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The map label for this gene is trx

Identifier: 170754340

GI number: 170754340

Start: 3745531

End: 3745848

Strand: Reverse

Name: trx

Synonym: CLD_1071

Alternate gene names: 170754340

Gene position: 3745848-3745531 (Counterclockwise)

Preceding gene: 170757432

Following gene: 170754359

Centisome position: 94.63

GC content: 32.39

Gene sequence:

>318_bases
ATGGTTAAAGAAATAAATGAAAGCATATTTGGCGAAGAAGTATTAAATTCAGAGATTCCTGTAGTAGTAGATTTTTGGGC
AACATGGTGCGGACCTTGTAAAATGCTTGCTCCTGTAGTGGAAGAAGTATCTCAAGAATTAGGACAAAAAGTAAAATTTG
TTAAAGTTAATGTAGATGAGAATCCGGTTATATCAACACAATATAAAATAGCTAGCATACCAACACTTATGACATTTAAA
GCAGGGAAAGCAGTAGAAACATTAGTTGGATTTAGACCAAAAGAAGCTATAAAATCAGCAGTAGAAAAGCATATTTAA

Upstream 100 bases:

>100_bases
TTTTTATAATACATTTTAAAACTATTGACTAATATATTTGTATATATTAGAATATAAGTAAATACATACCCTATAAGGGT
ATATCGGAGGGTGATTAATT

Downstream 100 bases:

>100_bases
TATAAAATAAATTGAGAATAGCATTAATGTTATTCTCAATTTTACATTTTTTAGGAGGAGATATTATGGGGAAAAGATAT
GATATAGCTATAATAGGTAG

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 105; Mature: 105

Protein sequence:

>105_residues
MVKEINESIFGEEVLNSEIPVVVDFWATWCGPCKMLAPVVEEVSQELGQKVKFVKVNVDENPVISTQYKIASIPTLMTFK
AGKAVETLVGFRPKEAIKSAVEKHI

Sequences:

>Translated_105_residues
MVKEINESIFGEEVLNSEIPVVVDFWATWCGPCKMLAPVVEEVSQELGQKVKFVKVNVDENPVISTQYKIASIPTLMTFK
AGKAVETLVGFRPKEAIKSAVEKHI
>Mature_105_residues
MVKEINESIFGEEVLNSEIPVVVDFWATWCGPCKMLAPVVEEVSQELGQKVKFVKVNVDENPVISTQYKIASIPTLMTFK
AGKAVETLVGFRPKEAIKSAVEKHI

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=96, Percent_Identity=37.5, Blast_Score=84, Evalue=2e-17,
Organism=Homo sapiens, GI50592994, Length=92, Percent_Identity=36.9565217391304, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788936, Length=94, Percent_Identity=44.6808510638298, Blast_Score=97, Evalue=2e-22,
Organism=Escherichia coli, GI87082331, Length=102, Percent_Identity=38.2352941176471, Blast_Score=95, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=36.5591397849462, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17507705, Length=84, Percent_Identity=35.7142857142857, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=85, Percent_Identity=36.4705882352941, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=85, Percent_Identity=36.4705882352941, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=84, Percent_Identity=41.6666666666667, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=86, Percent_Identity=33.7209302325581, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17554386, Length=82, Percent_Identity=37.8048780487805, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=81, Percent_Identity=48.1481481481481, Blast_Score=80, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321648, Length=85, Percent_Identity=43.5294117647059, Blast_Score=79, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319925, Length=85, Percent_Identity=38.8235294117647, Blast_Score=69, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321022, Length=80, Percent_Identity=36.25, Blast_Score=60, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=38.5416666666667, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24639826, Length=91, Percent_Identity=41.7582417582418, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21358065, Length=90, Percent_Identity=38.8888888888889, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17648013, Length=75, Percent_Identity=45.3333333333333, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583090, Length=75, Percent_Identity=45.3333333333333, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664269, Length=85, Percent_Identity=36.4705882352941, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=27.9569892473118, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 11664; Mature: 11664

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKEINESIFGEEVLNSEIPVVVDFWATWCGPCKMLAPVVEEVSQELGQKVKFVKVNVDE
CCCHHHHHHHHHHHHCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEECCC
NPVISTQYKIASIPTLMTFKAGKAVETLVGFRPKEAIKSAVEKHI
CCEECCCEEHHCCCHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MVKEINESIFGEEVLNSEIPVVVDFWATWCGPCKMLAPVVEEVSQELGQKVKFVKVNVDE
CCCHHHHHHHHHHHHCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEECCC
NPVISTQYKIASIPTLMTFKAGKAVETLVGFRPKEAIKSAVEKHI
CCEECCCEEHHCCCHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]