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The map label for this gene is manC [H]

Identifier: 170751522

GI number: 170751522

Start: 5466924

End: 5468354

Strand: Reverse

Name: manC [H]

Synonym: Mrad2831_5142

Alternate gene names: 170751522

Gene position: 5468354-5466924 (Counterclockwise)

Preceding gene: 170751525

Following gene: 170751521

Centisome position: 89.97

GC content: 72.4

Gene sequence:

>1431_bases
ATGTCCCGACCTTCGATCCAGATCCACCCGATGATCCTGTGCGGAGGGACGGGGACGCGGCTGTGGCCGGCGTCGCGGGA
GAGCATGCCCAAGCAGTTCGCCCGGCTGGTCGACGCCGAGCGCTCGACCTTCCAGGCGACGCTGGCGCGCGTATCGGACG
CCACCGTCTTCGCGACGCCTACCGTCATCGCCTCGGCCGAGGCCCGCTTCATCGTCGCCGAGCAGCGCGACCAGCTCGGT
CTCTCCGCCGACATCCTGCTCGAGCCGCAGGGCCGCGACTCCGCCGCCGCCGTGGCGGTCGCAGCCCTGCACGCCGCCGC
CAGCGACCCGCAGGCCGTGGTGCTGATCATGGCCGCCGACCACGTCGTGCCCGACACGGCCGCCTTCGTGGACGCCGTGC
AGCGCGCGGCCGCCGGGGCGCGCGCCGGCTACACGATGACGCTCGGCATCGAGCCCGACCGGCCGGCCACCGATTACGGC
TACATCCGCCGCGGCGAGCCGATCGCCGAAGCCCCGGGCGCGGCCCGCGTCGCCCGCTTCGTCGAGAAGCCCGACCGGGC
CGGCGCCGAGGCGCTGATCACCGACGGCGCCCTGTGGAACTCGGGCTACTTCCTGTTCCGCGCCGACCTGATGCTGGCCG
AGCTGGAAGCGTTCGTCCCCGAGGTGCTGGCGGCCGCGCGCGCGGCCCTGGAGGCGGCGGTGACCGACCTCGACTTCGTG
CGCCTCGACGCGACGGCCTTCGCTCAGGCGCCGAAGATCTCGATCGACTACGCGGTCATGGAGCGGACCGCCCGGGCCGG
CGTGCTGCCGGTGTCGTTCGCGTGGTCGGATGTCGGCACCTGGGACGCGGTCTGGCAGGTGCTGGACCACGACGAGGCCG
GCAACGCCGTGCGCGGCCGGGTGTCGCTGATCGGCACGAAGAACAGCCTCGTGCACAGCCAGGGCGAGGGCCTGACCGCG
GTGGTGGGCCTGGAGGACGTGGTGGTGGTCTCGACCCCCGACGCGGTGCTGGTGGCCTCCAAGGCGCATTCGGGCCAAGT
GAAGGAGCTGGTCGGCGCGCTGCGGGCCCGCGGGGAGCCGGAGGCGGACGCGCATCTGCGGATGTACCGGCCCTGGGGCT
GGTACCAGCGGATCGACATCGGCGAGCGCTTCCAGGTGAAGCGGATCCAGGTTGTGCCGGGCGGGCGGCTGTCGCTGCAG
AAGCACTACCACCGGGCGGAGCACTGGGTGGTGGTGCGCGGCACCGCCGAGGTGACGATCGACGAGCGGGTGGTGCTGGT
CCACGAGAACGAGGCGGTCTACCTGCCGATCGGGTCGATGCACCGGCTGGCCAACCCGGGCAAGATCCCGCTGGAGCTGA
TCGAGGTCCAGGTCGGCTCCTACACCGGCGAGGACGACATCATCCGCGTCGAGGACATCTACGGACGCTGA

Upstream 100 bases:

>100_bases
TAAGGGCAGATCCTGAAATCGGCGCCCGAGAGTCCATCGCACCCGCGCGGGGCGGGCTCGGCCACGCCAACCCCGCCGAG
CCTTCTCGGGAGACGTCGCC

Downstream 100 bases:

>100_bases
GTGCCCGGGCGGCCAGCCTGCGACCCGATCACCCGCGGGTGCGCCCGGAACATGCGGCCGCCCCGATCGATAGCCTAGCG
TGTGGCCGCTCCCGTGCGGC

Product: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MSRPSIQIHPMILCGGTGTRLWPASRESMPKQFARLVDAERSTFQATLARVSDATVFATPTVIASAEARFIVAEQRDQLG
LSADILLEPQGRDSAAAVAVAALHAAASDPQAVVLIMAADHVVPDTAAFVDAVQRAAAGARAGYTMTLGIEPDRPATDYG
YIRRGEPIAEAPGAARVARFVEKPDRAGAEALITDGALWNSGYFLFRADLMLAELEAFVPEVLAAARAALEAAVTDLDFV
RLDATAFAQAPKISIDYAVMERTARAGVLPVSFAWSDVGTWDAVWQVLDHDEAGNAVRGRVSLIGTKNSLVHSQGEGLTA
VVGLEDVVVVSTPDAVLVASKAHSGQVKELVGALRARGEPEADAHLRMYRPWGWYQRIDIGERFQVKRIQVVPGGRLSLQ
KHYHRAEHWVVVRGTAEVTIDERVVLVHENEAVYLPIGSMHRLANPGKIPLELIEVQVGSYTGEDDIIRVEDIYGR

Sequences:

>Translated_476_residues
MSRPSIQIHPMILCGGTGTRLWPASRESMPKQFARLVDAERSTFQATLARVSDATVFATPTVIASAEARFIVAEQRDQLG
LSADILLEPQGRDSAAAVAVAALHAAASDPQAVVLIMAADHVVPDTAAFVDAVQRAAAGARAGYTMTLGIEPDRPATDYG
YIRRGEPIAEAPGAARVARFVEKPDRAGAEALITDGALWNSGYFLFRADLMLAELEAFVPEVLAAARAALEAAVTDLDFV
RLDATAFAQAPKISIDYAVMERTARAGVLPVSFAWSDVGTWDAVWQVLDHDEAGNAVRGRVSLIGTKNSLVHSQGEGLTA
VVGLEDVVVVSTPDAVLVASKAHSGQVKELVGALRARGEPEADAHLRMYRPWGWYQRIDIGERFQVKRIQVVPGGRLSLQ
KHYHRAEHWVVVRGTAEVTIDERVVLVHENEAVYLPIGSMHRLANPGKIPLELIEVQVGSYTGEDDIIRVEDIYGR
>Mature_475_residues
SRPSIQIHPMILCGGTGTRLWPASRESMPKQFARLVDAERSTFQATLARVSDATVFATPTVIASAEARFIVAEQRDQLGL
SADILLEPQGRDSAAAVAVAALHAAASDPQAVVLIMAADHVVPDTAAFVDAVQRAAAGARAGYTMTLGIEPDRPATDYGY
IRRGEPIAEAPGAARVARFVEKPDRAGAEALITDGALWNSGYFLFRADLMLAELEAFVPEVLAAARAALEAAVTDLDFVR
LDATAFAQAPKISIDYAVMERTARAGVLPVSFAWSDVGTWDAVWQVLDHDEAGNAVRGRVSLIGTKNSLVHSQGEGLTAV
VGLEDVVVVSTPDAVLVASKAHSGQVKELVGALRARGEPEADAHLRMYRPWGWYQRIDIGERFQVKRIQVVPGGRLSLQK
HYHRAEHWVVVRGTAEVTIDERVVLVHENEAVYLPIGSMHRLANPGKIPLELIEVQVGSYTGEDDIIRVEDIYGR

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=478, Percent_Identity=48.744769874477, Blast_Score=423, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR018247
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 51398; Mature: 51267

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPSIQIHPMILCGGTGTRLWPASRESMPKQFARLVDAERSTFQATLARVSDATVFATP
CCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECC
TVIASAEARFIVAEQRDQLGLSADILLEPQGRDSAAAVAVAALHAAASDPQAVVLIMAAD
EEEECCCEEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECC
HVVPDTAAFVDAVQRAAAGARAGYTMTLGIEPDRPATDYGYIRRGEPIAEAPGAARVARF
CCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEECCCCCCCCCCHHHHHHH
VEKPDRAGAEALITDGALWNSGYFLFRADLMLAELEAFVPEVLAAARAALEAAVTDLDFV
HHCCCCCCCCEEEECCEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
RLDATAFAQAPKISIDYAVMERTARAGVLPVSFAWSDVGTWDAVWQVLDHDEAGNAVRGR
EECHHHHCCCCCCEEEHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHCCCCCCCEEEEE
VSLIGTKNSLVHSQGEGLTAVVGLEDVVVVSTPDAVLVASKAHSGQVKELVGALRARGEP
EEEEECCCCEEECCCCCEEEEEECCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCCC
EADAHLRMYRPWGWYQRIDIGERFQVKRIQVVPGGRLSLQKHYHRAEHWVVVRGTAEVTI
CCCCCEEEECCCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHCCCCEEEEEECCEEEEE
DERVVLVHENEAVYLPIGSMHRLANPGKIPLELIEVQVGSYTGEDDIIRVEDIYGR
CCEEEEEECCCEEEEECCCHHHCCCCCCCCEEEEEEEECCCCCCCCEEEEEECCCC
>Mature Secondary Structure 
SRPSIQIHPMILCGGTGTRLWPASRESMPKQFARLVDAERSTFQATLARVSDATVFATP
CCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECC
TVIASAEARFIVAEQRDQLGLSADILLEPQGRDSAAAVAVAALHAAASDPQAVVLIMAAD
EEEECCCEEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECC
HVVPDTAAFVDAVQRAAAGARAGYTMTLGIEPDRPATDYGYIRRGEPIAEAPGAARVARF
CCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEECCCCCCCCCCHHHHHHH
VEKPDRAGAEALITDGALWNSGYFLFRADLMLAELEAFVPEVLAAARAALEAAVTDLDFV
HHCCCCCCCCEEEECCEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
RLDATAFAQAPKISIDYAVMERTARAGVLPVSFAWSDVGTWDAVWQVLDHDEAGNAVRGR
EECHHHHCCCCCCEEEHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHCCCCCCCEEEEE
VSLIGTKNSLVHSQGEGLTAVVGLEDVVVVSTPDAVLVASKAHSGQVKELVGALRARGEP
EEEEECCCCEEECCCCCEEEEEECCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHCCCC
EADAHLRMYRPWGWYQRIDIGERFQVKRIQVVPGGRLSLQKHYHRAEHWVVVRGTAEVTI
CCCCCEEEECCCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHCCCCEEEEEECCEEEEE
DERVVLVHENEAVYLPIGSMHRLANPGKIPLELIEVQVGSYTGEDDIIRVEDIYGR
CCEEEEEECCCEEEEECCCHHHCCCCCCCCEEEEEEEECCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]