVKGFVHVGKDYGNAFWYGEYDSMFFG
DGNGLYFSSLAKALDVVGHELSHGVTNKQSDLKYEKESGALNESFSDIMGTAIEGKNFEIGEDCWIPSDRYGEIMRDMKD
PSRGNQPAHMKDFRDLPVDEDHDWGGVHTNSGIINHAAYLIADGFEKMGEKDSKDIMAKIFYIANCYYWDQITDFAKCRN
DVVKVAKDLYGDNSKEVQIVKNAFDQVGITATPQLPL
>Mature_597_residues
MKSKKLLATVLSAIITFSAVSAVSAVSAAPVGKESKSDPKTTTISWDKSEQNAKKATTDIKQKKFNNAQEITKFFEKNIS
KFGVKKGTLKSTKTLKDDKGKTHYHTIYEVEGIPVYYGRIVFTTEKDSTMDSINGRVDTVFENGNWKNKIKLSKEDAIAK
AKADIKNEKSNKEKAELYLYNFEGKPYVVYLVNSITNSGNWDIFVNAEDGSIVNKFNNTPTLLDTKAEKLPNAKKIKDEA
EKNEAKKANNMNNIIDVQGQSVKGLGRTSLDGLVNIDLTYGYGRYYLKDNNRKIYIYDLKNQVNDTDLENYLTWYPGNHN
EALMGRSELVSNSNNNFVDNDKVNSVDAYVNMGKSYDYYKNKLSRNSIDNKGMDVKGFVHVGKDYGNAFWYGEYDSMFFG
DGNGLYFSSLAKALDVVGHELSHGVTNKQSDLKYEKESGALNESFSDIMGTAIEGKNFEIGEDCWIPSDRYGEIMRDMKD
PSRGNQPAHMKDFRDLPVDEDHDWGGVHTNSGIINHAAYLIADGFEKMGEKDSKDIMAKIFYIANCYYWDQITDFAKCRN
DVVKVAKDLYGDNSKEVQIVKNAFDQVGITATPQLPL

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 67165; Mature: 67165

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKKLLATVLSAIITFSAVSAVSAVSAAPVGKESKSDPKTTTISWDKSEQNAKKATTDI
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
KQKKFNNAQEITKFFEKNISKFGVKKGTLKSTKTLKDDKGKTHYHTIYEVEGIPVYYGRI
HHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEEE
VFTTEKDSTMDSINGRVDTVFENGNWKNKIKLSKEDAIAKAKADIKNEKSNKEKAELYLY
EEEECCCCCHHHCCCCEEEEEECCCCCCEEEECHHHHHHHHHHHHCCCCCCCCEEEEEEE
NFEGKPYVVYLVNSITNSGNWDIFVNAEDGSIVNKFNNTPTLLDTKAEKLPNAKKIKDEA
EECCCEEEEEEEECCCCCCCEEEEEECCCCCHHHHCCCCCCEECCHHHHCCCHHHHHHHH
EKNEAKKANNMNNIIDVQGQSVKGLGRTSLDGLVNIDLTYGYGRYYLKDNNRKIYIYDLK
HHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEECCCEEEEECCCCEEEEEECC
NQVNDTDLENYLTWYPGNHNEALMGRSELVSNSNNNFVDNDKVNSVDAYVNMGKSYDYYK
CCCCCCCCCCCEEECCCCCCCHHCCHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCHHHH
NKLSRNSIDNKGMDVKGFVHVGKDYGNAFWYGEYDSMFFGDGNGLYFSSLAKALDVVGHE
HHHHHCCCCCCCCCEEEEEEECCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHH
LSHGVTNKQSDLKYEKESGALNESFSDIMGTAIEGKNFEIGEDCWIPSDRYGEIMRDMKD
HHCCCCCCHHCCCCCHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCC
PSRGNQPAHMKDFRDLPVDEDHDWGGVHTNSGIINHAAYLIADGFEKMGEKDSKDIMAKI
CCCCCCCCHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
FYIANCYYWDQITDFAKCRNDVVKVAKDLYGDNSKEVQIVKNAFDQVGITATPQLPL
HHHHHEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKSKKLLATVLSAIITFSAVSAVSAVSAAPVGKESKSDPKTTTISWDKSEQNAKKATTDI
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
KQKKFNNAQEITKFFEKNISKFGVKKGTLKSTKTLKDDKGKTHYHTIYEVEGIPVYYGRI
HHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEEE
VFTTEKDSTMDSINGRVDTVFENGNWKNKIKLSKEDAIAKAKADIKNEKSNKEKAELYLY
EEEECCCCCHHHCCCCEEEEEECCCCCCEEEECHHHHHHHHHHHHCCCCCCCCEEEEEEE
NFEGKPYVVYLVNSITNSGNWDIFVNAEDGSIVNKFNNTPTLLDTKAEKLPNAKKIKDEA
EECCCEEEEEEEECCCCCCCEEEEEECCCCCHHHHCCCCCCEECCHHHHCCCHHHHHHHH
EKNEAKKANNMNNIIDVQGQSVKGLGRTSLDGLVNIDLTYGYGRYYLKDNNRKIYIYDLK
HHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEECCCEEEEECCCCEEEEEECC
NQVNDTDLENYLTWYPGNHNEALMGRSELVSNSNNNFVDNDKVNSVDAYVNMGKSYDYYK
CCCCCCCCCCCEEECCCCCCCHHCCHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCHHHH
NKLSRNSIDNKGMDVKGFVHVGKDYGNAFWYGEYDSMFFGDGNGLYFSSLAKALDVVGHE
HHHHHCCCCCCCCCEEEEEEECCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHH
LSHGVTNKQSDLKYEKESGALNESFSDIMGTAIEGKNFEIGEDCWIPSDRYGEIMRDMKD
HHCCCCCCHHCCCCCHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCC
PSRGNQPAHMKDFRDLPVDEDHDWGGVHTNSGIINHAAYLIADGFEKMGEKDSKDIMAKI
CCCCCCCCHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
FYIANCYYWDQITDFAKCRNDVVKVAKDLYGDNSKEVQIVKNAFDQVGITATPQLPL
HHHHHEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7764969 [H]