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The map label for this gene is phbA [H]

Identifier: 170751498

GI number: 170751498

Start: 5440748

End: 5441932

Strand: Direct

Name: phbA [H]

Synonym: Mrad2831_5118

Alternate gene names: 170751498

Gene position: 5440748-5441932 (Clockwise)

Preceding gene: 170751495

Following gene: 170751499

Centisome position: 89.52

GC content: 70.72

Gene sequence:

>1185_bases
ATGGCAGGCAGCGAAGAGATCGTCATCGTCGGGGCGGCGCGCACGCCGGTCGGCTCGTTCGGCGGCGCCTTCGGGGCGGT
GCCGGCCCACGAGCTCGGCGCGACGGCGATCAAGGCCGCCCTGGAGCGGGCCAAGGTCTCGCCCGATGAGGTGGACGAGG
TGATCTTCGGGCAGGTCCTCACCGCGGGCGCCGGCCAGAACCCCGCCCGGCAGGCCGCCATCAAGGCCGGCATCCCCGAG
AAGGCCACCGCATGGGGCCTCAACCAGGTCTGCGGCTCGGGTCTGCGCACGGTCGCGATCGGCATGCAGCAGATCGCCAA
TGGCGACGCCAAGGTCATCGTGGCCGGCGGTCAGGAATCGATGTCCCTGTCGCCCCACGCGCAGTACCTGCGCGGCGGCC
AGAAGATGGGCGACGTGAAGCTCGTCGACACCATGATCAAGGACGGGCTCTGGGACGCCTTCAACGGCTACCACATGGGT
CAGACCGCCGAGAACGTCGCCCAGGCCTTCCAGCTCACCCGCGAGCAGCAGGACCAGTTCGCGACCCGCTCGCAGAACAA
GGCCGAGGCCGCCCGCAAGGAGGGCCGGTTCAAGGACGAGATCGTCCCCGTCACCGTGCCGGGCAAGAAGGGCGACACGG
TCGTCGACACCGACGAGTACATCCGCGACGGCGCCACCATCGAGGCGATGGCCAAGCTGAAGCCGGCCTTCACCAAGGAC
GGCACCGTCACGGCCGCCAACGCCTCGGGCCTCAACGACGGCGCCGCCGCCCTGGTGCTGATGTCGGCCTCGGAGGCCGA
GCGCCGCGGCCTGACCCCGCTCGCCCGGATCAAGTCCTGGGCGACCGCCGGCGTCGATCCGAAGGTCATGGGCACCGGCC
CGATCCCGGCCTCCCGCAAGGCCCTGGAGAAGGCCGGCTGGAAGCCGTCCGACCTCGACCTGATCGAGGCCAACGAGGCC
TTCGCGGCCCAGGCGCTGGCCGTGAACAAGGACATGGGCTGGGACGACGCGAAGGTGAACGTCAACGGCGGCGCCATCGC
CATCGGTCACCCGATCGGCGCCTCGGGCGCCCGCGTGCTCGTCACCCTGCTGCACGAGATGAAGCGCCGCGACGCCAAGA
AGGGCCTCGCCACGCTCTGCATCGGCGGTGGCATGGGCGTGGCGATGTGCGTCGAGCGGACCTGA

Upstream 100 bases:

>100_bases
AACCTTGACTTCGCCGACCTCAAGCCCTTCATCCCAGAGCCGGCACAGAGCGCGCCCCGGGACGTGGAGGCGCGCCGGCT
CGCGAGAGGAGAACGTTCAC

Downstream 100 bases:

>100_bases
TCGGTCTGTCACGACAGTATCGGCTCACAACATAGACTTAAGGCCGAAGTCAGAAAAAATCGCGTGCGGACGCCATCCGC
ACGCGGCATCAAGTGATGCG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MAGSEEIVIVGAARTPVGSFGGAFGAVPAHELGATAIKAALERAKVSPDEVDEVIFGQVLTAGAGQNPARQAAIKAGIPE
KATAWGLNQVCGSGLRTVAIGMQQIANGDAKVIVAGGQESMSLSPHAQYLRGGQKMGDVKLVDTMIKDGLWDAFNGYHMG
QTAENVAQAFQLTREQQDQFATRSQNKAEAARKEGRFKDEIVPVTVPGKKGDTVVDTDEYIRDGATIEAMAKLKPAFTKD
GTVTAANASGLNDGAAALVLMSASEAERRGLTPLARIKSWATAGVDPKVMGTGPIPASRKALEKAGWKPSDLDLIEANEA
FAAQALAVNKDMGWDDAKVNVNGGAIAIGHPIGASGARVLVTLLHEMKRRDAKKGLATLCIGGGMGVAMCVERT

Sequences:

>Translated_394_residues
MAGSEEIVIVGAARTPVGSFGGAFGAVPAHELGATAIKAALERAKVSPDEVDEVIFGQVLTAGAGQNPARQAAIKAGIPE
KATAWGLNQVCGSGLRTVAIGMQQIANGDAKVIVAGGQESMSLSPHAQYLRGGQKMGDVKLVDTMIKDGLWDAFNGYHMG
QTAENVAQAFQLTREQQDQFATRSQNKAEAARKEGRFKDEIVPVTVPGKKGDTVVDTDEYIRDGATIEAMAKLKPAFTKD
GTVTAANASGLNDGAAALVLMSASEAERRGLTPLARIKSWATAGVDPKVMGTGPIPASRKALEKAGWKPSDLDLIEANEA
FAAQALAVNKDMGWDDAKVNVNGGAIAIGHPIGASGARVLVTLLHEMKRRDAKKGLATLCIGGGMGVAMCVERT
>Mature_393_residues
AGSEEIVIVGAARTPVGSFGGAFGAVPAHELGATAIKAALERAKVSPDEVDEVIFGQVLTAGAGQNPARQAAIKAGIPEK
ATAWGLNQVCGSGLRTVAIGMQQIANGDAKVIVAGGQESMSLSPHAQYLRGGQKMGDVKLVDTMIKDGLWDAFNGYHMGQ
TAENVAQAFQLTREQQDQFATRSQNKAEAARKEGRFKDEIVPVTVPGKKGDTVVDTDEYIRDGATIEAMAKLKPAFTKDG
TVTAANASGLNDGAAALVLMSASEAERRGLTPLARIKSWATAGVDPKVMGTGPIPASRKALEKAGWKPSDLDLIEANEAF
AAQALAVNKDMGWDDAKVNVNGGAIAIGHPIGASGARVLVTLLHEMKRRDAKKGLATLCIGGGMGVAMCVERT

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=394, Percent_Identity=57.8680203045685, Blast_Score=474, Evalue=1e-134,
Organism=Homo sapiens, GI167614485, Length=400, Percent_Identity=43, Blast_Score=333, Evalue=1e-91,
Organism=Homo sapiens, GI4557237, Length=392, Percent_Identity=45.1530612244898, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI4501853, Length=398, Percent_Identity=41.4572864321608, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=35.377358490566, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI194353979, Length=394, Percent_Identity=30.7106598984772, Blast_Score=147, Evalue=1e-35,
Organism=Escherichia coli, GI87082165, Length=390, Percent_Identity=55.6410256410256, Blast_Score=445, Evalue=1e-126,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=58.1218274111675, Blast_Score=435, Evalue=1e-123,
Organism=Escherichia coli, GI1787663, Length=399, Percent_Identity=43.3583959899749, Blast_Score=308, Evalue=3e-85,
Organism=Escherichia coli, GI48994986, Length=402, Percent_Identity=42.7860696517413, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1788683, Length=424, Percent_Identity=34.9056603773585, Blast_Score=220, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI133906874, Length=396, Percent_Identity=44.1919191919192, Blast_Score=335, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI25147385, Length=386, Percent_Identity=43.5233160621762, Blast_Score=301, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=38.9312977099237, Blast_Score=255, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI17551802, Length=423, Percent_Identity=35.6973995271868, Blast_Score=214, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=33.6734693877551, Blast_Score=189, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6325229, Length=401, Percent_Identity=44.6384039900249, Blast_Score=300, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6322031, Length=390, Percent_Identity=37.6923076923077, Blast_Score=227, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24655093, Length=388, Percent_Identity=56.9587628865979, Blast_Score=463, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24640423, Length=392, Percent_Identity=45.4081632653061, Blast_Score=318, Evalue=4e-87,
Organism=Drosophila melanogaster, GI17648125, Length=396, Percent_Identity=42.1717171717172, Blast_Score=291, Evalue=7e-79,
Organism=Drosophila melanogaster, GI17137578, Length=430, Percent_Identity=34.8837209302326, Blast_Score=216, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40911; Mature: 40780

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGSEEIVIVGAARTPVGSFGGAFGAVPAHELGATAIKAALERAKVSPDEVDEVIFGQVL
CCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TAGAGQNPARQAAIKAGIPEKATAWGLNQVCGSGLRTVAIGMQQIANGDAKVIVAGGQES
HCCCCCCHHHHHHHHCCCCCHHHHCCHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCC
MSLSPHAQYLRGGQKMGDVKLVDTMIKDGLWDAFNGYHMGQTAENVAQAFQLTREQQDQF
CCCCHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
ATRSQNKAEAARKEGRFKDEIVPVTVPGKKGDTVVDTDEYIRDGATIEAMAKLKPAFTKD
HHHCCHHHHHHHHCCCCCCCEEEEEECCCCCCEEECCHHHHHCCCHHHHHHHHCCCCCCC
GTVTAANASGLNDGAAALVLMSASEAERRGLTPLARIKSWATAGVDPKVMGTGPIPASRK
CEEEECCCCCCCCCCEEEEEEECCHHHHCCCCHHHHHHHHHHCCCCCCEEECCCCCHHHH
ALEKAGWKPSDLDLIEANEAFAAQALAVNKDMGWDDAKVNVNGGAIAIGHPIGASGARVL
HHHHCCCCCCCCCEEECCHHHHHHHHEECCCCCCCCCEEEECCCEEEECCCCCCCHHHHH
VTLLHEMKRRDAKKGLATLCIGGGMGVAMCVERT
HHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECC
>Mature Secondary Structure 
AGSEEIVIVGAARTPVGSFGGAFGAVPAHELGATAIKAALERAKVSPDEVDEVIFGQVL
CCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TAGAGQNPARQAAIKAGIPEKATAWGLNQVCGSGLRTVAIGMQQIANGDAKVIVAGGQES
HCCCCCCHHHHHHHHCCCCCHHHHCCHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCC
MSLSPHAQYLRGGQKMGDVKLVDTMIKDGLWDAFNGYHMGQTAENVAQAFQLTREQQDQF
CCCCHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
ATRSQNKAEAARKEGRFKDEIVPVTVPGKKGDTVVDTDEYIRDGATIEAMAKLKPAFTKD
HHHCCHHHHHHHHCCCCCCCEEEEEECCCCCCEEECCHHHHHCCCHHHHHHHHCCCCCCC
GTVTAANASGLNDGAAALVLMSASEAERRGLTPLARIKSWATAGVDPKVMGTGPIPASRK
CEEEECCCCCCCCCCEEEEEEECCHHHHCCCCHHHHHHHHHHCCCCCCEEECCCCCHHHH
ALEKAGWKPSDLDLIEANEAFAAQALAVNKDMGWDDAKVNVNGGAIAIGHPIGASGARVL
HHHHCCCCCCCCCEEECCHHHHHHHHEECCCCCCCCCEEEECCCEEEECCCCCCCHHHHH
VTLLHEMKRRDAKKGLATLCIGGGMGVAMCVERT
HHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2878929; 2670935; 1673680; 10764581; 10545327; 12501183 [H]