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The map label for this gene is ghrA [H]

Identifier: 170751866

GI number: 170751866

Start: 5811473

End: 5812414

Strand: Direct

Name: ghrA [H]

Synonym: Mrad2831_5498

Alternate gene names: 170751866

Gene position: 5811473-5812414 (Clockwise)

Preceding gene: 170751865

Following gene: 170751868

Centisome position: 95.62

GC content: 72.82

Gene sequence:

>942_bases
ATGGCTGAGGCAATCGCCCTGGTCGGGTGCAAGGGGCCGGATCAGGAGGCAGAGTATCTGCGCATCCTGTCGGCGGCCAT
GCCCGAGGAGCGCCTGATCCCGTTCCGGACGATGGACGACGCGGCCCGGGCGGCGGCCCGAGTCGCCGTCGTGGCCAACC
CCGATCCGGCCGAGGTCGCGGCGCTGCCGGGGCTGGTCTGGGTGCAGAGCCTCTGGGCCGGGGTCGAGAAGCTCGTCGGC
GCCTTCGACCGGCCGCTGCCGATCGTCCGCCTCGTCGACCGCGAGATGGCCCGCACCATGGCGGAGGCCGTGCTGGCCTG
GACCTACTATCTCCAGCGCGACATGCCGGCCTACGCCAGCCAGCAGCGAGAGCGGGTCTGGCGCCCGCACGCCTACCGCA
AGCCGTCCGACACCACGGTCGGCCTGCTCGGCCTCGGGGCGCTCGGGACCGCGGCGGCGGAGCGTCTCACCGGCGCGGGC
TTCCGCGTCGTCGGCTGGAGCCGCAGCCCCAAGGCGGTGCCGGACCTCGACACGTTTCACGGTGCCGACAGCCTCACGGC
GATGCTCGGCCGGTGCGATATTCTGGTCTGCCTCGTGCCGCTGACATCGGAGACGCGGGGCCTCGTGAATGCCGAGCGCC
TCGCTGCCCTGAAGCCCGGCGCCGCGCTGATCAACTTCGCCCGCGGTCCGATCGTCGTCACCGAAGATCTGATCGCCGCT
CTGGACACCGGCCATCTCGCCCACGCGGTCCTCGACGTCTTCGCGGTCGAGCCGCTGCCGACCGAGTCGCCCCTGTGGTC
CCATCCCCGCGTGACGGTGCTGCCGCACGTCTCGGGGCCCACCGACATGGATTCGGCGGCCGCCACGGTGGCGGCCAACC
TGCGGGCCTATCGGCGGACCGGTCAGGTGCCGGACGGCGTCGACGCGGCGCGGGGGTACTGA

Upstream 100 bases:

>100_bases
GCCGGCGCCCGGCCCGTCTCGACGATCCGGGTCCTGTCAGGCACAGCGCCTGCTTCGCCCGCGCGTGGACGGGTGGAACG
GTACGGTGCGGAGGACGCGG

Downstream 100 bases:

>100_bases
GACGCGCGCGTCACAGCTTCGGGAATGTCGCCGCGAGGTGGTCGATCAGCACGCGCACGGCCGGCGGCAGCCCGCGCCGA
GTCGTGAAGACGATGTGCAC

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MAEAIALVGCKGPDQEAEYLRILSAAMPEERLIPFRTMDDAARAAARVAVVANPDPAEVAALPGLVWVQSLWAGVEKLVG
AFDRPLPIVRLVDREMARTMAEAVLAWTYYLQRDMPAYASQQRERVWRPHAYRKPSDTTVGLLGLGALGTAAAERLTGAG
FRVVGWSRSPKAVPDLDTFHGADSLTAMLGRCDILVCLVPLTSETRGLVNAERLAALKPGAALINFARGPIVVTEDLIAA
LDTGHLAHAVLDVFAVEPLPTESPLWSHPRVTVLPHVSGPTDMDSAAATVAANLRAYRRTGQVPDGVDAARGY

Sequences:

>Translated_313_residues
MAEAIALVGCKGPDQEAEYLRILSAAMPEERLIPFRTMDDAARAAARVAVVANPDPAEVAALPGLVWVQSLWAGVEKLVG
AFDRPLPIVRLVDREMARTMAEAVLAWTYYLQRDMPAYASQQRERVWRPHAYRKPSDTTVGLLGLGALGTAAAERLTGAG
FRVVGWSRSPKAVPDLDTFHGADSLTAMLGRCDILVCLVPLTSETRGLVNAERLAALKPGAALINFARGPIVVTEDLIAA
LDTGHLAHAVLDVFAVEPLPTESPLWSHPRVTVLPHVSGPTDMDSAAATVAANLRAYRRTGQVPDGVDAARGY
>Mature_312_residues
AEAIALVGCKGPDQEAEYLRILSAAMPEERLIPFRTMDDAARAAARVAVVANPDPAEVAALPGLVWVQSLWAGVEKLVGA
FDRPLPIVRLVDREMARTMAEAVLAWTYYLQRDMPAYASQQRERVWRPHAYRKPSDTTVGLLGLGALGTAAAERLTGAGF
RVVGWSRSPKAVPDLDTFHGADSLTAMLGRCDILVCLVPLTSETRGLVNAERLAALKPGAALINFARGPIVVTEDLIAAL
DTGHLAHAVLDVFAVEPLPTESPLWSHPRVTVLPHVSGPTDMDSAAATVAANLRAYRRTGQVPDGVDAARGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=185, Percent_Identity=30.8108108108108, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI6912396, Length=172, Percent_Identity=33.7209302325581, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI87081824, Length=302, Percent_Identity=36.4238410596026, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI87082289, Length=146, Percent_Identity=37.6712328767123, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789279, Length=219, Percent_Identity=28.7671232876712, Blast_Score=78, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=212, Percent_Identity=31.1320754716981, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=151, Percent_Identity=34.4370860927152, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320925, Length=320, Percent_Identity=23.75, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322116, Length=248, Percent_Identity=26.2096774193548, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574286, Length=143, Percent_Identity=36.3636363636364, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI45552429, Length=159, Percent_Identity=34.5911949685535, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24585514, Length=159, Percent_Identity=34.5911949685535, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28574282, Length=159, Percent_Identity=34.5911949685535, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45551003, Length=159, Percent_Identity=34.5911949685535, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28574284, Length=159, Percent_Identity=34.5911949685535, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24585516, Length=145, Percent_Identity=33.7931034482759, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28571528, Length=149, Percent_Identity=34.8993288590604, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19921140, Length=148, Percent_Identity=31.7567567567568, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646446, Length=182, Percent_Identity=30.2197802197802, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24646448, Length=182, Percent_Identity=30.2197802197802, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24646452, Length=182, Percent_Identity=30.2197802197802, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24646450, Length=182, Percent_Identity=30.2197802197802, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 33511; Mature: 33380

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAIALVGCKGPDQEAEYLRILSAAMPEERLIPFRTMDDAARAAARVAVVANPDPAEVA
CCCCEEEEECCCCCHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHEEEEEECCCHHHHH
ALPGLVWVQSLWAGVEKLVGAFDRPLPIVRLVDREMARTMAEAVLAWTYYLQRDMPAYAS
HCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
QQRERVWRPHAYRKPSDTTVGLLGLGALGTAAAERLTGAGFRVVGWSRSPKAVPDLDTFH
HHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHC
GADSLTAMLGRCDILVCLVPLTSETRGLVNAERLAALKPGAALINFARGPIVVTEDLIAA
CHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHCCCCEEEHHHHHHH
LDTGHLAHAVLDVFAVEPLPTESPLWSHPRVTVLPHVSGPTDMDSAAATVAANLRAYRRT
HCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHC
GQVPDGVDAARGY
CCCCCCCHHHCCC
>Mature Secondary Structure 
AEAIALVGCKGPDQEAEYLRILSAAMPEERLIPFRTMDDAARAAARVAVVANPDPAEVA
CCCEEEEECCCCCHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHEEEEEECCCHHHHH
ALPGLVWVQSLWAGVEKLVGAFDRPLPIVRLVDREMARTMAEAVLAWTYYLQRDMPAYAS
HCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
QQRERVWRPHAYRKPSDTTVGLLGLGALGTAAAERLTGAGFRVVGWSRSPKAVPDLDTFH
HHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHC
GADSLTAMLGRCDILVCLVPLTSETRGLVNAERLAALKPGAALINFARGPIVVTEDLIAA
CHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHCCCCEEEHHHHHHH
LDTGHLAHAVLDVFAVEPLPTESPLWSHPRVTVLPHVSGPTDMDSAAATVAANLRAYRRT
HCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHC
GQVPDGVDAARGY
CCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA