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The map label for this gene is rsbRA [H]

Identifier: 170751608

GI number: 170751608

Start: 5549877

End: 5550752

Strand: Direct

Name: rsbRA [H]

Synonym: Mrad2831_5229

Alternate gene names: 170751608

Gene position: 5549877-5550752 (Clockwise)

Preceding gene: 170751607

Following gene: 170751609

Centisome position: 91.31

GC content: 70.21

Gene sequence:

>876_bases
ATGACGACGGACGGCGCCGAGGTCCTGAGCAAGACCGTCACGCAGGACGAGGCCGCTATCCTCGACGCCTGGAACGCGGC
CCTGCGGGAGGGGACCTCCCTACAGAGCGGCCGCATCCGCGAGGCCGAGCTCCAGACCCAGGTCAAGGCCGTGTTCGGCC
AGCTCCGAGACGCGCTCGCGTCGGGCGGCTTTGACGCCGACGCGGCGGGCTTCGCATCCCTGCGCGAGACCCTCGCCGAC
ATCTCCCGCTCGCGGGCGATCCAGGGCTTCACCCCCACCGACACCGCCAACTTCGTCTTCTCGCTCAAGGAGCCGATCTT
CGAGGCCCTGAAGCGCGCGTCCGGCACGGACGCGACGTCCCTCGCGGCCGGCATCTGGGCGGCGGGCAAGGTCCTCGACC
GGCTCGGCCTTCAGACCATGGAGATTTTCCTGGCGAGCCGCGAGGAGGTGATCGGGCGCCAGGGCCAGGAGATCGCCGAG
CTCTCCACGCCCGTGGTGCGCCTCTGGGACGGCATCCTGGCGCTGCCGCTGATCGGCACCCTCGACAGCGCCCGCACCGG
CGTTGTGATGGAGAACCTGCTCCAGGCCATCGTCGACGAGGAGGCCGAGATCGCCATCATCGACATCACCGGCGTCCCGA
CCGTCGACACACTGGTGGCGCAGCACCTGCTGAAGACCGTCGCGGCGGCGCGCCTGATGGGGGCCGACTGCATCATCTCC
GGCATCAGGCCGCAGATCGCCCAGACCATGGTCCATCTTGGCGTGGAGCTAAACGTCGTCTCGAAGGCCACCCTGGCCGA
CGCCTTCGCGGTCGCCCTGAGGCGGACCGGCCGTAAGGTGGTGCGGCAGCAGGCGGCGGTCGAGGAGCGCCGCTGA

Upstream 100 bases:

>100_bases
CAGGGATAGCCACCTTTCGCCGACCCGGAGTGTGGCATCGCCGCCTATCGAACCCGCCCCGGACAGGTTAGAGGCTTTCG
GAATTGGCTAGGATGATTTG

Downstream 100 bases:

>100_bases
CGCCATGGAGCGCATCCCGATCCTCAAGCTGGGTGGCGTGCTGATCGTCACCATCCAGGTCGACATGCACGACCGCCTCG
CGCTCGCCCTGGAGGAGGAC

Product: anti-sigma-factor antagonist

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MTTDGAEVLSKTVTQDEAAILDAWNAALREGTSLQSGRIREAELQTQVKAVFGQLRDALASGGFDADAAGFASLRETLAD
ISRSRAIQGFTPTDTANFVFSLKEPIFEALKRASGTDATSLAAGIWAAGKVLDRLGLQTMEIFLASREEVIGRQGQEIAE
LSTPVVRLWDGILALPLIGTLDSARTGVVMENLLQAIVDEEAEIAIIDITGVPTVDTLVAQHLLKTVAAARLMGADCIIS
GIRPQIAQTMVHLGVELNVVSKATLADAFAVALRRTGRKVVRQQAAVEERR

Sequences:

>Translated_291_residues
MTTDGAEVLSKTVTQDEAAILDAWNAALREGTSLQSGRIREAELQTQVKAVFGQLRDALASGGFDADAAGFASLRETLAD
ISRSRAIQGFTPTDTANFVFSLKEPIFEALKRASGTDATSLAAGIWAAGKVLDRLGLQTMEIFLASREEVIGRQGQEIAE
LSTPVVRLWDGILALPLIGTLDSARTGVVMENLLQAIVDEEAEIAIIDITGVPTVDTLVAQHLLKTVAAARLMGADCIIS
GIRPQIAQTMVHLGVELNVVSKATLADAFAVALRRTGRKVVRQQAAVEERR
>Mature_290_residues
TTDGAEVLSKTVTQDEAAILDAWNAALREGTSLQSGRIREAELQTQVKAVFGQLRDALASGGFDADAAGFASLRETLADI
SRSRAIQGFTPTDTANFVFSLKEPIFEALKRASGTDATSLAAGIWAAGKVLDRLGLQTMEIFLASREEVIGRQGQEIAEL
STPVVRLWDGILALPLIGTLDSARTGVVMENLLQAIVDEEAEIAIIDITGVPTVDTLVAQHLLKTVAAARLMGADCIISG
IRPQIAQTMVHLGVELNVVSKATLADAFAVALRRTGRKVVRQQAAVEERR

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG1366

COG function: function code T; Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: NA

Molecular weight: Translated: 31018; Mature: 30887

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDGAEVLSKTVTQDEAAILDAWNAALREGTSLQSGRIREAELQTQVKAVFGQLRDALA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SGGFDADAAGFASLRETLADISRSRAIQGFTPTDTANFVFSLKEPIFEALKRASGTDATS
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHH
LAAGIWAAGKVLDRLGLQTMEIFLASREEVIGRQGQEIAELSTPVVRLWDGILALPLIGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LDSARTGVVMENLLQAIVDEEAEIAIIDITGVPTVDTLVAQHLLKTVAAARLMGADCIIS
HCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIRPQIAQTMVHLGVELNVVSKATLADAFAVALRRTGRKVVRQQAAVEERR
CCCHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTDGAEVLSKTVTQDEAAILDAWNAALREGTSLQSGRIREAELQTQVKAVFGQLRDALA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SGGFDADAAGFASLRETLADISRSRAIQGFTPTDTANFVFSLKEPIFEALKRASGTDATS
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHH
LAAGIWAAGKVLDRLGLQTMEIFLASREEVIGRQGQEIAELSTPVVRLWDGILALPLIGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LDSARTGVVMENLLQAIVDEEAEIAIIDITGVPTVDTLVAQHLLKTVAAARLMGADCIIS
HCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIRPQIAQTMVHLGVELNVVSKATLADAFAVALRRTGRKVVRQQAAVEERR
CCCHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]