| Definition | Methylobacterium radiotolerans JCM 2831 chromosome, complete genome. |
|---|---|
| Accession | NC_010505 |
| Length | 6,077,833 |
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The map label for this gene is yqhE [C]
Identifier: 170751830
GI number: 170751830
Start: 5773316
End: 5774146
Strand: Direct
Name: yqhE [C]
Synonym: Mrad2831_5462
Alternate gene names: 170751830
Gene position: 5773316-5774146 (Clockwise)
Preceding gene: 170751825
Following gene: 170751831
Centisome position: 94.99
GC content: 68.83
Gene sequence:
>831_bases ATGGCCGCAACTGCCCCGACCCTCGCACTGAACGACGGGCGCCGCATCCCGCAGATCGGCTACGGCTGCTGGCAGCTCTC GGACGCGCAGGCTCCGGACCTGGTCGGCCAAGCCCTCCGCGCCGGCTATCGGCTGATCGACACGGCCGCCGCGTACGGCA ACGAGGGGGGCGTCGGGCGCGGCATCCGGGACGCGGGGATCCCCCGCGCGGAGATTTTCCTCACCACGAAGCTCTGGAAC GACCGCCAGGGCCGGGACGAGGCACGCCGCGCCTTCGACGAGAGCCTGCGGCAGCTCGGTCTCCCATATGTCGACCTGTA CCTGATCCATTGGCCGTGTCCGCAGCGGCGCCTGTTCGTCGAGACCTGGAAGACGCTGATCGAACTCCGGAAGGAGGGCC GCACGAAGTCCATCGGCGTGTCGAACTTCACGCCCGAGCATCTCGCCACCCTGATCGGCGAGACCGGCGTGGCTCCGGCC GTCAATCAGATCGAGCTGCATCCCTATTTCCAGCGCGAGGATCCGCGCGTCGAGGACGCCCGTCACGGTATCGTGACCGA GTCATGGAGCCCGCTGGGGAGGGGCATGGAGCTGAACGACCCGGTCATTCTCGCGATCGCGAAGGCGCACGGGAAGACGC CCGCTCAGGTGGTGCTGCGCTGGCAGATCCAGATCGGCTGCGTGGCGATCCCGAAGACCGCCACCCCGCGACGCATCGCC GAGAACATCGCGCTGTTCGATTTCGAGCTCGGCGCCGACGAGATGGCGCGGATCGCCGGTCTCGACAGGCCGGACGGTCG CATCGGGCCGGACCCGGCGACCTTCTGCTGA
Upstream 100 bases:
>100_bases GCTCCGCTCGCAGCGACGTGCCGCTTCGGCGTGCCGCTTCGGAACGTGTTGCGCCGACGCCGTTTGGGTTGAGCGACAGC CGTCACCGGAGACACGCCGC
Downstream 100 bases:
>100_bases TCGCTTCGGCCTTCGGCGGCGCAGCGTAACATCGCACCGCAAAAGATTTATGCTCACAGCTAGCATATCTGGACAGGCGC GCGCGGCCCCCATAAGTTAG
Product: aldo/keto reductase
Products: 2-keto-L-gulonate; NADP [C]
Alternate protein names: NA
Number of amino acids: Translated: 276; Mature: 275
Protein sequence:
>276_residues MAATAPTLALNDGRRIPQIGYGCWQLSDAQAPDLVGQALRAGYRLIDTAAAYGNEGGVGRGIRDAGIPRAEIFLTTKLWN DRQGRDEARRAFDESLRQLGLPYVDLYLIHWPCPQRRLFVETWKTLIELRKEGRTKSIGVSNFTPEHLATLIGETGVAPA VNQIELHPYFQREDPRVEDARHGIVTESWSPLGRGMELNDPVILAIAKAHGKTPAQVVLRWQIQIGCVAIPKTATPRRIA ENIALFDFELGADEMARIAGLDRPDGRIGPDPATFC
Sequences:
>Translated_276_residues MAATAPTLALNDGRRIPQIGYGCWQLSDAQAPDLVGQALRAGYRLIDTAAAYGNEGGVGRGIRDAGIPRAEIFLTTKLWN DRQGRDEARRAFDESLRQLGLPYVDLYLIHWPCPQRRLFVETWKTLIELRKEGRTKSIGVSNFTPEHLATLIGETGVAPA VNQIELHPYFQREDPRVEDARHGIVTESWSPLGRGMELNDPVILAIAKAHGKTPAQVVLRWQIQIGCVAIPKTATPRRIA ENIALFDFELGADEMARIAGLDRPDGRIGPDPATFC >Mature_275_residues AATAPTLALNDGRRIPQIGYGCWQLSDAQAPDLVGQALRAGYRLIDTAAAYGNEGGVGRGIRDAGIPRAEIFLTTKLWND RQGRDEARRAFDESLRQLGLPYVDLYLIHWPCPQRRLFVETWKTLIELRKEGRTKSIGVSNFTPEHLATLIGETGVAPAV NQIELHPYFQREDPRVEDARHGIVTESWSPLGRGMELNDPVILAIAKAHGKTPAQVVLRWQIQIGCVAIPKTATPRRIAE NIALFDFELGADEMARIAGLDRPDGRIGPDPATFC
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=296, Percent_Identity=34.7972972972973, Blast_Score=195, Evalue=4e-50, Organism=Homo sapiens, GI5174391, Length=296, Percent_Identity=34.7972972972973, Blast_Score=195, Evalue=4e-50, Organism=Homo sapiens, GI223468663, Length=293, Percent_Identity=35.4948805460751, Blast_Score=180, Evalue=2e-45, Organism=Homo sapiens, GI310109922, Length=283, Percent_Identity=36.0424028268551, Blast_Score=178, Evalue=5e-45, Organism=Homo sapiens, GI45446745, Length=301, Percent_Identity=35.2159468438538, Blast_Score=176, Evalue=1e-44, Organism=Homo sapiens, GI4503285, Length=301, Percent_Identity=35.2159468438538, Blast_Score=176, Evalue=1e-44, Organism=Homo sapiens, GI310109920, Length=301, Percent_Identity=35.2159468438538, Blast_Score=176, Evalue=2e-44, Organism=Homo sapiens, GI5453543, Length=301, Percent_Identity=35.2159468438538, Blast_Score=175, Evalue=4e-44, Organism=Homo sapiens, GI24497583, Length=301, Percent_Identity=34.8837209302326, Blast_Score=174, Evalue=6e-44, Organism=Homo sapiens, GI93277124, Length=295, Percent_Identity=34.9152542372881, Blast_Score=174, Evalue=9e-44, Organism=Homo sapiens, GI4502049, Length=293, Percent_Identity=37.542662116041, Blast_Score=164, Evalue=6e-41, Organism=Homo sapiens, GI24497585, Length=294, Percent_Identity=33.3333333333333, Blast_Score=160, Evalue=8e-40, Organism=Homo sapiens, GI291291012, Length=263, Percent_Identity=35.7414448669202, Blast_Score=158, Evalue=6e-39, Organism=Homo sapiens, GI5174695, Length=302, Percent_Identity=32.4503311258278, Blast_Score=149, Evalue=3e-36, Organism=Homo sapiens, GI300116273, Length=284, Percent_Identity=31.6901408450704, Blast_Score=131, Evalue=5e-31, Organism=Homo sapiens, GI300116271, Length=282, Percent_Identity=31.5602836879433, Blast_Score=117, Evalue=1e-26, Organism=Homo sapiens, GI310109924, Length=144, Percent_Identity=38.1944444444444, Blast_Score=101, Evalue=9e-22, Organism=Homo sapiens, GI207028673, Length=132, Percent_Identity=37.1212121212121, Blast_Score=91, Evalue=9e-19, Organism=Homo sapiens, GI310109926, Length=132, Percent_Identity=37.1212121212121, Blast_Score=91, Evalue=1e-18, Organism=Escherichia coli, GI87082198, Length=275, Percent_Identity=50.5454545454545, Blast_Score=277, Evalue=5e-76, Organism=Escherichia coli, GI1786400, Length=258, Percent_Identity=39.1472868217054, Blast_Score=184, Evalue=5e-48, Organism=Escherichia coli, GI1788081, Length=287, Percent_Identity=32.404181184669, Blast_Score=96, Evalue=3e-21, Organism=Escherichia coli, GI87081735, Length=302, Percent_Identity=25.4966887417219, Blast_Score=71, Evalue=7e-14, Organism=Escherichia coli, GI1787674, Length=282, Percent_Identity=25.177304964539, Blast_Score=69, Evalue=2e-13, Organism=Escherichia coli, GI1788070, Length=189, Percent_Identity=30.1587301587302, Blast_Score=67, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17537077, Length=290, Percent_Identity=38.9655172413793, Blast_Score=195, Evalue=3e-50, Organism=Caenorhabditis elegans, GI17537075, Length=299, Percent_Identity=38.4615384615385, Blast_Score=191, Evalue=3e-49, Organism=Caenorhabditis elegans, GI71998625, Length=269, Percent_Identity=35.6877323420074, Blast_Score=186, Evalue=1e-47, Organism=Caenorhabditis elegans, GI17537079, Length=296, Percent_Identity=33.7837837837838, Blast_Score=166, Evalue=1e-41, Organism=Caenorhabditis elegans, GI17538386, Length=272, Percent_Identity=34.1911764705882, Blast_Score=164, Evalue=4e-41, Organism=Caenorhabditis elegans, GI17564128, Length=297, Percent_Identity=32.6599326599327, Blast_Score=163, Evalue=7e-41, Organism=Caenorhabditis elegans, GI17550248, Length=290, Percent_Identity=33.448275862069, Blast_Score=163, Evalue=1e-40, Organism=Caenorhabditis elegans, GI17561298, Length=270, Percent_Identity=32.962962962963, Blast_Score=163, Evalue=1e-40, Organism=Caenorhabditis elegans, GI17566692, Length=296, Percent_Identity=32.0945945945946, Blast_Score=158, Evalue=4e-39, Organism=Caenorhabditis elegans, GI17552492, Length=263, Percent_Identity=31.5589353612167, Blast_Score=149, Evalue=2e-36, Organism=Caenorhabditis elegans, GI17561300, Length=273, Percent_Identity=31.8681318681319, Blast_Score=141, Evalue=4e-34, Organism=Caenorhabditis elegans, GI17562292, Length=278, Percent_Identity=30.2158273381295, Blast_Score=129, Evalue=1e-30, Organism=Saccharomyces cerevisiae, GI6320576, Length=296, Percent_Identity=39.1891891891892, Blast_Score=207, Evalue=2e-54, Organism=Saccharomyces cerevisiae, GI6324694, Length=290, Percent_Identity=40.3448275862069, Blast_Score=206, Evalue=3e-54, Organism=Saccharomyces cerevisiae, GI6322556, Length=266, Percent_Identity=38.7218045112782, Blast_Score=187, Evalue=1e-48, Organism=Saccharomyces cerevisiae, GI6321896, Length=306, Percent_Identity=30.3921568627451, Blast_Score=149, Evalue=7e-37, Organism=Saccharomyces cerevisiae, GI6319625, Length=294, Percent_Identity=32.9931972789116, Blast_Score=145, Evalue=7e-36, Organism=Saccharomyces cerevisiae, GI6320079, Length=287, Percent_Identity=31.0104529616725, Blast_Score=135, Evalue=7e-33, Organism=Drosophila melanogaster, GI24644950, Length=296, Percent_Identity=37.8378378378378, Blast_Score=186, Evalue=1e-47, Organism=Drosophila melanogaster, GI20129731, Length=282, Percent_Identity=36.8794326241135, Blast_Score=181, Evalue=6e-46, Organism=Drosophila melanogaster, GI24657054, Length=277, Percent_Identity=37.1841155234657, Blast_Score=180, Evalue=8e-46, Organism=Drosophila melanogaster, GI221378297, Length=316, Percent_Identity=35.7594936708861, Blast_Score=179, Evalue=2e-45, Organism=Drosophila melanogaster, GI24663317, Length=287, Percent_Identity=34.1463414634146, Blast_Score=177, Evalue=6e-45, Organism=Drosophila melanogaster, GI45553081, Length=289, Percent_Identity=34.9480968858132, Blast_Score=172, Evalue=2e-43, Organism=Drosophila melanogaster, GI24662789, Length=294, Percent_Identity=34.0136054421769, Blast_Score=172, Evalue=2e-43, Organism=Drosophila melanogaster, GI21356425, Length=287, Percent_Identity=34.4947735191638, Blast_Score=166, Evalue=1e-41, Organism=Drosophila melanogaster, GI24662781, Length=278, Percent_Identity=36.6906474820144, Blast_Score=148, Evalue=4e-36, Organism=Drosophila melanogaster, GI281366140, Length=252, Percent_Identity=34.9206349206349, Blast_Score=147, Evalue=9e-36, Organism=Drosophila melanogaster, GI24662785, Length=280, Percent_Identity=37.1428571428571, Blast_Score=145, Evalue=2e-35,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: NA
Molecular weight: Translated: 30509; Mature: 30378
Theoretical pI: Translated: 7.03; Mature: 7.03
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 0.7 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAATAPTLALNDGRRIPQIGYGCWQLSDAQAPDLVGQALRAGYRLIDTAAAYGNEGGVGR CCCCCCEEEECCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCC GIRDAGIPRAEIFLTTKLWNDRQGRDEARRAFDESLRQLGLPYVDLYLIHWPCPQRRLFV CCHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHH ETWKTLIELRKEGRTKSIGVSNFTPEHLATLIGETGVAPAVNQIELHPYFQREDPRVEDA HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHH RHGIVTESWSPLGRGMELNDPVILAIAKAHGKTPAQVVLRWQIQIGCVAIPKTATPRRIA HCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHEEEEEEEEEEEEECCCCCCHHHHH ENIALFDFELGADEMARIAGLDRPDGRIGPDPATFC HHHEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCC >Mature Secondary Structure AATAPTLALNDGRRIPQIGYGCWQLSDAQAPDLVGQALRAGYRLIDTAAAYGNEGGVGR CCCCCEEEECCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCC GIRDAGIPRAEIFLTTKLWNDRQGRDEARRAFDESLRQLGLPYVDLYLIHWPCPQRRLFV CCHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHH ETWKTLIELRKEGRTKSIGVSNFTPEHLATLIGETGVAPAVNQIELHPYFQREDPRVEDA HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHH RHGIVTESWSPLGRGMELNDPVILAIAKAHGKTPAQVVLRWQIQIGCVAIPKTATPRRIA HCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHEEEEEEEEEEEEECCCCCCHHHHH ENIALFDFELGADEMARIAGLDRPDGRIGPDPATFC HHHEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 2,5-diketo-D-gluconate; NADPH [C]
Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA